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This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in... See more...
Aliases for ARPC1B Gene
Aliases for ARPC1B Gene
External Ids for ARPC1B Gene
- HGNC: 704
- NCBI Entrez Gene: 10095
- Ensembl: ENSG00000130429
- OMIM®: 604223
- UniProtKB/Swiss-Prot: O15143
Previous GeneCards Identifiers for ARPC1B Gene
- GC07P097507
- GC07P098569
- GC07P098583
- GC07P098616
- GC07P098705
- GC07P098810
- GC07P098937
- GC07P093608
- GC07P098971
Summaries for ARPC1B Gene
-
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
GeneCards Summary for ARPC1B Gene
ARPC1B (Actin Related Protein 2/3 Complex Subunit 1B) is a Protein Coding gene. Diseases associated with ARPC1B include Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia and Combined T And B Cell Immunodeficiency. Among its related pathways are Signaling by GPCR and Immune response CCR3 signaling in eosinophils. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC1A.
UniProtKB/Swiss-Prot Summary for ARPC1B Gene
-
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Additional gene information for ARPC1B Gene
- HGNC (704)
- NCBI Entrez Gene (10095)
- Ensembl (ENSG00000130429)
- OMIM® (604223)
- UniProtKB/Swiss-Prot (O15143)
- Open Targets Platform(ENSG00000130429)
- Alliance of Genome Resources
- Search for ARPC1B at DataMed
- Search for ARPC1B at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARPC1B Gene
Genomics for ARPC1B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARPC1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARPC1B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARPC1B
- Top Transcription factor binding sites by QIAGEN in the ARPC1B gene promoter:
-
- MRF-2
- MZF-1
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for ARPC1B Gene
Latest Assembly
- chr7:99,374,249-99,394,816
- (GRCh38/hg38)
- Size:
- 20,568 bases
- Orientation:
- Plus strand
Previous Assembly
- chr7:98,972,353-98,992,439
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 20,087 bases
- Orientation:
- Plus strand
Genomic View for ARPC1B Gene
Genes around ARPC1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q22.1 by HGNC
- 7q22.1 by Entrez Gene
- 7q22.1 by Ensembl
ARPC1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARPC1B Gene
Proteins for ARPC1B Gene
-
Protein details for ARPC1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15143-ARC1B_HUMAN
- Recommended name:
- Actin-related protein 2/3 complex subunit 1B
- Protein Accession:
- O15143
- Q9BU00
Protein attributes for ARPC1B Gene
- Size:
- 372 amino acids
- Molecular mass:
- 40950 Da
- Quaternary structure:
-
- Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
Protein Expression for ARPC1B Gene
Post-translational modifications for ARPC1B Gene
Other Protein References for ARPC1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences ARPC1B / p41-ARC / ARP2 Antibody (LS-B2744) and ARPC1B / p41-ARC / ARP2 Antibody (LS-B15074)
-
Custom Antibody ServicesOriGene Antibodies for ARPC1B
- Novus Biologicals Antibodies for ARPC1B
-
Abcam antibodies for ARPC1B
- Invitrogen Antibodies for ARPC1B (AFLGC-ARPC1B)
-
Boster Bio Antibodies for ARPC1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARPC1B
- Sino Biological Antibodies for ARPC1B
Protein products for research
-
OriGene Purified Proteins for ARPC1B
- Search Origene for MassSpec and Protein Over-expression Lysates for ARPC1B
- Origene Custom Protein Services for ARPC1B
-
Abcam proteins for ARPC1B
Assay products for research
- antibodies-online: Show 13 available ARPC1B Elisa Kits ranked by validation data
- Compare Top ARPC1B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ARPC1B Gene
Domains & Families for ARPC1B Gene
Gene Families for ARPC1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ARPC1B Gene
- InterPro:
- Blocks:
-
- G-protein beta WD-40 repeat signature
Suggested Antigen Peptide Sequences for ARPC1B Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA (A4D275_HUMAN)
- p41-ARC (ARC1B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15143- Family:
-
- Belongs to the WD repeat ARPC1 family.
Function for ARPC1B Gene
Molecular function for ARPC1B Gene
- UniProtKB/Swiss-Prot Function:
- Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Phenotypes From GWAS Catalog for ARPC1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | IDA | 11741539 |
| GO:0005515 | protein binding | IPI | 20404198 |
| GO:0044877 | protein-containing complex binding | IEA | -- |
| GO:0051015 | contributes_to actin filament binding | IDA | 11741539 |
Phenotypes for ARPC1B Gene
- MGI mutant phenotypes for ARPC1B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARPC1B:
Animal Models for ARPC1B Gene
- MGI Knock Outs for ARPC1B:
-
- Arpc1b Arpc1b<tm1a(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARPC1B - Starting at $85 >
- * ARPC1B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARPC1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARPC1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARPC1B
miRNA for ARPC1B Gene
- miRTarBase miRNAs that target ARPC1B
-
- hsa-miR-124-3p (MIRT002566)
- mmu-miR-9-5p (MIRT015250)
- mmu-miR-124-3p (MIRT015741)
- hsa-miR-218-5p (MIRT441178)
- hsa-miR-335-3p (MIRT612114)
- hsa-miR-1305 (MIRT612115)
- hsa-miR-3658 (MIRT612116)
- hsa-miR-3653-3p (MIRT612117)
- hsa-miR-153-5p (MIRT612118)
- hsa-miR-95-5p (MIRT612119)
- hsa-miR-1252-3p (MIRT612120)
- hsa-miR-3646 (MIRT612121)
- hsa-miR-4422 (MIRT612122)
- hsa-miR-2681-5p (MIRT616870)
- hsa-miR-466 (MIRT616871)
- hsa-miR-4672 (MIRT616872)
- hsa-miR-3941 (MIRT616873)
- hsa-miR-5003-3p (MIRT616874)
- hsa-miR-6768-5p (MIRT616875)
- hsa-miR-6803-5p (MIRT621195)
- hsa-miR-6751-5p (MIRT621196)
- hsa-miR-7109-5p (MIRT621197)
- hsa-miR-4665-5p (MIRT621198)
- hsa-miR-1275 (MIRT621199)
- hsa-miR-6848-5p (MIRT621200)
- hsa-miR-6846-5p (MIRT621201)
- hsa-miR-4697-5p (MIRT621202)
- hsa-miR-4488 (MIRT621203)
- hsa-miR-1237-5p (MIRT621204)
- hsa-miR-33b-5p (MIRT635903)
- hsa-miR-33a-5p (MIRT635904)
- hsa-miR-5572 (MIRT635905)
- hsa-miR-4260 (MIRT635906)
- hsa-miR-450a-2-3p (MIRT635907)
- hsa-miR-556-3p (MIRT750898)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARPC1B
- Browse OriGene Inhibitory RNA Products For ARPC1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC1B
Clone products for research
- Applied Biological Materials (abm): Clones for ARPC1B - Starting at $45 >
- * ARPC1B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ARPC1B
- Addgene plasmids for ARPC1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARPC1B
Cell Lines for research
-
Horizon Cell Lines for ARPC1B
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARPC1B Gene
Localization for ARPC1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARPC1B Gene
- Cytoplasm, cytoskeleton. Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| extracellular | 4 |
| nucleus | 4 |
| cytosol | 4 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005885 | Arp2/3 protein complex | IEA,IDA | 11741539 |
Pathways & Interactions for ARPC1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | G-protein signaling RAC1 in cellular process |
Cytoskeleton remodeling CDC42 in cellular processes
.37
G-protein signaling RAC1 in cellular process
.37
|
|
| 2 | EPH-Ephrin signaling |
Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
.35
|
|
| 3 | Regulation of actin dynamics for phagocytic cup formation | ||
| 4 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases |
Cell adhesion Integrin-mediated cell adhesion and migration
.49
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
|
Cytoskeleton remodeling Integrin outside-in signaling
.37
|
| 5 | Development Slit-Robo signaling |
Development Slit-Robo signaling
.44
Neurophysiological process Receptor-mediated axon growth repulsion
.44
|
|
Pathways by source for ARPC1B Gene
1 Sino Biological pathway for ARPC1B Gene
4 BioSystems pathways for ARPC1B Gene
12 Reactome pathways for ARPC1B Gene
9 KEGG pathways for ARPC1B Gene
14 GeneGo (Thomson Reuters) pathways for ARPC1B Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cell adhesion_Cadherin-mediated cell adhesion
- Cytoskeleton remodeling CDC42 in cellular processes
- Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
- Cytoskeleton remodeling Integrin outside-in signaling
2 Qiagen pathways for ARPC1B Gene
- Salmonella Infection
- THC Differentiation Pathway
Interacting Proteins for ARPC1B Gene
Selected Interacting proteins:
O15143-ARC1B_HUMAN
ENSP00000389631
for ARPC1B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARPC1B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030833 | regulation of actin filament polymerization | IEA | -- |
| GO:0032355 | response to estradiol | IEA | -- |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | IEA,IDA | 11741539 |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | -- |
| GO:0043627 | response to estrogen | IEA | -- |
Transcripts for ARPC1B Gene
mRNA/cDNA for ARPC1B Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000414376 572 nts (view in UCSC)
- ENST00000417330 1300 nts (view in UCSC)
- ENST00000418347 563 nts (view in UCSC)
- ENST00000427217 1578 nts (view in UCSC)
- ENST00000429246 376 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ARPC1B - Starting at $85 >
- * ARPC1B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ARPC1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARPC1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARPC1B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARPC1B
- Browse OriGene Inhibitory RNA Products For ARPC1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC1B
Clone products for research
- Applied Biological Materials (abm): Clones for ARPC1B - Starting at $45 >
- * ARPC1B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ARPC1B
- Addgene plasmids for ARPC1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARPC1B
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
| ExUns: | 12d | · | 12e | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | · | 16c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||
| SP14: | - | - | |||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||
| SP21: | - |
Relevant External Links for ARPC1B Gene
- GeneLoc Exon Structure for
- ARPC1B
Expression for ARPC1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Heart Tube
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
- Mesonephros
-
Gonad
- Mesonephric cells Mesonephros
- Primordial Germ Cells Allantois
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Testis (Reproductive System)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ARPC1B Gene
This gene is overexpressed in Whole Blood (x13.7).
This gene is overexpressed in NK cells (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC1B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARPC1B
SOURCE GeneReport for Unigene cluster for ARPC1B Gene:
Hs.489284Evidence on tissue expression from TISSUES for ARPC1B Gene
- Blood(4.3)
- Skin(4.2)
- Lung(4)
Primer products for research
-
OriGene qPCR primer pairs for ARPC1B
-
OriGene qPCR primer pairs and template standards for ARPC1B
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC1B Gene
Orthologs for ARPC1B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARPC1B 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARPC1B 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARPC1B 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARPC1B 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arpc1b 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Arpc1b 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARPC1B 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ARPC1B 29 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arpc1b 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | arx-3and3n122-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | arpc1b 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Sop2 30 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | arx-3 30 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARC40 30 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ARPC1B 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0817200 29 |
|
||
| Os.18424 29 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.12702 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10119 30 |
|
OneToMany |
- Species where no ortholog for ARPC1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARPC1B Gene
- ENSEMBL:
- Gene Tree for ARPC1B (if available)
- TreeFam:
- Gene Tree for ARPC1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARPC1B: view image
- Alliance of Genome Resources:
- Additional Orthologs for ARPC1B
Paralogs for ARPC1B Gene
Paralogs for ARPC1B Gene
(2) SIMAP similar genes for ARPC1B Gene using alignment to 14 proteins:
- ARC1B_HUMAN
- A4D275_HUMAN
- C9J4Z7_HUMAN
- C9J6C8_HUMAN
- C9JBJ7_HUMAN
- C9JEY1_HUMAN
- C9JFG9_HUMAN
- C9JM51_HUMAN
- C9JQM8_HUMAN
- C9JTT6_HUMAN
- C9K057_HUMAN
- F8VXW2_HUMAN
- F8WEB3_HUMAN
- L8EAG6_HUMAN
Variants for ARPC1B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARPC1B Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1006395 | Uncertain Significance: not provided | 99,391,178(+) |
C/T NM_005720.4(ARPC1B):c.708C>T (p.Ala236=) |
SYNONYMOUS | |
| 1030960 | Uncertain Significance: Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease | 99,389,996(+) |
T/G NM_005720.4(ARPC1B):c.484T>G (p.Cys162Gly) |
MISSENSE | |
| 1030961 | Uncertain Significance: Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease | 99,391,253(+) |
G/A NM_005720.4(ARPC1B):c.783G>A (p.Ala261=) |
SYNONYMOUS | |
| 1030962 | Uncertain Significance: Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease | 99,392,872(+) |
G/A NM_005720.4(ARPC1B):c.985G>A (p.Val329Ile) |
MISSENSE | |
| 1045125 | Uncertain Significance: not provided | 99,388,069(+) |
T/C NM_005720.4(ARPC1B):c.200T>C (p.Ile67Thr) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.78;
58.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARPC1B Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC1B Gene
Disorders for ARPC1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia |
|
|
| combined t and b cell immunodeficiency |
|
|
| combined immunodeficiency |
|
|
| thrombocytopenia |
|
|
Search ARPC1B in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ARC1B_HUMAN- Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID) [MIM:617718]: An autosomal recessive disorder characterized by platelet abnormalities, vasculitis, eosinophilia, and predisposition to inflammatory diseases. {ECO:0000269 PubMed:28368018}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for ARPC1B
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for ARPC1B Gene
Publications for ARPC1B Gene
- Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease. (PMID: 28368018) Kahr WH … Muise AM (Nature communications 2017) 3 4 72
- The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4
- T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency. (PMID: 30254128) Brigida I … Aiuti A (Blood 2018) 3 72
- Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B. (PMID: 29127144) Somech R … Zhang Y (Journal of immunology (Baltimore, Md. : 1950) 2017) 3 72
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for ARPC1B Gene
- Custom Antibody ServicesOriGene Antibodies for ARPC1B
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- Addgene plasmids for ARPC1B
- antibodies-online: Show 16 available ARPC1B Antibodies ranked by validation data
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- Boster Bio Antibodies for ARPC1B
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Sources for ARPC1B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
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- (54) Tocris
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- (56) Novus Biologicals
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- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
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- (80) BioGPS
- (81) Illumina
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- (142) GlyConnect
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- (146) RNAcentral
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- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
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- (176) Alliance of Genome Resources