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This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
ARL2 (ADP Ribosylation Factor Like GTPase 2) is a Protein Coding gene. Diseases associated with ARL2 include Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 1 and Tanycytic Ependymoma. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARL2-SNX15.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IMP | 10831612 |
GO:0005095 | GTPase inhibitor activity | TAS | 10831612 |
GO:0005515 | protein binding | IPI | 10831612 |
GO:0005525 | GTP binding | IBA,IMP | 10831612 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 18234692 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005739 | mitochondrion | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integration of energy metabolism | ||
2 | Metabolism |
.40
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3 | Metabolism of proteins | ||
4 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | ||
5 | Chaperonin-mediated protein folding |
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007021 | tubulin complex assembly | TAS | 10831612 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007098 | centrosome cycle | IMP | 16525022 |
GO:0010811 | positive regulation of cell-substrate adhesion | ISS | -- |
GO:0031113 | regulation of microtubule polymerization | IMP | 16525022 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Tagraxofusp | Approved, Investigational | Pharma | Target, binder | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARL2 30 |
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Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | ARL2 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | ARL2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Arl2 30 17 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Arl2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arl2 30 |
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||
MGC75676 30 |
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||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.11505 30 |
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||
Zebrafish (Danio rerio) |
Actinopterygii | arl2 30 31 |
|
OneToMany | |
Dr.13768 30 |
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||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1138 30 |
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||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005267 30 |
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||
Fruit Fly (Drosophila melanogaster) |
Insecta | Arf84F 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | evl-20 30 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CIN4 33 |
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|
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | TTN5 30 |
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||
Rice (Oryza sativa) |
Liliopsida | Os02g0327100 30 |
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||
Os.11794 30 |
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||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.4477 30 |
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||
Corn (Zea mays) |
Liliopsida | Zm.12954 30 |
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||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2707 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00218 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | alp41 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1357 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3626667 | CNV | loss | 21293372 |
esv3626668 | CNV | gain | 21293372 |
nsv526181 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1 |
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tanycytic ependymoma |
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papillary ependymoma |
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clear cell ependymoma |
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cellular ependymoma |
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