Aliases for ARMH3 Gene

Aliases for ARMH3 Gene

  • Armadillo Like Helical Domain Containing 3 2 3 5
  • Armadillo-Like Helical Domain-Containing Protein 3 3 4
  • C10orf76 3 4
  • Chromosome 10 Open Reading Frame 76 2
  • UPF0668 Protein C10orf76 3
  • FLJ13114 2
  • ARMH3 5

External Ids for ARMH3 Gene

Previous HGNC Symbols for ARMH3 Gene

  • C10orf76

Summaries for ARMH3 Gene

GeneCards Summary for ARMH3 Gene

ARMH3 (Armadillo Like Helical Domain Containing 3) is a Protein Coding gene. Diseases associated with ARMH3 include Crohn's Colitis.

UniProtKB/Swiss-Prot Summary for ARMH3 Gene

  • Involved in GBF1 recruitment, Golgi maintenance and protein secretion.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARMH3 Gene

Genomics for ARMH3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARMH3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102055 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 604.5 +0.7 705 2.9 SP1 CREB1 HNRNPL PRDM10 ZNF629 REST SIX5 ZNF692 POLR2A BACH1 ARMH3 lnc-HPS6-4 OGA NOLC1 KCNIP2 piR-43583-059
GH10J102057 Enhancer 0.9 ENCODE 600.7 -1.9 -1925 0.9 GATAD2A ZBTB33 ATF7 ZNF629 TFE3 LEF1 RCOR2 JUND RXRB PATZ1 ARMH3 lnc-HPS6-4 HPS6
GH10J101828 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +225.3 225256 4.4 SP1 CREB1 HNRNPL PRDM10 ZNF629 LEF1 KDM1A ZNF692 BACH1 TARDBP PPRC1 LDB1 LZTS2 GBF1 MRPL43 HPS6 NOLC1 SUFU ENSG00000272572 SLF2
GH10J102916 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -863.1 -863064 6.2 BRCA1 SP1 CREB1 CTCF TEAD4 ZNF629 TFE3 SIX5 IKZF1 NFKBIZ CNNM2 ENSG00000286575 LOC107984265 AS3MT ENSG00000260461 NOLC1 PPRC1 TAF5 PDCD11 BORCS7
GH10J101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10 +361.8 361848 3.2 GATAD2A PRDM10 ZNF629 TFE3 IKZF1 NFKBIZ POLR2A BACH1 ETV6 LARP7 ENSG00000286489 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 OGA TWNK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMH3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARMH3

Genomic Locations for ARMH3 Gene

Genomic Locations for ARMH3 Gene
210,639 bases
Minus strand
210,595 bases
Minus strand

Genomic View for ARMH3 Gene

Genes around ARMH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMH3 Gene

Proteins for ARMH3 Gene

  • Protein details for ARMH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo-like helical domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q2TB87
    • Q9H8Z9

    Protein attributes for ARMH3 Gene

    689 amino acids
    Molecular mass:
    78710 Da
    Quaternary structure:
    • Interacts with PI4KB (PubMed:23572552). Interacts with GBF1 (PubMed:31519766).
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ARMH3 Gene


neXtProt entry for ARMH3 Gene

Post-translational modifications for ARMH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMH3 Gene

Domains & Families for ARMH3 Gene

Gene Families for ARMH3 Gene

Protein Domains for ARMH3 Gene


Suggested Antigen Peptide Sequences for ARMH3 Gene

GenScript: Design optimal peptide antigens:
  • UPF0668 protein C10orf76 (CJ076_HUMAN)
  • C10orf76 protein (Q7Z2U8_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ARMH3 family.
  • Belongs to the ARMH3 family.
genes like me logo Genes that share domains with ARMH3: view

Function for ARMH3 Gene

Molecular function for ARMH3 Gene

UniProtKB/Swiss-Prot Function:
Involved in GBF1 recruitment, Golgi maintenance and protein secretion.

Phenotypes From GWAS Catalog for ARMH3 Gene

Gene Ontology (GO) - Molecular Function for ARMH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23572552
genes like me logo Genes that share ontologies with ARMH3: view
genes like me logo Genes that share phenotypes with ARMH3: view

Animal Models for ARMH3 Gene

MGI Knock Outs for ARMH3:
  • Armh3 Armh3<tm1a(EUCOMM)Wtsi>

miRNA for ARMH3 Gene

miRTarBase miRNAs that target ARMH3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARMH3 Gene

Localization for ARMH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMH3 Gene

Golgi apparatus membrane. Single-pass membrane protein. Cytoplasm. Note=The majority of ARMD3 is cytosolic, with a portion colocalizing with GBF1 at juxtanuclear Golgi sites. {ECO:0000269 PubMed:31519766}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMH3 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
plasma membrane 3
peroxisome 1
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARMH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,IDA 31519766
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IDA 31519766
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARMH3: view

Pathways & Interactions for ARMH3 Gene

PathCards logo

SuperPathways for ARMH3 Gene

No Data Available

Interacting Proteins for ARMH3 Gene

Gene Ontology (GO) - Biological Process for ARMH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903358 regulation of Golgi organization IMP 31519766
genes like me logo Genes that share ontologies with ARMH3: view

No data available for Pathways by source and SIGNOR curated interactions for ARMH3 Gene

Drugs & Compounds for ARMH3 Gene

No Compound Related Data Available

Transcripts for ARMH3 Gene

mRNA/cDNA for ARMH3 Gene

12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ARMH3 Gene

No ASD Table

Relevant External Links for ARMH3 Gene

GeneLoc Exon Structure for

Expression for ARMH3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARMH3

Evidence on tissue expression from TISSUES for ARMH3 Gene

  • Nervous system(2.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMH3 Gene

Orthologs for ARMH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARMH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia C10orf76 31
  • 100 (a)
C28H10orf76 30
  • 94.82 (n)
(Pan troglodytes)
Mammalia C10orf76 31
  • 100 (a)
C10H10orf76 30
  • 99.9 (n)
(Bos Taurus)
Mammalia C10orf76 31
  • 100 (a)
C26H10orf76 30
  • 95.21 (n)
(Monodelphis domestica)
Mammalia C10orf76 31
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf76 31
  • 93 (a)
(Mus musculus)
Mammalia 9130011E15Rik 30 31
  • 91.39 (n)
Armh3 17
(Rattus norvegicus)
Mammalia RGD1564887 30
  • 91.39 (n)
(Gallus gallus)
Aves C10orf76 31
  • 96 (a)
C6H10ORF76 30
  • 82.54 (n)
(Anolis carolinensis)
Reptilia C10orf76 31
  • 95 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488528 30
  • 79.25 (n)
Str.10588 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.32918 30
(Danio rerio)
Actinopterygii C22H10orf76 (1 of 2) 31
  • 85 (a)
C22H10orf76 (2 of 2) 31
  • 82 (a)
zgc:63733 30
  • 74.94 (n)
zgc63733 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG8379 30 31
  • 55.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012485 30
  • 50.43 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU08708 30
  • 42.72 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC20F10.02c 30
  • 38.32 (n)
Species where no ortholog for ARMH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ARMH3 Gene

Gene Tree for ARMH3 (if available)
Gene Tree for ARMH3 (if available)

Paralogs for ARMH3 Gene

No data available for Paralogs for ARMH3 Gene

Variants for ARMH3 Gene

Additional dbSNP identifiers (rs#s) for ARMH3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARMH3 Gene

Variant ID Type Subtype PubMed ID
esv1400220 CNV insertion 17803354
esv3309100 CNV mobile element insertion 20981092
esv3329487 CNV insertion 20981092
esv3338570 CNV insertion 20981092
esv3346415 CNV insertion 20981092
esv3414712 CNV insertion 20981092
esv3450028 CNV duplication 20981092
esv3624392 CNV loss 21293372
nsv472440 CNV novel sequence insertion 20440878
nsv479391 CNV novel sequence insertion 20440878
nsv513016 CNV insertion 21212237

Variation tolerance for ARMH3 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMH3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARMH3 Gene

Disorders for ARMH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARMH3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
crohn's colitis
  • crohn disease
- elite association - COSMIC cancer census association via MalaCards
Search ARMH3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ARMH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARMH3 Gene

Publications for ARMH3 Gene

  1. BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. (PMID: 31519766) Chan CJ … Melançon P (Molecular & cellular proteomics : MCP 2019) 2 3 4
  2. Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication. (PMID: 31829496) McPhail JA … Burke JE (EMBO reports 2020) 2 3
  3. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3

Products for ARMH3 Gene

Sources for ARMH3 Gene