Aliases for ARPC2 Gene
External Ids for ARPC2 Gene
Previous GeneCards Identifiers for ARPC2 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARPC2 Gene
ARPC2 (Actin Related Protein 2/3 Complex Subunit 2) is a Protein Coding gene. Diseases associated with ARPC2 include Wiskott-Aldrich Syndrome. Among its related pathways are Development Slit-Robo signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include actin filament binding and kinesin binding.
UniProtKB/Swiss-Prot Summary for ARPC2 Gene
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).