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Aliases for ARPIN Gene

Aliases for ARPIN Gene

  • Actin Related Protein 2/3 Complex Inhibitor 2 3 5
  • Arp2/3 Inhibition Protein 3 4
  • C15orf38 3 4
  • Actin-Related Protein 2/3 Complex Inhibitor 2
  • Chromosome 15 Open Reading Frame 38 2
  • UPF0552 Protein C15orf38 3
  • Arpin 3

External Ids for ARPIN Gene

Previous HGNC Symbols for ARPIN Gene

  • C15orf38

Summaries for ARPIN Gene

GeneCards Summary for ARPIN Gene

ARPIN (Actin Related Protein 2/3 Complex Inhibitor) is a Protein Coding gene. An important paralog of this gene is C15orf38-AP3S2.

UniProtKB/Swiss-Prot for ARPIN Gene

  • Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Additional gene information for ARPIN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPIN Gene

Genomics for ARPIN Gene

GeneHancer (GH) Regulatory Elements for ARPIN Gene

Promoters and enhancers for ARPIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J089910 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 707.4 +0.5 477 3.9 HDGF FOXA2 SREBF2 ZSCAN4 ARID4B SIN3A ZNF2 ZNF48 YY1 ZNF335 ARPIN C15orf38-AP3S2 POLG LOC100631255 GC15P089898
GH15J089898 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 652.4 +13.7 13699 1.4 CTCF RB1 FEZF1 RAD21 RFX5 CC2D1A ZNF121 ZFHX2 ARID2 EED ARPIN GC15P089898 RNU7-111P AP3S2 ANPEP C15orf38-AP3S2
GH15J089900 Promoter 0.6 EPDnew 650.4 +12.9 12882 0.1 ZMYM3 ARPIN GC15P089898 C15orf38-AP3S2
GH15J089892 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 21.3 +19.1 19083 2.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 AP3S2 POLG ENSG00000259314 LOC100631255 FANCI ENSG00000259212 KIF7 ARPIN RPL36AP43 WDR93
GH15J089383 Enhancer 1.1 ENCODE dbSUPER 36.1 +529.3 529285 0.9 SMAD1 FEZF1 ZNF2 YY1 GLIS2 ZNF213 YY2 ZNF662 TSHZ1 ZNF491 RPL36AP43 ENSG00000173867 ARPIN NIFKP5 POLG DET1 ENSG00000228998 MIR9-3HG GC15P089381 PIR56199
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARPIN Gene

Genomic Locations for ARPIN Gene
chr15:89,895,006-89,912,990
(GRCh38/hg38)
Size:
17,985 bases
Orientation:
Minus strand
chr15:90,443,159-90,456,222
(GRCh37/hg19)
Size:
13,064 bases
Orientation:
Minus strand

Genomic View for ARPIN Gene

Genes around ARPIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPIN Gene

Proteins for ARPIN Gene

  • Protein details for ARPIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K5-ARPIN_HUMAN
    Recommended name:
    Arpin
    Protein Accession:
    Q7Z6K5
    Secondary Accessions:
    • E2QRD5

    Protein attributes for ARPIN Gene

    Size:
    226 amino acids
    Molecular mass:
    24943 Da
    Quaternary structure:
    • Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.

    Three dimensional structures from OCA and Proteopedia for ARPIN Gene

    Alternative splice isoforms for ARPIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPIN Gene

Post-translational modifications for ARPIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARPIN Gene

No data available for DME Specific Peptides for ARPIN Gene

Domains & Families for ARPIN Gene

Gene Families for ARPIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARPIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARPIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6K5

UniProtKB/Swiss-Prot:

ARPIN_HUMAN :
  • The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.
  • Belongs to the Arpin family.
Domain:
  • The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.
Family:
  • Belongs to the Arpin family.
genes like me logo Genes that share domains with ARPIN: view

Function for ARPIN Gene

Molecular function for ARPIN Gene

UniProtKB/Swiss-Prot Function:
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Gene Ontology (GO) - Molecular Function for ARPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARPIN: view
genes like me logo Genes that share phenotypes with ARPIN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPIN

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPIN Gene

Localization for ARPIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPIN Gene

Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamelliupodium tip. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ARPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030027 lamellipodium ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARPIN: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ARPIN Gene

Pathways & Interactions for ARPIN Gene

SuperPathways for ARPIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030336 negative regulation of cell migration IMP 24132237
GO:0033058 directional locomotion IMP 24132237
GO:0051126 negative regulation of actin nucleation IEA,IDA 24132237
GO:2000393 negative regulation of lamellipodium morphogenesis IMP 24132237
genes like me logo Genes that share ontologies with ARPIN: view

No data available for Pathways by source and SIGNOR curated interactions for ARPIN Gene

Drugs & Compounds for ARPIN Gene

No Compound Related Data Available

Transcripts for ARPIN Gene

mRNA/cDNA for ARPIN Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPIN

Alternative Splicing Database (ASD) splice patterns (SP) for ARPIN Gene

No ASD Table

Relevant External Links for ARPIN Gene

GeneLoc Exon Structure for
ARPIN
ECgene alternative splicing isoforms for
ARPIN

Expression for ARPIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPIN Gene

Protein differential expression in normal tissues from HIPED for ARPIN Gene

This gene is overexpressed in Uterus (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARPIN Gene



Protein tissue co-expression partners for ARPIN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPIN Gene:

ARPIN

Evidence on tissue expression from TISSUES for ARPIN Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ARPIN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPIN Gene

Orthologs for ARPIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARPIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100170757 33
  • 98.97 (n)
AP3S2 34
  • 56 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C21H15orf38 34
  • 91 (a)
OneToMany
ARPIN 33
  • 88.35 (n)
dog
(Canis familiaris)
Mammalia C3H15orf38 34 33
  • 87.76 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1311021 33
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia 2610034B18Rik 34 33
  • 84.51 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf38 33
  • 62.96 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:112432 33
  • 59.29 (n)
C18H15orf38 34
  • 59 (a)
OneToMany
Dr.15865 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2502 33
Species where no ortholog for ARPIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPIN Gene

ENSEMBL:
Gene Tree for ARPIN (if available)
TreeFam:
Gene Tree for ARPIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPIN: view image

Paralogs for ARPIN Gene

Paralogs for ARPIN Gene

(2) SIMAP similar genes for ARPIN Gene using alignment to 1 proteins:

  • ARPIN_HUMAN
genes like me logo Genes that share paralogs with ARPIN: view

Variants for ARPIN Gene

Sequence variations from dbSNP and Humsavar for ARPIN Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000183807 -- 89,908,099(-) G/T intron_variant
rs1000280472 -- 89,897,341(-) C/T 3_prime_UTR_variant
rs1000583711 -- 89,914,209(-) G/A upstream_transcript_variant
rs1000699869 -- 89,896,929(-) T/C 3_prime_UTR_variant
rs1000884036 -- 89,898,167(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ARPIN Gene

Variant ID Type Subtype PubMed ID
esv3637206 CNV loss 21293372
nsv570389 CNV loss 21841781

Variation tolerance for ARPIN Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPIN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPIN Gene

Disorders for ARPIN Gene

Additional Disease Information for ARPIN

No disorders were found for ARPIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPIN Gene

Publications for ARPIN Gene

  1. Inhibitory signalling to the Arp2/3 complex steers cell migration. (PMID: 24132237) Dang I … Gautreau A (Nature 2013) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Restoration of Arpin suppresses aggressive phenotype of breast cancer cells. (PMID: 28531800) Li Y … Zhang X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58

Products for ARPIN Gene

Sources for ARPIN Gene

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