Aliases for ARPC5L Gene

Aliases for ARPC5L Gene

  • Actin Related Protein 2/3 Complex Subunit 5 Like 2 3 5
  • ARC16-2 2 3 4
  • Actin-Related Protein 2/3 Complex Subunit 5-Like Protein 3 4
  • Arp2/3 Complex 16 KDa Subunit 2 3 4
  • Actin Related Protein 2/3 Complex Subunit 5-Like 2
  • Epididymis Secretory Sperm Binding Protein 3
  • MGC3038 2
  • ARPC5L 5

External Ids for ARPC5L Gene

Previous GeneCards Identifiers for ARPC5L Gene

  • GC09P123007
  • GC09P124703
  • GC09P126664
  • GC09P127624
  • GC09P097243

Summaries for ARPC5L Gene

GeneCards Summary for ARPC5L Gene

ARPC5L (Actin Related Protein 2/3 Complex Subunit 5 Like) is a Protein Coding gene. Diseases associated with ARPC5L include Kleptomania and Leopard Syndrome 1. Among its related pathways are Yersinia infection and Shigellosis. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is ARPC5.

UniProtKB/Swiss-Prot Summary for ARPC5L Gene

  • May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARPC5L Gene

Genomics for ARPC5L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARPC5L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC5L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARPC5L

Top Transcription factor binding sites by QIAGEN in the ARPC5L gene promoter:
  • AML1a
  • c-Ets-1
  • C/EBPalpha
  • GATA-2
  • Pax-2
  • Pax-2a
  • Pax-2b
  • PPAR-gamma1
  • PPAR-gamma2
  • ZID

Genomic Locations for ARPC5L Gene

Latest Assembly
chr9:124,862,130-124,877,733
(GRCh38/hg38)
Size:
15,604 bases
Orientation:
Plus strand

Previous Assembly
chr9:127,624,409-127,640,012
(GRCh37/hg19 by Entrez Gene)
Size:
15,604 bases
Orientation:
Plus strand

chr9:127,624,409-127,640,003
(GRCh37/hg19 by Ensembl)
Size:
15,595 bases
Orientation:
Plus strand

Genomic View for ARPC5L Gene

Genes around ARPC5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5L Gene

Proteins for ARPC5L Gene

  • Protein details for ARPC5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX5-ARP5L_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5-like protein
    Protein Accession:
    Q9BPX5
    Secondary Accessions:
    • Q7Z523

    Protein attributes for ARPC5L Gene

    Size:
    153 amino acids
    Molecular mass:
    16941 Da
    Quaternary structure:
    • May be a component of the Arp2/3 complex in which it may replace ARPC5.

    Three dimensional structures from OCA and Proteopedia for ARPC5L Gene

neXtProt entry for ARPC5L Gene

Post-translational modifications for ARPC5L Gene

  • Ubiquitination at Lys69, Lys83, and Lys89
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC5L Gene

No data available for DME Specific Peptides for ARPC5L Gene

Domains & Families for ARPC5L Gene

Gene Families for ARPC5L Gene

Protein Domains for ARPC5L Gene

InterPro:
Blocks:
  • ARP2/3 complex 16 kDa subunit (p16-Arc)
ProtoNet:

Suggested Antigen Peptide Sequences for ARPC5L Gene

GenScript: Design optimal peptide antigens:
  • Arp2/3 complex 16 kDa subunit 2 (ARP5L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BPX5

UniProtKB/Swiss-Prot:

ARP5L_HUMAN :
  • Belongs to the ARPC5 family.
Family:
  • Belongs to the ARPC5 family.
genes like me logo Genes that share domains with ARPC5L: view

Function for ARPC5L Gene

Molecular function for ARPC5L Gene

UniProtKB/Swiss-Prot Function:
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Phenotypes From GWAS Catalog for ARPC5L Gene

Gene Ontology (GO) - Molecular Function for ARPC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16169070
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with ARPC5L: view
genes like me logo Genes that share phenotypes with ARPC5L: view

Animal Models for ARPC5L Gene

MGI Knock Outs for ARPC5L:
  • Arpc5l Arpc5l<tm1.1(KOMP)Vlcg>

miRNA for ARPC5L Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC5L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC5L Gene

Localization for ARPC5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5L Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC5L gene
Compartment Confidence
extracellular 4
cytoskeleton 4
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARPC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IBA 21873635
GO:0005925 focal adhesion HDA 21423176
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC5L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARPC5L Gene

Pathways & Interactions for ARPC5L Gene

genes like me logo Genes that share pathways with ARPC5L: view

Pathways by source for ARPC5L Gene

Gene Ontology (GO) - Biological Process for ARPC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016477 cell migration IBA 21873635
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IBA 21873635
genes like me logo Genes that share ontologies with ARPC5L: view

No data available for SIGNOR curated interactions for ARPC5L Gene

Drugs & Compounds for ARPC5L Gene

No Compound Related Data Available

Transcripts for ARPC5L Gene

mRNA/cDNA for ARPC5L Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC5L

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - - - - - - -
SP4:
SP5:
SP6:

Relevant External Links for ARPC5L Gene

GeneLoc Exon Structure for
ARPC5L

Expression for ARPC5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPC5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for ARPC5L Gene

This gene is overexpressed in Tlymphocyte (11.3) and NK cells (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC5L Gene



Protein tissue co-expression partners for ARPC5L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARPC5L

SOURCE GeneReport for Unigene cluster for ARPC5L Gene:

Hs.132499

Evidence on tissue expression from TISSUES for ARPC5L Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with ARPC5L: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC5L Gene

Orthologs for ARPC5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC5L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC739553 30
  • 100 (n)
ARPC5L 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ARPC5L 30 31
  • 95.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ARPC5L 30 31
  • 93.9 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5L 31
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arpc5l 30
  • 92.59 (n)
Mouse
(Mus musculus)
Mammalia Arpc5l 30 17 31
  • 91.72 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ARPC5L 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ARPC5L 31
  • 77 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARPC5L 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arpc5l 30
  • 74.34 (n)
Zebrafish
(Danio rerio)
Actinopterygii arpc5la 30 31
  • 74 (n)
OneToMany
arpc5lb 31
  • 72 (a)
OneToMany
zgc65881 30
Fruit Fly
(Drosophila melanogaster)
Insecta p16-ARC 31
  • 46 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea arx-7 31
  • 38 (a)
ManyToMany
C46H11.3 31
  • 32 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC15 33 33
Species where no ortholog for ARPC5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARPC5L Gene

ENSEMBL:
Gene Tree for ARPC5L (if available)
TreeFam:
Gene Tree for ARPC5L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC5L: view image

Paralogs for ARPC5L Gene

Paralogs for ARPC5L Gene

(1) SIMAP similar genes for ARPC5L Gene using alignment to 1 proteins:

  • ARP5L_HUMAN
genes like me logo Genes that share paralogs with ARPC5L: view

Variants for ARPC5L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARPC5L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for ARPC5L Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC5L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ARPC5L Gene

Disorders for ARPC5L Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARPC5L Gene - From: COP

Disorder Aliases PubMed IDs
kleptomania
  • pathological stealing
leopard syndrome 1
  • lprd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARPC5L

genes like me logo Genes that share disorders with ARPC5L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC5L Gene

Publications for ARPC5L Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3

Products for ARPC5L Gene

Sources for ARPC5L Gene