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Aliases for ARL5A Gene

Aliases for ARL5A Gene

  • ADP Ribosylation Factor Like GTPase 5A 2 3 5
  • ADP-Ribosylation Factor-Like 5A 2 3
  • ADP-Ribosylation Factor-Like 5 2 3
  • ARFLP5 3 4
  • ARL5 3 4
  • ADP-Ribosylation Factor-Like Protein 5A 3
  • ADP-Ribosylation Factor-Like Protein 5 3

External Ids for ARL5A Gene

Previous HGNC Symbols for ARL5A Gene

  • ARL5

Previous GeneCards Identifiers for ARL5A Gene

  • GC02M152485
  • GC02M152365
  • GC02M152645
  • GC02M144543

Summaries for ARL5A Gene

Entrez Gene Summary for ARL5A Gene

  • The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL5A Gene

ARL5A (ADP Ribosylation Factor Like GTPase 5A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL5B.

UniProtKB/Swiss-Prot for ARL5A Gene

  • Lacks ADP-ribosylation enhancing activity.

Additional gene information for ARL5A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5A Gene

Genomics for ARL5A Gene

GeneHancer (GH) Regulatory Elements for ARL5A Gene

Promoters and enhancers for ARL5A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I151826 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.6 600 2.8 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ARL5A PRPF40A STAM2 RIF1 ARL6IP6 RPL30P2 NEB PIR49049 ENSG00000283228
GH02I152334 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 5.7 -507.7 -507731 3.5 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF213 FMNL2 ARL5A STAM2 NUDCP1
GH02I151785 Enhancer 0.4 ENCODE dbSUPER 4.5 +42.1 42069 0.9 NEB ARL5A LOC101929356
GH02I152338 Enhancer 0.3 dbSUPER 5.8 -510.8 -510839 1.3 ZNF121 ARL5A FMNL2 NUDCP1
GH02I151788 Enhancer 1 dbSUPER 0.3 +38.6 38563 2.3 PKNOX1 ATF1 ARNT ZFP64 NCOA2 TCF12 ZNF766 GATA2 E2F8 ATF7 PRPF40A RIF1 STAM2 RPL30P2 NEB LOC101929356 ARL5A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARL5A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL5A gene promoter:

Genomic Locations for ARL5A Gene

Genomic Locations for ARL5A Gene
39,512 bases
Minus strand

Genomic View for ARL5A Gene

Genes around ARL5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5A Gene

Proteins for ARL5A Gene

  • Protein details for ARL5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 5A
    Protein Accession:
    Secondary Accessions:
    • Q580I5

    Protein attributes for ARL5A Gene

    179 amino acids
    Molecular mass:
    20728 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5A Gene

    Alternative splice isoforms for ARL5A Gene


neXtProt entry for ARL5A Gene

Post-translational modifications for ARL5A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL5A Gene

No data available for DME Specific Peptides for ARL5A Gene

Domains & Families for ARL5A Gene

Gene Families for ARL5A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARL5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5A: view

Function for ARL5A Gene

Molecular function for ARL5A Gene

UniProtKB/Swiss-Prot Function:
Lacks ADP-ribosylation enhancing activity.

Gene Ontology (GO) - Molecular Function for ARL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL5A: view
genes like me logo Genes that share phenotypes with ARL5A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL5A Gene

Localization for ARL5A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL5A gene
Compartment Confidence
cytosol 3
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for ARL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL5A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL5A Gene

Pathways & Interactions for ARL5A Gene

SuperPathways for ARL5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:1903292 protein localization to Golgi membrane IGI 25795912
genes like me logo Genes that share ontologies with ARL5A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL5A Gene

Drugs & Compounds for ARL5A Gene

(1) Drugs for ARL5A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARL5A: view

Transcripts for ARL5A Gene

Unigene Clusters for ARL5A Gene

ADP-ribosylation factor-like 5A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: -

Relevant External Links for ARL5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL5A Gene

Protein differential expression in normal tissues from HIPED for ARL5A Gene

This gene is overexpressed in Bone (41.7) and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL5A Gene

NURSA nuclear receptor signaling pathways regulating expression of ARL5A Gene:


SOURCE GeneReport for Unigene cluster for ARL5A Gene:


Evidence on tissue expression from TISSUES for ARL5A Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ARL5A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL5A Gene

Orthologs for ARL5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL5A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL5A 33 34
  • 99.63 (n)
(Monodelphis domestica)
Mammalia ARL5A 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia ARL5A 34
  • 98 (a)
(Canis familiaris)
Mammalia ARL5A 33 34
  • 96.95 (n)
(Bos Taurus)
Mammalia ARL5A 33 34
  • 96.46 (n)
(Rattus norvegicus)
Mammalia Arl5a 33
  • 92.36 (n)
(Mus musculus)
Mammalia Arl5a 33 16 34
  • 90.88 (n)
(Gallus gallus)
Aves ARL5A 34
  • 89 (a)
LOC100857935 33
  • 85.16 (n)
(Anolis carolinensis)
Reptilia ARL5A 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490823 33
  • 80.63 (n)
(Danio rerio)
Actinopterygii arl5a 33 34
  • 78.4 (n)
Dr.11356 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1360 33
fruit fly
(Drosophila melanogaster)
Insecta CG7197 33 34
  • 64.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011254 33
  • 64.57 (n)
(Caenorhabditis elegans)
Secernentea arl-5 34
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARFC1 33
  • 61.55 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5206 33
(Oryza sativa)
Liliopsida Os11g0586900 33
  • 55.49 (n)
(Hordeum vulgare)
Liliopsida Hv.1404 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for ARL5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5A Gene

Gene Tree for ARL5A (if available)
Gene Tree for ARL5A (if available)

Paralogs for ARL5A Gene

Paralogs for ARL5A Gene

(27) SIMAP similar genes for ARL5A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL5A: view

Variants for ARL5A Gene

Sequence variations from dbSNP and Humsavar for ARL5A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000148491 -- 151,825,691(-) G/A intron_variant
rs1000288134 -- 151,830,314(-) A/G upstream_transcript_variant
rs1000534599 -- 151,824,799(-) A/G intron_variant
rs1000774209 -- 151,801,587(-) A/G 3_prime_UTR_variant
rs1000853691 -- 151,815,236(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5A Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV loss 17911159
esv3584106 CNV loss 25503493
esv3592922 CNV loss 21293372
esv3592924 CNV loss 21293372
nsv820167 CNV loss 19587683
nsv979136 CNV duplication 23825009

Variation tolerance for ARL5A Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL5A Gene

Disorders for ARL5A Gene

Additional Disease Information for ARL5A

No disorders were found for ARL5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL5A Gene

Publications for ARL5A Gene

  1. 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins. (PMID: 15896705) Wang ZX … Liang DC (Biochemical and biophysical research communications 2005) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. (PMID: 12450215) He H … Zhao S (Gene expression 2002) 3 4 58
  4. A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. (PMID: 12414990) Lin CY … Lee FJ (Journal of cell science 2002) 3 22 58
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58

Products for ARL5A Gene

  • Addgene plasmids for ARL5A

Sources for ARL5A Gene

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