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Aliases for ARMCX4 Gene

Aliases for ARMCX4 Gene

  • Armadillo Repeat Containing X-Linked 4 2 3
  • Armadillo Repeat Containing, X-Linked 4 Pseudogene 2 3
  • Armadillo Repeat-Containing X-Linked Protein 4 3
  • Armadillo Repeat Containing, X-Linked 4 5
  • Chromosome X Open Reading Frame 35 2
  • CXorf35 3
  • GASP4 3

External Ids for ARMCX4 Gene

Previous HGNC Symbols for ARMCX4 Gene

  • CXorf35

Previous GeneCards Identifiers for ARMCX4 Gene

  • GC0XP100546
  • GC0XP100627
  • GC0XU901218
  • GC0XP100561
  • GC0XP100673
  • GC0XP090479

Summaries for ARMCX4 Gene

Entrez Gene Summary for ARMCX4 Gene

  • The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ARMCX4 Gene

ARMCX4 (Armadillo Repeat Containing X-Linked 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is GPRASP1.

Additional gene information for ARMCX4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX4 Gene

Genomics for ARMCX4 Gene

GeneHancer (GH) Regulatory Elements for ARMCX4 Gene

Promoters and enhancers for ARMCX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ101416 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 670.3 +0.2 239 3.3 KLF17 MZF1 GLI4 ZNF2 YY1 ZNF335 GLIS2 ZNF366 RUNX3 SP3 ARMCX4 GC0XM101414
GH0XJ101483 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 660.5 +66.9 66925 2.4 PKNOX1 USF1 POLR2A MAX CREB1 USF2 ZNF398 CHD2 ARMCX4 PIR42846 PPIAP90
GH0XJ101453 Promoter 0.5 EPDnew 650.3 +35.3 35328 0.1 ARMCX4 PPIAP90 PIR42846
GH0XJ101406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.9 -9.5 -9536 5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 GLA HNRNPH2 PPIAP90 RPL36A ARMCX4 ARMCX1 ENSG00000261101 RPL36A-HNRNPH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMCX4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARMCX4 Gene

Genomic Locations for ARMCX4 Gene
117,726 bases
Plus strand
115,181 bases
Plus strand

Genomic View for ARMCX4 Gene

Genes around ARMCX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMCX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMCX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX4 Gene

Proteins for ARMCX4 Gene

  • Protein details for ARMCX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing X-linked protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K928
    • B3KXA4
    • Q5H9K8
    • Q8N8D6

    Protein attributes for ARMCX4 Gene

    360 amino acids
    Molecular mass:
    39406 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARMCX4 Gene


neXtProt entry for ARMCX4 Gene

Post-translational modifications for ARMCX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARMCX4 Gene

No data available for DME Specific Peptides for ARMCX4 Gene

Domains & Families for ARMCX4 Gene

Gene Families for ARMCX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMCX4 Gene


Suggested Antigen Peptide Sequences for ARMCX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eutherian X-chromosome-specific Armcx family.
  • Belongs to the eutherian X-chromosome-specific Armcx family.
genes like me logo Genes that share domains with ARMCX4: view

Function for ARMCX4 Gene

Gene Ontology (GO) - Molecular Function for ARMCX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ARMCX4: view

Phenotypes for ARMCX4 Gene

genes like me logo Genes that share phenotypes with ARMCX4: view

Animal Model Products

miRNA for ARMCX4 Gene

miRTarBase miRNAs that target ARMCX4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMCX4 Gene

Localization for ARMCX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMCX4 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMCX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMCX4: view

Pathways & Interactions for ARMCX4 Gene

SuperPathways for ARMCX4 Gene

No Data Available

Interacting Proteins for ARMCX4 Gene

Gene Ontology (GO) - Biological Process for ARMCX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARMCX4 Gene

Drugs & Compounds for ARMCX4 Gene

No Compound Related Data Available

Transcripts for ARMCX4 Gene

mRNA/cDNA for ARMCX4 Gene

(2) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARMCX4 Gene

Armadillo repeat containing, X-linked 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: -
SP7: - - - - -
SP8: - - - -

Relevant External Links for ARMCX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMCX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMCX4 Gene

Protein differential expression in normal tissues from HIPED for ARMCX4 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARMCX4 Gene

Protein tissue co-expression partners for ARMCX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMCX4 Gene:


SOURCE GeneReport for Unigene cluster for ARMCX4 Gene:


Evidence on tissue expression from TISSUES for ARMCX4 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ARMCX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMCX4 Gene

Orthologs for ARMCX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ARMCX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC101058973 33
  • 98.67 (n)
  • 69 (a)
(Canis familiaris)
Mammalia ARMCX4 34 33
  • 80.85 (n)
(Bos Taurus)
Mammalia ARMCX4 34 33
  • 78.92 (n)
(Mus musculus)
Mammalia Armcx4 16 34 33
  • 78.6 (n)
(Rattus norvegicus)
Mammalia Armcx4 33
  • 76.05 (n)
Species where no ortholog for ARMCX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARMCX4 Gene

Gene Tree for ARMCX4 (if available)
Gene Tree for ARMCX4 (if available)
Evolutionary constrained regions (ECRs) for ARMCX4: view image

Paralogs for ARMCX4 Gene

Paralogs for ARMCX4 Gene

(5) SIMAP similar genes for ARMCX4 Gene using alignment to 4 proteins:

  • F8W8Y7_HUMAN
genes like me logo Genes that share paralogs with ARMCX4: view

Variants for ARMCX4 Gene

Sequence variations from dbSNP and Humsavar for ARMCX4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs863223372 benign, Abnormality of neuronal migration 101,489,163(+) A/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000015794 -- 101,457,275(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000066532 -- 101,456,635(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000176047 -- 101,466,594(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000264757 -- 101,448,090(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMCX4 Gene

Variant ID Type Subtype PubMed ID
esv1096204 CNV insertion 17803354
esv1282718 CNV insertion 17803354
esv2479084 CNV insertion 19546169
esv2675772 CNV deletion 23128226
esv2740356 CNV deletion 23290073
esv2740357 CNV deletion 23290073
esv2740358 CNV deletion 23290073
nsv1076718 CNV duplication 25765185
nsv1110616 CNV duplication 24896259
nsv1111387 CNV tandem duplication 24896259
nsv1128547 CNV deletion 24896259
nsv1132249 CNV deletion 24896259
nsv1141073 CNV deletion 24896259
nsv1146322 CNV duplication 26484159

Variation tolerance for ARMCX4 Gene

Gene Damage Index Score: 7.18; 80.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMCX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMCX4 Gene

Disorders for ARMCX4 Gene

Additional Disease Information for ARMCX4

No disorders were found for ARMCX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMCX4 Gene

Publications for ARMCX4 Gene

  1. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PMID: 22569362) López-Doménech G … Soriano E (Nature communications 2012) 2 3 58
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 3 4 58
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ARMCX4 Gene

Sources for ARMCX4 Gene

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