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Aliases for ARL16 Gene

Aliases for ARL16 Gene

  • ADP Ribosylation Factor Like GTPase 16 2 3 5
  • ADP-Ribosylation Factor-Like Protein 16 3
  • ADP-Ribosylation Factor Like GTPase 16 2

External Ids for ARL16 Gene

Previous GeneCards Identifiers for ARL16 Gene

  • GC17M077259
  • GC17M079649
  • GC17M075094

Summaries for ARL16 Gene

Entrez Gene Summary for ARL16 Gene

  • The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. [provided by RefSeq, Jul 2016]

GeneCards Summary for ARL16 Gene

ARL16 (ADP Ribosylation Factor Like GTPase 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding.

Additional gene information for ARL16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL16 Gene

Genomics for ARL16 Gene

GeneHancer (GH) Regulatory Elements for ARL16 Gene

Promoters and enhancers for ARL16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 729.7 -0.2 -230 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF213 ARL16 HGS ALYREF FOXK2 LOC105371942 CCDC137 PDE6G NPLOC4 TSPAN10 P4HB
GH17J081664 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 86 +17.1 17086 3.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 CCDC137 OXLD1 ARL16 CEP131 ALYREF ENSG00000262877 FOXK2 HGS FAAP100 LOC105371942
GH17J081709 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 76.9 -28.4 -28391 4.7 HNRNPUL1 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 GC17M081707 SLC25A10 ARL16 HGS ALYREF ENSG00000260563 NARF-IT1 ENSG00000262652 TEPSIN CEP131
GH17J081700 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 72 -18.9 -18866 4.2 HDGF CLOCK MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B MRPL12 ENSG00000262660 ENSG00000262049 ARL16 HGS FAAP100 CEP131 ENSG00000260563 TEPSIN NARF-IT1
GH17J081384 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 30.6 +287.8 287820 22.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF263 BAHCC1 ENSG00000279692 ENSG00000262877 CEP131 HGS FAAP100 ENSG00000265678 CCDC57 ARL16 RFNG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL16 gene promoter:
  • Roaz
  • AP-4
  • AML1a
  • Lmo2
  • CP2
  • PPAR-gamma1
  • PPAR-gamma2
  • Elk-1

Genomic Locations for ARL16 Gene

Genomic Locations for ARL16 Gene
2,770 bases
Minus strand
2,751 bases
Minus strand

Genomic View for ARL16 Gene

Genes around ARL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL16 Gene

Proteins for ARL16 Gene

  • Protein details for ARL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 16
    Protein Accession:

    Protein attributes for ARL16 Gene

    197 amino acids
    Molecular mass:
    20936 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL16 Gene

Post-translational modifications for ARL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL16 Gene

Domains & Families for ARL16 Gene

Gene Families for ARL16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ARL16 Gene

Suggested Antigen Peptide Sequences for ARL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL16: view

Function for ARL16 Gene

Phenotypes From GWAS Catalog for ARL16 Gene

Gene Ontology (GO) - Molecular Function for ARL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL16: view
genes like me logo Genes that share phenotypes with ARL16: view

Animal Model Products

miRNA for ARL16 Gene

miRTarBase miRNAs that target ARL16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL16 Gene

Localization for ARL16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL16 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL16 Gene

Pathways & Interactions for ARL16 Gene

SuperPathways for ARL16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL16 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL16 Gene

Drugs & Compounds for ARL16 Gene

No Compound Related Data Available

Transcripts for ARL16 Gene

mRNA/cDNA for ARL16 Gene

Unigene Clusters for ARL16 Gene

ADP-ribosylation factor-like 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL16 Gene

No ASD Table

Relevant External Links for ARL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL16 Gene

Protein differential expression in normal tissues from HIPED for ARL16 Gene

This gene is overexpressed in Plasma (59.1) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL16 Gene

Protein tissue co-expression partners for ARL16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL16 Gene:


SOURCE GeneReport for Unigene cluster for ARL16 Gene:


Evidence on tissue expression from TISSUES for ARL16 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ARL16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL16 Gene

Orthologs for ARL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL16 34 33
  • 99.32 (n)
(Bos Taurus)
Mammalia ARL16 34 33
  • 86.55 (n)
(Canis familiaris)
Mammalia ARL16 34 33
  • 85.08 (n)
(Mus musculus)
Mammalia Arl16 16 34 33
  • 84.71 (n)
(Rattus norvegicus)
Mammalia Arl16 33
  • 83.33 (n)
(Monodelphis domestica)
Mammalia ARL16 34
  • 83 (a)
(Gallus gallus)
Aves ARL16 34 33
  • 70.27 (n)
(Anolis carolinensis)
Reptilia ARL16 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl16 33
  • 62.36 (n)
Str.10245 33
(Danio rerio)
Actinopterygii arl16 34 33
  • 59.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13692 34
  • 21 (a)
Species where no ortholog for ARL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL16 Gene

Gene Tree for ARL16 (if available)
Gene Tree for ARL16 (if available)
Evolutionary constrained regions (ECRs) for ARL16: view image

Paralogs for ARL16 Gene Pseudogenes for ARL16 Gene

genes like me logo Genes that share paralogs with ARL16: view

No data available for Paralogs for ARL16 Gene

Variants for ARL16 Gene

Sequence variations from dbSNP and Humsavar for ARL16 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs863223352 likely-pathogenic, Childhood-Onset Schizophrenia 81,683,794(-) C/A coding_sequence_variant, missense_variant
rs1000298277 -- 81,681,733(-) T/G coding_sequence_variant, missense_variant
rs1000856090 -- 81,684,375(-) G/C upstream_transcript_variant
rs1000888873 -- 81,684,579(-) C/T upstream_transcript_variant
rs1002119525 -- 81,684,986(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL16 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for ARL16 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL16 Gene

Disorders for ARL16 Gene

Additional Disease Information for ARL16

No disorders were found for ARL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL16 Gene

Publications for ARL16 Gene

  1. ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner. (PMID: 21233210) Yang YK … Chen DY (The Journal of biological chemistry 2011) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for ARL16 Gene

Sources for ARL16 Gene

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