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Aliases for ARMC8 Gene

Aliases for ARMC8 Gene

  • Armadillo Repeat Containing 8 2 3 5
  • GID Complex Subunit 5, VID28 Homolog (S. Cerevisiae) 2
  • Armadillo Repeat-Containing Protein 8 3
  • GID Complex Subunit 5, VID28 Homolog 3
  • HSPC056 3
  • S863-2 3
  • VID28 3
  • GID5 3

External Ids for ARMC8 Gene

Previous GeneCards Identifiers for ARMC8 Gene

  • GC03P139389
  • GC03P137906
  • GC03P135282

Summaries for ARMC8 Gene

GeneCards Summary for ARMC8 Gene

ARMC8 (Armadillo Repeat Containing 8) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for ARMC8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC8 Gene

Genomics for ARMC8 Gene

GeneHancer (GH) Regulatory Elements for ARMC8 Gene

Promoters and enhancers for ARMC8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J138186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 530 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ARMC8 MRAS A4GNT GC03P138286
GH03J139118 Enhancer 1.3 FANTOM5 Ensembl ENCODE 5.2 +933.6 933598 4.3 ATF1 PKNOX1 FOXA2 YY1 TCF12 ZNF766 GATA2 ATF7 RXRA REST BPESC1 ARMC8 GC03M139047 MRPS22
GH03J138221 Enhancer 0.5 Ensembl ENCODE 12.3 +35.2 35153 1.2 GABPA ARMC8 DBR1 MRAS NME9 DZIP1L GC03P138286
GH03J138219 Enhancer 0.4 FANTOM5 13.6 +32.2 32221 0.2 JUN ARMC8 DBR1 DZIP1L GC03P138286
GH03J138645 Enhancer 0.6 FANTOM5 1.5 +459.0 458971 0.6 ZNF680 L3MBTL2 SETDB1 MGA GC03P138644 PPIAP72 FAIM ARMC8 PIK3CB GAPDHP39
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARMC8 gene promoter:
  • STAT3
  • C/EBPbeta
  • Cdc5
  • POU3F1
  • RFX1
  • c-Myb
  • AREB6
  • FAC1

Genomic Locations for ARMC8 Gene

Genomic Locations for ARMC8 Gene
111,142 bases
Plus strand
111,123 bases
Plus strand

Genomic View for ARMC8 Gene

Genes around ARMC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC8 Gene

Proteins for ARMC8 Gene

  • Protein details for ARMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A8K0L2
    • B7Z441
    • B7Z453
    • D3DNE6
    • F5GWK4
    • Q6PIL2
    • Q96D19
    • Q96HZ5
    • Q9NV02
    • Q9NV94
    • Q9Y4R9

    Protein attributes for ARMC8 Gene

    673 amino acids
    Molecular mass:
    75509 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91861.1; Type=Frameshift; Positions=468; Evidence={ECO:0000305}; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC8 Gene

neXtProt entry for ARMC8 Gene

Post-translational modifications for ARMC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ARMC8
  • Boster Bio Antibodies for ARMC8
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARMC8

No data available for DME Specific Peptides for ARMC8 Gene

Domains & Families for ARMC8 Gene

Gene Families for ARMC8 Gene

Protein Domains for ARMC8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMC8: view

No data available for UniProtKB/Swiss-Prot for ARMC8 Gene

Function for ARMC8 Gene

Gene Ontology (GO) - Molecular Function for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARMC8: view
genes like me logo Genes that share phenotypes with ARMC8: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC8 Gene

Localization for ARMC8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC8 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0034657 GID complex IBA --
GO:0035580 specific granule lumen TAS --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with ARMC8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARMC8 Gene

Pathways & Interactions for ARMC8 Gene

genes like me logo Genes that share pathways with ARMC8: view

Pathways by source for ARMC8 Gene

3 Reactome pathways for ARMC8 Gene

Gene Ontology (GO) - Biological Process for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ARMC8: view

No data available for SIGNOR curated interactions for ARMC8 Gene

Drugs & Compounds for ARMC8 Gene

No Compound Related Data Available

Transcripts for ARMC8 Gene

Unigene Clusters for ARMC8 Gene

Armadillo repeat containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7: - - -
SP8: - -
SP9: - - - - - -

ExUns: 15 ^ 16

Relevant External Links for ARMC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Testis (8.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMC8 Gene

Protein tissue co-expression partners for ARMC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMC8 Gene:


SOURCE GeneReport for Unigene cluster for ARMC8 Gene:


Evidence on tissue expression from TISSUES for ARMC8 Gene

  • Nervous system(4.9)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ARMC8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC8 Gene

Orthologs for ARMC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARMC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARMC8 34 33
  • 99.82 (n)
(Ornithorhynchus anatinus)
Mammalia ARMC8 34
  • 98 (a)
(Canis familiaris)
Mammalia ARMC8 34 33
  • 96.35 (n)
(Monodelphis domestica)
Mammalia ARMC8 34
  • 96 (a)
(Bos Taurus)
Mammalia ARMC8 34 33
  • 95.8 (n)
(Mus musculus)
Mammalia Armc8 16 34 33
  • 92.96 (n)
(Rattus norvegicus)
Mammalia Armc8 33
  • 92.15 (n)
(Gallus gallus)
Aves ARMC8 34 33
  • 84.5 (n)
(Anolis carolinensis)
Reptilia ARMC8 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc8 33
  • 79.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3735 33
(Danio rerio)
Actinopterygii armc8 34 33
  • 74.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006626 33
  • 50.34 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51350 33
  • 42.36 (n)
(Oryza sativa)
Liliopsida Os11g0638900 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2222 34
  • 39 (a)
Species where no ortholog for ARMC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC8 Gene

Gene Tree for ARMC8 (if available)
Gene Tree for ARMC8 (if available)
Evolutionary constrained regions (ECRs) for ARMC8: view image

Paralogs for ARMC8 Gene Pseudogenes for ARMC8 Gene

genes like me logo Genes that share paralogs with ARMC8: view

No data available for Paralogs for ARMC8 Gene

Variants for ARMC8 Gene

Sequence variations from dbSNP and Humsavar for ARMC8 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010339 -- 138,253,471(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000011875 -- 138,205,611(+) G/A intron_variant
rs1000022483 -- 138,262,137(+) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000234727 -- 138,234,158(+) T/C intron_variant
rs1000249386 -- 138,227,445(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC8 Gene

Variant ID Type Subtype PubMed ID
esv2759180 CNV loss 17122850
esv2762347 CNV gain 21179565
esv3597911 CNV gain 21293372
esv3597913 CNV gain 21293372
nsv4030 CNV insertion 18451855
nsv428422 CNV gain+loss 18775914
nsv822263 CNV loss 20364138
nsv822264 CNV loss 20364138
nsv998106 CNV gain 25217958

Variation tolerance for ARMC8 Gene

Residual Variation Intolerance Score: 12.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC8 Gene

Disorders for ARMC8 Gene

Additional Disease Information for ARMC8

No disorders were found for ARMC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC8 Gene

Publications for ARMC8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. (PMID: 28720576) Toloczko A … Chan SW (Cancer research 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for ARMC8 Gene

Sources for ARMC8 Gene

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