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Aliases for ARPC5 Gene

Aliases for ARPC5 Gene

  • Actin Related Protein 2/3 Complex Subunit 5 2 3 5
  • Arp2/3 Protein Complex Subunit P16 2 3
  • Arp2/3 Complex 16 KDa Subunit 3 4
  • ARC16 3 4
  • Actin Related Protein 2/3 Complex, Subunit 5 (16 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 5, 16kDa 3
  • Actin Related Protein 2/3 Complex Subunit 5, 16kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 5 3
  • DJ127C7.3 3
  • P16-Arc 3
  • P16-ARC 4

External Ids for ARPC5 Gene

Previous GeneCards Identifiers for ARPC5 Gene

  • GC01M181121
  • GC01M179023
  • GC01M180112
  • GC01M180834
  • GC01M180326
  • GC01M181859
  • GC01M154832

Summaries for ARPC5 Gene

Entrez Gene Summary for ARPC5 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARPC5 Gene

ARPC5 (Actin Related Protein 2/3 Complex Subunit 5) is a Protein Coding gene. Diseases associated with ARPC5 include Lung Squamous Cell Carcinoma. Among its related pathways are Developmental Biology and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.

UniProtKB/Swiss-Prot for ARPC5 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC5 Gene

Additional gene information for ARPC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC5 Gene

Genomics for ARPC5 Gene

GeneHancer (GH) Regulatory Elements for ARPC5 Gene

Promoters and enhancers for ARPC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J183632 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 669.8 +1.2 1240 4.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ARPC5 GC01M183630 RGL1 NCF2 DHX9
GH01J183602 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 30.2 +29.2 29240 8.2 HDGF PKNOX1 ATF1 FOXA2 SMAD1 ZNF133 YBX1 IRF4 YY1 ZNF207 NCF2 ARPC5 RGL1 APOBEC4 SMG7 GC01M183620
GH01J183588 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 +45.8 45806 2.8 HDGF PKNOX1 FOXA2 SMAD1 RB1 STAT5A BMI1 BATF KLF5 IRF4 NCF2 ARPC5 SMG7-AS1 SMG7 LOC100526839
GH01J183651 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 17.2 -17.0 -17023 2.8 PKNOX1 BMI1 RELA GATA3 EED ATF7 ETV6 IKZF2 RUNX3 SMARCA5 APOBEC4 ARPC5 RGL1
GH01J183622 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.4 +12.9 12875 1.3 ARID4B STAT5A RAD21 RFX5 ARID2 SCRT2 ZNF143 RUNX3 DEK ZNF654 GC01M183620 ARPC5 GC01M183630
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARPC5 gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • Ik-1
  • Cdc5
  • AML1a
  • Sox5
  • NF-AT
  • NF-AT1
  • NF-AT2

Genomic Locations for ARPC5 Gene

Genomic Locations for ARPC5 Gene
chr1:183,620,846-183,635,941
(GRCh38/hg38)
Size:
15,096 bases
Orientation:
Minus strand
chr1:183,592,401-183,604,985
(GRCh37/hg19)
Size:
12,585 bases
Orientation:
Minus strand

Genomic View for ARPC5 Gene

Genes around ARPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5 Gene

Proteins for ARPC5 Gene

  • Protein details for ARPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15511-ARPC5_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5
    Protein Accession:
    O15511
    Secondary Accessions:
    • A6NEC4
    • Q6PG42

    Protein attributes for ARPC5 Gene

    Size:
    151 amino acids
    Molecular mass:
    16320 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Alternative splice isoforms for ARPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC5 Gene

Post-translational modifications for ARPC5 Gene

  • Polyubiquitinated by RNF128 with Lys-63-linked chains, leading to proteasomal degradation.
  • Ubiquitination at posLast=131131, posLast=112112, posLast=108108, posLast=100100, Lys67, posLast=6060, and posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC5 Gene

No data available for DME Specific Peptides for ARPC5 Gene

Domains & Families for ARPC5 Gene

Gene Families for ARPC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARPC5 Gene

Suggested Antigen Peptide Sequences for ARPC5 Gene

Graphical View of Domain Structure for InterPro Entry

O15511

UniProtKB/Swiss-Prot:

ARPC5_HUMAN :
  • Belongs to the ARPC5 family.
Family:
  • Belongs to the ARPC5 family.
genes like me logo Genes that share domains with ARPC5: view

Function for ARPC5 Gene

Molecular function for ARPC5 Gene

UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Phenotypes From GWAS Catalog for ARPC5 Gene

Gene Ontology (GO) - Molecular Function for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC5: view
genes like me logo Genes that share phenotypes with ARPC5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPC5 Gene

Localization for ARPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
endosome 2
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm TAS 9359840
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC5: view

Pathways & Interactions for ARPC5 Gene

genes like me logo Genes that share pathways with ARPC5: view

Gene Ontology (GO) - Biological Process for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014909 smooth muscle cell migration IEA --
GO:0016477 cell migration IMP 22378351
GO:0021769 orbitofrontal cortex development IEA --
GO:0030011 maintenance of cell polarity IEA --
GO:0030036 actin cytoskeleton organization TAS 9359840
genes like me logo Genes that share ontologies with ARPC5: view

No data available for SIGNOR curated interactions for ARPC5 Gene

Drugs & Compounds for ARPC5 Gene

(2) Drugs for ARPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC5: view

Transcripts for ARPC5 Gene

mRNA/cDNA for ARPC5 Gene

Unigene Clusters for ARPC5 Gene

Actin related protein 2/3 complex, subunit 5, 16kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ARPC5 Gene

GeneLoc Exon Structure for
ARPC5
ECgene alternative splicing isoforms for
ARPC5

Expression for ARPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC5 Gene

This gene is overexpressed in Whole Blood (x9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC5 Gene



Protein tissue co-expression partners for ARPC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC5 Gene:

ARPC5

SOURCE GeneReport for Unigene cluster for ARPC5 Gene:

Hs.518609

Evidence on tissue expression from TISSUES for ARPC5 Gene

  • Nervous system(4.8)
  • Blood(4.7)
  • Liver(4.4)
  • Skin(4.4)
  • Intestine(3.5)
  • Lung(3.3)
  • Kidney(2.4)
  • Gall bladder(2.2)
  • Lymph node(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with ARPC5: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC5 Gene

Orthologs for ARPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC5 34 33
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC5 34 33
  • 93.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc5 33
  • 92.94 (n)
dog
(Canis familiaris)
Mammalia ARPC5 34 33
  • 92.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc5 16 34 33
  • 91.83 (n)
Gm16372 34
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARPC5 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC5 34 33
  • 82.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
OneToMany
-- 34
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc5 33
  • 75.78 (n)
Str.319 33
zebrafish
(Danio rerio)
Actinopterygii arpc5b 34
  • 81 (a)
OneToMany
arpc5a 34 33
  • 74.67 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2688 33
fruit fly
(Drosophila melanogaster)
Insecta Arpc5 33
  • 58.85 (n)
p16-ARC 34 35
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008895 33
  • 33.33 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-7 34 33
  • 50 (n)
ManyToMany
C46H11.3 34
  • 36 (a)
ManyToMany
Species where no ortholog for ARPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC5 Gene

ENSEMBL:
Gene Tree for ARPC5 (if available)
TreeFam:
Gene Tree for ARPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC5: view image

Paralogs for ARPC5 Gene

Paralogs for ARPC5 Gene

(1) SIMAP similar genes for ARPC5 Gene using alignment to 3 proteins:

  • ARPC5_HUMAN
  • B1ALC0_HUMAN
  • Q6IPM3_HUMAN
genes like me logo Genes that share paralogs with ARPC5: view

Variants for ARPC5 Gene

Sequence variations from dbSNP and Humsavar for ARPC5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000194118 -- 183,634,762(-) C/G intron_variant
rs1000349050 -- 183,628,335(-) TTTTTTTT/TTTTTTTTT intron_variant
rs1000356554 -- 183,632,926(-) T/C intron_variant
rs1000691769 -- 183,634,980(-) C/T intron_variant
rs1000899543 -- 183,632,072(-) G/T intron_variant

Variation tolerance for ARPC5 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARPC5 Gene

Disorders for ARPC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARPC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search ARPC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARPC5

genes like me logo Genes that share disorders with ARPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC5 Gene

Publications for ARPC5 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4 58
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky LM … Segal AW (The Biochemical journal 1997) 2 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (PMID: 12451597) Millard TH … Machesky LM (Cell motility and the cytoskeleton 2003) 3 22 58

Products for ARPC5 Gene

Sources for ARPC5 Gene

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