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Aliases for ARMH3 Gene

Aliases for ARMH3 Gene

  • Armadillo-Like Helical Domain Containing 3 2 3
  • Chromosome 10 Open Reading Frame 76 2 5
  • C10orf76 3 5
  • UPF0668 Protein C10orf76 3

External Ids for ARMH3 Gene

Previous HGNC Symbols for ARMH3 Gene

  • C10orf76

Summaries for ARMH3 Gene

GeneCards Summary for ARMH3 Gene

ARMH3 (Armadillo-Like Helical Domain Containing 3) is a Protein Coding gene.

Additional gene information for ARMH3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMH3 Gene

Genomics for ARMH3 Gene

GeneHancer (GH) Regulatory Elements for ARMH3 Gene

Promoters and enhancers for ARMH3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102054 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 654.5 +0.6 594 2.5 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ARMH3 OGA LDB1 PPRC1 NOLC1 SUFU KCNIP2 ENSG00000222430
GH10J102057 Enhancer 0.9 ENCODE 650.7 -1.9 -1930 0.9 ATF1 FOXA2 ARNT ARID4B DMAP1 POLR2B ZNF766 ATF7 ZNF592 NFIL3 ARMH3 HPS6
GH10J102916 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -862.4 -862417 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 CNNM2 AS3MT TAF5 PDCD11 GBF1 ENSG00000260461 PPRC1 ARMH3 NOLC1 LDB1
GH10J101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10 +361.9 361885 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 OGA TWNK SLF2
GH10J101828 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +225.2 225249 4.4 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF2 ZBTB7B ZNF766 ZNF416 PPRC1 LDB1 GBF1 LZTS2 MRPL43 HPS6 NOLC1 SUFU ENSG00000272572 SLF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMH3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARMH3 Gene

Genomic Locations for ARMH3 Gene
chr10:101,845,599-102,056,232
(GRCh38/hg38)
Size:
210,634 bases
Orientation:
Minus strand
chr10:103,605,356-103,815,950
(GRCh37/hg19)
Size:
210,595 bases
Orientation:
Minus strand

Genomic View for ARMH3 Gene

Genes around ARMH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMH3 Gene

Proteins for ARMH3 Gene

  • Protein details for ARMH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2E6-CJ076_HUMAN
    Recommended name:
    UPF0668 protein C10orf76
    Protein Accession:
    Q5T2E6
    Secondary Accessions:
    • Q2TB87
    • Q9H8Z9

    Protein attributes for ARMH3 Gene

    Size:
    689 amino acids
    Molecular mass:
    78710 Da
    Quaternary structure:
    • Interacts with PI4KB.

    Alternative splice isoforms for ARMH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMH3 Gene

Post-translational modifications for ARMH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMH3 Gene

Domains & Families for ARMH3 Gene

Gene Families for ARMH3 Gene

Protein Domains for ARMH3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARMH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T2E6

UniProtKB/Swiss-Prot:

CJ076_HUMAN :
  • Belongs to the UPF0668 family.
Family:
  • Belongs to the UPF0668 family.
genes like me logo Genes that share domains with ARMH3: view

Function for ARMH3 Gene

Phenotypes From GWAS Catalog for ARMH3 Gene

Gene Ontology (GO) - Molecular Function for ARMH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23572552
genes like me logo Genes that share ontologies with ARMH3: view
genes like me logo Genes that share phenotypes with ARMH3: view

Animal Models for ARMH3 Gene

MGI Knock Outs for ARMH3:
  • Armh3 Armh3<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for ARMH3 Gene

miRTarBase miRNAs that target ARMH3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARMH3 Gene

Localization for ARMH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMH3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMH3 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARMH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMH3: view

Pathways & Interactions for ARMH3 Gene

SuperPathways for ARMH3 Gene

No Data Available

Interacting Proteins for ARMH3 Gene

Gene Ontology (GO) - Biological Process for ARMH3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMH3 Gene

Drugs & Compounds for ARMH3 Gene

No Compound Related Data Available

Transcripts for ARMH3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ARMH3 Gene

No ASD Table

Relevant External Links for ARMH3 Gene

GeneLoc Exon Structure for
ARMH3
ECgene alternative splicing isoforms for
ARMH3

Expression for ARMH3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMH3 Gene:

ARMH3

Evidence on tissue expression from TISSUES for ARMH3 Gene

  • Nervous system(2.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMH3 Gene

Orthologs for ARMH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARMH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10orf76 34
  • 100 (a)
OneToOne
C26H10orf76 33
  • 95.21 (n)
chimpanzee
(Pan troglodytes)
Mammalia C10orf76 34
  • 100 (a)
OneToOne
C10H10orf76 33
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia C10orf76 34
  • 100 (a)
OneToOne
C28H10orf76 33
  • 94.82 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf76 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf76 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9130011E15Rik 34 33
  • 91.39 (n)
OneToOne
Armh3 16
rat
(Rattus norvegicus)
Mammalia RGD1564887 33
  • 91.39 (n)
chicken
(Gallus gallus)
Aves C10orf76 34
  • 96 (a)
OneToOne
C6H10ORF76 33
  • 82.54 (n)
lizard
(Anolis carolinensis)
Reptilia C10orf76 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488528 33
  • 79.25 (n)
Str.10588 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32918 33
zebrafish
(Danio rerio)
Actinopterygii C22H10orf76 (1 of 2) 34
  • 85 (a)
OneToMany
C22H10orf76 (2 of 2) 34
  • 82 (a)
OneToMany
zgc:63733 33
  • 74.94 (n)
zgc63733 33
fruit fly
(Drosophila melanogaster)
Insecta CG8379 34 33
  • 55.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012485 33
  • 50.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08708 33
  • 42.72 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC20F10.02c 33
  • 38.32 (n)
Species where no ortholog for ARMH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMH3 Gene

ENSEMBL:
Gene Tree for ARMH3 (if available)
TreeFam:
Gene Tree for ARMH3 (if available)

Paralogs for ARMH3 Gene

No data available for Paralogs for ARMH3 Gene

Variants for ARMH3 Gene

Sequence variations from dbSNP and Humsavar for ARMH3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000029857 -- 101,971,304(-) C/T intron_variant
rs1000060749 -- 101,912,249(-) C/T intron_variant
rs1000061344 -- 101,958,126(-) C/T intron_variant
rs1000061739 -- 102,026,111(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000075626 -- 102,045,211(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMH3 Gene

Variant ID Type Subtype PubMed ID
esv1400220 CNV insertion 17803354
esv3309100 CNV mobile element insertion 20981092
esv3329487 CNV insertion 20981092
esv3338570 CNV insertion 20981092
esv3346415 CNV insertion 20981092
esv3414712 CNV insertion 20981092
esv3450028 CNV duplication 20981092
esv3624392 CNV loss 21293372
nsv472440 CNV novel sequence insertion 20440878
nsv479391 CNV novel sequence insertion 20440878
nsv513016 CNV insertion 21212237

Variation tolerance for ARMH3 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMH3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMH3 Gene

Disorders for ARMH3 Gene

Additional Disease Information for ARMH3

No disorders were found for ARMH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMH3 Gene

Publications for ARMH3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 58

Products for ARMH3 Gene

Sources for ARMH3 Gene

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