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Aliases for ARMC8 Gene
Aliases for ARMC8 Gene
External Ids for ARMC8 Gene
- HGNC: 24999
- Entrez Gene: 25852
- Ensembl: ENSG00000114098
- OMIM: 618521
- UniProtKB: Q8IUR7
Previous GeneCards Identifiers for ARMC8 Gene
- GC03P139389
- GC03P137906
- GC03P135282
Summaries for ARMC8 Gene
GeneCards Summary for ARMC8 Gene
ARMC8 (Armadillo Repeat Containing 8) is a Protein Coding gene. Diseases associated with ARMC8 include Marinesco-Sjogren Syndrome. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for ARMC8 Gene
-
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
Additional gene information for ARMC8 Gene
- HGNC(24999)
- Entrez Gene(25852)
- Ensembl(ENSG00000114098)
- OMIM(618521)
- UniProtKB(Q8IUR7)
- Open Targets Platform(ENSG00000114098)
- Search for ARMC8 at DataMed
- Search for ARMC8 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARMC8 Gene
Genomics for ARMC8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARMC8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03J138186 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.8 | 782 | 3.5 | CREB1 GATAD2A HNRNPL PRDM10 REST ZNF629 IKZF1 ZNF692 NFRKB POLR2A | ARMC8 MRAS A4GNT HSALNG0029252 NME9 | |
| GH03J138221 | Promoter/Enhancer | 0.6 | Ensembl ENCODE | 12.3 | +35.1 | 35068 | 0.6 | GABPA | HSALNG0029252 ARMC8 DBR1 MRAS NME9 DZIP1L | |
| GH03J139117 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 5.2 | +933.1 | 933119 | 7.5 | GATAD2A TFE3 RFX1 JUND FOXA1 MTA2 ZSCAN4 PKNOX1 SP1 ZNF24 | BPESC1 ARMC8 piR-44198-015 PRR23C MRPS22 COPB2 | |
| GH03J138211 | Enhancer | 0.5 | Ensembl | 12.8 | +26.1 | 26053 | 3.8 | JUND FOSL1 SPI1 ATF3 PRDM6 | ARMC8 DBR1 NME9 DZIP1L A4GNT PRR23C ESYT3 HSALNG0029252 | |
| GH03J138235 | Enhancer | 0.4 | Ensembl | 12.1 | +47.9 | 47852 | 0.2 | RUNX3 JUNB TCF7 | DBR1 ARMC8 DZIP1L HSALNG0029252 piR-35674-370 NME9 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARMC8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARMC8
- Top Transcription factor binding sites by QIAGEN in the ARMC8 gene promoter:
-
- AREB6
- c-Myb
- C/EBPbeta
- Cdc5
- FAC1
- POU3F1
- RFX1
- STAT3
Genomic Locations for ARMC8 Gene
Genomic Locations for ARMC8 Gene
- chr3:138,187,248-138,298,389
- (GRCh38/hg38)
- Size:
- 111,142 bases
- Orientation:
- Plus strand
- chr3:137,906,109-138,017,231
- (GRCh37/hg19)
- Size:
- 111,123 bases
- Orientation:
- Plus strand
Genomic View for ARMC8 Gene
Genes around ARMC8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q22.3 by HGNC
- 3q22.3 by Entrez Gene
- 3q22.3 by Ensembl
ARMC8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARMC8 Gene
Proteins for ARMC8 Gene
-
Protein details for ARMC8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUR7-ARMC8_HUMAN
- Recommended name:
- Armadillo repeat-containing protein 8
- Protein Accession:
- Q8IUR7
- A8K0L2
- B7Z441
- B7Z453
- D3DNE6
- F5GWK4
- Q6PIL2
- Q96D19
- Q96HZ5
- Q9NV02
- Q9NV94
- Q9Y4R9
Protein attributes for ARMC8 Gene
- Size:
- 673 amino acids
- Molecular mass:
- 75509 Da
- Quaternary structure:
-
- Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972).
- SequenceCaution:
-
- Sequence=BAA91861.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Protein Expression for ARMC8 Gene
Post-translational modifications for ARMC8 Gene
Other Protein References for ARMC8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-ARMC8 (aa 10-178) polyclonal antibody
- Creative Biolabs Recombinant Mouse Anti-Human ARMC8 Antibody
- Novus Biologicals Antibodies for ARMC8
-
Abcam antibodies for ARMC8
- Invitrogen Antibodies for ARMC8 (AFLGC-ARMC8)
- antibodies-online: Show 8 available ARMC8 Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARMC8
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ARMC8
- Origene Custom Protein Services for ARMC8
-
Signalway Proteins for ARMC8
-
Abcam proteins for ARMC8
No data available for DME Specific Peptides for ARMC8 Gene
Domains & Families for ARMC8 Gene
Gene Families for ARMC8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ARMC8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARMC8 Gene
- GenScript: Design optimal peptide antigens:
-
- Armadillo repeat-containing protein 8 (ARMC8_HUMAN)
- cDNA FLJ56387, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA (B7Z441_HUMAN)
- cDNA FLJ53383, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA (B7Z637_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARMC8 Gene
Function for ARMC8 Gene
Molecular function for ARMC8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
Phenotypes From GWAS Catalog for ARMC8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17467196 |
Phenotypes for ARMC8 Gene
- MGI mutant phenotypes for ARMC8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARMC8:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARMC8 - Select products 50% OFF >
- * ARMC8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARMC8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARMC8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARMC8
miRNA for ARMC8 Gene
- miRTarBase miRNAs that target ARMC8
-
- hsa-miR-26b-5p (MIRT030148)
- hsa-let-7a-3p (MIRT038998)
- hsa-let-7f-5p (MIRT051358)
- hsa-let-7c-5p (MIRT051825)
- mmu-miR-466q (MIRT593344)
- hsa-miR-19b-3p (MIRT728307)
- hsa-miR-19a-3p (MIRT728308)
- mmu-miR-382-3p (MIRT791349)
- mmu-miR-466f-3p (MIRT791367)
- mmu-miR-466i-3p (MIRT791478)
- mmu-miR-467f (MIRT791641)
- mmu-miR-669c-3p (MIRT791807)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARMC8
- Browse OriGene Inhibitory RNA Products For ARMC8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARMC8
Clone Products
- Applied Biological Materials (abm): Clones for ARMC8 - Select products 50% OFF >
- * ARMC8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206256
- MG219078
- MR206256
- MR206256L3
- MR206256L4
- MR219078
- MR219078L3
- MR219078L4
- RC202341
- RC202341L3
- RC202341L4
- RC207532
- RC207532L3
- RC207532L4
- RC215221
- RC215221L3
- RC215221L4
- RC233008
- RC233050
- RC239047
- RG202341
- RG207532
- RG215221
- RG233008
- RG233050
- RR217090
- MR206256L3V
- MR206256L4V
- MR219078L3V
- MR219078L4V
- RC202341L3V
- RC202341L4V
- RC207532L3V
- RC207532L4V
- RC215221L3V
- RC215221L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARMC8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARMC8
Cell Line Products
-
Horizon Cell Lines for ARMC8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC8 Gene
Localization for ARMC8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARMC8 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 29911972 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IEA,IDA | 17467196 |
| GO:0005737 | cytoplasm | IEA,IDA | 17467196 |
| GO:0034657 | GID complex | IBA | 21873635 |
Pathways & Interactions for ARMC8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for ARMC8 Gene
3 Reactome pathways for ARMC8 Gene
Interacting Proteins for ARMC8 Gene
Selected Interacting proteins:
Q8IUR7-ARMC8_HUMAN
ENSP00000420333
for ARMC8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARMC8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | 21873635 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for ARMC8 Gene
Transcripts for ARMC8 Gene
mRNA/cDNA for ARMC8 Gene
- 8 REFSEQ mRNAs :
- 25 NCBI additional mRNA sequence :
- 23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000481646 3043 nts (view in UCSC)
- ENST00000469044 4757 nts (view in UCSC)
- ENST00000491704 2777 nts (view in UCSC)
- ENST00000461600 731 nts (view in UCSC)
- ENST00000466749 807 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARMC8 - Select products 50% OFF >
- * ARMC8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARMC8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARMC8
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARMC8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARMC8
- Browse OriGene Inhibitory RNA Products For ARMC8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARMC8
Clone Products
- Applied Biological Materials (abm): Clones for ARMC8 - Select products 50% OFF >
- * ARMC8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206256
- MG219078
- MR206256
- MR206256L3
- MR206256L4
- MR219078
- MR219078L3
- MR219078L4
- RC202341
- RC202341L3
- RC202341L4
- RC207532
- RC207532L3
- RC207532L4
- RC215221
- RC215221L3
- RC215221L4
- RC233008
- RC233050
- RC239047
- RG202341
- RG207532
- RG215221
- RG233008
- RG233050
- RR217090
- MR206256L3V
- MR206256L4V
- MR219078L3V
- MR219078L4V
- RC202341L3V
- RC202341L4V
- RC207532L3V
- RC207532L4V
- RC215221L3V
- RC215221L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ARMC8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARMC8
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - |
| ExUns: | 15 | ^ | 16 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: |
Relevant External Links for ARMC8 Gene
- GeneLoc Exon Structure for
- ARMC8
Expression for ARMC8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
- Blood (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Testis (8.5), and Heart (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMC8 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARMC8
SOURCE GeneReport for Unigene cluster for ARMC8 Gene:
Hs.744868Evidence on tissue expression from TISSUES for ARMC8 Gene
- Nervous system(4.9)
- Lung(4.3)
Primer Products
-
OriGene qPCR primer pairs for ARMC8
-
OriGene qPCR primer pairs and template standards for ARMC8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC8 Gene
Orthologs for ARMC8 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARMC8 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARMC8 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARMC8 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ARMC8 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARMC8 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Armc8 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Armc8 30 |
|
||
| Chicken (Gallus gallus) |
Aves | ARMC8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ARMC8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | armc8 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3735 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | armc8 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006626 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G51350 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os11g0638900 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2222 31 |
|
OneToOne |
- Species where no ortholog for ARMC8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ARMC8 Gene
- ENSEMBL:
- Gene Tree for ARMC8 (if available)
- TreeFam:
- Gene Tree for ARMC8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARMC8: view image
Paralogs for ARMC8 Gene
Pseudogenes.org Pseudogenes for ARMC8 Gene
No data available for Paralogs for ARMC8 Gene
Variants for ARMC8 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759180 | CNV | loss | 17122850 |
| esv2762347 | CNV | gain | 21179565 |
| esv3597911 | CNV | gain | 21293372 |
| esv3597913 | CNV | gain | 21293372 |
| nsv4030 | CNV | insertion | 18451855 |
| nsv428422 | CNV | gain+loss | 18775914 |
| nsv822263 | CNV | loss | 20364138 |
| nsv822264 | CNV | loss | 20364138 |
| nsv998106 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.16;
23.37% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARMC8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARMC8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARMC8 Gene
Disorders for ARMC8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| marinesco-sjogren syndrome |
|
|
Search ARMC8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARMC8
No data available for UniProtKB/Swiss-Prot and Genatlas for ARMC8 Gene
Publications for ARMC8 Gene
- The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4
- RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. (PMID: 17467196) Kobayashi N … Ishigatsubo Y (Gene 2007) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for ARMC8 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ARMC8
- Origene Custom Protein Services for ARMC8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARMC8
- Browse OriGene Inhibitory RNA Products For ARMC8
- OriGene qPCR primer pairs for ARMC8
- OriGene qPCR primer pairs and template standards for ARMC8
- OriGene CRISPR knockouts for ARMC8
- MG206256
- MG219078
- MR206256
- MR206256L3
- MR206256L4
- MR219078
- MR219078L3
- MR219078L4
- RC202341
- RC202341L3
- RC202341L4
- RC207532
- RC207532L3
- RC207532L4
- RC215221
- RC215221L3
- RC215221L4
- RC233008
- RC233050
- RC239047
- RG202341
- RG207532
- RG215221
- RG233008
- RG233050
- RR217090
- MR206256L3V
- MR206256L4V
- MR219078L3V
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- RC215221L3V
- RC215221L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder Custom and pre-made DNA vectors for ARMC8 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ARMC8 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 8 available ARMC8 Antibodies ranked by validation data
- antibodies-online: Search results for available ARMC8 related products ranked by validation data
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- Signalway Proteins for ARMC8
Sources for ARMC8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB