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Aliases for ARPC4-TTLL3 Gene

Aliases for ARPC4-TTLL3 Gene

  • ARPC4-TTLL3 Readthrough 2 3 5

External Ids for ARPC4-TTLL3 Gene

Previous GeneCards Identifiers for ARPC4-TTLL3 Gene

  • GC03U901686
  • GC03P009838

Summaries for ARPC4-TTLL3 Gene

Entrez Gene Summary for ARPC4-TTLL3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin related protein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARPC4-TTLL3 Gene

ARPC4-TTLL3 (ARPC4-TTLL3 Readthrough) is a Protein Coding gene. An important paralog of this gene is TTLL3.

Additional gene information for ARPC4-TTLL3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC4-TTLL3 Gene

Genomics for ARPC4-TTLL3 Gene

GeneHancer (GH) Regulatory Elements for ARPC4-TTLL3 Gene

Promoters and enhancers for ARPC4-TTLL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I009791 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.1 1055 4.8 HDGF HNRNPUL1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 TADA3 ARPC4 ARPC4-TTLL3 BRPF1 RAD18 SETD5 TTLL3 JAGN1 BRK1 SEC13
GH03I010247 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +456.7 456678 3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000272410 PIR49172 PIR32642 PIR57492 PIR36484 PIR45247 TATDN2 GHRLOS GHRL IRAK2
GH03I009896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.3 +107.7 107660 8.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 YY1 IL17RE GC03P009922 GC03P009923 IL17RC JAGN1 FANCD2 CRELD1 PRRT3-AS1 RPUSD3 PRRT3
GH03I009861 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +71.1 71078 4.9 HDGF PKNOX1 SMAD1 ATF1 ARID4B FEZF1 DMAP1 ZNF48 POLR2B ZNF766 IL17RC JAGN1 CIDEC TADA3 IL17RE FANCD2 ARPC4 RNU6-882P THUMPD3 TTLL3
GH03I009975 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.1 +185.7 185665 4.8 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 PIR57234 FANCD2 TTLL3 BRPF1 THUMPD3-AS1 BRK1 SETD5 PRRT3 CIDECP ENSG00000269894
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARPC4-TTLL3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARPC4-TTLL3 Gene

Genomic Locations for ARPC4-TTLL3 Gene
chr3:9,792,548-9,836,356
(GRCh38/hg38)
Size:
43,809 bases
Orientation:
Plus strand
chr3:9,834,232-9,878,040
(GRCh37/hg19)

Genomic View for ARPC4-TTLL3 Gene

Genes around ARPC4-TTLL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC4-TTLL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC4-TTLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC4-TTLL3 Gene

Proteins for ARPC4-TTLL3 Gene

  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYG9
    Recommended name:
    Protein ARPC4-TTLL3
    Protein Accession:
    A0A0A6YYG9

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    625 amino acids
    Molecular mass:
    71719 Da
    Quaternary structure:
    No Data Available
  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WCF6
    Recommended name:
    Actin-related protein 2/3 complex subunit 4
    Protein Accession:
    F8WCF6

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    181 amino acids
    Molecular mass:
    21059 Da
    Quaternary structure:
    No Data Available
  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WE39
    Recommended name:
    ARPC4-TTLL3 readthrough
    Protein Accession:
    F8WE39

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    47 amino acids
    Molecular mass:
    5236 Da
    Quaternary structure:
    No Data Available
  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H7C0A3
    Recommended name:
    ARPC4-TTLL3 readthrough
    Protein Accession:
    H7C0A3

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    167 amino acids
    Molecular mass:
    19400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARPC4-TTLL3 Gene

Post-translational modifications for ARPC4-TTLL3 Gene

No Post-translational modifications

Other Protein References for ARPC4-TTLL3 Gene

No data available for DME Specific Peptides for ARPC4-TTLL3 Gene

Domains & Families for ARPC4-TTLL3 Gene

Gene Families for ARPC4-TTLL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARPC4-TTLL3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARPC4-TTLL3: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARPC4-TTLL3 Gene

Function for ARPC4-TTLL3 Gene

Gene Ontology (GO) - Molecular Function for ARPC4-TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005524 ATP binding IEA --
GO:0070735 protein-glycine ligase activity IEA --
genes like me logo Genes that share ontologies with ARPC4-TTLL3: view

Phenotypes for ARPC4-TTLL3 Gene

genes like me logo Genes that share phenotypes with ARPC4-TTLL3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARPC4-TTLL3 Gene

Localization for ARPC4-TTLL3 Gene

Gene Ontology (GO) - Cellular Components for ARPC4-TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC4-TTLL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ARPC4-TTLL3 Gene

Pathways & Interactions for ARPC4-TTLL3 Gene

SuperPathways for ARPC4-TTLL3 Gene

No Data Available

Interacting Proteins for ARPC4-TTLL3 Gene

Gene Ontology (GO) - Biological Process for ARPC4-TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0018094 protein polyglycylation IEA --
GO:0030041 actin filament polymerization IEA --
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA --
genes like me logo Genes that share ontologies with ARPC4-TTLL3: view

No data available for Pathways by source and SIGNOR curated interactions for ARPC4-TTLL3 Gene

Drugs & Compounds for ARPC4-TTLL3 Gene

No Compound Related Data Available

Transcripts for ARPC4-TTLL3 Gene

mRNA/cDNA for ARPC4-TTLL3 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC4-TTLL3 Gene

No ASD Table

Relevant External Links for ARPC4-TTLL3 Gene

GeneLoc Exon Structure for
ARPC4-TTLL3
ECgene alternative splicing isoforms for
ARPC4-TTLL3

Expression for ARPC4-TTLL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC4-TTLL3 Gene

Protein differential expression in normal tissues from HIPED for ARPC4-TTLL3 Gene

This gene is overexpressed in NK cells (8.2), Spleen (7.6), and Fetal gut (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for ARPC4-TTLL3 Gene



Protein tissue co-expression partners for ARPC4-TTLL3 Gene

genes like me logo Genes that share expression patterns with ARPC4-TTLL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC4-TTLL3 Gene

Orthologs for ARPC4-TTLL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC4-TTLL3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TTLL3 33
  • 88.68 (n)
-- 34
  • 52 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ttll3 34
  • 46 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ttll3 34
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TTLL3B 34
  • 22 (a)
ManyToMany
TTLL3A 34
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for ARPC4-TTLL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPC4-TTLL3 Gene

ENSEMBL:
Gene Tree for ARPC4-TTLL3 (if available)
TreeFam:
Gene Tree for ARPC4-TTLL3 (if available)

Paralogs for ARPC4-TTLL3 Gene

Paralogs for ARPC4-TTLL3 Gene

(2) SIMAP similar genes for ARPC4-TTLL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARPC4-TTLL3: view

Variants for ARPC4-TTLL3 Gene

Sequence variations from dbSNP and Humsavar for ARPC4-TTLL3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000014508 -- 9,816,365(+) T/C intron_variant
rs1000075445 -- 9,818,378(+) T/G intron_variant
rs1000147122 -- 9,819,896(+) T/C intron_variant
rs1000147499 -- 9,800,462(+) T/A intron_variant
rs1000236905 -- 9,817,821(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC4-TTLL3 Gene

Variant ID Type Subtype PubMed ID
esv3342578 CNV duplication 20981092
esv3595249 CNV gain 21293372
nsv1010768 CNV gain 25217958
nsv237238 CNV deletion 16902084
nsv819644 CNV gain 19587683
nsv834615 CNV loss 17160897

Variation tolerance for ARPC4-TTLL3 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.13; 93.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC4-TTLL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC4-TTLL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC4-TTLL3 Gene

Disorders for ARPC4-TTLL3 Gene

Additional Disease Information for ARPC4-TTLL3

No disorders were found for ARPC4-TTLL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC4-TTLL3 Gene

Publications for ARPC4-TTLL3 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ARPC4-TTLL3 Gene

Sources for ARPC4-TTLL3 Gene

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