Aliases for ARL4C Gene
External Ids for ARL4C Gene
Previous HGNC Symbols for ARL4C Gene
Previous GeneCards Identifiers for ARL4C Gene
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARL4C Gene
ARL4C (ADP Ribosylation Factor Like GTPase 4C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and alpha-tubulin binding. An important paralog of this gene is ARL4A.
UniProtKB/Swiss-Prot Summary for ARL4C Gene
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.