ARMC8 Gene (Protein Coding)

Armadillo Repeat Containing 8

GC03P138187
GIFtS:
34

Aliases for ARMC8 Gene

Aliases for ARMC8 Gene

  • Armadillo Repeat Containing 8 2 3 5
  • Armadillo Repeat-Containing Protein 8 3 4
  • GID Complex Subunit 5, VID28 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 5, VID28 Homolog 3
  • HSPC056 3
  • S863-2 3
  • VID28 3
  • GID5 3

External Ids for ARMC8 Gene

Previous GeneCards Identifiers for ARMC8 Gene

  • GC03P139389
  • GC03P137906
  • GC03P135282

Summaries for ARMC8 Gene

GeneCards Summary for ARMC8 Gene

ARMC8 (Armadillo Repeat Containing 8) is a Protein Coding gene. Diseases associated with ARMC8 include Marinesco-Sjogren Syndrome and Intraductal Breast Neoplasm. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for ARMC8 Gene

  • Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.

Additional gene information for ARMC8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARMC8 Gene

Genomics for ARMC8 Gene

GeneHancer (GH) Regulatory Elements for ARMC8 Gene

Promoters and enhancers for ARMC8 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03J138186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 782 3.5 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 SIN3A NRF1 POLR2G PHF8 ZNF639 ARMC8 MRAS CEP70 A4GNT HSALNG0029252
GH03J138221 Promoter/Enhancer 0.6 Ensembl ENCODE 12.3 +35.1 35068 0.6 GABPA HSALNG0029252 ARMC8 DBR1 MRAS NME9 DZIP1L
GH03J139117 Enhancer 1.2 FANTOM5 Ensembl ENCODE 5.2 +933.1 933119 7.5 ZBTB11 RFX1 HES1 MYC CTBP1 TEAD1 FOXA2 NCOR1 CEBPB NFIC BPESC1 ARMC8 piR-44198-015 MRPS22
GH03J138219 Enhancer 0.4 FANTOM5 13.6 +32.2 32221 0.2 FOS GATA2 JUN ARMC8 DBR1 DZIP1L HSALNG0029252
GH03J138211 Enhancer 0.4 Ensembl 12.8 +26.1 26053 3.8 SPI1 FOSL1 PRDM6 ATF3 JUND ARMC8 DBR1 NME9 DZIP1L A4GNT PRR23C ESYT3 HSALNG0029252
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMC8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARMC8

Top Transcription factor binding sites by QIAGEN in the ARMC8 gene promoter:
  • AREB6
  • c-Myb
  • C/EBPbeta
  • Cdc5
  • FAC1
  • POU3F1
  • RFX1
  • STAT3

Genomic Locations for ARMC8 Gene

Genomic Locations for ARMC8 Gene
chr3:138,187,248-138,298,389
(GRCh38/hg38)
Size:
111,142 bases
Orientation:
Plus strand
chr3:137,906,109-138,017,231
(GRCh37/hg19)
Size:
111,123 bases
Orientation:
Plus strand

Genomic View for ARMC8 Gene

Genes around ARMC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ARMC8 Gene

Proteins for ARMC8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ARMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR7-ARMC8_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 8
    Protein Accession:
    Q8IUR7
    Secondary Accessions:
    • A8K0L2
    • B7Z441
    • B7Z453
    • D3DNE6
    • F5GWK4
    • Q6PIL2
    • Q96D19
    • Q96HZ5
    • Q9NV02
    • Q9NV94
    • Q9Y4R9

    Protein attributes for ARMC8 Gene

    Size:
    673 amino acids
    Molecular mass:
    75509 Da
    Quaternary structure:
    • Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196, PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972).
    SequenceCaution:
    • Sequence=BAA91861.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMC8 Gene

Protein Expression for ARMC8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ARMC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARMC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ARMC8
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARMC8

No data available for DME Specific Peptides for ARMC8 Gene

Domains & Families for ARMC8 Gene

Gene Families for ARMC8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMC8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARMC8 Gene

GenScript: Design optimal peptide antigens:
  • Armadillo repeat-containing protein 8 (ARMC8_HUMAN)
  • cDNA FLJ56387, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA (B7Z441_HUMAN)
  • cDNA FLJ53383, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA (B7Z637_HUMAN)
genes like me logo Genes that share domains with ARMC8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARMC8 Gene

Function for ARMC8 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ARMC8 Gene

UniProtKB/Swiss-Prot Function:
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.

Phenotypes From GWAS Catalog for ARMC8 Gene

Gene Ontology (GO) - Molecular Function for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17467196
genes like me logo Genes that share ontologies with ARMC8: view
genes like me logo Genes that share phenotypes with ARMC8: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC8 Gene

Localization for ARMC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMC8 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC8 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 29911972
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA,IEA 17467196
GO:0005737 cytoplasm IEA,IDA 17467196
GO:0034657 GID complex IBA 21873635
genes like me logo Genes that share ontologies with ARMC8: view

Pathways & Interactions for ARMC8 Gene

PathCards logo

SuperPathways for ARMC8 Gene

genes like me logo Genes that share pathways with ARMC8: view

Pathways by source for ARMC8 Gene

3 Reactome pathways for ARMC8 Gene

Gene Ontology (GO) - Biological Process for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ARMC8: view

No data available for SIGNOR curated interactions for ARMC8 Gene

Drugs & Compounds for ARMC8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ARMC8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ARMC8 Gene

8 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7: - - -
SP8: - -
SP9: - - - - - -

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARMC8 Gene

GeneLoc Exon Structure for
ARMC8

Expression for ARMC8 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARMC8 Gene

mRNA expression in normal human tissues for ARMC8 Gene
mRNA expression by GTEx for ARMC8 GenemRNA expression by BioGPS for ARMC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Testis (8.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMC8 Gene



Protein tissue co-expression partners for ARMC8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARMC8

SOURCE GeneReport for Unigene cluster for ARMC8 Gene:

Hs.744868

Evidence on tissue expression from TISSUES for ARMC8 Gene

  • Nervous system(4.9)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ARMC8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC8 Gene

Orthologs for ARMC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARMC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ARMC8 31 30
  • 99.82 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ARMC8 31
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ARMC8 31 30
  • 96.35 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ARMC8 31
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia ARMC8 31 30
  • 95.8 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Armc8 17 31 30
  • 92.96 (n)
rat
(Rattus norvegicus)
 Mammalia Armc8 30
  • 92.15 (n)
chicken
(Gallus gallus)
 Aves ARMC8 31 30
  • 84.5 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ARMC8 31
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia armc8 30
  • 79.32 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.3735 30
zebrafish
(Danio rerio)
 Actinopterygii armc8 31 30
  • 74.06 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006626 30
  • 50.34 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G51350 30
  • 42.36 (n)
rice
(Oryza sativa)
 Liliopsida Os11g0638900 30
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2222 31
  • 39 (a)
 OneToOne
Species where no ortholog for ARMC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC8 Gene

ENSEMBL:
Gene Tree for ARMC8 (if available)
TreeFam:
Gene Tree for ARMC8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARMC8: view image

Paralogs for ARMC8 Gene

Pseudogenes.org Pseudogenes for ARMC8 Gene

genes like me logo Genes that share paralogs with ARMC8: view

No data available for Paralogs for ARMC8 Gene

Variants for ARMC8 Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for ARMC8 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARMC8 Gene

Variant ID Type Subtype PubMed ID
esv2759180 CNV loss 17122850
esv2762347 CNV gain 21179565
esv3597911 CNV gain 21293372
esv3597913 CNV gain 21293372
nsv4030 CNV insertion 18451855
nsv428422 CNV gain+loss 18775914
nsv822263 CNV loss 20364138
nsv822264 CNV loss 20364138
nsv998106 CNV gain 25217958

Variation tolerance for ARMC8 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMC8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARMC8 Gene

Disorders for ARMC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARMC8 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ARMC8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARMC8

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARMC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARMC8 Gene

Publications for ARMC8 Gene

  1. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4 54
  2. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. (PMID: 17467196) Kobayashi N … Ishigatsubo Y (Gene 2007) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

ExternalLinks

View latest publications for ARMC8 gene in Mastermind

Products for ARMC8 Gene

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