ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010] See more...

Aliases for ARL5B Gene

Aliases for ARL5B Gene

  • ADP Ribosylation Factor Like GTPase 5B 2 3 5
  • ADP-Ribosylation Factor-Like Protein 5B 3 4
  • ADP-Ribosylation Factor-Like Protein 8 3 4
  • ADP-Ribosylation Factor-Like 5B 2 3
  • ADP-Ribosylation Factor-Like 8 2 3
  • ARL8 3 4
  • ADP-Ribosylation-Like Factor 8 3

External Ids for ARL5B Gene

Previous HGNC Symbols for ARL5B Gene

  • ARL8

Previous GeneCards Identifiers for ARL5B Gene

  • GC10P018989
  • GC10P018608
  • GC10P018948

Summaries for ARL5B Gene

Entrez Gene Summary for ARL5B Gene

  • ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

GeneCards Summary for ARL5B Gene

ARL5B (ADP Ribosylation Factor Like GTPase 5B) is a Protein Coding gene. Diseases associated with ARL5B include Ulceroglandular Tularemia. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARL5A.

UniProtKB/Swiss-Prot Summary for ARL5B Gene

Additional gene information for ARL5B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL5B Gene

Genomics for ARL5B Gene

GeneHancer (GH) Regulatory Elements for ARL5B Gene

Promoters and enhancers for ARL5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL5B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL5B

Top Transcription factor binding sites by QIAGEN in the ARL5B gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • Oct-B1
  • oct-B2
  • oct-B3
  • p53
  • POU2F1
  • POU2F1a

Genomic Locations for ARL5B Gene

Genomic Locations for ARL5B Gene
chr10:18,659,335-18,681,639
(GRCh38/hg38)
Size:
22,305 bases
Orientation:
Plus strand
chr10:18,948,313-18,970,568
(GRCh37/hg19)
Size:
22,256 bases
Orientation:
Plus strand

Genomic View for ARL5B Gene

Genes around ARL5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5B Gene

Proteins for ARL5B Gene

  • Protein details for ARL5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KC2-ARL5B_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 5B
    Protein Accession:
    Q96KC2

    Protein attributes for ARL5B Gene

    Size:
    179 amino acids
    Molecular mass:
    20375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5B Gene

neXtProt entry for ARL5B Gene

Post-translational modifications for ARL5B Gene

  • Ubiquitination at Lys103
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5B Gene

Domains & Families for ARL5B Gene

Gene Families for ARL5B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL5B Gene

Blocks:
  • ADP-ribosylation factor
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARL5B Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like protein 8 (ARL5B_HUMAN)
  • ADP-ribosylation factor-like protein 5B (B0YIW9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KC2

UniProtKB/Swiss-Prot:

ARL5B_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5B: view

Function for ARL5B Gene

Molecular function for ARL5B Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Phenotypes From GWAS Catalog for ARL5B Gene

Gene Ontology (GO) - Molecular Function for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with ARL5B: view
genes like me logo Genes that share phenotypes with ARL5B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL5B

CRISPR Products

miRNA for ARL5B Gene

miRTarBase miRNAs that target ARL5B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL5B Gene

Localization for ARL5B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL5B gene
Compartment Confidence
golgi apparatus 4
extracellular 2
cytoskeleton 2
endosome 2
cytosol 2
lysosome 2
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005802 trans-Golgi network IBA 21873635
genes like me logo Genes that share ontologies with ARL5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL5B Gene

Pathways & Interactions for ARL5B Gene

PathCards logo

SuperPathways for ARL5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
GO:1903292 protein localization to Golgi membrane IMP 25795912
genes like me logo Genes that share ontologies with ARL5B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL5B Gene

Drugs & Compounds for ARL5B Gene

(2) Drugs for ARL5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL5B: view

Transcripts for ARL5B Gene

mRNA/cDNA for ARL5B Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL5B

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5B Gene

No ASD Table

Relevant External Links for ARL5B Gene

GeneLoc Exon Structure for
ARL5B

Expression for ARL5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL5B Gene

mRNA differential expression in normal tissues according to GTEx for ARL5B Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for ARL5B Gene

This gene is overexpressed in Bone (40.0) and Plasma (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARL5B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL5B

SOURCE GeneReport for Unigene cluster for ARL5B Gene:

Hs.25362
genes like me logo Genes that share expression patterns with ARL5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL5B Gene

Orthologs for ARL5B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL5B 31 30
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL5B 31
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL5B 31 30
  • 96.46 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL5B 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL5B 31 30
  • 95.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arl5b 17 31 30
  • 92.36 (n)
chicken
(Gallus gallus)
Aves ARL5B 31 30
  • 85.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL5B 31
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5a 30
  • 82.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5203 30
zebrafish
(Danio rerio)
Actinopterygii arl8 31 30
  • 81.01 (n)
OneToOne
wufi17a05 30
fruit fly
(Drosophila melanogaster)
Insecta CG7197 31
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-5 31
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
ManyToMany
Cin.11870 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11870 30
Species where no ortholog for ARL5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5B Gene

ENSEMBL:
Gene Tree for ARL5B (if available)
TreeFam:
Gene Tree for ARL5B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL5B: view image

Paralogs for ARL5B Gene

(30) SIMAP similar genes for ARL5B Gene using alignment to 2 proteins:

  • ARL5B_HUMAN
  • B0YIW9_HUMAN

Pseudogenes.org Pseudogenes for ARL5B Gene

genes like me logo Genes that share paralogs with ARL5B: view

Variants for ARL5B Gene

Additional dbSNP identifiers (rs#s) for ARL5B Gene

Structural Variations from Database of Genomic Variants (DGV) for ARL5B Gene

Variant ID Type Subtype PubMed ID
nsv466762 CNV gain 19166990
nsv550042 CNV gain 21841781
nsv550121 CNV gain 21841781

Variation tolerance for ARL5B Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL5B Gene

Human Gene Mutation Database (HGMD)
ARL5B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL5B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL5B Gene

Disorders for ARL5B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL5B Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulceroglandular tularemia
- elite association - COSMIC cancer census association via MalaCards
Search ARL5B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL5B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARL5B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL5B Gene

Publications for ARL5B Gene

  1. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. (PMID: 12853149) Sebald E … Krakow D (Gene 2003) 2 3 4 54
  2. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. (PMID: 22245584) Houghton FJ … Gleeson PA (Experimental cell research 2012) 2 3 54
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 41 54
  4. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. (PMID: 20932310) Han MR … Alzheimer's Disease Neuroimaging Initiative (BMC neurology 2010) 3 41 54
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54

Products for ARL5B Gene

Sources for ARL5B Gene