Aliases for ARPC5 Gene
External Ids for ARPC5 Gene
Previous GeneCards Identifiers for ARPC5 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for ARPC5 Gene
ARPC5 (Actin Related Protein 2/3 Complex Subunit 5) is a Protein Coding gene. Diseases associated with ARPC5 include Myasthenic Syndrome, Congenital, 4C, Associated With Acetylcholine Receptor Deficiency. Among its related pathways are Signaling by GPCR and Immune response CCR3 signaling in eosinophils. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.
UniProtKB/Swiss-Prot Summary for ARPC5 Gene
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).