Aliases for ARL8A Gene

Aliases for ARL8A Gene

  • ADP Ribosylation Factor Like GTPase 8A 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 2 3 4
  • ADP-Ribosylation Factor-Like Protein 8A 3 4
  • ADP-Ribosylation Factor-Like 10B 2 3
  • ADP-Ribosylation Factor-Like 8A 2 3
  • ARL10B 3 4
  • GIE2 3 4
  • ADP-Ribosylation Factor-Like Protein 10B 4

External Ids for ARL8A Gene

Previous HGNC Symbols for ARL8A Gene

  • ARL10B

Previous GeneCards Identifiers for ARL8A Gene

  • GC01M198834
  • GC01M200368
  • GC01M202102
  • GC01M173267

Summaries for ARL8A Gene

GeneCards Summary for ARL8A Gene

ARL8A (ADP Ribosylation Factor Like GTPase 8A) is a Protein Coding gene. Diseases associated with ARL8A include Drug-Induced Lupus Erythematosus. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARL8B.

UniProtKB/Swiss-Prot Summary for ARL8A Gene

  • Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).

Gene Wiki entry for ARL8A Gene

Additional gene information for ARL8A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL8A Gene

Genomics for ARL8A Gene

GeneHancer (GH) Regulatory Elements for ARL8A Gene

Promoters and enhancers for ARL8A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J202142 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 758 +0.6 642 3.4 ZBTB40 SREBF1 FOXA1 RBPJ SMARCE1 POLR2A NR2F1 NR2F6 MIXL1 HLF ARL8A lnc-GPR37L1-7 ENSG00000236390 ENSG00000234761 PTPRVP GPR37L1 RF00017-441
GH01J202213 Promoter/Enhancer 1.1 EPDnew Ensembl dbSUPER 11.1 -69.7 -69657 1.2 CTCF POLR2A ETS1 KLF1 LGR6 PTPRVP PTPN7 ARL8A HSALNG0009715 RF01210-033
GH01J201999 Enhancer 0.9 ENCODE dbSUPER 10.8 +145.0 144955 0.2 CTCF CC2D1A RAD21 ZSCAN21 IKZF1 PKNOX1 ARID2 RXRA REST ZEB2 ENSG00000224818 LMOD1 GPR37L1 TIMM17A ARL8A PTPN7 MIR6740 RF00017-438 ELF3-AS1 RNPEP
GH01J201709 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +431.4 431401 8.7 CTCF ZBTB6 SMARCE1 POLR2A CC2D1A RAD21 ZNF121 MNT ZBTB33 SP1 NAV1 MIR1231 ENSG00000236439 ENSG00000236390 ENSG00000224536 CSRP1 IPO9-AS1 PHLDA3 ENSG00000224818 ARL8A
GH01J202214 Enhancer 0.6 ENCODE dbSUPER 11.1 -68.8 -68845 0.2 CTCF TCF7L2 ZNF143 PTPRVP PTPN7 ARL8A HSALNG0009715 LGR6 RF01210-033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL8A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL8A gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • Hand1

Genomic Locations for ARL8A Gene

Genomic Locations for ARL8A Gene
chr1:202,133,404-202,144,743
(GRCh38/hg38)
Size:
11,340 bases
Orientation:
Minus strand
chr1:202,101,977-202,113,869
(GRCh37/hg19)
Size:
11,893 bases
Orientation:
Minus strand

Genomic View for ARL8A Gene

Genes around ARL8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8A Gene

Proteins for ARL8A Gene

  • Protein details for ARL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BM9-ARL8A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 8A
    Protein Accession:
    Q96BM9
    Secondary Accessions:
    • B3KXD0

    Protein attributes for ARL8A Gene

    Size:
    186 amino acids
    Molecular mass:
    21416 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL8A Gene

neXtProt entry for ARL8A Gene

Post-translational modifications for ARL8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL8A Gene

Domains & Families for ARL8A Gene

Gene Families for ARL8A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL8A Gene

Suggested Antigen Peptide Sequences for ARL8A Gene

GenScript: Design optimal peptide antigens:
  • Novel small G protein indispensable for equal chromosome segregation 2 (ARL8A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96BM9

UniProtKB/Swiss-Prot:

ARL8A_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8A: view

Function for ARL8A Gene

Molecular function for ARL8A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).

Phenotypes From GWAS Catalog for ARL8A Gene

Gene Ontology (GO) - Molecular Function for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15331635
GO:0005515 protein binding IPI 24955142
GO:0005525 GTP binding IDA,IEA 15331635
GO:0043014 alpha-tubulin binding ISS 15331635
GO:0048487 beta-tubulin binding ISS 15331635
genes like me logo Genes that share ontologies with ARL8A: view
genes like me logo Genes that share phenotypes with ARL8A: view

Animal Model Products

CRISPR Products

miRNA for ARL8A Gene

miRTarBase miRNAs that target ARL8A

Clone Products

  • Addgene plasmids for ARL8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL8A Gene

Localization for ARL8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8A Gene

Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Cell junction, synapse. Note=Localizes with microtubules at the spindle mid-zone during mitosis. {ECO:0000250 UniProtKB:Q9NVJ2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL8A gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
lysosome 4
endosome 3
cytosol 2
nucleus 1
extracellular 0

Gene Ontology (GO) - Cellular Components for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 15331635
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IBA 21873635
GO:0005768 endosome IEA --
GO:0005774 vacuolar membrane IBA 21873635
genes like me logo Genes that share ontologies with ARL8A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARL8A Gene

Pathways & Interactions for ARL8A Gene

PathCards logo

SuperPathways for ARL8A Gene

genes like me logo Genes that share pathways with ARL8A: view

Pathways by source for ARL8A Gene

3 Reactome pathways for ARL8A Gene

Gene Ontology (GO) - Biological Process for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation ISS 14871887
GO:0008089 anterograde axonal transport IEA --
GO:0015031 protein transport IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ARL8A: view

No data available for SIGNOR curated interactions for ARL8A Gene

Drugs & Compounds for ARL8A Gene

No Compound Related Data Available

Transcripts for ARL8A Gene

mRNA/cDNA for ARL8A Gene

CRISPR Products

Clone Products

  • Addgene plasmids for ARL8A

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8A Gene

No ASD Table

Relevant External Links for ARL8A Gene

GeneLoc Exon Structure for
ARL8A
ECgene alternative splicing isoforms for
ARL8A

Expression for ARL8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARL8A Gene

This gene is overexpressed in Nasal epithelium (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARL8A Gene



Protein tissue co-expression partners for ARL8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL8A Gene:

ARL8A

SOURCE GeneReport for Unigene cluster for ARL8A Gene:

Hs.497399

mRNA Expression by UniProt/SwissProt for ARL8A Gene:

Q96BM9-ARL8A_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ARL8A Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ARL8A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL8A Gene

Orthologs for ARL8A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 99 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ARL8A 33 32
  • 98.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl8a 32
  • 93.01 (n)
cow
(Bos Taurus)
Mammalia ARL8A 33 32
  • 92.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arl8a 17 33 32
  • 92.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARL8A 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 33
  • 93 (a)
ManyToMany
ARL8A 32
  • 88.17 (n)
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 98 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8a 32
  • 81.54 (n)
zebrafish
(Danio rerio)
Actinopterygii arl8a 33 32
  • 84.59 (n)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Gie 33
  • 87 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-8 33 32
  • 72.07 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1D 32
  • 62.64 (n)
rice
(Oryza sativa)
Liliopsida Os03g0200800 32
  • 60.84 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.3262 32
bread mold
(Neurospora crassa)
Ascomycetes NCU08618 32
  • 56.91 (n)
Species where no ortholog for ARL8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARL8A Gene

ENSEMBL:
Gene Tree for ARL8A (if available)
TreeFam:
Gene Tree for ARL8A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL8A: view image

Paralogs for ARL8A Gene

(28) SIMAP similar genes for ARL8A Gene using alignment to 1 proteins:

  • ARL8A_HUMAN
genes like me logo Genes that share paralogs with ARL8A: view

Variants for ARL8A Gene

Sequence variations from dbSNP and Humsavar for ARL8A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000012952 -- 202,143,583(-) CAT/ intron_variant
rs1000299850 -- 202,133,299(-) C/T downstream_transcript_variant
rs1000415742 -- 202,133,576(-) A/G 3_prime_UTR_variant
rs1000940744 -- 202,140,481(-) C/T intron_variant
rs1001718058 -- 202,134,700(-) T/G intron_variant

Variation tolerance for ARL8A Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL8A Gene

Human Gene Mutation Database (HGMD)
ARL8A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL8A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL8A Gene

Disorders for ARL8A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL8A Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
drug-induced lupus erythematosus
  • dil
- elite association - COSMIC cancer census association via MalaCards
Search ARL8A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL8A

genes like me logo Genes that share disorders with ARL8A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL8A Gene

Publications for ARL8A Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I … Munro S (Journal of cell science 2006) 3 4 23 56
  2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T … Katada T (Journal of cell science 2004) 3 4 23 56
  3. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schröder B … Hasilik A (Traffic (Copenhagen, Denmark) 2007) 3 4 56
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for ARL8A Gene

Sources for ARL8A Gene