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Aliases for ARMC6 Gene

Aliases for ARMC6 Gene

  • Armadillo Repeat Containing 6 2 3 5
  • Armadillo Repeat-Containing Protein 6 3
  • R30923_1 3

External Ids for ARMC6 Gene

Previous GeneCards Identifiers for ARMC6 Gene

  • GC19P019006
  • GC19P019144
  • GC19P018708
  • GC19P019165
  • GC19P019161
  • GC19P019353
  • GC19P019684

Summaries for ARMC6 Gene

Entrez Gene Summary for ARMC6 Gene

  • The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARMC6 Gene

ARMC6 (Armadillo Repeat Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Gene Wiki entry for ARMC6 Gene

Additional gene information for ARMC6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC6 Gene

Genomics for ARMC6 Gene

GeneHancer (GH) Regulatory Elements for ARMC6 Gene

Promoters and enhancers for ARMC6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J019031 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 653.3 -0.2 -199 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ARMC6 SUGP2 ATP13A1 TMEM161A MEF2B ENSG00000268030 NR2C2AP ENSG00000268938 UPF1 ENSG00000269191
GH19J019104 Promoter/Enhancer 1.4 Ensembl ENCODE 7.8 +72.0 71969 2.2 HDAC1 PKNOX1 FOXA2 ARID4B SIN3A ETS1 POLR2B ZNF614 EGR1 ATF7 TMEM161A ARMC6 GC19P020576 SLC25A42
GH19J019112 Enhancer 0.8 Ensembl ENCODE 12 +79.6 79633 0.7 CTCF SP2 REST RAD21 ZNF614 POLR2A GLIS1 VEZF1 RBM22 ZNF600 TMEM161A SLC25A42 ARMC6 SUGP2 MEF2B RFXANK BORCS8 BORCS8-MEF2B HAPLN4 GC19P020576
GH19J019053 Enhancer 0.7 ENCODE 12.1 +20.4 20392 0.2 ELF3 CTCF RB1 TEAD4 MAX EBF1 RAD21 YY1 TEAD3 CC2D1A PIR39711 ARMC6 MEF2B RFXANK BORCS8-MEF2B BORCS8 SUGP2 GC19M019046
GH19J018995 Enhancer 0.7 ENCODE 11.9 -37.6 -37576 1.2 HDGF CTCF PKNOX1 SIN3A RAD21 ZNF121 ZNF335 ZFHX2 POLR2A EGR1 SUGP2 ARMC6 CERS1 GDF1 GC19M018978
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARMC6 gene promoter:
  • C/EBPalpha
  • GCNF-2
  • GCNF-1
  • GCNF
  • IRF-1
  • YY1
  • Gfi-1
  • Pax-5
  • NF-1
  • NF-1/L

Genomic Locations for ARMC6 Gene

Genomic Locations for ARMC6 Gene
26,737 bases
Plus strand
26,180 bases
Plus strand

Genomic View for ARMC6 Gene

Genes around ARMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC6 Gene

Proteins for ARMC6 Gene

  • Protein details for ARMC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • B4DI98
    • O94999
    • Q9BTH5

    Protein attributes for ARMC6 Gene

    501 amino acids
    Molecular mass:
    54142 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD03162.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH67125.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC6 Gene


neXtProt entry for ARMC6 Gene

Post-translational modifications for ARMC6 Gene

  • Ubiquitination at Lys450, posLast=432432, Lys422, posLast=361361, Lys345, posLast=284284, posLast=274274, Lys208, Lys134, and posLast=125125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARMC6 Gene

Domains & Families for ARMC6 Gene

Gene Families for ARMC6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMC6 Gene

Suggested Antigen Peptide Sequences for ARMC6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ARMC6 family.
  • Belongs to the ARMC6 family.
genes like me logo Genes that share domains with ARMC6: view

Function for ARMC6 Gene

Gene Ontology (GO) - Molecular Function for ARMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ARMC6: view
genes like me logo Genes that share phenotypes with ARMC6: view

Animal Model Products

miRNA for ARMC6 Gene

miRTarBase miRNAs that target ARMC6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC6 Gene

Localization for ARMC6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC6 gene
Compartment Confidence
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ARMC6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARMC6 Gene

Pathways & Interactions for ARMC6 Gene

SuperPathways for ARMC6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IBA --
genes like me logo Genes that share ontologies with ARMC6: view

No data available for Pathways by source and SIGNOR curated interactions for ARMC6 Gene

Drugs & Compounds for ARMC6 Gene

No Compound Related Data Available

Transcripts for ARMC6 Gene

Unigene Clusters for ARMC6 Gene

Armadillo repeat containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a ·
SP1: - - -
SP2: - -
SP3: -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8: -
SP9: - - - - - -

ExUns: 12b

Relevant External Links for ARMC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMC6 Gene

Protein differential expression in normal tissues from HIPED for ARMC6 Gene

This gene is overexpressed in Bone (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMC6 Gene

Protein tissue co-expression partners for ARMC6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMC6 Gene:


SOURCE GeneReport for Unigene cluster for ARMC6 Gene:


Evidence on tissue expression from TISSUES for ARMC6 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with ARMC6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC6 Gene

Orthologs for ARMC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARMC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARMC6 34 33
  • 98.8 (n)
(Bos Taurus)
Mammalia ARMC6 34 33
  • 85.11 (n)
(Canis familiaris)
Mammalia ARMC6 34 33
  • 84.01 (n)
(Mus musculus)
Mammalia Armc6 16 34 33
  • 81.3 (n)
(Rattus norvegicus)
Mammalia Armc6 33
  • 80.57 (n)
(Monodelphis domestica)
Mammalia ARMC6 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ARMC6 34
  • 65 (a)
(Gallus gallus)
Aves ARMC6 34 33
  • 67.37 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc6 33
  • 62.72 (n)
Str.9830 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.20487 33
(Danio rerio)
Actinopterygii LOC555425 33
  • 64.52 (n)
ARMC6 34
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006617 33
  • 47.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5721 34 33
  • 47.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G33945 33
  • 39.53 (n)
(Oryza sativa)
Liliopsida Os02g0761200 33
  • 40.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3480 34
  • 32 (a)
Species where no ortholog for ARMC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC6 Gene

Gene Tree for ARMC6 (if available)
Gene Tree for ARMC6 (if available)
Evolutionary constrained regions (ECRs) for ARMC6: view image

Paralogs for ARMC6 Gene

(6) SIMAP similar genes for ARMC6 Gene using alignment to 17 proteins:

  • B4E1N1_HUMAN
  • F5H052_HUMAN
  • F5H2K4_HUMAN
  • F5H2X2_HUMAN
  • F5H3X1_HUMAN
  • F5H3Y9_HUMAN
  • F5H4H6_HUMAN
  • F5H4P3_HUMAN
  • F5H6J3_HUMAN
  • F5H7V0_HUMAN
  • H0YH65_HUMAN
genes like me logo Genes that share paralogs with ARMC6: view

No data available for Paralogs for ARMC6 Gene

Variants for ARMC6 Gene

Sequence variations from dbSNP and Humsavar for ARMC6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000002236 -- 19,031,960(+) G/A upstream_transcript_variant
rs1000034789 -- 19,032,282(+) C/T upstream_transcript_variant
rs1000076824 -- 19,048,222(+) T/C intron_variant
rs1000188350 -- 19,056,471(+) A/G intron_variant
rs1000246592 -- 19,032,645(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC6 Gene

Variant ID Type Subtype PubMed ID
nsv1059305 CNV loss 25217958
nsv1151217 CNV deletion 26484159
nsv833778 CNV loss 17160897
nsv833779 CNV loss 17160897
nsv952424 CNV deletion 24416366

Variation tolerance for ARMC6 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC6 Gene

Disorders for ARMC6 Gene

Additional Disease Information for ARMC6

No disorders were found for ARMC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC6 Gene

Publications for ARMC6 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations. (PMID: 28378594) Sala S … Ampe C (Journal of proteome research 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ARMC6 Gene

Sources for ARMC6 Gene

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