Aliases for ARL5C Gene

Aliases for ARL5C Gene

  • ADP Ribosylation Factor Like GTPase 5C 2 3 5
  • Putative ADP-Ribosylation Factor-Like Protein 5C 3 4
  • ADP-Ribosylation Factor-Like Protein 12 3 4
  • ADP-Ribosylation Factor-Like 5C 2 3
  • ARL12 3 4
  • ADP-Ribosylation Factor-Like 12 2

External Ids for ARL5C Gene

Previous HGNC Symbols for ARL5C Gene

  • ARL12

Previous GeneCards Identifiers for ARL5C Gene

  • GC17M034563
  • GC17U900719
  • GC17M037313
  • GC17M033108

Summaries for ARL5C Gene

GeneCards Summary for ARL5C Gene

ARL5C (ADP Ribosylation Factor Like GTPase 5C) is a Protein Coding gene. Diseases associated with ARL5C include Usher Syndrome, Type If and Usher Syndrome, Type I. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL5B.

UniProtKB/Swiss-Prot Summary for ARL5C Gene

Additional gene information for ARL5C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL5C Gene

Genomics for ARL5C Gene

GeneHancer (GH) Regulatory Elements for ARL5C Gene

Promoters and enhancers for ARL5C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J039164 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 510.1 +1.4 1366 4.2 CTCF TCF12 SP1 FOS GABPA RAD21 CTBP1 TRIM22 NFYB SMC3 ARL5C ENSG00000280177 NONHSAG021690.2 lnc-ARL5C-1 MED1 MED24 SNORA21 CDK12 RPL23 MRPL45
GH17J039168 Promoter/Enhancer 0.8 Ensembl dbSUPER 500.7 -1.0 -1017 0.2 NFATC3 NFYC ASH1L CC2D1A ARL5C lnc-ARL5C-1 ENSG00000266101
GH17J039056 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 11.2 +110.2 110202 1.8 NRF1 POLR2G ZBTB10 ZBTB26 KLF7 MYC TGIF2 CTBP1 POLR2A MXI1 RDM1P5 lnc-LINC00672-5 PLXDC1 ARL5C LINC00672 lnc-ARL5C-9
GH17J039013 Enhancer 1.1 Ensembl ENCODE 10.5 +150.6 150607 5.8 GTF2E2 FOS ZBTB11 TRIM28 HINFP ZEB1 TAF9B NCOR1 NFRKB RELA FBXO47 ARL5C MED1 CDK12 CACNB1 RPL19 CWC25 STARD3 ENSG00000266588 RF00994-400
GH17J039174 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 5.6 -7.4 -7410 1.6 CTCF REST RAD21 ZBTB7A TRIM22 SMC3 POLR2A ZNF491 POLR2G MYRF ENSG00000266101 LOC105371768 CACNB1 RPL19 SNORD124 PSMB3 TBC1D3 ARL5C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL5C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL5C

Top Transcription factor binding sites by QIAGEN in the ARL5C gene promoter:
  • AML1a
  • c-Myc
  • COMP1
  • FOXO4
  • Max
  • Pax-4a
  • POU2F1
  • SEF-1 (1)

Genomic Locations for ARL5C Gene

Genomic Locations for ARL5C Gene
chr17:39,156,894-39,167,484
(GRCh38/hg38)
Size:
10,591 bases
Orientation:
Minus strand
chr17:37,313,147-37,323,737
(GRCh37/hg19)
Size:
10,591 bases
Orientation:
Minus strand

Genomic View for ARL5C Gene

Genes around ARL5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5C Gene

Proteins for ARL5C Gene

  • Protein details for ARL5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NH57-ARL5C_HUMAN
    Recommended name:
    Putative ADP-ribosylation factor-like protein 5C
    Protein Accession:
    A6NH57

    Protein attributes for ARL5C Gene

    Size:
    179 amino acids
    Molecular mass:
    20591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL5C Gene

Post-translational modifications for ARL5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL5C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5C Gene

Domains & Families for ARL5C Gene

Gene Families for ARL5C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL5C Gene

Suggested Antigen Peptide Sequences for ARL5C Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like protein 12 (ARL5C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NH57

UniProtKB/Swiss-Prot:

ARL5C_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5C: view

Function for ARL5C Gene

Molecular function for ARL5C Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Phenotypes From GWAS Catalog for ARL5C Gene

Gene Ontology (GO) - Molecular Function for ARL5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with ARL5C: view
genes like me logo Genes that share phenotypes with ARL5C: view

Animal Models for ARL5C Gene

MGI Knock Outs for ARL5C:
  • Arl5c Arl5c<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for ARL5C Gene

miRTarBase miRNAs that target ARL5C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL5C Gene

Localization for ARL5C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL5C gene
Compartment Confidence
golgi apparatus 3
cytosol 2
extracellular 1
nucleus 1
endosome 1
lysosome 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for ARL5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005802 trans-Golgi network IBA 21873635
genes like me logo Genes that share ontologies with ARL5C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL5C Gene

Pathways & Interactions for ARL5C Gene

PathCards logo

SuperPathways for ARL5C Gene

No Data Available

Interacting Proteins for ARL5C Gene

;

Gene Ontology (GO) - Biological Process for ARL5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
GO:1903292 protein localization to Golgi membrane IBA 21873635
genes like me logo Genes that share ontologies with ARL5C: view

No data available for Pathways by source and SIGNOR curated interactions for ARL5C Gene

Drugs & Compounds for ARL5C Gene

(1) Drugs for ARL5C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL5C: view

Transcripts for ARL5C Gene

mRNA/cDNA for ARL5C Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5C Gene

No ASD Table

Relevant External Links for ARL5C Gene

GeneLoc Exon Structure for
ARL5C

Expression for ARL5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL5C Gene

mRNA differential expression in normal tissues according to GTEx for ARL5C Gene

This gene is overexpressed in Pancreas (x7.2) and Brain - Putamen (basal ganglia) (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL5C

SOURCE GeneReport for Unigene cluster for ARL5C Gene:

Hs.568007
genes like me logo Genes that share expression patterns with ARL5C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL5C Gene

Orthologs for ARL5C Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL5C 31 30
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARL5C 31 30
  • 86.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC787781 30
  • 85.47 (n)
ARL5C 31
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl5c 17 31 30
  • 82.5 (n)
rat
(Rattus norvegicus)
Mammalia Arl5c 30
  • 81.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ARL5C 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5b 30
  • 70.58 (n)
zebrafish
(Danio rerio)
Actinopterygii arl5c 31 30
  • 68.34 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7197 31
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-5 31 30
  • 52.71 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10998 31
  • 31 (a)
ManyToMany
Species where no ortholog for ARL5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5C Gene

ENSEMBL:
Gene Tree for ARL5C (if available)
TreeFam:
Gene Tree for ARL5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL5C: view image

Paralogs for ARL5C Gene

(20) SIMAP similar genes for ARL5C Gene using alignment to 2 proteins:

  • ARL5C_HUMAN
  • K7EM39_HUMAN

Pseudogenes.org Pseudogenes for ARL5C Gene

genes like me logo Genes that share paralogs with ARL5C: view

Variants for ARL5C Gene

Additional dbSNP identifiers (rs#s) for ARL5C Gene

Structural Variations from Database of Genomic Variants (DGV) for ARL5C Gene

Variant ID Type Subtype PubMed ID
esv2671727 CNV deletion 23128226
esv3640539 CNV loss 21293372
esv3893011 CNV loss 25118596
nsv1146669 OTHER inversion 26484159
nsv833440 CNV loss 17160897
nsv833441 CNV loss 17160897

Variation tolerance for ARL5C Gene

Gene Damage Index Score: 13.81; 95.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL5C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL5C Gene

Disorders for ARL5C Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARL5C Gene - From: DISEASES

Disorder Aliases PubMed IDs
usher syndrome, type if
  • ush1f
usher syndrome, type i
  • ush1
- elite association - COSMIC cancer census association via MalaCards
Search ARL5C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL5C

genes like me logo Genes that share disorders with ARL5C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL5C Gene

Publications for ARL5C Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 54

Products for ARL5C Gene

Sources for ARL5C Gene