Aliases for ARL17B Gene

Aliases for ARL17B Gene

  • ADP Ribosylation Factor Like GTPase 17B 2 3 5
  • ADP-Ribosylation Factor-Like Protein 17 3 4
  • ADP-Ribosylation Factor-Like 17B 2 3
  • ARL17A 3 4
  • ADP-Ribosylation Factor 7 Variant 4
  • ADP-Ribosylation Factor-Like 17 2
  • ADP-Ribosylation Factor 7 3
  • ARL17P1 4
  • ARF1P2 4
  • ARL17 3

External Ids for ARL17B Gene

Previous HGNC Symbols for ARL17B Gene

  • ARL17

Previous GeneCards Identifiers for ARL17B Gene

  • GC17M041732
  • GC17M044596
  • GC17Pp43777
  • GC17M044377
  • GC17M044352

Summaries for ARL17B Gene

GeneCards Summary for ARL17B Gene

ARL17B (ADP Ribosylation Factor Like GTPase 17B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL17A.

UniProtKB/Swiss-Prot Summary for ARL17B Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Additional gene information for ARL17B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL17B Gene

Genomics for ARL17B Gene

GeneHancer (GH) Regulatory Elements for ARL17B Gene

Promoters and enhancers for ARL17B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J046360 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.8 763 3 SP1 KLF9 CREB1 SP2 DDX20 PKNOX1 PRDM10 ATF2 ARL17B piR-58066-001
GH17J046578 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 500.1 -217.3 -217337 2.8 CREB1 SP2 ZNF18 PKNOX1 ARL17A ARL17B piR-58066-002
GH17J046189 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 46.3 +168.5 168491 7.6 HNRNPK FOXK2 ZNF217 EP300 CTCF TCF12 SIN3A MYC NRF1 USF1 KANSL1 KANSL1-AS1 FJ009034 LINC02210 LRRC37A4P ENSG00000262372 ARL17A ARL17B RPS7P11 ENSG00000239291
GH17J046071 Enhancer 1.2 Ensembl ENCODE dbSUPER 84.4 +289.2 289163 3.8 ZSCAN5C RBAK JUND ZNF639 ZNF354C ZNF623 ZNF510 KLF7 TEAD1 ZEB1 LINC02210 ARL17A ARL17B LRRC37A4P ENSG00000262372 KANSL1 RPS7P11 LRRC37A17P NSFP1 FAM215B
GH17J046364 Enhancer 0.2 Ensembl 500.7 -1.8 -1849 1 ARL17B NSFP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL17B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL17B

Genomic Locations for ARL17B Gene

Genomic Locations for ARL17B Gene
87,881 bases
Minus strand
86,985 bases
Minus strand

Genomic View for ARL17B Gene

Genes around ARL17B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL17B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL17B Gene

Proteins for ARL17B Gene

  • Protein details for ARL17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 17
    Protein Accession:
    Secondary Accessions:
    • B0AZR6
    • Q59FW5
    • Q8N6E2
    • Q8TD73
    • Q8WW54
    • Q9NZD5
    • Q9P158

    Protein attributes for ARL17B Gene

    177 amino acids
    Molecular mass:
    19388 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF64278.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF69643.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL17B Gene


neXtProt entry for ARL17B Gene

Post-translational modifications for ARL17B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL17B Gene

Domains & Families for ARL17B Gene

Gene Families for ARL17B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL17B Gene

  • ADP-ribosylation factor

Suggested Antigen Peptide Sequences for ARL17B Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor 7 variant (ARL17_HUMAN)
  • ARL17 protein (Q9BVU5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL17B: view

Function for ARL17B Gene

Molecular function for ARL17B Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Phenotypes From GWAS Catalog for ARL17B Gene

Gene Ontology (GO) - Molecular Function for ARL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IBA,IEA 21873635
genes like me logo Genes that share ontologies with ARL17B: view

Phenotypes for ARL17B Gene

genes like me logo Genes that share phenotypes with ARL17B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL17B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL17B Gene

Localization for ARL17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL17B Gene

Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL17B gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3
extracellular 1
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ARL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with ARL17B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARL17B Gene

Pathways & Interactions for ARL17B Gene

PathCards logo

SuperPathways for ARL17B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IBA 21873635
genes like me logo Genes that share ontologies with ARL17B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL17B Gene

Drugs & Compounds for ARL17B Gene

No Compound Related Data Available

Transcripts for ARL17B Gene

mRNA/cDNA for ARL17B Gene

16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL17B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL17B Gene

No ASD Table

Relevant External Links for ARL17B Gene

GeneLoc Exon Structure for

Expression for ARL17B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL17B Gene

Protein differential expression in normal tissues from HIPED for ARL17B Gene

This gene is overexpressed in Cerebrospinal fluid (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL17B Gene

Protein tissue co-expression partners for ARL17B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL17B

SOURCE GeneReport for Unigene cluster for ARL17B Gene:


Evidence on tissue expression from TISSUES for ARL17B Gene

  • Nervous system(4.5)
  • Kidney(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ARL17B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL17B Gene

Orthologs for ARL17B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARL17B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
-- 31
  • 81 (a)
-- 31
  • 76 (a)
Species where no ortholog for ARL17B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARL17B Gene

Gene Tree for ARL17B (if available)
Gene Tree for ARL17B (if available)

Paralogs for ARL17B Gene

(13) SIMAP similar genes for ARL17B Gene using alignment to 4 proteins:

  • I3L1A0_HUMAN
  • I3L1V5_HUMAN
  • I3L3L1_HUMAN
genes like me logo Genes that share paralogs with ARL17B: view

Variants for ARL17B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL17B Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs62073222 Benign: not specified 46,297,344(-) A/G SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ARL17B Gene

Structural Variations from Database of Genomic Variants (DGV) for ARL17B Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv13n31 CNV gain 19718026
dgv14n31 CNV gain 19718026
dgv15n14 CNV loss 18776910
dgv16n14 CNV loss 18776910
dgv29e213 CNV loss 24956385
dgv30e213 CNV gain 24956385
dgv3184n100 CNV gain 25217958
dgv3185n100 CNV gain 25217958
dgv3188n100 CNV gain 25217958
dgv3189n100 CNV gain 25217958
dgv3190n100 CNV gain 25217958
dgv3196n100 CNV gain+loss 25217958
dgv3198n100 CNV loss 25217958
dgv3206n100 CNV loss 25217958
dgv3209n100 CNV gain 25217958
dgv3214n100 CNV gain+loss 25217958
dgv3232n100 CNV loss 25217958
dgv3233n100 CNV gain 25217958
dgv3238n100 CNV gain 25217958
dgv3239n100 CNV gain 25217958
dgv3240n100 CNV gain 25217958
dgv3241n100 CNV loss 25217958
dgv3242n100 CNV gain+loss 25217958
dgv3244n100 CNV loss 25217958
dgv3245n100 CNV gain+loss 25217958
dgv3246n100 CNV gain+loss 25217958
dgv3247n100 CNV gain 25217958
dgv3248n100 CNV loss 25217958
dgv3249n100 CNV gain 25217958
dgv3250n100 CNV gain+loss 25217958
dgv3251n100 CNV loss 25217958
dgv3252n100 CNV loss 25217958
dgv3253n100 CNV loss 25217958
dgv3254n100 CNV gain+loss 25217958
dgv3255n100 CNV gain 25217958
dgv3256n100 CNV loss 25217958
dgv3257n100 CNV loss 25217958
dgv3258n100 CNV gain+loss 25217958
dgv3259n100 CNV loss 25217958
dgv3260n100 CNV loss 25217958
dgv5618n54 CNV gain 21841781
dgv5623n54 CNV loss 21841781
dgv5628n54 CNV loss 21841781
dgv5638n54 CNV gain 21841781
dgv5641n54 CNV loss 21841781
dgv5642n54 CNV loss 21841781
dgv5643n54 CNV gain 21841781
dgv5644n54 CNV gain 21841781
dgv5645n54 CNV loss 21841781
dgv5646n54 CNV gain+loss 21841781
dgv5647n54 CNV loss 21841781
dgv5648n54 CNV gain+loss 21841781
dgv5649n54 CNV loss 21841781
dgv5650n54 CNV gain 21841781
dgv5651n54 CNV loss 21841781
dgv5657n54 CNV loss 21841781
dgv5658n54 CNV loss 21841781
dgv5659n54 CNV loss 21841781
dgv5660n54 CNV gain+loss 21841781
dgv939e212 CNV gain 25503493
dgv940e212 CNV loss 25503493
esv1003686 CNV gain 20482838
esv21783 CNV gain+loss 19812545
esv2421412 OTHER complex 20811451
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv2760451 CNV gain+loss 21179565
esv2762433 CNV gain+loss 21179565
esv33048 CNV gain+loss 17666407
esv3395024 CNV duplication 20981092
esv3430044 CNV duplication 20981092
esv3444693 CNV duplication 20981092
esv3584722 CNV loss 24956385
esv3893017 CNV gain+loss 25118596
esv3893019 CNV gain+loss 25118596
esv3893020 CNV gain 25118596
esv3893021 CNV gain 25118596
esv3893023 CNV gain+loss 25118596
esv3893024 CNV gain 25118596
nsv1061687 CNV loss 25217958
nsv1063349 CNV gain 25217958
nsv1063380 CNV gain 25217958
nsv1070410 CNV deletion 25765185
nsv1072741 CNV deletion 25765185
nsv1118761 CNV deletion 24896259
nsv1126463 CNV deletion 24896259
nsv1133408 CNV deletion 24896259
nsv1136238 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1160492 CNV duplication 26073780
nsv1160494 CNV deletion 26073780
nsv163 CNV deletion 15895083
nsv2070 CNV deletion 18451855
nsv428343 CNV gain+loss 18775914
nsv433450 CNV gain 18776910
nsv433451 CNV gain 18776910
nsv442749 CNV gain+loss 18776908
nsv469644 CNV gain+loss 16826518
nsv469697 CNV gain+loss 16826518
nsv471401 CNV gain+loss 19718026
nsv471514 CNV gain 19718026
nsv471698 CNV gain+loss 15918152
nsv471700 CNV gain+loss 15918152
nsv482202 CNV gain 20164927
nsv510715 CNV deletion 20534489
nsv511057 OTHER complex 20534489
nsv516807 CNV gain+loss 19592680
nsv575266 CNV gain 21841781
nsv575272 CNV loss 21841781
nsv575314 CNV gain+loss 21841781
nsv575387 CNV gain+loss 21841781
nsv575388 CNV gain 21841781
nsv575389 CNV loss 21841781
nsv819319 CNV loss 19587683
nsv820933 CNV deletion 20802225
nsv821581 CNV deletion 20802225
nsv821687 CNV gain 15273396
nsv833463 CNV loss 17160897
nsv833464 CNV gain 17160897
nsv953912 CNV deletion 24416366
nsv953916 CNV duplication 24416366
nsv9564 CNV gain+loss 18304495
nsv960494 CNV duplication 23825009
nsv960495 CNV duplication 23825009
nsv960604 CNV duplication 23825009
nsv978553 CNV duplication 23825009

Additional Variant Information for ARL17B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ARL17B Gene

Disorders for ARL17B Gene

Additional Disease Information for ARL17B

No disorders were found for ARL17B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL17B Gene

Publications for ARL17B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 3 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for ARL17B Gene

Sources for ARL17B Gene