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Aliases for ARL4A Gene

Aliases for ARL4A Gene

  • ADP Ribosylation Factor Like GTPase 4A 2 3 5
  • ADP-Ribosylation Factor-Like 4A 2 3
  • ADP-Ribosylation Factor-Like 4 2 3
  • ARL4 3 4
  • ADP-Ribosylation Factor-Like Protein 4A 3

External Ids for ARL4A Gene

Previous HGNC Symbols for ARL4A Gene

  • ARL4

Previous GeneCards Identifiers for ARL4A Gene

  • GC07P012471
  • GC07P012499
  • GC07P012693
  • GC07P012726

Summaries for ARL4A Gene

Entrez Gene Summary for ARL4A Gene

  • ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL4A Gene

ARL4A (ADP Ribosylation Factor Like GTPase 4A) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL4C.

UniProtKB/Swiss-Prot for ARL4A Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Wiki entry for ARL4A Gene

Additional gene information for ARL4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL4A Gene

Genomics for ARL4A Gene

GeneHancer (GH) Regulatory Elements for ARL4A Gene

Promoters and enhancers for ARL4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J012684 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 657.3 +0.7 733 6.5 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC NBN ARL4A GC07P012685 LOC100505995 GC07P012698
GH07J012721 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.9 +36.0 35978 1.6 HDAC1 HDGF ATF1 TAF9B ARNT NFRKB NCOA2 TCF12 ZNF766 ATF7 ARL4A GC07M012701 LOC105375161
GH07J012951 Enhancer 1.1 Ensembl ENCODE 5.1 +264.9 264940 1 ATF1 PKNOX1 ARNT ZNF133 NEUROD1 SIN3A NCOA2 TCF12 GATA2 FOS TMEM106B ARL4A GC07M012931 LOC105375158 LOC105375161
GH07J012717 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.6 +32.7 32740 3.5 HDAC1 PKNOX1 NFRKB EGR1 CREM SMARCC1 CEBPB ZNF592 ZNF148 SMARCA4 GC07M012701 ARL4A ENSG00000199470 GC07M012700
GH07J012669 Enhancer 1 Ensembl ENCODE 5.2 -16.1 -16082 1.8 FOXA2 THRB RARA ETS1 CREM CEBPB KLF16 CEBPA KDM1A FOXP1 ARL4A LOC105375157 ENSG00000229233
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL4A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL4A gene promoter:
  • POU2F1a
  • POU2F1
  • oct-B3
  • oct-B2
  • Oct-B1

Genomic Locations for ARL4A Gene

Genomic Locations for ARL4A Gene
chr7:12,686,827-12,690,934
(GRCh38/hg38)
Size:
4,108 bases
Orientation:
Plus strand
chr7:12,726,452-12,730,559
(GRCh37/hg19)
Size:
4,108 bases
Orientation:
Plus strand

Genomic View for ARL4A Gene

Genes around ARL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL4A Gene

Proteins for ARL4A Gene

  • Protein details for ARL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40617-ARL4A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 4A
    Protein Accession:
    P40617
    Secondary Accessions:
    • A4D119
    • P80418
    • Q49AF5

    Protein attributes for ARL4A Gene

    Size:
    200 amino acids
    Molecular mass:
    22615 Da
    Quaternary structure:
    • Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.

neXtProt entry for ARL4A Gene

Post-translational modifications for ARL4A Gene

No data available for DME Specific Peptides for ARL4A Gene

Domains & Families for ARL4A Gene

Gene Families for ARL4A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL4A Gene

Suggested Antigen Peptide Sequences for ARL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40617

UniProtKB/Swiss-Prot:

ARL4A_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL4A: view

Function for ARL4A Gene

Molecular function for ARL4A Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Phenotypes From GWAS Catalog for ARL4A Gene

Gene Ontology (GO) - Molecular Function for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10980193
GO:0005525 GTP binding IDA 10980193
genes like me logo Genes that share ontologies with ARL4A: view
genes like me logo Genes that share phenotypes with ARL4A: view

Animal Models for ARL4A Gene

MGI Knock Outs for ARL4A:

Animal Model Products

CRISPR Products

miRNA for ARL4A Gene

miRTarBase miRNAs that target ARL4A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL4A

Clone Products

  • Addgene plasmids for ARL4A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL4A Gene

Localization for ARL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL4A Gene

Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL4A gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 10980193
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA,IEA 10980193
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARL4A: view

Pathways & Interactions for ARL4A Gene

SuperPathways for ARL4A Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with ARL4A: view

Pathways by source for ARL4A Gene

1 BioSystems pathway for ARL4A Gene

Gene Ontology (GO) - Biological Process for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050873 brown fat cell differentiation IEA --
genes like me logo Genes that share ontologies with ARL4A: view

No data available for SIGNOR curated interactions for ARL4A Gene

Drugs & Compounds for ARL4A Gene

No Compound Related Data Available

Transcripts for ARL4A Gene

mRNA/cDNA for ARL4A Gene

Unigene Clusters for ARL4A Gene

ADP-ribosylation factor-like 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL4A

Clone Products

  • Addgene plasmids for ARL4A

Alternative Splicing Database (ASD) splice patterns (SP) for ARL4A Gene

No ASD Table

Relevant External Links for ARL4A Gene

GeneLoc Exon Structure for
ARL4A
ECgene alternative splicing isoforms for
ARL4A

Expression for ARL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL4A Gene

mRNA differential expression in normal tissues according to GTEx for ARL4A Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for ARL4A Gene

This gene is overexpressed in Ovary (46.9) and Spleen (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARL4A Gene



Protein tissue co-expression partners for ARL4A Gene

NURSA nuclear receptor signaling pathways regulating expression of ARL4A Gene:

ARL4A

SOURCE GeneReport for Unigene cluster for ARL4A Gene:

Hs.245540

Evidence on tissue expression from TISSUES for ARL4A Gene

  • Nervous system(4.5)
  • Heart(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ARL4A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL4A Gene

Orthologs for ARL4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL4A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ARL4A 34
  • 100 (a)
OneToOne
LOC100684100 33
  • 94.67 (n)
chimpanzee
(Pan troglodytes)
Mammalia ARL4A 34 33
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARL4A 34 33
  • 94.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl4a 33
  • 93.33 (n)
mouse
(Mus musculus)
Mammalia Arl4a 16 34 33
  • 92.5 (n)
oppossum
(Monodelphis domestica)
Mammalia ARL4A 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL4A 34 33
  • 80.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL4A 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl4a 33
  • 79.33 (n)
Str.10753 33
zebrafish
(Danio rerio)
Actinopterygii arl4ab 34 33
  • 69.83 (n)
OneToOne
zgc77800 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6635 33
fruit fly
(Drosophila melanogaster)
Insecta CG2219 34 33
  • 60.16 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 34
  • 40 (a)
OneToMany
Species where no ortholog for ARL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL4A Gene

ENSEMBL:
Gene Tree for ARL4A (if available)
TreeFam:
Gene Tree for ARL4A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL4A: view image

Paralogs for ARL4A Gene

Paralogs for ARL4A Gene

(28) SIMAP similar genes for ARL4A Gene using alignment to 2 proteins:

  • ARL4A_HUMAN
  • C9J7Q9_HUMAN

Pseudogenes.org Pseudogenes for ARL4A Gene

genes like me logo Genes that share paralogs with ARL4A: view

Variants for ARL4A Gene

Sequence variations from dbSNP and Humsavar for ARL4A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000324874 -- 12,690,015(+) A/C 3_prime_UTR_variant
rs1001298906 -- 12,686,843(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001548547 -- 12,685,775(+) C/G upstream_transcript_variant
rs1002062919 -- 12,690,732(+) T/G 3_prime_UTR_variant
rs1002498737 -- 12,690,444(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL4A Gene

Variant ID Type Subtype PubMed ID
nsv830907 CNV loss 17160897
nsv830908 CNV gain 17160897
nsv970447 CNV duplication 23825009

Variation tolerance for ARL4A Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL4A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL4A Gene

Disorders for ARL4A Gene

Additional Disease Information for ARL4A

No disorders were found for ARL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL4A Gene

Publications for ARL4A Gene

  1. ARL4A acts with GCC185 to modulate Golgi complex organization. (PMID: 22159419) Lin YC … Lee FJ (Journal of cell science 2011) 2 3 58
  2. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I … Munro S (Current biology : CB 2007) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. (PMID: 10980193) Lin CY … Lee FJ (The Journal of biological chemistry 2000) 3 4 58

Products for ARL4A Gene

Sources for ARL4A Gene

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