This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms h... See more...

Aliases for ARPC5 Gene

Aliases for ARPC5 Gene

  • Actin Related Protein 2/3 Complex Subunit 5 2 3 5
  • ARC16 2 3 4
  • Actin-Related Protein 2/3 Complex Subunit 5 3 4
  • Arp2/3 Protein Complex Subunit P16 2 3
  • Arp2/3 Complex 16 KDa Subunit 3 4
  • DJ127C7.3 2 3
  • P16-Arc 2 3
  • Actin Related Protein 2/3 Complex, Subunit 5 (16 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 5, 16kDa 3
  • Actin Related Protein 2/3 Complex Subunit 5, 16kDa 2
  • P16-ARC 4
  • ARPC5 5

External Ids for ARPC5 Gene

Previous GeneCards Identifiers for ARPC5 Gene

  • GC01M181121
  • GC01M179023
  • GC01M180112
  • GC01M180834
  • GC01M180326
  • GC01M181859
  • GC01M183592
  • GC01M154832

Summaries for ARPC5 Gene

Entrez Gene Summary for ARPC5 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARPC5 Gene

ARPC5 (Actin Related Protein 2/3 Complex Subunit 5) is a Protein Coding gene. Diseases associated with ARPC5 include Myasthenic Syndrome, Congenital, 4C, Associated With Acetylcholine Receptor Deficiency. Among its related pathways are Signaling by GPCR and Immune response CCR3 signaling in eosinophils. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.

UniProtKB/Swiss-Prot Summary for ARPC5 Gene

  • Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Gene Wiki entry for ARPC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARPC5 Gene

Genomics for ARPC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARPC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J183630 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 269.7 +1.8 1782 6.8 SP1 ZNF207 IKZF1 MYC ZNF600 SSRP1 JUND ZNF580 POLR2A CEBPA ARPC5 HSALNG0008981 RGL1 lnc-APOBEC4-3 NCF2 LAMC1 MN308837
GH01J183602 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 30.2 +30.7 30677 4.9 SP1 ZNF207 JUND ATF2 YY1 BCL11A CTCF ZNF592 TRIM22 FOXA2 NCF2 ARPC5 LAMC1 RGL1 APOBEC4 SMG7 LOC107985235 HSALNG0008978 MN296899
GH01J183586 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 +46.3 46314 4.1 BCLAF1 SP1 ZNF207 POLR2A BCL11A CTCF SIN3A TARDBP TRIM22 SMC3 NCF2 LOC100526839 MN296899 ARPC5 APOBEC4 SMG7-AS1 SMG7 NONHSAG003690.2
GH01J183651 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 17.2 -18.0 -18017 4.8 IKZF1 ZNF654 YY1 CTCF REST TRIM22 ZNF217 RAD21 RFX5 SMC3 APOBEC4 lnc-APOBEC4-2 ARPC5 RGL1 piR-38344-005 COLGALT2
GH01J183619 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.5 +14.5 14482 5 ZNF654 POLR2A JUND CTCF REST CEBPB DEK TRIM22 MAX EP300 lnc-ARPC5-1 ARPC5 piR-30444-017 ENSG00000286966 NCF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARPC5

Top Transcription factor binding sites by QIAGEN in the ARPC5 gene promoter:
  • AhR
  • AML1a
  • Arnt
  • C/EBPalpha
  • Cdc5
  • Ik-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • Sox5

Genomic Locations for ARPC5 Gene

Latest Assembly
chr1:183,620,846-183,635,783
(GRCh38/hg38)
Size:
14,938 bases
Orientation:
Minus strand

Previous Assembly
chr1:183,589,981-183,604,918
(GRCh37/hg19 by Entrez Gene)
Size:
14,938 bases
Orientation:
Minus strand

chr1:183,592,401-183,604,892
(GRCh37/hg19 by Ensembl)
Size:
12,492 bases
Orientation:
Minus strand

Genomic View for ARPC5 Gene

Genes around ARPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5 Gene

Proteins for ARPC5 Gene

  • Protein details for ARPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15511-ARPC5_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5
    Protein Accession:
    O15511
    Secondary Accessions:
    • A6NEC4
    • Q6PG42

    Protein attributes for ARPC5 Gene

    Size:
    151 amino acids
    Molecular mass:
    16320 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Three dimensional structures from OCA and Proteopedia for ARPC5 Gene

    Alternative splice isoforms for ARPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC5 Gene

Post-translational modifications for ARPC5 Gene

  • Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.
  • Ubiquitination at Lys3, Lys60, Lys67, Lys100, Lys112, and Lys131
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC5 Gene

No data available for DME Specific Peptides for ARPC5 Gene

Domains & Families for ARPC5 Gene

Gene Families for ARPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARPC5 Gene

InterPro:
Blocks:
  • ARP2/3 complex 16 kDa subunit (p16-Arc)

Suggested Antigen Peptide Sequences for ARPC5 Gene

GenScript: Design optimal peptide antigens:
  • Arp2/3 complex 16 kDa subunit (ARPC5_HUMAN)
  • Actin-related protein 2/3 complex subunit 5 (B1ALC0_HUMAN)
  • ARPC5 protein (Q6IPM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15511

UniProtKB/Swiss-Prot:

ARPC5_HUMAN :
  • Belongs to the ARPC5 family.
Family:
  • Belongs to the ARPC5 family.
genes like me logo Genes that share domains with ARPC5: view

Function for ARPC5 Gene

Molecular function for ARPC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Phenotypes From GWAS Catalog for ARPC5 Gene

Gene Ontology (GO) - Molecular Function for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC5: view
genes like me logo Genes that share phenotypes with ARPC5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPC5 Gene

Localization for ARPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5 Gene

Cytoplasm, cytoskeleton. Cell projection. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 4
endosome 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARPC5: view

Pathways & Interactions for ARPC5 Gene

PathCards logo

SuperPathways for ARPC5 Gene

SuperPathway Contained pathways
1 G-protein signaling RAC1 in cellular process
.37
.37
2 EPH-Ephrin signaling
.35
3 Regulation of actin dynamics for phagocytic cup formation
4 Innate Immune System
5 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.37
genes like me logo Genes that share pathways with ARPC5: view

Pathways by source for ARPC5 Gene

14 GeneGo (Thomson Reuters) pathways for ARPC5 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling
1 Qiagen pathway for ARPC5 Gene
  • Salmonella Infection

SIGNOR curated interactions for ARPC5 Gene

Other effect:

Gene Ontology (GO) - Biological Process for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014909 smooth muscle cell migration IEA --
GO:0016477 cell migration IMP 22378351
GO:0021769 orbitofrontal cortex development IEA --
GO:0030011 maintenance of cell polarity IEA --
GO:0030036 actin cytoskeleton organization TAS 9359840
genes like me logo Genes that share ontologies with ARPC5: view

Drugs & Compounds for ARPC5 Gene

(2) Drugs for ARPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC5: view

Transcripts for ARPC5 Gene

mRNA/cDNA for ARPC5 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC5

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ARPC5 Gene

GeneLoc Exon Structure for
ARPC5

Expression for ARPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC5 Gene

This gene is overexpressed in Whole Blood (x9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC5 Gene



Protein tissue co-expression partners for ARPC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARPC5

SOURCE GeneReport for Unigene cluster for ARPC5 Gene:

Hs.518609

Evidence on tissue expression from TISSUES for ARPC5 Gene

  • Nervous system(4.8)
  • Blood(4.7)
  • Skin(4.6)
  • Liver(4.4)
  • Intestine(3.8)
  • Lung(3.5)
  • Kidney(2.8)
  • Lymph node(2.6)
  • Spleen(2.5)
  • Muscle(2.2)
  • Heart(2.2)
  • Thyroid gland(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with ARPC5: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC5 Gene

Orthologs for ARPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPC5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARPC5 29 30
  • 100 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ARPC5 29 30
  • 93.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arpc5 29
  • 92.94 (n)
Dog
(Canis familiaris)
Mammalia ARPC5 29 30
  • 92.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Arpc5 29 16 30
  • 91.83 (n)
OneToMany
Gm16372 30
  • 89 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ARPC5 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ARPC5 29 30
  • 82.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 94 (a)
OneToMany
-- 30
  • 94 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arpc5 29
  • 75.78 (n)
Str.319 29
Zebrafish
(Danio rerio)
Actinopterygii arpc5b 30
  • 81 (a)
OneToMany
arpc5a 29 30
  • 74.67 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2688 29
Fruit Fly
(Drosophila melanogaster)
Insecta Arpc5 29
  • 58.85 (n)
p16-ARC 30 31
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008895 29
  • 33.33 (n)
Worm
(Caenorhabditis elegans)
Secernentea arx-7 29 30
  • 50 (n)
ManyToMany
C46H11.3 30
  • 36 (a)
ManyToMany
Species where no ortholog for ARPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARPC5 Gene

ENSEMBL:
Gene Tree for ARPC5 (if available)
TreeFam:
Gene Tree for ARPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC5: view image
Alliance of Genome Resources:
Additional Orthologs for ARPC5

Paralogs for ARPC5 Gene

Paralogs for ARPC5 Gene

(1) SIMAP similar genes for ARPC5 Gene using alignment to 3 proteins:

  • ARPC5_HUMAN
  • B1ALC0_HUMAN
  • Q6IPM3_HUMAN
genes like me logo Genes that share paralogs with ARPC5: view

Variants for ARPC5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARPC5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for ARPC5 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC5
Leiden Open Variation Database (LOVD)
ARPC5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ARPC5 Gene

Disorders for ARPC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARPC5 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search ARPC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARPC5

genes like me logo Genes that share disorders with ARPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC5 Gene

Publications for ARPC5 Gene

  1. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky LM … Segal AW (The Biochemical journal 1997) 2 3 4
  2. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4

Products for ARPC5 Gene

Sources for ARPC5 Gene