Aliases for ARL15 Gene

Aliases for ARL15 Gene

  • ADP Ribosylation Factor Like GTPase 15 2 3 5
  • ADP-Ribosylation Factor-Related Protein 2 3 4
  • ADP-Ribosylation Factor-Like Protein 15 3 4
  • ARF-Related Protein 2 3 4
  • ARFRP2 3 4
  • ADP-Ribosylation Factor Related Protein 2 2
  • ADP-Ribosylation Factor Like GTPase 15 2
  • ADP-Ribosylation Factor-Like 15 3

External Ids for ARL15 Gene

Previous HGNC Symbols for ARL15 Gene

  • ARFRP2

Previous GeneCards Identifiers for ARL15 Gene

  • GC05M053217
  • GC05M053180
  • GC05M050152

Summaries for ARL15 Gene

GeneCards Summary for ARL15 Gene

ARL15 (ADP Ribosylation Factor Like GTPase 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARF3.

Additional gene information for ARL15 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL15 Gene

Genomics for ARL15 Gene

GeneHancer (GH) Regulatory Elements for ARL15 Gene

Promoters and enhancers for ARL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J054308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.3 285 4.6 SP1 CTCF ZBTB6 MLX SMARCE1 POLR2A CREB1 ZNF362 CC2D1A NFYC LINC01033 ARL15 LINC02105 ENSG00000249016 GPX8 DHX29 MTREX ENSG00000279638
GH05J054273 Enhancer 0.9 Ensembl ENCODE 19.2 +36.7 36655 1 ZNF148 BACH1 SMARCA4 ZNF639 TRIM24 MTA1 DPF2 ATF1 LEF1 ZNF316 ARL15 piR-56037-006 ENSG00000279638
GH05J054251 Enhancer 0.7 Ensembl ENCODE 16.6 +58.3 58343 2.1 TCF7L2 PRDM1 FOSL2 PRDM10 ZSCAN5C LEF1 FOSL1 GATA3 FOS CBFA2T3 ARL15 piR-56037-006 piR-43105-537
GH05J054215 Enhancer 0.9 UCNEbase Ensembl ENCODE 11.5 +96.1 96085 5 PRDM1 PKNOX1 PRDM6 ZBTB33 ARL15 FST piR-43105-537 piR-56037-006
GH05J054359 Enhancer 0.7 Ensembl ENCODE 11 -51.1 -51115 4.2 TEAD4 POLR2A PKNOX1 SP1 FOSL1 FOSL2 FOS JUND BHLHE40 IKZF1 ARL15 HSPB3 NDUFS4 piR-38352-441 LINC01033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL15 gene promoter:
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • Meis-1
  • Meis-1a
  • POU2F1
  • POU2F1a
  • POU3F2

Genomic Locations for ARL15 Gene

Genomic Locations for ARL15 Gene
chr5:53,883,942-54,310,586
(GRCh38/hg38)
Size:
426,645 bases
Orientation:
Minus strand
chr5:53,179,775-53,606,412
(GRCh37/hg19)
Size:
426,638 bases
Orientation:
Minus strand

Genomic View for ARL15 Gene

Genes around ARL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL15 Gene

Proteins for ARL15 Gene

  • Protein details for ARL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXU5-ARL15_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 15
    Protein Accession:
    Q9NXU5
    Secondary Accessions:
    • Q6IAD0

    Protein attributes for ARL15 Gene

    Size:
    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL15 Gene

Post-translational modifications for ARL15 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL15 Gene

No data available for DME Specific Peptides for ARL15 Gene

Domains & Families for ARL15 Gene

Gene Families for ARL15 Gene

Protein Domains for ARL15 Gene

Suggested Antigen Peptide Sequences for ARL15 Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-related protein 2 (ARL15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXU5

UniProtKB/Swiss-Prot:

ARL15_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL15: view

Function for ARL15 Gene

Phenotypes From GWAS Catalog for ARL15 Gene

Gene Ontology (GO) - Molecular Function for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL15: view
genes like me logo Genes that share phenotypes with ARL15: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL15 Gene

Localization for ARL15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL15 gene
Compartment Confidence
cytosol 3
extracellular 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ARL15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL15 Gene

Pathways & Interactions for ARL15 Gene

PathCards logo

SuperPathways for ARL15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ARL15: view

No data available for Pathways by source and SIGNOR curated interactions for ARL15 Gene

Drugs & Compounds for ARL15 Gene

No Compound Related Data Available

Transcripts for ARL15 Gene

mRNA/cDNA for ARL15 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL15 Gene

No ASD Table

Relevant External Links for ARL15 Gene

GeneLoc Exon Structure for
ARL15
ECgene alternative splicing isoforms for
ARL15

Expression for ARL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARL15 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARL15 Gene:

ARL15

SOURCE GeneReport for Unigene cluster for ARL15 Gene:

Hs.659125

Evidence on tissue expression from TISSUES for ARL15 Gene

  • Intestine(4.2)
  • Nervous system(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with ARL15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL15 Gene

Orthologs for ARL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL15 33 32
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARL15 33 32
  • 95.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARL15 33 32
  • 93.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arl15 17 33 32
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Arl15 32
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARL15 33
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL15 33
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL15 33 32
  • 85.79 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL15 33
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl15 32
  • 79.51 (n)
Str.3925 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.15654 32
zebrafish
(Danio rerio)
Actinopterygii arl15b 33 32
  • 73.12 (n)
OneToMany
arl15a 33
  • 67 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3759 32
worm
(Caenorhabditis elegans)
Secernentea arl-13 33
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL1 33
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3634 33
  • 13 (a)
ManyToMany
Species where no ortholog for ARL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL15 Gene

ENSEMBL:
Gene Tree for ARL15 (if available)
TreeFam:
Gene Tree for ARL15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL15: view image

Paralogs for ARL15 Gene

(18) SIMAP similar genes for ARL15 Gene using alignment to 2 proteins:

  • ARL15_HUMAN
  • R4GN67_HUMAN
genes like me logo Genes that share paralogs with ARL15: view

Variants for ARL15 Gene

Sequence variations from dbSNP and Humsavar for ARL15 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000002505 -- 53,892,937(-) G/C intron_variant
rs1000003530 -- 54,150,721(-) C/T intron_variant
rs1000003904 -- 54,011,151(-) T/G intron_variant
rs1000011793 -- 54,294,424(-) T/C intron_variant
rs1000014241 -- 54,110,652(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL15 Gene

Variant ID Type Subtype PubMed ID
dgv5666n100 CNV gain 25217958
dgv5668n100 CNV gain 25217958
dgv9786n54 CNV gain 21841781
esv1766790 CNV insertion 17803354
esv2542415 CNV deletion 19546169
esv2663755 CNV deletion 23128226
esv2730185 CNV deletion 23290073
esv3570146 CNV loss 25503493
esv3605079 CNV loss 21293372
esv3605080 CNV loss 21293372
esv3605081 CNV gain 21293372
esv3605082 CNV loss 21293372
esv3605083 CNV loss 21293372
esv7542 CNV loss 19470904
esv997418 CNV insertion 20482838
nsv1024281 CNV gain 25217958
nsv328114 CNV deletion 16902084
nsv329076 CNV insertion 16902084
nsv329660 CNV deletion 16902084
nsv472823 CNV novel sequence insertion 20440878
nsv476695 CNV novel sequence insertion 20440878
nsv4829 CNV insertion 18451855
nsv4830 CNV deletion 18451855
nsv524694 CNV gain 19592680
nsv598175 CNV gain 21841781
nsv598178 CNV loss 21841781
nsv823074 CNV loss 20364138
nsv830298 CNV gain 17160897
nsv830299 CNV gain 17160897

Variation tolerance for ARL15 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL15 Gene

Human Gene Mutation Database (HGMD)
ARL15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL15 Gene

Disorders for ARL15 Gene

Additional Disease Information for ARL15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ARL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL15 Gene

Publications for ARL15 Gene

  1. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. (PMID: 20011104) Richards JB … GIANT Consortium (PLoS genetics 2009) 3 23 43 56
  2. ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity. (PMID: 28322786) Zhao J … Zhang X (Biochemical and biophysical research communications 2017) 2 3 56
  3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 43 56
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 43 56

Products for ARL15 Gene

Sources for ARL15 Gene