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Aliases for ARL9 Gene

Aliases for ARL9 Gene

  • ADP Ribosylation Factor Like GTPase 9 2 3 5
  • ADP-Ribosylation Factor-Like Protein 9 3
  • ADP-Ribosylation Factor Like GTPase 9 2
  • ADP-Ribosylation Factor-Like 9 3

External Ids for ARL9 Gene

Previous GeneCards Identifiers for ARL9 Gene

  • GC00U914119
  • GC04P057287
  • GC04P057212
  • GC04P057066
  • GC04P057371
  • GC04P053325

Summaries for ARL9 Gene

Entrez Gene Summary for ARL9 Gene

  • ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008]

GeneCards Summary for ARL9 Gene

ARL9 (ADP Ribosylation Factor Like GTPase 9) is a Protein Coding gene. Diseases associated with ARL9 include Bone Marrow Failure Syndrome 1. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL10.

Additional gene information for ARL9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL9 Gene

Genomics for ARL9 Gene

GeneHancer (GH) Regulatory Elements for ARL9 Gene

Promoters and enhancers for ARL9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J056504 Promoter/Enhancer 1.1 Ensembl ENCODE 658.6 +0.5 501 1.7 ZNF687 USF1 MAX SIN3A EBF1 RBM22 ZBTB33 PRDM1 EZH2 ARL9 SRP72 AASDH LOC105377665
GH04J056501 Promoter 0.5 EPDnew 650.7 -3.4 -3367 0.1 ARL9 GC04M056462 SRP72
GH04J056530 Promoter/Enhancer 1.3 Ensembl ENCODE 19.1 +25.5 25471 1.4 TAF9B MZF1 SIN3A BMI1 ZNF335 POLR2B EGR1 SCRT2 ZHX1 SP3 THEGL LOC105377665 SRP72 ARL9 ENSG00000251799 SPINK2 GLDCP1
GH04J056465 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.1 -38.1 -38059 4.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 YY1 POLR2B FOS SRP72 GC04M056462 AASDH PPAT PAICS SPINK2 ENSG00000251799 ARL9 GC04P056465
GH04J056433 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.7 -69.3 -69347 4.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PAICS PPAT GC04P056437 GC04P056436 SRP72 CEP135 AASDH POLR2B RN7SKP30 ENSG00000269921
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARL9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL9 gene promoter:

Genomic Locations for ARL9 Gene

Genomic Locations for ARL9 Gene
20,273 bases
Plus strand

Genomic View for ARL9 Gene

Genes around ARL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL9 Gene

Proteins for ARL9 Gene

  • Protein details for ARL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 9
    Protein Accession:

    Protein attributes for ARL9 Gene

    187 amino acids
    Molecular mass:
    20755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARL9 Gene


neXtProt entry for ARL9 Gene

Post-translational modifications for ARL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL9 Gene

No data available for DME Specific Peptides for ARL9 Gene

Domains & Families for ARL9 Gene

Gene Families for ARL9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL9 Gene

Suggested Antigen Peptide Sequences for ARL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL9: view

Function for ARL9 Gene

Phenotypes From GWAS Catalog for ARL9 Gene

Gene Ontology (GO) - Molecular Function for ARL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL9: view
genes like me logo Genes that share phenotypes with ARL9: view

Animal Models for ARL9 Gene

MGI Knock Outs for ARL9:
  • Arl9 Arl9<tm1.1(KOMP)Vlcg>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL9 Gene

Localization for ARL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL9 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL9 Gene

Pathways & Interactions for ARL9 Gene

No Data Available

Interacting Proteins for ARL9 Gene

Gene Ontology (GO) - Biological Process for ARL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL9 Gene

Drugs & Compounds for ARL9 Gene

No Compound Related Data Available

Transcripts for ARL9 Gene

mRNA/cDNA for ARL9 Gene

(32) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL9 Gene

ADP-ribosylation factor-like 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL9 Gene

No ASD Table

Relevant External Links for ARL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL9 Gene

mRNA differential expression in normal tissues according to GTEx for ARL9 Gene

This gene is overexpressed in Testis (x10.4).

NURSA nuclear receptor signaling pathways regulating expression of ARL9 Gene:


SOURCE GeneReport for Unigene cluster for ARL9 Gene:

genes like me logo Genes that share expression patterns with ARL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL9 Gene

Orthologs for ARL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL9 34 33
  • 99.46 (n)
(Canis familiaris)
Mammalia ARL9 34 33
  • 90.24 (n)
(Bos Taurus)
Mammalia ARL9 34 33
  • 89.89 (n)
(Mus musculus)
Mammalia Arl9 16 34 33
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Arl9 33
  • 83.61 (n)
(Monodelphis domestica)
Mammalia ARL9 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia ARL9 34
  • 40 (a)
(Gallus gallus)
Aves ARL9 34 33
  • 71.82 (n)
(Anolis carolinensis)
Reptilia ARL9 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl9 33
  • 63.66 (n)
Str.15113 33
(Danio rerio)
Actinopterygii arl9 34 33
  • 55.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gie 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea arl-8 34
  • 19 (a)
Species where no ortholog for ARL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL9 Gene

Gene Tree for ARL9 (if available)
Gene Tree for ARL9 (if available)
Evolutionary constrained regions (ECRs) for ARL9: view image

Paralogs for ARL9 Gene

Paralogs for ARL9 Gene

(19) SIMAP similar genes for ARL9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL9: view

Variants for ARL9 Gene

Sequence variations from dbSNP and Humsavar for ARL9 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1142851 benign, Bone marrow failure syndrome 1 56,503,464(+) A/G upstream_transcript_variant
rs192226722 likely-benign, Bone marrow failure syndrome 1 56,503,625(+) A/G upstream_transcript_variant
rs886059503 uncertain-significance, Bone marrow failure syndrome 1 56,503,539(+) C/T upstream_transcript_variant
rs886059504 uncertain-significance, Bone marrow failure syndrome 1 56,503,630(+) T/G upstream_transcript_variant
rs1000146355 -- 56,518,944(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL9 Gene

Variant ID Type Subtype PubMed ID
dgv5213n100 CNV gain 25217958
esv2657721 CNV deletion 23128226
esv3600576 CNV loss 21293372
nsv1161086 CNV duplication 26073780
nsv829941 CNV loss 17160897

Variation tolerance for ARL9 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL9 Gene

Disorders for ARL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL9 Gene - From: GeneCards

Disorder Aliases PubMed IDs
bone marrow failure syndrome 1
  • bmfs1
- elite association - COSMIC cancer census association via MalaCards
Search ARL9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL9

genes like me logo Genes that share disorders with ARL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL9 Gene

Publications for ARL9 Gene

  1. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. (PMID: 15033445) Louro R … Reis EM (Biochemical and biophysical research communications 2004) 3 4 58
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for ARL9 Gene

Sources for ARL9 Gene

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