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Aliases for ARMC12 Gene

Aliases for ARMC12 Gene

  • Armadillo Repeat Containing 12 2 3 5
  • C6orf81 3 4
  • Armadillo Repeat-Containing Protein 12 3
  • Chromosome 6 Open Reading Frame 81 2

External Ids for ARMC12 Gene

Previous HGNC Symbols for ARMC12 Gene

  • C6orf81

Previous GeneCards Identifiers for ARMC12 Gene

  • GC06P035705
  • GC06P035821
  • GC06P036312
  • GC06P037299
  • GC06P036829
  • GC06P036910
  • GC06P037773
  • GC06P038397
  • GC06P038987
  • GC06P039576
  • GC06P040136

Summaries for ARMC12 Gene

GeneCards Summary for ARMC12 Gene

ARMC12 (Armadillo Repeat Containing 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for ARMC12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC12 Gene

Genomics for ARMC12 Gene

GeneHancer (GH) Regulatory Elements for ARMC12 Gene

Promoters and enhancers for ARMC12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I035737 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +3.2 3240 0.1 ARMC12 LOC285847 ENSG00000232909 ENSG00000228559 LOC100652794
GH06I035734 Enhancer 0.4 dbSUPER 550.8 +1.6 1558 0.9 KLF9 BATF ARMC12 LOC285847 ENSG00000232909 ENSG00000228559
GH06I035723 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -4.7 -4708 10.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 MCM3 SP3 NFYC FKBP5 TAF11 SRSF3 ZNF76 ENSG00000272374 RPL10A STK38 ENSG00000219023 FANCE PPARD
GH06I035686 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -46.0 -45988 3.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 FKBP5 TAF11 SRSF3 ENSG00000272374 MAPK14 ZNF76 RPL10A ARMC12 ENSG00000232909 STK38
GH06I036675 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.1 +947.0 947044 10.4 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 CDKN1A SRSF3 CMTR1 STK38 MAPK14 ENSG00000237719 RNF8 RNU1-88P C6orf89 ARMC12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARMC12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARMC12 Gene

Genomic Locations for ARMC12 Gene
chr6:35,733,805-35,749,079
(GRCh38/hg38)
Size:
15,275 bases
Orientation:
Plus strand
chr6:35,704,809-35,716,856
(GRCh37/hg19)

Genomic View for ARMC12 Gene

Genes around ARMC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC12 Gene

Proteins for ARMC12 Gene

  • Protein details for ARMC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9G4-ARM12_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 12
    Protein Accession:
    Q5T9G4
    Secondary Accessions:
    • Q8NEB2
    • Q96LL8

    Protein attributes for ARMC12 Gene

    Size:
    340 amino acids
    Molecular mass:
    38632 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARMC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMC12 Gene

Post-translational modifications for ARMC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC12 Gene

Domains & Families for ARMC12 Gene

Gene Families for ARMC12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMC12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMC12: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARMC12 Gene

Function for ARMC12 Gene

Phenotypes From GWAS Catalog for ARMC12 Gene

genes like me logo Genes that share phenotypes with ARMC12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC12 Gene

Localization for ARMC12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC12 gene
Compartment Confidence
nucleus 5
plasma membrane 2
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with ARMC12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARMC12 Gene

Pathways & Interactions for ARMC12 Gene

SuperPathways for ARMC12 Gene

No Data Available

Interacting Proteins for ARMC12 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000288065%0d%0a9606.ENSP00000381891%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: ENSP00000288065 Q5T9G4-ARM12_HUMAN for ARMC12 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ARMC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMC12 Gene

Drugs & Compounds for ARMC12 Gene

No Compound Related Data Available

Transcripts for ARMC12 Gene

Unigene Clusters for ARMC12 Gene

Armadillo repeat containing 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3: -

Relevant External Links for ARMC12 Gene

GeneLoc Exon Structure for
ARMC12
ECgene alternative splicing isoforms for
ARMC12

Expression for ARMC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARMC12 Gene

This gene is overexpressed in Testis (x17.9).

Protein differential expression in normal tissues from HIPED for ARMC12 Gene

This gene is overexpressed in Testis (26.5), Fetal gut (16.9), Spleen (13.4), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARMC12 Gene



Protein tissue co-expression partners for ARMC12 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMC12 Gene:

ARMC12

SOURCE GeneReport for Unigene cluster for ARMC12 Gene:

Hs.533066
genes like me logo Genes that share expression patterns with ARMC12: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC12 Gene

Orthologs for ARMC12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMC12 33 34
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia ARMC12 33 34
  • 89.55 (n)
cow
(Bos Taurus)
Mammalia ARMC12 33 34
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Armc12 33 16 34
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Armc12 33
  • 81.67 (n)
oppossum
(Monodelphis domestica)
Mammalia ARMC12 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARMC12 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
Species where no ortholog for ARMC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARMC12 Gene

ENSEMBL:
Gene Tree for ARMC12 (if available)
TreeFam:
Gene Tree for ARMC12 (if available)

Paralogs for ARMC12 Gene

No data available for Paralogs for ARMC12 Gene

Variants for ARMC12 Gene

Sequence variations from dbSNP and Humsavar for ARMC12 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs193921111 uncertain-significance, Malignant tumor of prostate 35,747,417(+) G/T coding_sequence_variant, missense_variant
rs386352286 uncertain-significance, not provided 35,737,299(+) C/T coding_sequence_variant, intron_variant, missense_variant
rs1000036435 -- 35,741,483(+) C/T intron_variant
rs1000196976 -- 35,741,246(+) G/A intron_variant
rs1000274524 -- 35,736,097(+) G/ 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC12 Gene

Variant ID Type Subtype PubMed ID
esv2759420 CNV gain 17122850
esv3608689 CNV gain 21293372
esv3608690 CNV gain 21293372
esv3890842 CNV gain 25118596
nsv1028947 CNV gain 25217958
nsv428143 CNV gain 18775914
nsv602924 CNV gain 21841781
nsv821646 CNV loss 15273396

Variation tolerance for ARMC12 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC12 Gene

Disorders for ARMC12 Gene

Additional Disease Information for ARMC12

No disorders were found for ARMC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC12 Gene

Publications for ARMC12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 58

Products for ARMC12 Gene

Sources for ARMC12 Gene

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