This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in... See more...

Aliases for ARPC1A Gene

Aliases for ARPC1A Gene

  • Actin Related Protein 2/3 Complex Subunit 1A 2 3 5
  • SOP2-Like Protein 2 3 4
  • SOP2L 2 3 4
  • Actin Binding Protein (Schizosaccharomyces Pombe Sop2-Like) 2 3
  • Actin-Related Protein 2/3 Complex Subunit 1A 3 4
  • SOP2Hs 2 3
  • Arc40 2 3
  • Actin Related Protein 2/3 Complex, Subunit 1A (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa 3
  • Actin Related Protein 2/3 Complex Subunit 1A, 41kDa 2
  • Epididymis Secretory Sperm Binding Protein 3
  • Epididymis Secretory Protein Li 307 3
  • Epididymis Luminal Protein 68 3
  • HEL-S-307 3
  • HEL-68 3
  • ARPC1A 5

External Ids for ARPC1A Gene

Previous GeneCards Identifiers for ARPC1A Gene

  • GC07P097458
  • GC07P098521
  • GC07P098534
  • GC07P098568
  • GC07P098761
  • GC07P098923
  • GC07P093559

Summaries for ARPC1A Gene

Entrez Gene Summary for ARPC1A Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ARPC1A Gene

ARPC1A (Actin Related Protein 2/3 Complex Subunit 1A) is a Protein Coding gene. Diseases associated with ARPC1A include Fanconi Anemia, Complementation Group G and Scapuloperoneal Myopathy. Among its related pathways are Signaling by GPCR and Immune response CCR3 signaling in eosinophils. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is ENSG00000284292.

UniProtKB/Swiss-Prot Summary for ARPC1A Gene

  • Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARPC1A Gene

Genomics for ARPC1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARPC1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J099324 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +2.5 2540 7.7 ZNF207 MYC NCOR1 IKZF1 ZNF600 JUND ZNF580 KLF9 POLR2A CEBPA ARPC1A ZSCAN25 TRRAP ZNF655 ENSG00000242798 ZNF3 PTCD1 AP4M1 RNF14P3 ARPC1B
GH07J099365 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.3 +39.8 39829 0.6 IKZF1 MYC CTCF REST SIN3A RAD21 SMC3 ZNF384 ZNF48 RLF ARPC1A ARPC1B PDAP1 BUD31 HSALNG0059872 NONHSAG048309.2 ENSG00000284292
GH07J099362 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.3 +37.3 37263 1.6 NCOR1 IKZF1 JUND TAL1 ZNF316 NFE2 EHMT2 FOXK2 MAFG TCF12 ARPC1A BUD31 PDAP1 LAMTOR4 ATP5MF NONHSAG048309.2 HSALNG0059872 ARPC1B ENSG00000284292
GH07J099348 Promoter 0.3 EPDnew 250.4 +22.9 22942 0.1 piR-54820 ARPC1A ARPC1B PDAP1 BUD31 ENSG00000284292
GH07J099358 Promoter 0.3 EPDnew 250.3 +32.4 32441 0.1 NONHSAG048309.2 ARPC1A BUD31 PDAP1 piR-54820 ARPC1B ENSG00000284292
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARPC1A

Top Transcription factor binding sites by QIAGEN in the ARPC1A gene promoter:
  • AhR
  • AREB6
  • Arnt
  • Msx-1
  • POU2F1
  • POU2F1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ARPC1A Gene

Latest Assembly
chr7:99,325,898-99,366,262
(GRCh38/hg38)
Size:
40,365 bases
Orientation:
Plus strand

Previous Assembly
chr7:98,923,521-98,963,885
(GRCh37/hg19 by Entrez Gene)
Size:
40,365 bases
Orientation:
Plus strand

chr7:98,923,521-98,985,787
(GRCh37/hg19 by Ensembl)
Size:
62,267 bases
Orientation:
Plus strand

Genomic View for ARPC1A Gene

Genes around ARPC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1A Gene

Proteins for ARPC1A Gene

  • Protein details for ARPC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92747-ARC1A_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 1A
    Protein Accession:
    Q92747
    Secondary Accessions:
    • A4D276
    • B4DLQ7
    • D6W5S1
    • Q7Z5U8
    • Q86WU5
    • Q8IXQ0

    Protein attributes for ARPC1A Gene

    Size:
    370 amino acids
    Molecular mass:
    41569 Da
    Quaternary structure:
    • Probable component of the Arp2/3 complex in which it may replace ARPC1B (Probable). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).

    Three dimensional structures from OCA and Proteopedia for ARPC1A Gene

    Alternative splice isoforms for ARPC1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC1A Gene

Post-translational modifications for ARPC1A Gene

  • Ubiquitination at Lys87, Lys63, and Lys290
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC1A Gene

No data available for DME Specific Peptides for ARPC1A Gene

Domains & Families for ARPC1A Gene

Gene Families for ARPC1A Gene

Protein Domains for ARPC1A Gene

InterPro:
Blocks:
  • G-protein beta WD-40 repeat signature

Suggested Antigen Peptide Sequences for ARPC1A Gene

GenScript: Design optimal peptide antigens:
  • SOP2-like protein (ARC1A_HUMAN)
  • cDNA FLJ57124, highly similar to Actin-related protein 2/3 complex subunit 1A (B4DLQ7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92747

UniProtKB/Swiss-Prot:

ARC1A_HUMAN :
  • Belongs to the WD repeat ARPC1 family.
Family:
  • Belongs to the WD repeat ARPC1 family.
genes like me logo Genes that share domains with ARPC1A: view

Function for ARPC1A Gene

Molecular function for ARPC1A Gene

UniProtKB/Swiss-Prot Function:
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Phenotypes From GWAS Catalog for ARPC1A Gene

Gene Ontology (GO) - Molecular Function for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,TAS 8978670
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with ARPC1A: view
genes like me logo Genes that share phenotypes with ARPC1A: view

miRNA for ARPC1A Gene

miRTarBase miRNAs that target ARPC1A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPC1A Gene

Localization for ARPC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1A Gene

Cytoplasm, cytoskeleton. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC1A gene
Compartment Confidence
extracellular 4
cytoskeleton 4
nucleus 4
cytosol 4
plasma membrane 1
mitochondrion 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA,ISS --
genes like me logo Genes that share ontologies with ARPC1A: view

Pathways & Interactions for ARPC1A Gene

PathCards logo

SuperPathways for ARPC1A Gene

SuperPathway Contained pathways
1 EPH-Ephrin signaling
.35
2 Regulation of actin dynamics for phagocytic cup formation
3 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.37
4 Development Slit-Robo signaling
.44
.44
5 Salmonella infection (KEGG)
genes like me logo Genes that share pathways with ARPC1A: view

Pathways by source for ARPC1A Gene

1 Sino Biological pathway for ARPC1A Gene
1 BioSystems pathway for ARPC1A Gene
14 GeneGo (Thomson Reuters) pathways for ARPC1A Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling

Gene Ontology (GO) - Biological Process for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization TAS 8978670
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA,IBA 21873635
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ARPC1A: view

No data available for SIGNOR curated interactions for ARPC1A Gene

Drugs & Compounds for ARPC1A Gene

No Compound Related Data Available

Transcripts for ARPC1A Gene

mRNA/cDNA for ARPC1A Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC1A

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1A Gene

No ASD Table

Relevant External Links for ARPC1A Gene

GeneLoc Exon Structure for
ARPC1A

Expression for ARPC1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPC1A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC1A Gene



Protein tissue co-expression partners for ARPC1A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARPC1A

SOURCE GeneReport for Unigene cluster for ARPC1A Gene:

Hs.124126

Evidence on tissue expression from TISSUES for ARPC1A Gene

  • Pancreas(4.8)
  • Skin(4.5)
  • Nervous system(4.4)
  • Lung(4.2)
  • Intestine(3.6)
  • Kidney(2.9)
  • Blood(2.4)
  • Spleen(2.3)
  • Eye(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with ARPC1A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC1A Gene

Orthologs for ARPC1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC1A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARPC1A 29 30
  • 99.55 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ARPC1A 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ARPC1A 29 30
  • 94.59 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ARPC1A 30
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ARPC1A 29 30
  • 91.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arpc1a 29
  • 90.99 (n)
Mouse
(Mus musculus)
Mammalia Arpc1a 29 16 30
  • 90.81 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ARPC1A 29 30
  • 83.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARPC1A 30
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arpc1a-prov 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia MGC76015 29
Zebrafish
(Danio rerio)
Actinopterygii arpc1a 29 30
  • 77.66 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Arpc1 29
  • 59.54 (n)
Sop2 30 31
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008908 29
  • 57.83 (n)
Worm
(Caenorhabditis elegans)
Secernentea arx-3 29 30
  • 58.1 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFL022W 29
  • 50.93 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10615g 29
  • 49.16 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 29 30 32
  • 45.73 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10119 30
  • 56 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc1 29
  • 52.3 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02781 29
  • 50.86 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3148 29
Species where no ortholog for ARPC1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARPC1A Gene

ENSEMBL:
Gene Tree for ARPC1A (if available)
TreeFam:
Gene Tree for ARPC1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARPC1A: view image
Alliance of Genome Resources:
Additional Orthologs for ARPC1A

Paralogs for ARPC1A Gene

Paralogs for ARPC1A Gene

(1) SIMAP similar genes for ARPC1A Gene using alignment to 5 proteins:

  • ARC1A_HUMAN
  • B4DLQ7_HUMAN
  • E9PF58_HUMAN
  • F8WFD3_HUMAN
  • Q75MY0_HUMAN
genes like me logo Genes that share paralogs with ARPC1A: view

Variants for ARPC1A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARPC1A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARPC1A Gene

Variant ID Type Subtype PubMed ID
nsv5863 CNV insertion 18451855
nsv831068 CNV loss 17160897
nsv831069 CNV loss 17160897
nsv970909 CNV duplication 23825009

Variation tolerance for ARPC1A Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC1A
Leiden Open Variation Database (LOVD)
ARPC1A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARPC1A Gene

Disorders for ARPC1A Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARPC1A Gene - From: COP

Disorder Aliases PubMed IDs
fanconi anemia, complementation group g
  • fancg
scapuloperoneal myopathy
  • myopathy, scapuloperoneal
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARPC1A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ARPC1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC1A Gene

Publications for ARPC1A Gene

  1. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. (PMID: 8978670) Balasubramanian MK … Gould KL (The EMBO journal 1996) 2 3 4
  2. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PMID: 21533175) Zhai G … Wallaschofski H (PLoS genetics 2011) 3 40
  3. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (PMID: 20570966) McGovern DP … International IBD Genetics Consortium (Human molecular genetics 2010) 3 40
  4. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PMID: 17072959) Piepoli A … Perri F (World journal of gastroenterology 2006) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ARPC1A Gene

Sources for ARPC1A Gene