This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] See more...

Aliases for ARPC3 Gene

Aliases for ARPC3 Gene

  • Actin Related Protein 2/3 Complex Subunit 3 2 3 5
  • ARC21 2 3 4
  • Actin-Related Protein 2/3 Complex Subunit 3 3 4
  • Arp2/3 Complex 21 KDa Subunit 3 4
  • P21-Arc 2 3
  • Actin Related Protein 2/3 Complex, Subunit 3 (21 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 3, 21kDa 3
  • Actin Related Protein 2/3 Complex Subunit 3, 21kDa 2
  • ARP2/3 Protein Complex Subunit P21 3
  • P21-ARC 4
  • ARPC3 5

External Ids for ARPC3 Gene

Previous GeneCards Identifiers for ARPC3 Gene

  • GC12M109896
  • GC12M110668
  • GC12M110714
  • GC12M109284
  • GC12M109335
  • GC12M110872
  • GC12M107890

Summaries for ARPC3 Gene

Entrez Gene Summary for ARPC3 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for ARPC3 Gene

ARPC3 (Actin Related Protein 2/3 Complex Subunit 3) is a Protein Coding gene. Diseases associated with ARPC3 include Spinocerebellar Ataxia, Autosomal Recessive 4 and Porokeratosis. Among its related pathways are Development Slit-Robo signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot Summary for ARPC3 Gene

  • Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Gene Wiki entry for ARPC3 Gene

Additional gene information for ARPC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARPC3 Gene

Genomics for ARPC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARPC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARPC3

Top Transcription factor binding sites by QIAGEN in the ARPC3 gene promoter:
  • AP-2gamma
  • AP-4
  • ATF6
  • c-Ets-1
  • E2F
  • E2F-1
  • GR
  • GR-alpha
  • MRF-2
  • NRSF form 1

Genomic Locations for ARPC3 Gene

Genomic Locations for ARPC3 Gene
chr12:110,434,823-110,450,422
(GRCh38/hg38)
Size:
15,600 bases
Orientation:
Minus strand
chr12:110,872,630-110,888,227
(GRCh37/hg19)
Size:
15,598 bases
Orientation:
Minus strand

Genomic View for ARPC3 Gene

Genes around ARPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC3 Gene

Proteins for ARPC3 Gene

  • Protein details for ARPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15145-ARPC3_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 3
    Protein Accession:
    O15145
    Secondary Accessions:
    • O00554

    Protein attributes for ARPC3 Gene

    Size:
    178 amino acids
    Molecular mass:
    20547 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC3 Gene

Post-translational modifications for ARPC3 Gene

  • Ubiquitination at Lys14, Lys56, Lys158, and Lys171
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC3 Gene

Antibody Products

  • Abcam antibodies for ARPC3
  • Boster Bio Antibodies for ARPC3

No data available for DME Specific Peptides for ARPC3 Gene

Domains & Families for ARPC3 Gene

Gene Families for ARPC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARPC3 Gene

InterPro:
Blocks:
  • ARP2/3 complex, 21 kDa p21-Arc subunit
ProtoNet:

Suggested Antigen Peptide Sequences for ARPC3 Gene

GenScript: Design optimal peptide antigens:
  • Arp2/3 complex 21 kDa subunit (ARPC3_HUMAN)
  • cDNA FLJ51245, highly similar to Actin-related protein 2/3 complex subunit 3 (B4DM63_HUMAN)
  • Actin related protein 2/3 complex (Q2LE71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15145

UniProtKB/Swiss-Prot:

ARPC3_HUMAN :
  • Belongs to the ARPC3 family.
Family:
  • Belongs to the ARPC3 family.
genes like me logo Genes that share domains with ARPC3: view

Function for ARPC3 Gene

Molecular function for ARPC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
GENATLAS Biochemistry:
actin related protein 2/3 complex,subunit 3 (21kDa),localized to the lamellipodia of stationary and locomoting fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion

Phenotypes From GWAS Catalog for ARPC3 Gene

Gene Ontology (GO) - Molecular Function for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC3: view
genes like me logo Genes that share phenotypes with ARPC3: view

Animal Models for ARPC3 Gene

MGI Knock Outs for ARPC3:
  • Arpc3 Arpc3<tm1a(EUCOMM)Wtsi>
  • Arpc3 Arpc3<tm1Jtak>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC3 Gene

Localization for ARPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC3 Gene

Cytoplasm, cytoskeleton. Cell projection. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA,IDA 11741539
genes like me logo Genes that share ontologies with ARPC3: view

Pathways & Interactions for ARPC3 Gene

PathCards logo

SuperPathways for ARPC3 Gene

SuperPathway Contained pathways
1 G-protein signaling RAC1 in cellular process
.37
.37
2 EPH-Ephrin signaling
.35
3 Regulation of actin dynamics for phagocytic cup formation
4 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.37
5 Development Slit-Robo signaling
.44
.44
genes like me logo Genes that share pathways with ARPC3: view

Pathways by source for ARPC3 Gene

14 GeneGo (Thomson Reuters) pathways for ARPC3 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling
3 Qiagen pathways for ARPC3 Gene
  • BRCA1 Pathway
  • DNA Repair Mechanisms
  • Salmonella Infection

Gene Ontology (GO) - Biological Process for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA,IDA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with ARPC3: view

No data available for SIGNOR curated interactions for ARPC3 Gene

Drugs & Compounds for ARPC3 Gene

(3) Drugs for ARPC3 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
CK-636 Pharma Arp2/3 complex inhibitor 0

(1) ApexBio Compounds for ARPC3 Gene

Compound Action Cas Number
CK-636 Arp2/3 complex inhibitor 442632-72-6
genes like me logo Genes that share compounds with ARPC3: view

Drug Products

Transcripts for ARPC3 Gene

mRNA/cDNA for ARPC3 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC3

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for ARPC3 Gene

GeneLoc Exon Structure for
ARPC3

Expression for ARPC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC3 Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for ARPC3 Gene

This gene is overexpressed in Tlymphocyte (6.9) and Spleen (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARPC3 Gene



Protein tissue co-expression partners for ARPC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARPC3

SOURCE GeneReport for Unigene cluster for ARPC3 Gene:

Hs.524741

Evidence on tissue expression from TISSUES for ARPC3 Gene

  • Nervous system(4.9)
  • Blood(4.6)
  • Liver(4.6)
  • Skin(4.5)
  • Pancreas(4)
  • Lung(3.8)
  • Intestine(3.1)
  • Spleen(2.9)
  • Heart(2.8)
  • Kidney(2.8)
  • Lymph node(2.7)
  • Muscle(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with ARPC3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC3 Gene

Orthologs for ARPC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARPC3 30 31
  • 99.63 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 98 (a)
OneToMany
-- 31
  • 97 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia ARPC3 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ARPC3 30 31
  • 94.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ARPC3 30 31
  • 94.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arpc3 30
  • 88.39 (n)
Mouse
(Mus musculus)
Mammalia Arpc3 30 17 31
  • 86.7 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ARPC3 30 31
  • 83.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARPC3 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arpc3 30
  • 79.03 (n)
Str.10867 30
Zebrafish
(Danio rerio)
Actinopterygii arpc3 30 31
  • 78.46 (n)
OneToOne
gng3 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8941 30
Fruit Fly
(Drosophila melanogaster)
Insecta Arpc3A 30 31
  • 62.34 (n)
OneToMany
Arpc3B 31
  • 61 (a)
OneToMany
CG8936 32
  • 60 (a)
CG4560 32
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001712 30
  • 60.26 (n)
Worm
(Caenorhabditis elegans)
Secernentea arx-5 30 31
  • 59.05 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07821g 30
  • 54.14 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC18 30 31 33
  • 52.99 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR584C 30
  • 51.06 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ARPC3 30
  • 53.61 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0235000 30
  • 52.8 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 60 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc3 30
  • 55.43 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09572 30
  • 52.6 (n)
Species where no ortholog for ARPC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARPC3 Gene

ENSEMBL:
Gene Tree for ARPC3 (if available)
TreeFam:
Gene Tree for ARPC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC3: view image

Paralogs for ARPC3 Gene

genes like me logo Genes that share paralogs with ARPC3: view

No data available for Paralogs for ARPC3 Gene

Variants for ARPC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARPC3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
777238 Benign: not provided 110,436,687(-) G/GAAAA INTRON_VARIANT
785427 Benign: not provided 110,436,687(-) G/GAAAAA INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ARPC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARPC3 Gene

Variant ID Type Subtype PubMed ID
nsv976651 CNV duplication 23825009

Variation tolerance for ARPC3 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC3 Gene

Human Gene Mutation Database (HGMD)
ARPC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC3 Gene

Disorders for ARPC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARPC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 4
  • scar4
porokeratosis
  • porokeratosis of mibelli
- elite association - COSMIC cancer census association via MalaCards
Search ARPC3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ARPC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC3 Gene

Publications for ARPC3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky LM … Segal AW (The Biochemical journal 1997) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4
  5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H … Welch MD (Molecular cell 2001) 3 4

Products for ARPC3 Gene

  • Signalway Proteins for ARPC3

Sources for ARPC3 Gene