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Aliases for ARL8B Gene

Aliases for ARL8B Gene

  • ADP Ribosylation Factor Like GTPase 8B 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 1 3 4
  • ADP-Ribosylation Factor-Like Protein 10C 3 4
  • ADP-Ribosylation Factor-Like 10C 2 3
  • ADP-Ribosylation Factor-Like 8B 2 3
  • ARL10C 3 4
  • Gie1 3 4
  • ADP-Ribosylation Factor-Like Protein 8B 3

External Ids for ARL8B Gene

Previous HGNC Symbols for ARL8B Gene

  • ARL10C

Previous GeneCards Identifiers for ARL8B Gene

  • GC03P005139
  • GC03P005163
  • GC03P005096

Summaries for ARL8B Gene

GeneCards Summary for ARL8B Gene

ARL8B (ADP Ribosylation Factor Like GTPase 8B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8A.

UniProtKB/Swiss-Prot for ARL8B Gene

  • May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635).

Gene Wiki entry for ARL8B Gene

Additional gene information for ARL8B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8B Gene

Genomics for ARL8B Gene

GeneHancer (GH) Regulatory Elements for ARL8B Gene

Promoters and enhancers for ARL8B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I005121 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562.5 +1.3 1259 3.7 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 ARL8B EDEM1 ENSG00000233912 SETMAR
GH03I005180 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.5 +68.4 68418 20.6 CLOCK DMAP1 IRF4 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D GLIS1 EDEM1 ARL8B BHLHE40 ENSG00000233912 ENSG00000268509 PIR54874
GH03I005136 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 33.7 +16.5 16492 5 PKNOX1 FOXA2 SMAD1 FEZF1 ETS1 ZNF121 ZNF143 ATF7 RUNX3 RXRA ARL8B EDEM1 ENSG00000233912 BHLHE40
GH03I004866 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.4 -254.1 -254070 4 HDGF FOXA2 PKNOX1 CLOCK ARNT SIN3A FEZF1 YY1 POLR2B ZNF766 ARL8B EGOT BHLHE40 EDEM1 ITPR1 ENSG00000235978
GH03I004717 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.7 -401.5 -401464 5.7 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A YBX1 IRF4 YY1 E2F8 ARL8B BHLHE40 EGOT BHLHE40-AS1 ENSG00000235978 EDEM1 ENSG00000275981 LOC105376933 ITPR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARL8B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL8B gene promoter:

Genomic Locations for ARL8B Gene

Genomic Locations for ARL8B Gene
58,697 bases
Plus strand

Genomic View for ARL8B Gene

Genes around ARL8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8B Gene

Proteins for ARL8B Gene

  • Protein details for ARL8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 8B
    Protein Accession:
    Secondary Accessions:
    • B4DI85

    Protein attributes for ARL8B Gene

    186 amino acids
    Molecular mass:
    21539 Da
    Quaternary structure:
    • Interacts with tubulin (PubMed:15331635, Ref.16). Interacts with BORCS5; recruits ARL8B to lysosomes (PubMed:25898167).

    Three dimensional structures from OCA and Proteopedia for ARL8B Gene

    Alternative splice isoforms for ARL8B Gene


neXtProt entry for ARL8B Gene

Post-translational modifications for ARL8B Gene

  • Ubiquitination at posLast=141141 and posLast=146146
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL8B Gene

No data available for DME Specific Peptides for ARL8B Gene

Domains & Families for ARL8B Gene

Gene Families for ARL8B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8B: view

Function for ARL8B Gene

Molecular function for ARL8B Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635).

Phenotypes From GWAS Catalog for ARL8B Gene

Gene Ontology (GO) - Molecular Function for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15331635
GO:0005515 protein binding IPI 25898167
GO:0005525 GTP binding IDA 15331635
GO:0019003 GDP binding IDA 15331635
GO:0043014 alpha-tubulin binding IDA 15331635
genes like me logo Genes that share ontologies with ARL8B: view
genes like me logo Genes that share phenotypes with ARL8B: view

Animal Models for ARL8B Gene

MGI Knock Outs for ARL8B:

Animal Model Products

CRISPR Products

miRNA for ARL8B Gene

miRTarBase miRNAs that target ARL8B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL8B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL8B Gene

Localization for ARL8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8B Gene

Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=Localizes with microtubules at the spindle mid-zone during mitosis. {ECO:0000269 PubMed:15331635}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL8B gene
Compartment Confidence
extracellular 5
cytoskeleton 5
lysosome 4
endosome 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 15331635
GO:0005764 lysosome IEA --
GO:0005765 colocalizes_with lysosomal membrane IDA,IEA 25898167
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with ARL8B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARL8B Gene

Pathways & Interactions for ARL8B Gene

SuperPathways for ARL8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IMP 14871887
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0032418 lysosome localization IMP 25898167
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ARL8B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL8B Gene

Drugs & Compounds for ARL8B Gene

No Compound Related Data Available

Transcripts for ARL8B Gene

Unigene Clusters for ARL8B Gene

ADP-ribosylation factor-like 8B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL8B

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: - - -
SP8: - - - - - -
SP9: -

Relevant External Links for ARL8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL8B Gene

Protein tissue co-expression partners for ARL8B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL8B Gene:


SOURCE GeneReport for Unigene cluster for ARL8B Gene:


mRNA Expression by UniProt/SwissProt for ARL8B Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ARL8B Gene

  • Nervous system(5)
  • Liver(4.3)
  • Spleen(2.4)
  • Skin(2.1)
  • Heart(2)
  • Lymph node(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with ARL8B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL8B Gene

Orthologs for ARL8B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL8B 33 34
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia ARL8B 34
  • 100 (a)
(Bos Taurus)
Mammalia ARL8B 33 34
  • 96.59 (n)
(Canis familiaris)
Mammalia ARL8B 33 34
  • 96.59 (n)
(Mus musculus)
Mammalia Arl8b 33 16 34
  • 94.62 (n)
(Monodelphis domestica)
Mammalia ARL8B 34
  • 94 (a)
(Rattus norvegicus)
Mammalia Arl8b 33
  • 93.91 (n)
(Gallus gallus)
Aves ARL8A 34
  • 98 (a)
ARL8B 33
  • 89.61 (n)
(Anolis carolinensis)
Reptilia ARL8B 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8b 33
  • 81.36 (n)
(Danio rerio)
Actinopterygii arl8ba 34
  • 97 (a)
arl8bb 33 34
  • 78.85 (n)
Dr.19764 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5047 33
fruit fly
(Drosophila melanogaster)
Insecta Gie 34
  • 87 (a)
(Caenorhabditis elegans)
Secernentea arl-8 34
  • 85 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1A 33
  • 62.27 (n)
(Oryza sativa)
Liliopsida Os02g0732500 33
  • 60.87 (n)
Os.9284 33
(Hordeum vulgare)
Liliopsida Hv.9524 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4095 34
  • 85 (a)
Species where no ortholog for ARL8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL8B Gene

Gene Tree for ARL8B (if available)
Gene Tree for ARL8B (if available)

Paralogs for ARL8B Gene

Paralogs for ARL8B Gene Pseudogenes for ARL8B Gene

genes like me logo Genes that share paralogs with ARL8B: view

Variants for ARL8B Gene

Sequence variations from dbSNP and Humsavar for ARL8B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007277 -- 5,148,683(+) C/T intron_variant
rs1000092948 -- 5,135,928(+) A/C intron_variant
rs1000142054 -- 5,121,641(+) C/T upstream_transcript_variant
rs1000152136 -- 5,133,723(+) T/G intron_variant
rs1000205079 -- 5,133,428(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL8B Gene

Variant ID Type Subtype PubMed ID
esv2484755 CNV deletion 19546169
esv2671785 CNV deletion 23128226
esv3595124 CNV loss 21293372
esv3595125 CNV loss 21293372
nsv1002376 CNV gain 25217958
nsv966985 CNV duplication 23825009

Variation tolerance for ARL8B Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL8B Gene

Disorders for ARL8B Gene

Additional Disease Information for ARL8B

No disorders were found for ARL8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL8B Gene

Publications for ARL8B Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I … Munro S (Journal of cell science 2006) 3 4 22 58
  2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T … Katada T (Journal of cell science 2004) 3 4 22 58
  3. BORC, a multisubunit complex that regulates lysosome positioning. (PMID: 25898167) Pu J … Bonifacino JS (Developmental cell 2015) 3 4 58
  4. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. (PMID: 24088571) Tuli A … Brenner MB (Molecular biology of the cell 2013) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ARL8B Gene

  • Addgene plasmids for ARL8B

Sources for ARL8B Gene

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