Aliases for ARPP19 Gene
External Ids for ARPP19 Gene
Previous GeneCards Identifiers for ARPP19 Gene
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
GeneCards Summary for ARPP19 Gene
ARPP19 (CAMP Regulated Phosphoprotein 19) is a Protein Coding gene. Among its related pathways are DNA Damage and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein phosphatase inhibitor activity. An important paralog of this gene is ENSA.
UniProtKB/Swiss-Prot Summary for ARPP19 Gene
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.