Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARPC1A Gene

Aliases for ARPC1A Gene

  • Actin Related Protein 2/3 Complex Subunit 1A 2 3 5
  • SOP2-Like Protein 2 3 4
  • Actin Binding Protein (Schizosaccharomyces Pombe Sop2-Like) 2 3
  • SOP2L 3 4
  • Actin Related Protein 2/3 Complex, Subunit 1A (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa 3
  • Actin Related Protein 2/3 Complex Subunit 1A, 41kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 1A 3
  • Epididymis Secretory Protein Li 307 3
  • Epididymis Luminal Protein 68 3
  • HEL-S-307 3
  • HEL-68 3
  • SOP2Hs 3
  • Arc40 3

External Ids for ARPC1A Gene

Previous GeneCards Identifiers for ARPC1A Gene

  • GC07P097458
  • GC07P098521
  • GC07P098534
  • GC07P098568
  • GC07P098761
  • GC07P098923
  • GC07P093559

Summaries for ARPC1A Gene

Entrez Gene Summary for ARPC1A Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ARPC1A Gene

ARPC1A (Actin Related Protein 2/3 Complex Subunit 1A) is a Protein Coding gene. Diseases associated with ARPC1A include Tomato Allergy and Radial Neuropathy. Among its related pathways are Developmental Biology and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is ENSG00000284292.

UniProtKB/Swiss-Prot for ARPC1A Gene

  • Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC1A Gene

Additional gene information for ARPC1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC1A Gene

Genomics for ARPC1A Gene

GeneHancer (GH) Regulatory Elements for ARPC1A Gene

Promoters and enhancers for ARPC1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J099324 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +2.8 2765 7.3 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 NFYC MEF2D ARPC1A TRRAP ZSCAN25 ENSG00000242798 ZNF655 ZNF3 ARPC1B CPSF4 PTCD1 TRIM4
GH07J099362 Promoter/Enhancer 1.2 EPDnew ENCODE 650.3 +37.3 37288 1.6 TEAD4 TAL1 BACH1 FOSL1 TCF12 ZNF766 ZNF316 FOXK2 NCOR1 VEZF1 ARPC1A PDAP1 BUD31 LAMTOR4 ATP5MF PIR48819 ARPC1B ENSG00000284292
GH07J099367 Promoter 0.9 EPDnew 650.3 +40.1 40109 0.1 GATAD2A CTCF KLF1 KLF17 SIN3A XRCC5 IKZF1 RLF CREB1 ZNF444 ARPC1A PDAP1 BUD31 ARPC1B PIR48819 ENSG00000284292
GH07J099348 Promoter 0.6 EPDnew 650.3 +23.0 22967 0.1 MITF PIR48819 ARPC1A ARPC1B BUD31 PDAP1 ENSG00000284292
GH07J099354 Promoter 0.5 EPDnew 650.3 +28.2 28165 0.1 ARPC1A BUD31 PDAP1 PIR48819 ARPC1B ENSG00000284292
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARPC1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARPC1A gene promoter:
  • Msx-1
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • AhR
  • Arnt
  • AREB6
  • POU2F1a
  • POU2F1

Genomic Locations for ARPC1A Gene

Genomic Locations for ARPC1A Gene
40,390 bases
Plus strand
62,292 bases
Plus strand

Genomic View for ARPC1A Gene

Genes around ARPC1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1A Gene

Proteins for ARPC1A Gene

  • Protein details for ARPC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein 2/3 complex subunit 1A
    Protein Accession:
    Secondary Accessions:
    • A4D276
    • B4DLQ7
    • D6W5S1
    • Q7Z5U8
    • Q86WU5
    • Q8IXQ0

    Protein attributes for ARPC1A Gene

    370 amino acids
    Molecular mass:
    41569 Da
    Quaternary structure:
    • Probable component of the Arp2/3 complex in which it may replace ARPC1B.

    Alternative splice isoforms for ARPC1A Gene


neXtProt entry for ARPC1A Gene

Post-translational modifications for ARPC1A Gene

  • Ubiquitination at Lys290, posLast=8787, and Lys63
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARPC1A Gene

Domains & Families for ARPC1A Gene

Gene Families for ARPC1A Gene

Suggested Antigen Peptide Sequences for ARPC1A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat ARPC1 family.
  • Belongs to the WD repeat ARPC1 family.
genes like me logo Genes that share domains with ARPC1A: view

Function for ARPC1A Gene

Molecular function for ARPC1A Gene

UniProtKB/Swiss-Prot Function:
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Phenotypes From GWAS Catalog for ARPC1A Gene

Gene Ontology (GO) - Molecular Function for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 8978670
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with ARPC1A: view
genes like me logo Genes that share phenotypes with ARPC1A: view

Animal Model Products

CRISPR Products

miRNA for ARPC1A Gene

miRTarBase miRNAs that target ARPC1A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPC1A Gene

Localization for ARPC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC1A gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 2
lysosome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA,IBA --
GO:0015629 actin cytoskeleton TAS,IEA 8978670
genes like me logo Genes that share ontologies with ARPC1A: view

Pathways & Interactions for ARPC1A Gene

genes like me logo Genes that share pathways with ARPC1A: view

Gene Ontology (GO) - Biological Process for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization TAS 8978670
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA,IBA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ARPC1A: view

No data available for SIGNOR curated interactions for ARPC1A Gene

Drugs & Compounds for ARPC1A Gene

No Compound Related Data Available

Transcripts for ARPC1A Gene

mRNA/cDNA for ARPC1A Gene

Unigene Clusters for ARPC1A Gene

Actin related protein 2/3 complex, subunit 1A, 41kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARPC1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1A Gene

No ASD Table

Relevant External Links for ARPC1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARPC1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC1A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPC1A Gene

Protein tissue co-expression partners for ARPC1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC1A Gene:


SOURCE GeneReport for Unigene cluster for ARPC1A Gene:


Evidence on tissue expression from TISSUES for ARPC1A Gene

  • Pancreas(4.8)
  • Nervous system(4.6)
  • Skin(4.5)
  • Lung(4.4)
  • Intestine(4)
  • Kidney(3.3)
  • Blood(3.1)
  • Muscle(2.7)
  • Eye(2.5)
  • Heart(2.5)
  • Liver(2.5)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ARPC1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC1A Gene

Orthologs for ARPC1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARPC1A 34 33
  • 99.55 (n)
(Ornithorhynchus anatinus)
Mammalia ARPC1A 34
  • 96 (a)
(Canis familiaris)
Mammalia ARPC1A 34 33
  • 94.59 (n)
(Monodelphis domestica)
Mammalia ARPC1A 34
  • 93 (a)
(Bos Taurus)
Mammalia ARPC1A 34 33
  • 91.53 (n)
(Rattus norvegicus)
Mammalia Arpc1a 33
  • 90.99 (n)
(Mus musculus)
Mammalia Arpc1a 16 34 33
  • 90.81 (n)
(Gallus gallus)
Aves ARPC1A 34 33
  • 83.69 (n)
(Anolis carolinensis)
Reptilia ARPC1A 34
  • 95 (a)
African clawed frog
(Xenopus laevis)
Amphibia arpc1a-prov 33
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76015 33
(Danio rerio)
Actinopterygii arpc1a 34 33 33
  • 77.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arpc1 33
  • 59.54 (n)
Sop2 34 35
  • 55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008908 33
  • 57.83 (n)
(Caenorhabditis elegans)
Secernentea arx-3 34 33
  • 58.1 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL022W 33
  • 50.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10615g 33
  • 49.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 36 34 33
  • 45.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10119 34
  • 56 (a)
Cin.3148 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc1 33
  • 52.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02781 33
  • 50.86 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3148 33
Species where no ortholog for ARPC1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC1A Gene

Gene Tree for ARPC1A (if available)
Gene Tree for ARPC1A (if available)
Evolutionary constrained regions (ECRs) for ARPC1A: view image

Paralogs for ARPC1A Gene

Paralogs for ARPC1A Gene

(1) SIMAP similar genes for ARPC1A Gene using alignment to 5 proteins:

  • E9PF58_HUMAN
  • Q75MY0_HUMAN
genes like me logo Genes that share paralogs with ARPC1A: view

Variants for ARPC1A Gene

Sequence variations from dbSNP and Humsavar for ARPC1A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000013567 -- 99,325,481(+) C/T upstream_transcript_variant
rs1000043131 -- 99,325,722(+) G/A upstream_transcript_variant
rs1000097630 -- 99,353,762(+) A/T intron_variant
rs1000184445 -- 99,356,981(+) C/T intron_variant
rs1000360963 -- 99,328,375(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC1A Gene

Variant ID Type Subtype PubMed ID
nsv5863 CNV insertion 18451855
nsv831068 CNV loss 17160897
nsv831069 CNV loss 17160897
nsv970909 CNV duplication 23825009

Variation tolerance for ARPC1A Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARPC1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC1A Gene

Disorders for ARPC1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for ARPC1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
tomato allergy
  • solanum lycopersicum fruit allergy
radial neuropathy
boomerang dysplasia
  • boomerang-like skeletal dysplasia
  • atelosteogenesis, type 1
diaphragmatic eventration
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARPC1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARPC1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC1A Gene

Publications for ARPC1A Gene

  1. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. (PMID: 8978670) Balasubramanian MK … Gould KL (The EMBO journal 1996) 2 3 4 58
  2. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PMID: 21533175) Zhai G … Wallaschofski H (PLoS genetics 2011) 3 44 58
  3. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (PMID: 20570966) McGovern DP … International IBD Genetics Consortium (Human molecular genetics 2010) 3 44 58
  4. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PMID: 17072959) Piepoli A … Perri F (World journal of gastroenterology 2006) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ARPC1A Gene

Sources for ARPC1A Gene

Loading form....