Aliases for ARL2 Gene
External Ids for ARL2 Gene
Previous GeneCards Identifiers for ARL2 Gene
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARL2 Gene
ARL2 (ADP Ribosylation Factor Like GTPase 2) is a Protein Coding gene. Diseases associated with ARL2 include Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 1 and Tanycytic Ependymoma. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARL2-SNX15.
UniProtKB/Swiss-Prot Summary for ARL2 Gene
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.