Aliases for ARPC3 Gene
External Ids for ARPC3 Gene
Previous GeneCards Identifiers for ARPC3 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
GeneCards Summary for ARPC3 Gene
ARPC3 (Actin Related Protein 2/3 Complex Subunit 3) is a Protein Coding gene. Diseases associated with ARPC3 include Spinocerebellar Ataxia, Autosomal Recessive 4 and Porokeratosis. Among its related pathways are Signaling by GPCR and Immune response CCR3 signaling in eosinophils. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton.
UniProtKB/Swiss-Prot Summary for ARPC3 Gene
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).