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Aliases for ARMT1 Gene

Aliases for ARMT1 Gene

  • Acidic Residue Methyltransferase 1 2 3 4 5
  • C6orf211 3 4
  • Protein-Glutamate O-Methyltransferase 3
  • Chromosome 6 Open Reading Frame 211 2
  • UPF0364 Protein C6orf211 3
  • EC 2.1.1.- 4

External Ids for ARMT1 Gene

Previous HGNC Symbols for ARMT1 Gene

  • C6orf211

Summaries for ARMT1 Gene

GeneCards Summary for ARMT1 Gene

ARMT1 (Acidic Residue Methyltransferase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot for ARMT1 Gene

  • O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.

Additional gene information for ARMT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMT1 Gene

Genomics for ARMT1 Gene

GeneHancer (GH) Regulatory Elements for ARMT1 Gene

Promoters and enhancers for ARMT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J151450 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.0 43 3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RMND1 ARMT1 HSPA8P15 ZBTB2 CCDC170
GH06J151492 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 11.3 +41.8 41846 2.4 FOXA2 ARID4B SIN3A DMAP1 ZNF48 MXD4 RFX3 MXD3 KDM1A BRD4 CCDC170 RMND1 HSPA8P15 ZBTB2 ARMT1 ESR1 GC06M151579
GH06J151497 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.2 +46.5 46543 3.2 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 CREM THAP11 MIXL1 RMND1 ARMT1 RNU6-813P CCDC170 ZBTB2 GC06M151579
GH06J151501 Enhancer 0.9 Ensembl ENCODE 10.6 +49.9 49909 1.8 SOX13 FOXA2 JUN FOS FOSL2 CREM MAFK TCF7L2 TEAD1 NFIA RMND1 ARMT1 CCDC170 GC06M151579
GH06J151806 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 5.8 +356.1 356121 2.8 USF1 ZNF777 SUZ12 SIN3A ZIC2 RAD21 E2F1 ZFHX2 GATA3 GLIS2 ESR1 ARMT1 GC06P151812 GC06P151669
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMT1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARMT1 Gene

Genomic Locations for ARMT1 Gene
17,844 bases
Plus strand
17,815 bases
Plus strand

Genomic View for ARMT1 Gene

Genes around ARMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMT1 Gene

Proteins for ARMT1 Gene

  • Protein details for ARMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-glutamate O-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q96FC6
    • Q9UFY5

    Protein attributes for ARMT1 Gene

    441 amino acids
    Molecular mass:
    51172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARMT1 Gene

Post-translational modifications for ARMT1 Gene

Other Protein References for ARMT1 Gene

No data available for DME Specific Peptides for ARMT1 Gene

Domains & Families for ARMT1 Gene

Gene Families for ARMT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMT1 Gene

Suggested Antigen Peptide Sequences for ARMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ARMT1 family.
  • Belongs to the ARMT1 family.
genes like me logo Genes that share domains with ARMT1: view

Function for ARMT1 Gene

Molecular function for ARMT1 Gene

UniProtKB/Swiss-Prot Function:
O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Enzyme Numbers (IUBMB) for ARMT1 Gene

Phenotypes From GWAS Catalog for ARMT1 Gene

Gene Ontology (GO) - Molecular Function for ARMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25732820
GO:0008168 methyltransferase activity IEA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 25732820
GO:0016740 transferase activity IEA --
GO:0019899 enzyme binding IPI 25732820
genes like me logo Genes that share ontologies with ARMT1: view
genes like me logo Genes that share phenotypes with ARMT1: view

Animal Model Products

miRNA for ARMT1 Gene

miRTarBase miRNAs that target ARMT1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMT1 Gene

Localization for ARMT1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMT1 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMT1 Gene

Pathways & Interactions for ARMT1 Gene

SuperPathways for ARMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0032259 methylation IEA,IDA 25732820
GO:2001020 regulation of response to DNA damage stimulus IMP 25732820
genes like me logo Genes that share ontologies with ARMT1: view

No data available for Pathways by source and SIGNOR curated interactions for ARMT1 Gene

Drugs & Compounds for ARMT1 Gene

No Compound Related Data Available

Transcripts for ARMT1 Gene

mRNA/cDNA for ARMT1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -

Relevant External Links for ARMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMT1 Gene

This gene is overexpressed in Breast (6.7), Oral epithelium (6.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMT1 Gene

Protein tissue co-expression partners for ARMT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMT1 Gene:


Evidence on tissue expression from TISSUES for ARMT1 Gene

  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ARMT1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMT1 Gene

Orthologs for ARMT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf211 33
  • 99.55 (n)
C6orf211 34
  • 99 (a)
(Canis familiaris)
Mammalia C1H6orf211 33
  • 88.13 (n)
C6ORF211 34
  • 88 (a)
(Bos Taurus)
Mammalia C9H6orf211 34 33
  • 86.39 (n)
(Rattus norvegicus)
Mammalia RGD1305235 33
  • 80.33 (n)
(Mus musculus)
Mammalia 1700052N19Rik 34 33
  • 79.35 (n)
Armt1 16
(Ornithorhynchus anatinus)
Mammalia C6orf211 34
  • 69 (a)
(Monodelphis domestica)
Mammalia C6orf211 34
  • 65 (a)
(Gallus gallus)
Aves C6ORF211 33
  • 72.25 (n)
C6orf211 34
  • 68 (a)
(Anolis carolinensis)
Reptilia C6orf211 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf211 33
  • 65.58 (n)
(Danio rerio)
Actinopterygii zgc:110816 33
  • 61.07 (n)
C20H6orf211 34
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010723 33
  • 47.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11474 34 33
  • 45.77 (n)
CG2921 34
  • 31 (a)
CG4161 34
  • 29 (a)
CG11475 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F31D4.2 34 33
  • 50.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR027W 33
  • 46.78 (n)
-- 34
  • 28 (a)
-- 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12859g 33
  • 46.7 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1393.13 33
  • 46.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07814 33
  • 43.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for ARMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARMT1 Gene

Gene Tree for ARMT1 (if available)
Gene Tree for ARMT1 (if available)
Evolutionary constrained regions (ECRs) for ARMT1: view image

Paralogs for ARMT1 Gene

No data available for Paralogs for ARMT1 Gene

Variants for ARMT1 Gene

Sequence variations from dbSNP and Humsavar for ARMT1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1053585744 likely-benign, not specified 151,452,029(+) GAG/ upstream_transcript_variant
rs936571707 likely-benign, not specified 151,452,026(+) GAAGAGAAGA/GAAGA upstream_transcript_variant
rs3736175 benign, not specified 151,452,029(+) G/A upstream_transcript_variant
rs1000014192 -- 151,461,229(+) T/C intron_variant
rs1000066432 -- 151,461,587(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMT1 Gene

Variant ID Type Subtype PubMed ID
esv3576236 CNV gain 25503493
nsv1016522 CNV gain 25217958

Variation tolerance for ARMT1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 64.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMT1 Gene

Disorders for ARMT1 Gene

Additional Disease Information for ARMT1

No disorders were found for ARMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMT1 Gene

Publications for ARMT1 Gene

  1. Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response. (PMID: 25732820) Perry JJ … Hoelz DJ (Cell reports 2015) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ARMT1 Gene

Sources for ARMT1 Gene

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