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Aliases for ARMC2 Gene

Aliases for ARMC2 Gene

  • Armadillo Repeat Containing 2 2 3 5
  • Armadillo Repeat-Containing Protein 2 3
  • BA787I22.1 3

External Ids for ARMC2 Gene

Previous GeneCards Identifiers for ARMC2 Gene

  • GC06P109215
  • GC06P109276
  • GC06P106736
  • GC06P109169

Summaries for ARMC2 Gene

GeneCards Summary for ARMC2 Gene

ARMC2 (Armadillo Repeat Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for ARMC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC2 Gene

Genomics for ARMC2 Gene

GeneHancer (GH) Regulatory Elements for ARMC2 Gene

Promoters and enhancers for ARMC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J108847 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 659.3 +0.1 91 1.6 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B KLF13 SP3 ARMC2 ENSG00000271730 RPS12P13
GH06J108895 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +48.1 48056 2.7 FOXA2 KLF17 RAD21 ZEB1 KLF7 FOS RUNX3 SP3 ZNF280D RXRA ARMC2 RNU6-653P ARMC2-AS1 OSTM1-AS1 FOXO3 CD164 ATP5MFP2 RPS12P13
GH06J108871 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +25.3 25292 4.1 BMI1 BATF ZIC2 IRF4 NFATC1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 ARMC2 RNU6-653P ARMC2-AS1 ZBTB24 SESN1 RPS12P13 ATP5MFP2
GH06J108903 Enhancer 1 ENCODE dbSUPER 24.8 +56.9 56924 3.2 PKNOX1 FOXA2 BATF ATF7 ETV6 IKZF2 RUNX3 CREM MIXL1 HMG20B ARMC2 RNU6-653P ATP5MFP2 RPS12P13
GH06J108781 Enhancer 1.1 Ensembl ENCODE 15 -66.1 -66054 1.8 CLOCK ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF213 ZNF143 KLF7 ARMC2 ARMC2-AS1 CCDC162P ZNF259P1 LINC00222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARMC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARMC2 gene promoter:
  • GATA-3
  • NRSF form 2
  • NRSF form 1
  • NF-kappaB2
  • NF-kappaB1
  • NF-kappaB
  • Pax-5
  • MZF-1
  • GR
  • GR-alpha

Genomic Locations for ARMC2 Gene

Genomic Locations for ARMC2 Gene
150,093 bases
Plus strand
125,734 bases
Plus strand

Genomic View for ARMC2 Gene

Genes around ARMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC2 Gene

Proteins for ARMC2 Gene

  • Protein details for ARMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K8Y4
    • B4DGF5
    • G5E993
    • Q5VVY8
    • Q9H0K9

    Protein attributes for ARMC2 Gene

    867 amino acids
    Molecular mass:
    96867 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30603.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16717.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC2 Gene


neXtProt entry for ARMC2 Gene

Post-translational modifications for ARMC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC2 Gene

Domains & Families for ARMC2 Gene

Gene Families for ARMC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMC2 Gene


Suggested Antigen Peptide Sequences for ARMC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMC2: view

No data available for UniProtKB/Swiss-Prot for ARMC2 Gene

Function for ARMC2 Gene

Phenotypes From GWAS Catalog for ARMC2 Gene

Gene Ontology (GO) - Molecular Function for ARMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with ARMC2: view
genes like me logo Genes that share phenotypes with ARMC2: view

Animal Model Products

miRNA for ARMC2 Gene

miRTarBase miRNAs that target ARMC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC2 Gene

Localization for ARMC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC2 gene
Compartment Confidence
nucleus 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMC2 Gene

Pathways & Interactions for ARMC2 Gene

SuperPathways for ARMC2 Gene

No Data Available

Interacting Proteins for ARMC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8NEN0-ARMC2_HUMAN ENSP00000376417 for ARMC2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ARMC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARMC2 Gene

Drugs & Compounds for ARMC2 Gene

No Compound Related Data Available

Transcripts for ARMC2 Gene

Unigene Clusters for ARMC2 Gene

Armadillo repeat containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20

Relevant External Links for ARMC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARMC2 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ARMC2 Gene

This gene is overexpressed in Plasma (46.9) and Serum (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARMC2 Gene

Protein tissue co-expression partners for ARMC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMC2 Gene:


SOURCE GeneReport for Unigene cluster for ARMC2 Gene:

genes like me logo Genes that share expression patterns with ARMC2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC2 Gene

Orthologs for ARMC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARMC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARMC2 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia ARMC2 34 33
  • 88.47 (n)
(Bos Taurus)
Mammalia ARMC2 34 33
  • 87.17 (n)
(Mus musculus)
Mammalia Armc2 16 34 33
  • 77.4 (n)
(Rattus norvegicus)
Mammalia Armc2 33
  • 76.92 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
-- 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ARMC2 34
  • 55 (a)
(Gallus gallus)
Aves ARMC2 34 33
  • 65.93 (n)
(Anolis carolinensis)
Reptilia ARMC2 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc2 33
  • 60.55 (n)
(Danio rerio)
Actinopterygii armc2 34 33
  • 53.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32668 34
  • 24 (a)
Species where no ortholog for ARMC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC2 Gene

Gene Tree for ARMC2 (if available)
Gene Tree for ARMC2 (if available)
Evolutionary constrained regions (ECRs) for ARMC2: view image

Paralogs for ARMC2 Gene

No data available for Paralogs for ARMC2 Gene

Variants for ARMC2 Gene

Sequence variations from dbSNP and Humsavar for ARMC2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000068839 -- 108,975,510(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000071607 -- 108,861,636(+) T/C intron_variant
rs1000081975 -- 108,968,352(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000110782 -- 108,976,786(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000124550 -- 108,944,576(+) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC2 Gene

Variant ID Type Subtype PubMed ID
esv2656715 CNV deletion 23128226
esv2673947 CNV deletion 23128226
esv3610328 CNV loss 21293372
esv3610329 CNV loss 21293372
esv3610330 CNV loss 21293372
esv3610331 CNV loss 21293372
esv3610332 CNV loss 21293372
nsv604483 CNV gain 21841781
nsv830768 CNV gain 17160897

Variation tolerance for ARMC2 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC2 Gene

Disorders for ARMC2 Gene

Additional Disease Information for ARMC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC2 Gene

Publications for ARMC2 Gene

  1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 44 58
  2. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 44 58
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for ARMC2 Gene

Sources for ARMC2 Gene

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