Aliases for ARPC3 Gene
External Ids for ARPC3 Gene
Previous GeneCards Identifiers for ARPC3 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
GeneCards Summary for ARPC3 Gene
ARPC3 (Actin Related Protein 2/3 Complex Subunit 3) is a Protein Coding gene. Diseases associated with ARPC3 include Spinocerebellar Ataxia, Autosomal Recessive 4 and Porokeratosis. Among its related pathways are Development Slit-Robo signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton.
UniProtKB/Swiss-Prot Summary for ARPC3 Gene
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).