This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in... See more...

Aliases for ARPC1B Gene

Aliases for ARPC1B Gene

  • Actin Related Protein 2/3 Complex Subunit 1B 2 3 5
  • Actin-Related Protein 2/3 Complex Subunit 1B 3 4
  • ARP2/3 Protein Complex Subunit P41 2 3
  • Arp2/3 Complex 41 KDa Subunit 3 4
  • P41-ARC 3 4
  • ARC41 3 4
  • Actin Related Protein 2/3 Complex, Subunit 1A (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1B (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa 3
  • Actin Related Protein 2/3 Complex Subunit 1B, 41kDa 2
  • P40-ARC 3
  • PLTEID 3

External Ids for ARPC1B Gene

Previous GeneCards Identifiers for ARPC1B Gene

  • GC07P097507
  • GC07P098569
  • GC07P098583
  • GC07P098616
  • GC07P098705
  • GC07P098810
  • GC07P098937
  • GC07P093608
  • GC07P098971

Summaries for ARPC1B Gene

Entrez Gene Summary for ARPC1B Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

GeneCards Summary for ARPC1B Gene

ARPC1B (Actin Related Protein 2/3 Complex Subunit 1B) is a Protein Coding gene. Diseases associated with ARPC1B include Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC1A.

UniProtKB/Swiss-Prot Summary for ARPC1B Gene

  • Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Gene Wiki entry for ARPC1B Gene

Additional gene information for ARPC1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARPC1B Gene

Genomics for ARPC1B Gene

GeneHancer (GH) Regulatory Elements for ARPC1B Gene

Promoters and enhancers for ARPC1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARPC1B

Top Transcription factor binding sites by QIAGEN in the ARPC1B gene promoter:
  • MRF-2
  • MZF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ARPC1B Gene

Genomic Locations for ARPC1B Gene
chr7:99,374,249-99,394,816
(GRCh38/hg38)
Size:
20,568 bases
Orientation:
Plus strand
chr7:98,971,872-98,992,424
(GRCh37/hg19)
Size:
20,553 bases
Orientation:
Plus strand

Genomic View for ARPC1B Gene

Genes around ARPC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1B Gene

Proteins for ARPC1B Gene

  • Protein details for ARPC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15143-ARC1B_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 1B
    Protein Accession:
    O15143
    Secondary Accessions:
    • Q9BU00

    Protein attributes for ARPC1B Gene

    Size:
    372 amino acids
    Molecular mass:
    40950 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC1B Gene

Post-translational modifications for ARPC1B Gene

  • Ubiquitination at Lys18, Lys49, Lys82, Lys87, Lys110, and Lys341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARPC1B Gene

Domains & Families for ARPC1B Gene

Gene Families for ARPC1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARPC1B Gene

Blocks:
  • G-protein beta WD-40 repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARPC1B Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA (A4D275_HUMAN)
  • p41-ARC (ARC1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15143

UniProtKB/Swiss-Prot:

ARC1B_HUMAN :
  • Belongs to the WD repeat ARPC1 family.
Family:
  • Belongs to the WD repeat ARPC1 family.
genes like me logo Genes that share domains with ARPC1B: view

Function for ARPC1B Gene

Molecular function for ARPC1B Gene

UniProtKB/Swiss-Prot Function:
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Phenotypes From GWAS Catalog for ARPC1B Gene

Gene Ontology (GO) - Molecular Function for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IEA,IPI 20404198
GO:0044877 protein-containing complex binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view
genes like me logo Genes that share phenotypes with ARPC1B: view

Human Phenotype Ontology for ARPC1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ARPC1B Gene

MGI Knock Outs for ARPC1B:
  • Arpc1b Arpc1b<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARPC1B Gene

Localization for ARPC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1B Gene

Cytoplasm, cytoskeleton. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC1B gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA,IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view

Pathways & Interactions for ARPC1B Gene

PathCards logo

SuperPathways for ARPC1B Gene

SuperPathway Contained pathways
1 G-protein signaling RAC1 in cellular process
.37
.37
2 EPH-Ephrin signaling
.35
3 Regulation of actin dynamics for phagocytic cup formation
4 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.37
5 Development Slit-Robo signaling
.44
.44
genes like me logo Genes that share pathways with ARPC1B: view

Pathways by source for ARPC1B Gene

14 GeneGo (Thomson Reuters) pathways for ARPC1B Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling
2 Qiagen pathways for ARPC1B Gene
  • Salmonella Infection
  • THC Differentiation Pathway

SIGNOR curated interactions for ARPC1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030833 regulation of actin filament polymerization IEA --
GO:0032355 response to estradiol IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA,IEA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0043627 response to estrogen IEA --
genes like me logo Genes that share ontologies with ARPC1B: view

Drugs & Compounds for ARPC1B Gene

(2) Drugs for ARPC1B Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC1B: view

Transcripts for ARPC1B Gene

mRNA/cDNA for ARPC1B Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - - -
SP12: - -
SP13:
SP14:
SP15: - - - -
SP16: - - - - - -
SP17: - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - -
SP20:
SP21:

ExUns: 12d · 12e ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -

Relevant External Links for ARPC1B Gene

GeneLoc Exon Structure for
ARPC1B

Expression for ARPC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC1B Gene

This gene is overexpressed in Whole Blood (x13.7).

Protein differential expression in normal tissues from HIPED for ARPC1B Gene

This gene is overexpressed in NK cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC1B Gene



Protein tissue co-expression partners for ARPC1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARPC1B

SOURCE GeneReport for Unigene cluster for ARPC1B Gene:

Hs.489284

Evidence on tissue expression from TISSUES for ARPC1B Gene

  • Blood(4)
  • Lung(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with ARPC1B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC1B Gene

Orthologs for ARPC1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC1B 31 30
  • 99.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC1B 31 30
  • 90.57 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC1B 31 30
  • 90.05 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC1B 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc1b 30
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Arpc1b 17 31 30
  • 88.8 (n)
oppossum
(Monodelphis domestica)
Mammalia ARPC1B 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC1B 31 30
  • 85.09 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc1b 30
  • 72.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia arx-3and3n122-prov 30
zebrafish
(Danio rerio)
Actinopterygii arpc1b 31 30
  • 74.73 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sop2 31 32
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arx-3 31
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 31
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC1B 30
  • 50.46 (n)
rice
(Oryza sativa)
Liliopsida Os02g0817200 30
  • 48.42 (n)
Os.18424 30
barley
(Hordeum vulgare)
Liliopsida Hv.12702 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10119 31
  • 51 (a)
OneToMany
Species where no ortholog for ARPC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC1B Gene

ENSEMBL:
Gene Tree for ARPC1B (if available)
TreeFam:
Gene Tree for ARPC1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC1B: view image

Paralogs for ARPC1B Gene

Paralogs for ARPC1B Gene

(2) SIMAP similar genes for ARPC1B Gene using alignment to 14 proteins:

  • ARC1B_HUMAN
  • A4D275_HUMAN
  • C9J4Z7_HUMAN
  • C9J6C8_HUMAN
  • C9JBJ7_HUMAN
  • C9JEY1_HUMAN
  • C9JFG9_HUMAN
  • C9JM51_HUMAN
  • C9JQM8_HUMAN
  • C9JTT6_HUMAN
  • C9K057_HUMAN
  • F8VXW2_HUMAN
  • F8WEB3_HUMAN
  • L8EAG6_HUMAN
genes like me logo Genes that share paralogs with ARPC1B: view

Variants for ARPC1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARPC1B Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
636660 Uncertain Significance: not provided 99,392,819(+) C/G MISSENSE_VARIANT
rs1186149065 Pathogenic: PLATELET ABNORMALITIES WITH EOSINOPHILIA AND IMMUNE-MEDIATED INFLAMMATORY DISEASE 99,388,183(+) C/T MISSENSE_VARIANT
rs147238850 Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID) [MIM:617718] p.Ala238Thr
VAR_080353 Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID) [MIM:617718] p.Ala105Val
rs1045012 - p.Lys37Asn

Additional dbSNP identifiers (rs#s) for ARPC1B Gene

Structural Variations from Database of Genomic Variants (DGV) for ARPC1B Gene

Variant ID Type Subtype PubMed ID
nsv1124247 CNV deletion 24896259
nsv831068 CNV loss 17160897
nsv831069 CNV loss 17160897
nsv951379 CNV deletion 24416366

Variation tolerance for ARPC1B Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC1B Gene

Human Gene Mutation Database (HGMD)
ARPC1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC1B Gene

Disorders for ARPC1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARPC1B Gene - From: OMIM, ClinVar, GTR, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ARC1B_HUMAN
  • Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID) [MIM:617718]: An autosomal recessive disorder characterized by platelet abnormalities, vasculitis, eosinophilia, and predisposition to inflammatory diseases. {ECO:0000269 PubMed:28368018}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ARPC1B

genes like me logo Genes that share disorders with ARPC1B: view

No data available for Genatlas for ARPC1B Gene

Publications for ARPC1B Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4 54
  2. Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease. (PMID: 28368018) Kahr WH … Muise AM (Nature communications 2017) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PMID: 14749719) Vadlamudi RK … Kumar R (EMBO reports 2004) 3 23 54
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 54

Products for ARPC1B Gene

Sources for ARPC1B Gene