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Aliases for ARMH4 Gene

Aliases for ARMH4 Gene

  • Armadillo-Like Helical Domain Containing 4 2 3
  • Chromosome 14 Open Reading Frame 37 2 5
  • Upstream Of MTORC2 2 3
  • C14orf37 3 5
  • Uncharacterized Protein C14orf37 3
  • C14_5376 3
  • UT2 3

External Ids for ARMH4 Gene

Previous HGNC Symbols for ARMH4 Gene

  • C14orf37

Summaries for ARMH4 Gene

GeneCards Summary for ARMH4 Gene

ARMH4 (Armadillo-Like Helical Domain Containing 4) is a Protein Coding gene.

Additional gene information for ARMH4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMH4 Gene

Genomics for ARMH4 Gene

GeneHancer (GH) Regulatory Elements for ARMH4 Gene

Promoters and enhancers for ARMH4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J058296 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -0.3 -286 4.5 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 PSMA3-AS1 ARID4A ARMH4 KIAA0586 ENSG00000258682 TIMM9 TOMM20L ACTR10 GC14P058345
GH14J058151 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 660.5 +146.1 146060 1.7 SIN3A KLF14 ZNF335 GLIS2 EGR1 EGR2 SP3 GATAD2B MTA1 GLIS1 ARMH4 GC14P058142 RN7SL598P GC14P058110
GH14J058242 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.6 +53.5 53534 3.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PSMA3 RNU6-341P ARID4A ARMH4 PSMA3-AS1 ENSG00000258682 TRK-CTT1-1 GC14P058110
GH14J058199 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.9 +97.7 97732 2.4 ATF1 ARID4B SIN3A DMAP1 NCOA2 GLIS2 ZNF207 ZNF143 KLF7 RUNX3 ACTR10 PSMA3-AS1 ARMH4 TRK-CTT1-1 GC14P058110
GH14J058081 Enhancer 0.9 Ensembl ENCODE 10.6 +215.8 215761 1.9 MEIS2 USF1 JUN BACH1 FOSL1 ZNF316 POLR2A NFE2 FOSL2 FOS ARMH4 LOC100420347 GC14M058071 GC14M058040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARMH4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARMH4 Gene

Genomic Locations for ARMH4 Gene
chr14:57,993,531-58,298,139
(GRCh38/hg38)
Size:
304,609 bases
Orientation:
Minus strand
chr14:58,466,453-58,764,857
(GRCh37/hg19)
Size:
298,405 bases
Orientation:
Minus strand

Genomic View for ARMH4 Gene

Genes around ARMH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMH4 Gene

Proteins for ARMH4 Gene

  • Protein details for ARMH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TY3-CN037_HUMAN
    Recommended name:
    Uncharacterized protein C14orf37
    Protein Accession:
    Q86TY3
    Secondary Accessions:
    • A8K8Z8
    • Q6P5Q1
    • Q86TY1

    Protein attributes for ARMH4 Gene

    Size:
    774 amino acids
    Molecular mass:
    84173 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARMH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMH4 Gene

Post-translational modifications for ARMH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARMH4 Gene

No data available for DME Specific Peptides for ARMH4 Gene

Domains & Families for ARMH4 Gene

Gene Families for ARMH4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ARMH4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARMH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMH4: view

No data available for UniProtKB/Swiss-Prot for ARMH4 Gene

Function for ARMH4 Gene

Phenotypes From GWAS Catalog for ARMH4 Gene

genes like me logo Genes that share phenotypes with ARMH4: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMH4 Gene

Localization for ARMH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMH4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMH4 gene
Compartment Confidence
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMH4: view

Pathways & Interactions for ARMH4 Gene

SuperPathways for ARMH4 Gene

No Data Available

Interacting Proteins for ARMH4 Gene

Gene Ontology (GO) - Biological Process for ARMH4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMH4 Gene

Drugs & Compounds for ARMH4 Gene

No Compound Related Data Available

Transcripts for ARMH4 Gene

mRNA/cDNA for ARMH4 Gene

(5) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMH4 Gene

No ASD Table

Relevant External Links for ARMH4 Gene

GeneLoc Exon Structure for
ARMH4
ECgene alternative splicing isoforms for
ARMH4

Expression for ARMH4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMH4 Gene:

ARMH4

Evidence on tissue expression from TISSUES for ARMH4 Gene

  • Kidney(4.3)
  • Intestine(3.8)
  • Stomach(3.6)
  • Lung(2.7)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ARMH4: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMH4 Gene

Orthologs for ARMH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf37 33
  • 99.01 (n)
C14ORF37 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf37 33
  • 83.68 (n)
C14orf37 34
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H14orf37 33
  • 82.14 (n)
C14orf37 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3632451O06Rik 34 33
  • 72.38 (n)
OneToOne
Armh4 16
rat
(Rattus norvegicus)
Mammalia RGD1310110 33
  • 71.52 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf37 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf37 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF37 33
  • 54.11 (n)
C14orf37 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf37 34
  • 88 (a)
OneToOne
Species where no ortholog for ARMH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARMH4 Gene

ENSEMBL:
Gene Tree for ARMH4 (if available)
TreeFam:
Gene Tree for ARMH4 (if available)

Paralogs for ARMH4 Gene

No data available for Paralogs for ARMH4 Gene

Variants for ARMH4 Gene

Sequence variations from dbSNP and Humsavar for ARMH4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000004846 -- 58,149,035(-) T/C intron_variant
rs1000036507 -- 58,080,889(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000043790 -- 58,124,448(-) G/A intron_variant
rs1000050068 -- 58,107,256(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000060433 -- 57,997,585(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMH4 Gene

Variant ID Type Subtype PubMed ID
nsv826959 CNV loss 20364138
nsv507752 OTHER sequence alteration 20534489
nsv1046422 CNV gain 25217958
nsv1042675 CNV gain 25217958
nsv1038569 CNV gain 25217958
esv3634620 CNV loss 21293372
esv3634619 CNV loss 21293372
esv3634618 CNV loss 21293372
esv34185 CNV loss 18971310
esv3412182 CNV insertion 20981092
esv2677940 CNV deletion 23128226
esv2657771 CNV deletion 23128226
esv2319201 CNV deletion 18987734

Variation tolerance for ARMH4 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.96; 97.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMH4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMH4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMH4 Gene

Disorders for ARMH4 Gene

Additional Disease Information for ARMH4

No disorders were found for ARMH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMH4 Gene

Publications for ARMH4 Gene

  1. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. (PMID: 26927669) Lee D … Scadden DT (The Journal of clinical investigation 2016) 2 3 58
  2. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. (PMID: 25418727) Lee D … Scadden DT (Stem cell reports 2014) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for ARMH4 Gene

Sources for ARMH4 Gene

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