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Aliases for ARL5B Gene

Aliases for ARL5B Gene

  • ADP Ribosylation Factor Like GTPase 5B 2 3 5
  • ADP-Ribosylation Factor-Like Protein 8 3 4
  • ADP-Ribosylation Factor-Like 5B 2 3
  • ADP-Ribosylation Factor-Like 8 2 3
  • ARL8 3 4
  • ADP-Ribosylation Factor-Like Protein 5B 3
  • ADP-Ribosylation-Like Factor 8 3

External Ids for ARL5B Gene

Previous HGNC Symbols for ARL5B Gene

  • ARL8

Previous GeneCards Identifiers for ARL5B Gene

  • GC10P018989
  • GC10P018948

Summaries for ARL5B Gene

Entrez Gene Summary for ARL5B Gene

  • ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

GeneCards Summary for ARL5B Gene

ARL5B (ADP Ribosylation Factor Like GTPase 5B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL5A.

UniProtKB/Swiss-Prot for ARL5B Gene

  • Binds and exchanges GTP and GDP.

Additional gene information for ARL5B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5B Gene

Genomics for ARL5B Gene

GeneHancer (GH) Regulatory Elements for ARL5B Gene

Promoters and enhancers for ARL5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I018657 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 559.7 +0.3 323 4.8 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 NSUN6 ARL5B ENSG00000240291 LOC105376438 GC10P018678
GH10I018607 Enhancer 1.2 FANTOM5 Ensembl ENCODE 23.3 -51.3 -51261 1.7 SMAD1 ZSCAN26 ZBTB6 NFIB JUN ZNF529 ZNF195 FOSL1 ZNF335 LCORL ARL5B NSUN6 ENSG00000240291
GH10I018609 Enhancer 1.2 Ensembl ENCODE 19.2 -48.2 -48201 2.6 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 ZNF48 ETS1 YY1 NSUN6 ARL5B ENSG00000240291
GH10I018626 Enhancer 1.1 Ensembl ENCODE 20.1 -31.7 -31656 1.6 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B GLIS2 ZNF143 KLF7 NSUN6 ENSG00000240291 ARL5B
GH10I018681 Enhancer 0.9 Ensembl ENCODE 20.5 +23.1 23108 2.8 FOXA2 JUN ZFP64 CEBPG ETS1 FOSL1 POLR2A SCRT2 PRDM10 FOSL2 ENSG00000240291 ARL5B NSUN6 GC10P018678 LOC105376440
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARL5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL5B gene promoter:

Genomic Locations for ARL5B Gene

Genomic Locations for ARL5B Gene
22,305 bases
Plus strand

Genomic View for ARL5B Gene

Genes around ARL5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5B Gene

Proteins for ARL5B Gene

  • Protein details for ARL5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 5B
    Protein Accession:

    Protein attributes for ARL5B Gene

    179 amino acids
    Molecular mass:
    20375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5B Gene

neXtProt entry for ARL5B Gene

Post-translational modifications for ARL5B Gene

Other Protein References for ARL5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5B Gene

Domains & Families for ARL5B Gene

Gene Families for ARL5B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARL5B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5B: view

Function for ARL5B Gene

Molecular function for ARL5B Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Phenotypes From GWAS Catalog for ARL5B Gene

Gene Ontology (GO) - Molecular Function for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL5B: view
genes like me logo Genes that share phenotypes with ARL5B: view

Animal Model Products

CRISPR Products

miRNA for ARL5B Gene

miRTarBase miRNAs that target ARL5B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL5B Gene

Localization for ARL5B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL5B gene
Compartment Confidence
extracellular 2
cytosol 2
lysosome 2
endosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL5B Gene

Pathways & Interactions for ARL5B Gene

SuperPathways for ARL5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:1903292 protein localization to Golgi membrane IMP 25795912
genes like me logo Genes that share ontologies with ARL5B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL5B Gene

Drugs & Compounds for ARL5B Gene

(2) Drugs for ARL5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL5B: view

Transcripts for ARL5B Gene

mRNA/cDNA for ARL5B Gene

Unigene Clusters for ARL5B Gene

ADP-ribosylation factor-like 5B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL5B

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5B Gene

No ASD Table

Relevant External Links for ARL5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL5B Gene

mRNA differential expression in normal tissues according to GTEx for ARL5B Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for ARL5B Gene

This gene is overexpressed in Bone (40.0) and Plasma (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL5B Gene

NURSA nuclear receptor signaling pathways regulating expression of ARL5B Gene:


SOURCE GeneReport for Unigene cluster for ARL5B Gene:

genes like me logo Genes that share expression patterns with ARL5B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL5B Gene

Orthologs for ARL5B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL5B 33 34
  • 100 (n)
(Monodelphis domestica)
Mammalia ARL5B 34
  • 98 (a)
(Bos Taurus)
Mammalia ARL5B 33 34
  • 96.46 (n)
(Ornithorhynchus anatinus)
Mammalia ARL5B 34
  • 96 (a)
(Canis familiaris)
Mammalia ARL5B 33 34
  • 95.53 (n)
(Mus musculus)
Mammalia Arl5b 33 16 34
  • 92.36 (n)
(Gallus gallus)
Aves ARL5B 33 34
  • 85.29 (n)
(Anolis carolinensis)
Reptilia ARL5B 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5a 33
  • 82.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5203 33
(Danio rerio)
Actinopterygii arl8 33 34
  • 81.01 (n)
wufi17a05 33
fruit fly
(Drosophila melanogaster)
Insecta CG7197 34
  • 71 (a)
(Caenorhabditis elegans)
Secernentea arl-5 34
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11870 33
Species where no ortholog for ARL5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5B Gene

Gene Tree for ARL5B (if available)
Gene Tree for ARL5B (if available)

Paralogs for ARL5B Gene

Paralogs for ARL5B Gene Pseudogenes for ARL5B Gene

genes like me logo Genes that share paralogs with ARL5B: view

Variants for ARL5B Gene

Sequence variations from dbSNP and Humsavar for ARL5B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000019736 -- 18,673,761(+) TTTTTTTTTTT/TTTTTTTTTT intron_variant
rs1000235601 -- 18,666,977(+) C/T intron_variant
rs1000284909 -- 18,669,387(+) A/G/T intron_variant
rs1000421865 -- 18,681,368(+) A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000436293 -- 18,664,165(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5B Gene

Variant ID Type Subtype PubMed ID
nsv466762 CNV gain 19166990
nsv550042 CNV gain 21841781
nsv550121 CNV gain 21841781

Variation tolerance for ARL5B Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL5B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL5B Gene

Disorders for ARL5B Gene

Additional Disease Information for ARL5B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARL5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL5B Gene

Publications for ARL5B Gene

  1. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. (PMID: 12853149) Sebald E … Krakow D (Gene 2003) 2 3 4 58
  2. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. (PMID: 22245584) Houghton FJ … Gleeson PA (Experimental cell research 2012) 2 3 58
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
  4. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study. (PMID: 20932310) Han MR … Alzheimer's Disease Neuroimaging Initiative (BMC neurology 2010) 3 44 58
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58

Products for ARL5B Gene

Sources for ARL5B Gene

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