Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARMC8 Gene

Aliases for ARMC8 Gene

  • Armadillo Repeat Containing 8 2 3 5
  • GID Complex Subunit 5, VID28 Homolog (S. Cerevisiae) 2
  • Armadillo Repeat-Containing Protein 8 3
  • GID Complex Subunit 5, VID28 Homolog 3
  • HSPC056 3
  • S863-2 3
  • VID28 3
  • GID5 3

External Ids for ARMC8 Gene

Previous GeneCards Identifiers for ARMC8 Gene

  • GC03P139389
  • GC03P137906
  • GC03P135282

Summaries for ARMC8 Gene

GeneCards Summary for ARMC8 Gene

ARMC8 (Armadillo Repeat Containing 8) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for ARMC8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC8 Gene

Genomics for ARMC8 Gene

GeneHancer (GH) Regulatory Elements for ARMC8 Gene

Promoters and enhancers for ARMC8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I138186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 530 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ARMC8 MRAS CEP70 A4GNT GC03P138286
GH03I139118 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5.2 +933.6 933598 4.3 ATF1 PKNOX1 FOXA2 YY1 TCF12 ZNF766 GATA2 ATF7 REST NFIL3 BPESC1 ARMC8 GC03M139047 MRPS22
GH03I138221 Enhancer 0.5 Ensembl ENCODE 12.3 +35.2 35153 1.2 GABPA ARMC8 DBR1 MRAS NME9 DZIP1L GC03P138286
GH03I138219 Enhancer 0.4 FANTOM5 13.6 +32.2 32221 0.2 JUN ARMC8 DBR1 DZIP1L GC03P138286
GH03I138645 Enhancer 0.6 FANTOM5 1.5 +459.0 458971 0.6 ZNF680 L3MBTL2 SETDB1 MGA GC03P138644 PPIAP72 FAIM ARMC8 PIK3CB GAPDHP39
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARMC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARMC8 gene promoter:

Genomic Locations for ARMC8 Gene

Genomic Locations for ARMC8 Gene
chr3:138,187,248-138,298,389
(GRCh38/hg38)
Size:
111,142 bases
Orientation:
Plus strand
chr3:137,906,109-138,017,231
(GRCh37/hg19)

Genomic View for ARMC8 Gene

Genes around ARMC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC8 Gene

Proteins for ARMC8 Gene

  • Protein details for ARMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR7-ARMC8_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 8
    Protein Accession:
    Q8IUR7
    Secondary Accessions:
    • A8K0L2
    • B7Z441
    • B7Z453
    • D3DNE6
    • F5GWK4
    • Q6PIL2
    • Q96D19
    • Q96HZ5
    • Q9NV02
    • Q9NV94
    • Q9Y4R9

    Protein attributes for ARMC8 Gene

    Size:
    673 amino acids
    Molecular mass:
    75509 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91861.1; Type=Frameshift; Positions=468; Evidence={ECO:0000305}; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC8 Gene

neXtProt entry for ARMC8 Gene

Post-translational modifications for ARMC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC8 Gene

Domains & Families for ARMC8 Gene

Gene Families for ARMC8 Gene

Protein Domains for ARMC8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMC8: view

No data available for UniProtKB/Swiss-Prot for ARMC8 Gene

Function for ARMC8 Gene

Gene Ontology (GO) - Molecular Function for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARMC8: view

Phenotypes for ARMC8 Gene

genes like me logo Genes that share phenotypes with ARMC8: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC8 Gene

Localization for ARMC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC8 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0035580 specific granule lumen TAS --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with ARMC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARMC8 Gene

Pathways & Interactions for ARMC8 Gene

genes like me logo Genes that share pathways with ARMC8: view

Pathways by source for ARMC8 Gene

3 Reactome pathways for ARMC8 Gene

Gene Ontology (GO) - Biological Process for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ARMC8: view

No data available for SIGNOR curated interactions for ARMC8 Gene

Drugs & Compounds for ARMC8 Gene

No Compound Related Data Available

Transcripts for ARMC8 Gene

mRNA/cDNA for ARMC8 Gene

Unigene Clusters for ARMC8 Gene

Armadillo repeat containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7: - - -
SP8: - -
SP9: - - - - - -

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARMC8 Gene

GeneLoc Exon Structure for
ARMC8
ECgene alternative splicing isoforms for
ARMC8

Expression for ARMC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Testis (8.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMC8 Gene



Protein tissue co-expression partners for ARMC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMC8 Gene:

ARMC8

SOURCE GeneReport for Unigene cluster for ARMC8 Gene:

Hs.744868

Evidence on tissue expression from TISSUES for ARMC8 Gene

  • Nervous system(4.9)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ARMC8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC8 Gene

Orthologs for ARMC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARMC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMC8 33 34
  • 99.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARMC8 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARMC8 33 34
  • 96.35 (n)
oppossum
(Monodelphis domestica)
Mammalia ARMC8 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARMC8 33 34
  • 95.8 (n)
mouse
(Mus musculus)
Mammalia Armc8 33 16 34
  • 92.96 (n)
rat
(Rattus norvegicus)
Mammalia Armc8 33
  • 92.15 (n)
chicken
(Gallus gallus)
Aves ARMC8 33 34
  • 84.5 (n)
lizard
(Anolis carolinensis)
Reptilia ARMC8 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia armc8 33
  • 79.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3735 33
zebrafish
(Danio rerio)
Actinopterygii armc8 33 34
  • 74.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006626 33
  • 50.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51350 33
  • 42.36 (n)
rice
(Oryza sativa)
Liliopsida Os11g0638900 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2222 34
  • 39 (a)
OneToOne
Species where no ortholog for ARMC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC8 Gene

ENSEMBL:
Gene Tree for ARMC8 (if available)
TreeFam:
Gene Tree for ARMC8 (if available)

Paralogs for ARMC8 Gene

Pseudogenes.org Pseudogenes for ARMC8 Gene

genes like me logo Genes that share paralogs with ARMC8: view

No data available for Paralogs for ARMC8 Gene

Variants for ARMC8 Gene

Sequence variations from dbSNP and Humsavar for ARMC8 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010339 -- 138,253,471(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000011875 -- 138,205,611(+) G/A intron_variant
rs1000022483 -- 138,262,137(+) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000234727 -- 138,234,158(+) T/C intron_variant
rs1000249386 -- 138,227,445(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC8 Gene

Variant ID Type Subtype PubMed ID
esv2759180 CNV loss 17122850
esv2762347 CNV gain 21179565
esv3597911 CNV gain 21293372
esv3597913 CNV gain 21293372
nsv4030 CNV insertion 18451855
nsv428422 CNV gain+loss 18775914
nsv822263 CNV loss 20364138
nsv822264 CNV loss 20364138
nsv998106 CNV gain 25217958

Variation tolerance for ARMC8 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMC8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC8 Gene

Disorders for ARMC8 Gene

Additional Disease Information for ARMC8

No disorders were found for ARMC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC8 Gene

Publications for ARMC8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58

Products for ARMC8 Gene

Sources for ARMC8 Gene

Content
Loading form....