Aliases for ARPC1B Gene
Aliases for ARPC1B Gene
External Ids for ARPC1B Gene
- HGNC: 704
- Entrez Gene: 10095
- Ensembl: ENSG00000130429
- OMIM: 604223
- UniProtKB: O15143
Previous GeneCards Identifiers for ARPC1B Gene
- GC07P097507
- GC07P098569
- GC07P098583
- GC07P098616
- GC07P098705
- GC07P098810
- GC07P098937
- GC07P093608
- GC07P098971
Summaries for ARPC1B Gene
-
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
GeneCards Summary for ARPC1B Gene
ARPC1B (Actin Related Protein 2/3 Complex Subunit 1B) is a Protein Coding gene. Diseases associated with ARPC1B include Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease. Among its related pathways are Development Slit-Robo signaling and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ENSG00000284292.
UniProtKB/Swiss-Prot for ARPC1B Gene
-
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Additional gene information for ARPC1B Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC1B Gene
Genomics for ARPC1B Gene
GeneHancer (GH) Regulatory Elements for ARPC1B Gene
Promoters and enhancers for ARPC1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ARPC1B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ARPC1B Gene
Genomic Locations for ARPC1B Gene
- chr7:99,374,249-99,394,801
- (GRCh38/hg38)
- Size:
- 20,553 bases
- Orientation:
- Plus strand
- chr7:98,971,872-98,992,424
- (GRCh37/hg19)
Genomic View for ARPC1B Gene
Genes around ARPC1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22.1 by Entrez Gene
- 7q22.1 by HGNC
ARPC1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARPC1B Gene
Proteins for ARPC1B Gene
-
Protein details for ARPC1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15143-ARC1B_HUMAN
- Recommended name:
- Actin-related protein 2/3 complex subunit 1B
- Protein Accession:
- O15143
- Q9BU00
Protein attributes for ARPC1B Gene
- Size:
- 372 amino acids
- Molecular mass:
- 40950 Da
- Quaternary structure:
-
- Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
Protein Expression for ARPC1B Gene
Post-translational modifications for ARPC1B Gene
- Ubiquitination at Lys49, posLast=8282, Lys87, posLast=110110, and Lys341
Other Protein References for ARPC1B Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ARPC1B
- Novus Biologicals Antibodies for ARPC1B
-
Abcam antibodies for ARPC1B
- Invitrogen Antibodies for ARPC1B
- GeneTex ARPC1B antibody for ARPC1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARPC1B
- Sino Biological Antibodies for ARPC1B
Protein Products
-
OriGene Purified Proteins for ARPC1B
- Search Origene for MassSpec and Protein Over-expression Lysates for ARPC1B
- Origene Custom Protein Services for ARPC1B
- Search GeneTex for Proteins for ARPC1B
-
Abcam proteins for ARPC1B
Assay Products
No data available for DME Specific Peptides for ARPC1B Gene
Domains & Families for ARPC1B Gene
Gene Families for ARPC1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ARPC1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARPC1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15143- Family:
-
- Belongs to the WD repeat ARPC1 family.
Function for ARPC1B Gene
Molecular function for ARPC1B Gene
- UniProtKB/Swiss-Prot Function:
- Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Phenotypes From GWAS Catalog for ARPC1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005200 | structural constituent of cytoskeleton | IDA | 11741539 |
| GO:0005515 | protein binding | IPI | 20404198 |
| GO:0032403 | protein complex binding | IEA | -- |
| GO:0051015 | contributes_to actin filament binding | IDA | 11741539 |
Phenotypes for ARPC1B Gene
- MGI mutant phenotypes for ARPC1B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARPC1B:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell migration
Animal Models for ARPC1B Gene
- MGI Knock Outs for ARPC1B:
-
- Arpc1b tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARPC1B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ARPC1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARPC1B gene
- Search ViGene Biosciences for ARPC1B
CRISPR Products
-
OriGene CRISPR knockouts for ARPC1B
- genomics-online: gRNA clones - Search results for 148 available ARPC1B gene related products
- Overview of 148 available ARPC1B gene related products
- Applied Biological Materials CRISPR for ARPC1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARPC1B
- GenScript: Design CRISPR guide RNA sequences for ARPC1B
miRNA for ARPC1B Gene
- miRTarBase miRNAs that target ARPC1B
-
- hsa-mir-124-3p (MIRT002566)
- hsa-mir-218-5p (MIRT441178)
- hsa-mir-335-3p (MIRT612114)
- hsa-mir-1305 (MIRT612115)
- hsa-mir-3658 (MIRT612116)
- hsa-mir-3653-3p (MIRT612117)
- hsa-mir-153-5p (MIRT612118)
- hsa-mir-95-5p (MIRT612119)
- hsa-mir-1252-3p (MIRT612120)
- hsa-mir-3646 (MIRT612121)
- hsa-mir-4422 (MIRT612122)
- hsa-mir-2681-5p (MIRT616870)
- hsa-mir-466 (MIRT616871)
- hsa-mir-4672 (MIRT616872)
- hsa-mir-3941 (MIRT616873)
- hsa-mir-5003-3p (MIRT616874)
- hsa-mir-6768-5p (MIRT616875)
- hsa-mir-6803-5p (MIRT621195)
- hsa-mir-6751-5p (MIRT621196)
- hsa-mir-7109-5p (MIRT621197)
- hsa-mir-4665-5p (MIRT621198)
- hsa-mir-1275 (MIRT621199)
- hsa-mir-6848-5p (MIRT621200)
- hsa-mir-6846-5p (MIRT621201)
- hsa-mir-4697-5p (MIRT621202)
- hsa-mir-4488 (MIRT621203)
- hsa-mir-1237-5p (MIRT621204)
- hsa-mir-33b-5p (MIRT635903)
- hsa-mir-33a-5p (MIRT635904)
- hsa-mir-5572 (MIRT635905)
- hsa-mir-4260 (MIRT635906)
- hsa-mir-450a-2-3p (MIRT635907)
- hsa-mir-556-3p (MIRT750898)
miRNA Products
- Search ViGene Biosciences for ARPC1B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ARPC1B
- Browse OriGene Inhibitory RNA Products For ARPC1B
- genomics-online: shRNA clones - Search results for 148 available ARPC1B gene related products
- Overview of 148 available ARPC1B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARPC1B gene
Clone Products
- Sino Biological Human cDNA Clone for ARPC1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARPC1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARPC1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ARPC1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ARPC1B
-
ViGene Biosciences adenoviral particle packaged cDNA for ARPC1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ARPC1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARPC1B gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC1B Gene
Localization for ARPC1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARPC1B Gene
- Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 4 |
- Cytosol (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005885 | Arp2/3 protein complex | IEA,IDA | 11741539 |
| GO:0005925 | focal adhesion | IDA,HDA | 21423176 |
Pathways & Interactions for ARPC1B Gene
Pathways by source for ARPC1B Gene
1 Sino Biological pathway for ARPC1B Gene
4 BioSystems pathways for ARPC1B Gene
12 Reactome pathways for ARPC1B Gene
7 KEGG pathways for ARPC1B Gene
14 GeneGo (Thomson Reuters) pathways for ARPC1B Gene
2 Qiagen pathways for ARPC1B Gene
Interacting Proteins for ARPC1B Gene
Selected Interacting proteins:
O15143-ARC1B_HUMAN
ENSP00000252725
for ARPC1B Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006928 | movement of cell or subcellular component | TAS | 9230079 |
| GO:0030833 | regulation of actin filament polymerization | IEA | -- |
| GO:0032355 | response to estradiol | IEA | -- |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | IDA,IEA | 11741539 |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | -- |
Transcripts for ARPC1B Gene
mRNA/cDNA for ARPC1B Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (1160) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARPC1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for ARPC1B
- genomics-online: gRNA clones - Search results for 148 available ARPC1B gene related products
- Overview of 148 available ARPC1B gene related products
- Applied Biological Materials CRISPR for ARPC1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARPC1B
- GenScript: Design CRISPR guide RNA sequences for ARPC1B
miRNA Products
- Search ViGene Biosciences for ARPC1B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ARPC1B
- Browse OriGene Inhibitory RNA Products For ARPC1B
- genomics-online: shRNA clones - Search results for 148 available ARPC1B gene related products
- Overview of 148 available ARPC1B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ARPC1B gene
Clone Products
- Sino Biological Human cDNA Clone for ARPC1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ARPC1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARPC1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ARPC1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
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| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: |
| ExUns: | 12d | · | 12e | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | · | 16c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
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| SP4: | |||||||||||||||||||||||||
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| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||
| SP14: | - | - | |||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||
| SP21: | - |
Expression for ARPC1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Heart Tube
-
Intermediate Mesoderm (Gastrulation Derivatives)
- Mesonephric cells Mesonephros
- Mesonephros
-
Gonad
- Mesonephric cells Mesonephros
- Primordial Germ Cells Allantois
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Testis (Reproductive System)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ARPC1B Gene
This gene is overexpressed in Whole Blood (x13.7).
This gene is overexpressed in NK cells (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPC1B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ARPC1B Gene:
ARPC1BSOURCE GeneReport for Unigene cluster for ARPC1B Gene:
Hs.489284Evidence on tissue expression from TISSUES for ARPC1B Gene
- Blood(4)
- Lung(4)
- Skin(4)
Primer Products
-
OriGene qPCR primer pairs for ARPC1B
-
OriGene qPCR primer pairs and template standards for ARPC1B
- genomics-online: primer clones - Search results for 148 available ARPC1B gene related products
- Overview of 148 available ARPC1B gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC1B Gene
Orthologs for ARPC1B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARPC1B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ARPC1B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ARPC1B 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ARPC1B 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Arpc1b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Arpc1b 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ARPC1B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ARPC1B 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arpc1b 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | arx-3and3n122-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | arpc1b 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Sop2 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | arx-3 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARC40 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ARPC1B 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0817200 33 |
|
||
| Os.18424 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.12702 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10119 34 |
|
OneToMany |
- Species where no ortholog for ARPC1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARPC1B Gene
Paralogs for ARPC1B Gene
(2) SIMAP similar genes for ARPC1B Gene using alignment to 14 proteins:
Variants for ARPC1B Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000067653 | -- | 99,393,494(+) | G/A | intron_variant | |
| rs1000078522 | -- | 99,393,737(+) | C/G | intron_variant | |
| rs1000195668 | -- | 99,382,117(+) | G/A | intron_variant | |
| rs1000240346 | -- | 99,387,886(+) | C/T | intron_variant | |
| rs1000649885 | -- | 99,387,519(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.78;
58.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARPC1B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC1B Gene
Disorders for ARPC1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| platelet abnormalities with eosinophilia and immune-mediated inflammatory disease |
|
Search ARPC1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARPC1B
No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC1B Gene
Publications for ARPC1B Gene
- The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PMID: 14749719) Vadlamudi RK … Kumar R (EMBO reports 2004) 3 22 58
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
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Sources for ARPC1B Gene
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