Aliases for ARL4D Gene
External Ids for ARL4D Gene
Previous HGNC Symbols for ARL4D Gene
Previous GeneCards Identifiers for ARL4D Gene
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008]
GeneCards Summary for ARL4D Gene
ARL4D (ADP Ribosylation Factor Like GTPase 4D) is a Protein Coding gene. Diseases associated with ARL4D include Bardet-Biedl Syndrome. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL4A.
UniProtKB/Swiss-Prot Summary for ARL4D Gene
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.