Aliases for ARL17A Gene

Aliases for ARL17A Gene

  • ADP Ribosylation Factor Like GTPase 17A 2 3 5
  • ARL17P1 3 4
  • ARF1P2 3 4
  • ADP-Ribosylation Factor-Like 17 Pseudogene 1 2
  • ADP-Ribosylation Factor Like GTPase 17A 2
  • ADP-Ribosylation Factor-Like Protein 17 4
  • ADP-Ribosylation Factor 1 Pseudogene 2 2
  • ADP-Ribosylation Factor-Like 17-Like 3
  • ADP-Ribosylation Factor 7 Variant 4
  • ADP-Ribosylation Factor 7 3
  • ARL17A 5

External Ids for ARL17A Gene

Previous HGNC Symbols for ARL17A Gene

  • ARF1P2
  • ARL17P1

Previous GeneCards Identifiers for ARL17A Gene

  • GC17Pp43776
  • GC17M044595

Summaries for ARL17A Gene

GeneCards Summary for ARL17A Gene

ARL17A (ADP Ribosylation Factor Like GTPase 17A) is a Protein Coding gene. Diseases associated with ARL17A include Bardet-Biedl Syndrome and Retinitis Pigmentosa. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL17B.

UniProtKB/Swiss-Prot Summary for ARL17A Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL17A Gene

Genomics for ARL17A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARL17A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL17A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL17A

Genomic Locations for ARL17A Gene

Latest Assembly
79,568 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
71,044 bases
Minus strand

(GRCh37/hg19 by Ensembl)
63,021 bases
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_2):1,028,373-1,099,388 (-)

Genomic View for ARL17A Gene

Genes around ARL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL17A Gene

Proteins for ARL17A Gene

  • Protein details for ARL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 17
    Protein Accession:
    Secondary Accessions:
    • B0AZR6
    • Q59FW5
    • Q8N6E2
    • Q8TD73
    • Q8WW54
    • Q9NZD5
    • Q9P158

    Protein attributes for ARL17A Gene

    177 amino acids
    Molecular mass:
    19388 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF64278.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF69643.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL17A Gene


neXtProt entry for ARL17A Gene

Post-translational modifications for ARL17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL17A Gene

Domains & Families for ARL17A Gene

Gene Families for ARL17A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL17A Gene

  • ADP-ribosylation factor

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL17A: view

No data available for Suggested Antigen Peptide Sequences for ARL17A Gene

Function for ARL17A Gene

Molecular function for ARL17A Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Phenotypes From GWAS Catalog for ARL17A Gene

Gene Ontology (GO) - Molecular Function for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005525 GTP binding IBA --
genes like me logo Genes that share ontologies with ARL17A: view
genes like me logo Genes that share phenotypes with ARL17A: view

miRNA for ARL17A Gene

miRTarBase miRNAs that target ARL17A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL17A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL17A Gene

Localization for ARL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL17A Gene

Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL17A gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3
extracellular 1
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with ARL17A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARL17A Gene

Pathways & Interactions for ARL17A Gene

PathCards logo

SuperPathways for ARL17A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with ARL17A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL17A Gene

Drugs & Compounds for ARL17A Gene

(1) Drugs for ARL17A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL17A: view

Transcripts for ARL17A Gene

mRNA/cDNA for ARL17A Gene

23 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL17A

Alternative Splicing Database (ASD) splice patterns (SP) for ARL17A Gene

No ASD Table

Relevant External Links for ARL17A Gene

GeneLoc Exon Structure for

Expression for ARL17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL17A Gene

Protein differential expression in normal tissues from HIPED for ARL17A Gene

This gene is overexpressed in Cerebrospinal fluid (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL17A Gene

Protein tissue co-expression partners for ARL17A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL17A

Evidence on tissue expression from TISSUES for ARL17A Gene

  • Nervous system(4.2)
  • Bone marrow(4)
  • Kidney(4)
genes like me logo Genes that share expression patterns with ARL17A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL17A Gene

Orthologs for ARL17A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARL17A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 30
  • 99 (a)
-- 30
  • 81 (a)
-- 30
  • 76 (a)
Species where no ortholog for ARL17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ARL17A Gene

Gene Tree for ARL17A (if available)
Gene Tree for ARL17A (if available)
Alliance of Genome Resources:
Additional Orthologs for ARL17A

Paralogs for ARL17A Gene

(13) SIMAP similar genes for ARL17A Gene using alignment to 2 proteins:

  • I3L2E4_HUMAN
genes like me logo Genes that share paralogs with ARL17A: view

Variants for ARL17A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL17A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
VAR_017170 -- p.Leu170Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARL17A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARL17A Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv13n31 CNV gain 19718026
dgv14n31 CNV gain 19718026
dgv15n14 CNV loss 18776910
dgv16n14 CNV loss 18776910
dgv1773e59 CNV duplication 20981092
dgv29e213 CNV loss 24956385
dgv30e213 CNV gain 24956385
dgv3185n100 CNV gain 25217958
dgv3188n100 CNV gain 25217958
dgv3189n100 CNV gain 25217958
dgv3190n100 CNV gain 25217958
dgv3196n100 CNV gain+loss 25217958
dgv3198n100 CNV loss 25217958
dgv3206n100 CNV loss 25217958
dgv3214n100 CNV gain+loss 25217958
dgv3232n100 CNV loss 25217958
dgv3233n100 CNV gain 25217958
dgv3239n100 CNV gain 25217958
dgv3240n100 CNV gain 25217958
dgv3241n100 CNV loss 25217958
dgv3242n100 CNV gain+loss 25217958
dgv3245n100 CNV gain+loss 25217958
dgv3246n100 CNV gain+loss 25217958
dgv3247n100 CNV gain 25217958
dgv3248n100 CNV loss 25217958
dgv3249n100 CNV gain 25217958
dgv3250n100 CNV gain+loss 25217958
dgv3251n100 CNV loss 25217958
dgv3252n100 CNV loss 25217958
dgv3253n100 CNV loss 25217958
dgv3254n100 CNV gain+loss 25217958
dgv3255n100 CNV gain 25217958
dgv3256n100 CNV loss 25217958
dgv3257n100 CNV loss 25217958
dgv3258n100 CNV gain+loss 25217958
dgv3259n100 CNV loss 25217958
dgv3260n100 CNV loss 25217958
dgv5623n54 CNV loss 21841781
dgv5628n54 CNV loss 21841781
dgv5641n54 CNV loss 21841781
dgv5642n54 CNV loss 21841781
dgv5643n54 CNV gain 21841781
dgv5644n54 CNV gain 21841781
dgv5645n54 CNV loss 21841781
dgv5646n54 CNV gain+loss 21841781
dgv5647n54 CNV loss 21841781
dgv5648n54 CNV gain+loss 21841781
dgv5649n54 CNV loss 21841781
dgv5650n54 CNV gain 21841781
dgv5651n54 CNV loss 21841781
dgv5656n54 CNV loss 21841781
dgv5657n54 CNV loss 21841781
dgv5658n54 CNV loss 21841781
dgv5659n54 CNV loss 21841781
dgv5660n54 CNV gain+loss 21841781
dgv939e212 CNV gain 25503493
dgv940e212 CNV loss 25503493
esv1003686 CNV gain 20482838
esv21783 CNV gain+loss 19812545
esv2421412 OTHER complex 20811451
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv2760451 CNV gain+loss 21179565
esv2762433 CNV gain+loss 21179565
esv33048 CNV gain+loss 17666407
esv3359586 CNV duplication 20981092
esv3411572 CNV duplication 20981092
esv3430044 CNV duplication 20981092
esv3893017 CNV gain+loss 25118596
esv3893019 CNV gain+loss 25118596
esv3893020 CNV gain 25118596
esv3893021 CNV gain 25118596
esv3893023 CNV gain+loss 25118596
esv3893024 CNV gain 25118596
nsv1061687 CNV loss 25217958
nsv1063349 CNV gain 25217958
nsv1063380 CNV gain 25217958
nsv1070410 CNV deletion 25765185
nsv1072741 CNV deletion 25765185
nsv1126463 CNV deletion 24896259
nsv1133408 CNV deletion 24896259
nsv1136238 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1160494 CNV deletion 26073780
nsv163 CNV deletion 15895083
nsv2070 CNV deletion 18451855
nsv428343 CNV gain+loss 18775914
nsv433450 CNV gain 18776910
nsv433451 CNV gain 18776910
nsv442749 CNV gain+loss 18776908
nsv469644 CNV gain+loss 16826518
nsv471401 CNV gain+loss 19718026
nsv471514 CNV gain 19718026
nsv471700 CNV gain+loss 15918152
nsv482202 CNV gain 20164927
nsv510715 CNV deletion 20534489
nsv511057 OTHER complex 20534489
nsv516807 CNV gain+loss 19592680
nsv575266 CNV gain 21841781
nsv575272 CNV loss 21841781
nsv575314 CNV gain+loss 21841781
nsv575369 CNV loss 21841781
nsv575387 CNV gain+loss 21841781
nsv575388 CNV gain 21841781
nsv575389 CNV loss 21841781
nsv819319 CNV loss 19587683
nsv820933 CNV deletion 20802225
nsv821581 CNV deletion 20802225
nsv821687 CNV gain 15273396
nsv833463 CNV loss 17160897
nsv833464 CNV gain 17160897
nsv953915 CNV deletion 24416366
nsv953916 CNV duplication 24416366
nsv9564 CNV gain+loss 18304495
nsv960494 CNV duplication 23825009
nsv960495 CNV duplication 23825009
nsv960604 CNV duplication 23825009
nsv978553 CNV duplication 23825009

Additional Variant Information for ARL17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ARL17A Gene

Disorders for ARL17A Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARL17A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • bbs
retinitis pigmentosa
  • rp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARL17A

genes like me logo Genes that share disorders with ARL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL17A Gene

Publications for ARL17A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. (PMID: 18981177) Bailey LK … Mott HR (The Journal of biological chemistry 2009) 22

Products for ARL17A Gene

Sources for ARL17A Gene