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Aliases for ARL4C Gene

Subcategory (RNA class) for ARL4C Gene

lncRNA

Aliases for ARL4C Gene

  • ADP Ribosylation Factor Like GTPase 4C 2 3 5
  • ADP-Ribosylation Factor-Like Protein LAK 3 4
  • ADP-Ribosylation Factor-Like Protein 4C 3 4
  • ADP-Ribosylation Factor-Like 4C 2 3
  • ADP-Ribosylation Factor-Like 7 2 3
  • ARL7 3 4
  • ADP Ribosylation Factor-Like Protein 7 3
  • ADP-Ribosylation Factor-Like Protein 7 4
  • LAK 3

External Ids for ARL4C Gene

ORGUL Members for ARL4C Gene

Previous HGNC Symbols for ARL4C Gene

  • ARL7

Previous GeneCards Identifiers for ARL4C Gene

  • GC02M235184
  • GC02M235066
  • GC02M235401
  • GC02M227201

Summaries for ARL4C Gene

Entrez Gene Summary for ARL4C Gene

  • ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL4C Gene

ARL4C (ADP Ribosylation Factor Like GTPase 4C) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with ARL4C include Lung Squamous Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include GTP binding and alpha-tubulin binding. An important paralog of this gene is ARL4A.

UniProtKB/Swiss-Prot for ARL4C Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.

Additional gene information for ARL4C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL4C Gene

Genomics for ARL4C Gene

GeneHancer (GH) Regulatory Elements for ARL4C Gene

Promoters and enhancers for ARL4C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J234482 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 620.6 +5.9 5941 16.9 PRDM1 IKZF1 CREB1 GLIS2 RNF2 RFX1 ZNF600 ATF1 POLR2A ATF7 ARL4C TRPM8 HSPE1P9
GH02J234443 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.7 +47.6 47580 12.2 SP1 ZNF687 MAFK RELA IKZF1 POLR2A ZNF316 EZH2 ZSCAN5C ELF1 ARL4C GC02P234445 HSPE1P9 LINC01891 ENSG00000228162
GH02J234288 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 27.1 +204.5 204522 7.9 SP1 CTCF MNT CEBPG ZNF687 TFE3 SP7 RELA RAD21 IKZF1 ARL4C SH3BP4 LOC105373933 ENSG00000261298
GH02J234161 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 21.5 +332.5 332486 5.6 CREB1 CTBP1 MAFK ZKSCAN1 ZNF217 DPF2 FOXA1 RCOR1 EBF1 ARL4C SPP2 LOC105373932 ENSG00000226442
GH02J234132 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.4 +361.7 361739 6.2 CTCF MAFK RAD21 PRDM10 SCRT2 SP1 ATF3 SCRT1 SMC3 FOSL2 ARL4C SPP2 ENSG00000226442 LOC105373932
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL4C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL4C gene promoter:
  • ATF
  • c-Ets-1
  • HOXA9
  • HOXA9B
  • HSF2
  • Meis-1
  • Meis-1b
  • Nkx3-1
  • Nkx3-1 v1
  • POU6F1 (c2)

Genomic Locations for ARL4C Gene

Genomic Locations for ARL4C Gene
chr2:234,493,041-234,497,081
(GRCh38/hg38)
Size:
4,041 bases
Orientation:
Minus strand
chr2:235,401,685-235,405,697
(GRCh37/hg19)
Size:
4,013 bases
Orientation:
Minus strand

Genomic View for ARL4C Gene

Genes around ARL4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL4C Gene

Proteins for ARL4C Gene

  • Protein details for ARL4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56559-ARL4C_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 4C
    Protein Accession:
    P56559
    Secondary Accessions:
    • Q4A519
    • Q53R10
    • Q9BVN1
    • Q9UQ34

    Protein attributes for ARL4C Gene

    Size:
    192 amino acids
    Molecular mass:
    21487 Da
    Quaternary structure:
    • Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding status.
    SequenceCaution:
    • Sequence=BAA75473.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL4C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL4C Gene

Post-translational modifications for ARL4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL4C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL4C Gene

Domains & Families for ARL4C Gene

Gene Families for ARL4C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARL4C Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like protein LAK (ARL4C_HUMAN)
  • ADP ribosylation factor-like protein 7 (Q4A519_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56559

UniProtKB/Swiss-Prot:

ARL4C_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL4C: view

Function for ARL4C Gene

Molecular function for ARL4C Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
UniProtKB/Swiss-Prot Induction:
By liver X-receptor/retinoid X receptor agonists or cholesterol loading.

Phenotypes From GWAS Catalog for ARL4C Gene

Gene Ontology (GO) - Molecular Function for ARL4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 10462049
GO:0005515 protein binding IPI 17398095
GO:0005525 GTP binding IBA 21873635
GO:0043014 alpha-tubulin binding IDA 19409876
genes like me logo Genes that share ontologies with ARL4C: view
genes like me logo Genes that share phenotypes with ARL4C: view

Animal Model Products

CRISPR Products

miRNA for ARL4C Gene

miRTarBase miRNAs that target ARL4C

Clone Products

  • Applied Biological Materials (abm): Clones for ARL4C - Now 50% OFF >
  • * ARL4C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARL4C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for ARL4C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL4C Gene

Localization for ARL4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL4C Gene

Cell projection, filopodium. Cell membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL4C gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10462049
GO:0005737 cytoplasm IDA,IBA 19409876
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IBA,IDA 17398095
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARL4C: view

Pathways & Interactions for ARL4C Gene

PathCards logo

SuperPathways for ARL4C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
GO:0032456 endocytic recycling IBA,IDA 19409876
genes like me logo Genes that share ontologies with ARL4C: view

No data available for Pathways by source and SIGNOR curated interactions for ARL4C Gene

Drugs & Compounds for ARL4C Gene

(1) Drugs for ARL4C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL4C: view

Transcripts for ARL4C Gene

mRNA/cDNA for ARL4C Gene

(2) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(333) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ARL4C Gene

ADP-ribosylation factor-like 4C:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ARL4C - Now 50% OFF >
  • * ARL4C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ARL4C tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for ARL4C

Alternative Splicing Database (ASD) splice patterns (SP) for ARL4C Gene

No ASD Table

Relevant External Links for ARL4C Gene

GeneLoc Exon Structure for
ARL4C
ECgene alternative splicing isoforms for
ARL4C

Expression for ARL4C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL4C Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for ARL4C Gene

This gene is overexpressed in Bone (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL4C Gene



Protein tissue co-expression partners for ARL4C Gene

NURSA nuclear receptor signaling pathways regulating expression of ARL4C Gene:

ARL4C

SOURCE GeneReport for Unigene cluster for ARL4C Gene:

Hs.111554

mRNA Expression by UniProt/SwissProt for ARL4C Gene:

P56559-ARL4C_HUMAN
Tissue specificity: Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.

Evidence on tissue expression from TISSUES for ARL4C Gene

  • Nervous system(4.6)
  • Kidney(4.3)
  • Liver(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with ARL4C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL4C Gene

Orthologs for ARL4C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL4C 35 34
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARL4C 35 34
  • 98.1 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL4C 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL4C 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL4C 35 34
  • 97.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arl4c 17 35 34
  • 95.49 (n)
chicken
(Gallus gallus)
Aves ARL4C 35 34
  • 93.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL4C 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl4c 34
  • 81.94 (n)
Str.17765 34
zebrafish
(Danio rerio)
Actinopterygii arl4ca 35
  • 95 (a)
OneToMany
arl4cb 35 34
  • 78.12 (n)
OneToMany
wufc01g11 34
fruit fly
(Drosophila melanogaster)
Insecta CG2219 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 35
  • 39 (a)
OneToMany
Species where no ortholog for ARL4C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL4C Gene

ENSEMBL:
Gene Tree for ARL4C (if available)
TreeFam:
Gene Tree for ARL4C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL4C: view image

Paralogs for ARL4C Gene

(27) SIMAP similar genes for ARL4C Gene using alignment to 1 proteins:

  • ARL4C_HUMAN
genes like me logo Genes that share paralogs with ARL4C: view

Variants for ARL4C Gene

Sequence variations from dbSNP and Humsavar for ARL4C Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000477576 -- 234,494,986(-) C/T 3_prime_UTR_variant
rs1000529579 -- 234,494,601(-) G/A 3_prime_UTR_variant
rs1001478834 -- 234,497,135(-) C/T upstream_transcript_variant
rs1001846046 -- 234,497,374(-) C/G upstream_transcript_variant
rs1002097888 -- 234,495,370(-) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL4C Gene

Variant ID Type Subtype PubMed ID
nsv1013712 CNV loss 25217958
nsv953207 CNV deletion 24416366

Variation tolerance for ARL4C Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL4C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL4C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL4C Gene

Disorders for ARL4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL4C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search ARL4C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL4C

genes like me logo Genes that share disorders with ARL4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL4C Gene

Publications for ARL4C Gene

  1. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PMID: 19409876) Wei SM … Cai JT (Biochemical and biophysical research communications 2009) 3 4 23 58
  2. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. (PMID: 10462049) Jacobs S … Joost HG (FEBS letters 1999) 2 3 4 58
  3. Genome-wide association study of pancreatic cancer in Japanese population. (PMID: 20686608) Low SK … Sakamoto H (PloS one 2010) 3 45 58
  4. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I … Munro S (Current biology : CB 2007) 3 4 58
  5. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. (PMID: 15147902) Engel T … Seedorf U (FEBS letters 2004) 3 4 58

Products for ARL4C Gene

Sources for ARL4C Gene

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