Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL6IP5 Gene

Aliases for ARL6IP5 Gene

  • ADP Ribosylation Factor Like GTPase 6 Interacting Protein 5 2 3 5
  • ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 5 3 4
  • ADP-Ribosylation Factor-Like 6 Interacting Protein 5 2 3
  • Cytoskeleton-Related Vitamin A-Responsive Protein 3 4
  • Glutamate Transporter EAAC1-Interacting Protein 3 4
  • Prenylated Rab Acceptor Protein 2 3 4
  • ARL-6-Interacting Protein 5 3 4
  • PRA1 Domain Family 3 2 3
  • Protein JWa 3 4
  • GTRAP3-18 3 4
  • DERP11 3 4
  • Aip-5 3 4
  • PRAF3 3 4
  • JM5 3 4
  • JWA 3 4
  • ADP-Ribosylation Factor GTPase 6 Interacting Protein 5 3
  • ADP-Ribosylation-Like Factor 6 Interacting Protein 5 3
  • Glutamate Transporter EEAC1-Associated Protein 3
  • Putative MAPK Activating Protein PM27 3
  • Putative MAPK-Activating Protein PM27 4
  • Dermal Papilla Derived Protein 11 3
  • Dermal Papilla-Derived Protein 11 4
  • PRA1 Family Protein 3 3
  • Addicsin 3
  • HSPC127 3
  • Yip6b 3
  • Hp22 3
  • PRA2 4
  • Jmx 3

External Ids for ARL6IP5 Gene

Previous GeneCards Identifiers for ARL6IP5 Gene

  • GC03P069216

Summaries for ARL6IP5 Gene

Entrez Gene Summary for ARL6IP5 Gene

  • Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL6IP5 Gene

ARL6IP5 (ADP Ribosylation Factor Like GTPase 6 Interacting Protein 5) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is PRAF2.

UniProtKB/Swiss-Prot for ARL6IP5 Gene

  • Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.

Gene Wiki entry for ARL6IP5 Gene

Additional gene information for ARL6IP5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL6IP5 Gene

Genomics for ARL6IP5 Gene

GeneHancer (GH) Regulatory Elements for ARL6IP5 Gene

Promoters and enhancers for ARL6IP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I069079 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 578 +3.6 3590 18.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 IRF4 ARL6IP5 UBA3 TMF1 EOGT LMOD3 GC03M069083
GH03I069050 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 18.1 -33.0 -33026 3 PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 YY1 SLC30A9 TMF1 UBA3 ARL6IP5 MIR3136 ENSG00000244513
GH03I069008 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 7.6 -73.4 -73359 6.4 CLOCK ARID4B SIN3A DMAP1 ZNF766 ZNF143 SP3 MXD4 REST ZNF592 EOGT TMF1 ENSG00000244513 UBA3 ARL6IP5 GC03P068964
GH03I069102 Enhancer 0.5 dbSUPER 30.2 +20.3 20313 4.6 ZNF362 ZNF316 ATF7 ATF2 YY1 ARL6IP5 TMF1 GC03M069083 LMOD3
GH03I069101 Enhancer 0.5 ENCODE dbSUPER 28.8 +17.3 17254 0.8 NR2F2 GC03M069083 ARL6IP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARL6IP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL6IP5 gene promoter:

Genomic Locations for ARL6IP5 Gene

Genomic Locations for ARL6IP5 Gene
21,150 bases
Plus strand

Genomic View for ARL6IP5 Gene

Genes around ARL6IP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL6IP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL6IP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL6IP5 Gene

Proteins for ARL6IP5 Gene

  • Protein details for ARL6IP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRA1 family protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R6V5
    • Q53ES3
    • Q5KU08

    Protein attributes for ARL6IP5 Gene

    188 amino acids
    Molecular mass:
    21615 Da
    Quaternary structure:
    • Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with prenylated RAB1A, RAB3A and SLC1A1/EAAC1. Does not interact with VAMP1, VAMP2 or VAMP3. Interacts with ARL6. Interacts with SLC1A1/EAAC1.
    • Sequence=BAD97286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARL6IP5 Gene

Post-translational modifications for ARL6IP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL6IP5 Gene

No data available for DME Specific Peptides for ARL6IP5 Gene

Domains & Families for ARL6IP5 Gene

Gene Families for ARL6IP5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for ARL6IP5 Gene


Suggested Antigen Peptide Sequences for ARL6IP5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRA1 family.
  • Belongs to the PRA1 family.
genes like me logo Genes that share domains with ARL6IP5: view

Function for ARL6IP5 Gene

Molecular function for ARL6IP5 Gene

UniProtKB/Swiss-Prot Function:
Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.
UniProtKB/Swiss-Prot Induction:
By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat stress.

Phenotypes From GWAS Catalog for ARL6IP5 Gene

Gene Ontology (GO) - Molecular Function for ARL6IP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARL6IP5: view
genes like me logo Genes that share phenotypes with ARL6IP5: view

Animal Models for ARL6IP5 Gene

MGI Knock Outs for ARL6IP5:

Animal Model Products

CRISPR Products

miRNA for ARL6IP5 Gene

miRTarBase miRNAs that target ARL6IP5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL6IP5 Gene

Localization for ARL6IP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL6IP5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. {ECO:0000250 UniProtKB:Q9ES40}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL6IP5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 4
endoplasmic reticulum 4
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL6IP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARL6IP5: view

Pathways & Interactions for ARL6IP5 Gene

genes like me logo Genes that share pathways with ARL6IP5: view

Gene Ontology (GO) - Biological Process for ARL6IP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002037 negative regulation of L-glutamate transport ISS --
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA 18387645
GO:0010917 negative regulation of mitochondrial membrane potential IMP 18387645
GO:0015813 L-glutamate transport ISS,IEA --
GO:0032874 positive regulation of stress-activated MAPK cascade IMP 18387645
genes like me logo Genes that share ontologies with ARL6IP5: view

No data available for SIGNOR curated interactions for ARL6IP5 Gene

Drugs & Compounds for ARL6IP5 Gene

(2) Additional Compounds for ARL6IP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARL6IP5: view

Transcripts for ARL6IP5 Gene

Unigene Clusters for ARL6IP5 Gene

ADP-ribosylation-like factor 6 interacting protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP3: -

Relevant External Links for ARL6IP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL6IP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL6IP5 Gene

Protein differential expression in normal tissues from HIPED for ARL6IP5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.4) and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL6IP5 Gene

Protein tissue co-expression partners for ARL6IP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL6IP5 Gene:


SOURCE GeneReport for Unigene cluster for ARL6IP5 Gene:


Evidence on tissue expression from TISSUES for ARL6IP5 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Skin(4.5)
  • Adrenal gland(4.4)
  • Blood(4.4)
  • Spleen(4.4)
  • Bone marrow(4.3)
  • Liver(4.3)
  • Kidney(3.3)
  • Heart(2.7)
  • Eye(2.6)
  • Pancreas(2.6)
  • Muscle(2.4)
  • Intestine(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ARL6IP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL6IP5 Gene

Orthologs for ARL6IP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL6IP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL6IP5 33 34
  • 99.65 (n)
(Canis familiaris)
Mammalia ARL6IP5 33 34
  • 90.43 (n)
(Ornithorhynchus anatinus)
Mammalia ARL6IP5 34
  • 89 (a)
(Bos Taurus)
Mammalia ARL6IP5 33 34
  • 88.48 (n)
(Mus musculus)
Mammalia Arl6ip5 33 16 34
  • 87.41 (n)
(Rattus norvegicus)
Mammalia Arl6ip5 33
  • 86.88 (n)
(Monodelphis domestica)
Mammalia ARL6IP5 34
  • 85 (a)
(Gallus gallus)
Aves ARL6IP5 33 34
  • 76.95 (n)
(Anolis carolinensis)
Reptilia ARL6IP5 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl6ip5 33
  • 70.74 (n)
(Danio rerio)
Actinopterygii arl6ip5a 33 34
  • 65.41 (n)
arl6ip5b 34
  • 61 (a)
arl6ip5 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10349 33
fruit fly
(Drosophila melanogaster)
Insecta Jwa 33 34
  • 53.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005121 33
  • 52.98 (n)
(Caenorhabditis elegans)
Secernentea praf-3 33 34
  • 46.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9659 34
  • 40 (a)
Species where no ortholog for ARL6IP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL6IP5 Gene

Gene Tree for ARL6IP5 (if available)
Gene Tree for ARL6IP5 (if available)

Paralogs for ARL6IP5 Gene

Variants for ARL6IP5 Gene

Sequence variations from dbSNP and Humsavar for ARL6IP5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000100629 -- 69,095,410(+) A/G intron_variant
rs1000113822 -- 69,095,563(+) C/G intron_variant
rs1000126139 -- 69,091,679(+) G/T intron_variant
rs1000233848 -- 69,094,987(+) C/T intron_variant
rs1000547972 -- 69,095,739(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL6IP5 Gene

Variant ID Type Subtype PubMed ID
esv3596491 CNV gain 21293372

Variation tolerance for ARL6IP5 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL6IP5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL6IP5 Gene

Disorders for ARL6IP5 Gene

Additional Disease Information for ARL6IP5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARL6IP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL6IP5 Gene

Publications for ARL6IP5 Gene

  1. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo CS … Bachmann AS (Gene 2006) 3 4 22 58
  2. JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PMID: 15757671) Schweneker M … Moelling K (FEBS letters 2005) 3 4 22 58
  3. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. (PMID: 11242046) Lin CI … Rothstein JD (Nature 2001) 2 3 22 58
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  5. Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane. (PMID: 17646425) Watabe M … Nakaki T (Molecular pharmacology 2007) 3 22 58

Products for ARL6IP5 Gene

Sources for ARL6IP5 Gene

Loading form....