Aliases for ARPC5 Gene
External Ids for ARPC5 Gene
Previous GeneCards Identifiers for ARPC5 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for ARPC5 Gene
ARPC5 (Actin Related Protein 2/3 Complex Subunit 5) is a Protein Coding gene. Diseases associated with ARPC5 include Lung Squamous Cell Carcinoma. Among its related pathways are Development Slit-Robo signaling and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.
UniProtKB/Swiss-Prot for ARPC5 Gene
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.