Aliases for ARL15 Gene

Aliases for ARL15 Gene

  • ADP Ribosylation Factor Like GTPase 15 2 3 5
  • ADP-Ribosylation Factor-Related Protein 2 3 4
  • ADP-Ribosylation Factor-Like Protein 15 3 4
  • ARF-Related Protein 2 3 4
  • ARFRP2 3 4
  • ADP-Ribosylation Factor Related Protein 2 2
  • ADP-Ribosylation Factor Like GTPase 15 2
  • ADP-Ribosylation Factor-Like 15 3
  • FLJ20051 2
  • ARL15 5

External Ids for ARL15 Gene

Previous HGNC Symbols for ARL15 Gene

  • ARFRP2

Previous GeneCards Identifiers for ARL15 Gene

  • GC05M053217
  • GC05M053180
  • GC05M050152

Summaries for ARL15 Gene

GeneCards Summary for ARL15 Gene

ARL15 (ADP Ribosylation Factor Like GTPase 15) is a Protein Coding gene. Diseases associated with ARL15 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 and Lipodystrophy, Familial Partial, Type 1. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARF6.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL15 Gene

Genomics for ARL15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARL15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J054308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.3 289 4.6 SP1 HNRNPL CTCF PRDM10 ZNF629 REST IKZF1 RFX5 ZNF692 POLR2A ARL15 LINC01033 DHX29 MTREX GPX8 ENSG00000279638 NDUFS4
GH05J054273 Enhancer 0.9 Ensembl ENCODE 19.2 +36.7 36659 1 LEF1 MTA2 MTA1 ZNF24 DPF2 SOX6 EP300 ETS1 CBX3 MTA3 ARL15 piR-56037-006 ENSG00000279638 NDUFS4
GH05J054251 Enhancer 0.8 Ensembl ENCODE 16.7 +58.3 58347 2.1 PRDM10 JUND PRDM1 ZSCAN5C LEF1 FOSL1 GATA3 ATF3 ZNF24 FOS ARL15 piR-56037-006 piR-43105-537 NDUFS4
GH05J054215 Enhancer 1 UCNEbase Ensembl ENCODE 11.5 +96.1 96089 5 TEAD4 FOXA1 PRDM1 PRDM6 ZBTB33 MEIS2 PKNOX1 ARL15 FST piR-43105-537 piR-56037-006 NDUFS4
GH05J054359 Enhancer 0.7 Ensembl ENCODE 11 -51.1 -51111 4.2 JUND PKNOX1 SP1 FOSL1 FOSL2 SPI1 BHLHE40 VEZF1 FOS IKZF1 ARL15 HSPB3 NDUFS4 piR-38352-441 LINC01033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL15

Top Transcription factor binding sites by QIAGEN in the ARL15 gene promoter:
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • Meis-1
  • Meis-1a
  • POU2F1
  • POU2F1a
  • POU3F2

Genomic Locations for ARL15 Gene

Genomic Locations for ARL15 Gene
426,649 bases
Minus strand
426,638 bases
Minus strand

Genomic View for ARL15 Gene

Genes around ARL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL15 Gene

Proteins for ARL15 Gene

  • Protein details for ARL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 15
    Protein Accession:
    Secondary Accessions:
    • Q6IAD0

    Protein attributes for ARL15 Gene

    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL15 Gene

Post-translational modifications for ARL15 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL15 Gene

Antibody Products

  • Abcam antibodies for ARL15
  • Boster Bio Antibodies for ARL15

No data available for DME Specific Peptides for ARL15 Gene

Domains & Families for ARL15 Gene

Gene Families for ARL15 Gene

Protein Domains for ARL15 Gene

Suggested Antigen Peptide Sequences for ARL15 Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-related protein 2 (ARL15_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL15: view

Function for ARL15 Gene

Phenotypes From GWAS Catalog for ARL15 Gene

Gene Ontology (GO) - Molecular Function for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16169070
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL15: view

Phenotypes for ARL15 Gene

genes like me logo Genes that share phenotypes with ARL15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL15 Gene

Localization for ARL15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL15 gene
Compartment Confidence
extracellular 4
cytosol 3
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ARL15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL15 Gene

Pathways & Interactions for ARL15 Gene

PathCards logo

SuperPathways for ARL15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ARL15: view

No data available for Pathways by source and SIGNOR curated interactions for ARL15 Gene

Drugs & Compounds for ARL15 Gene

No Compound Related Data Available

Transcripts for ARL15 Gene

mRNA/cDNA for ARL15 Gene

5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL15

Alternative Splicing Database (ASD) splice patterns (SP) for ARL15 Gene

No ASD Table

Relevant External Links for ARL15 Gene

GeneLoc Exon Structure for

Expression for ARL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARL15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL15

SOURCE GeneReport for Unigene cluster for ARL15 Gene:


Evidence on tissue expression from TISSUES for ARL15 Gene

  • Intestine(4.2)
  • Nervous system(2.6)
  • Muscle(2.1)
  • Skin(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ARL15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL15 Gene

Orthologs for ARL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL15 30 31
  • 99.51 (n)
(Canis familiaris)
Mammalia ARL15 30 31
  • 95.26 (n)
(Bos Taurus)
Mammalia ARL15 30 31
  • 93.73 (n)
(Mus musculus)
Mammalia Arl15 30 17 31
  • 90.36 (n)
(Rattus norvegicus)
Mammalia Arl15 30
  • 88.83 (n)
(Ornithorhynchus anatinus)
Mammalia ARL15 31
  • 85 (a)
(Monodelphis domestica)
Mammalia ARL15 31
  • 84 (a)
(Gallus gallus)
Aves ARL15 30 31
  • 85.79 (n)
(Anolis carolinensis)
Reptilia ARL15 31
  • 87 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arl15 30
  • 79.51 (n)
Str.3925 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15654 30
(Danio rerio)
Actinopterygii arl15b 30 31
  • 73.12 (n)
arl15a 31
  • 67 (a)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3759 30
(Caenorhabditis elegans)
Secernentea arl-13 31
  • 13 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL1 31
  • 32 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3634 31
  • 13 (a)
Species where no ortholog for ARL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARL15 Gene

Gene Tree for ARL15 (if available)
Gene Tree for ARL15 (if available)
Evolutionary constrained regions (ECRs) for ARL15: view image

Paralogs for ARL15 Gene

(18) SIMAP similar genes for ARL15 Gene using alignment to 2 proteins:

  • R4GN67_HUMAN
genes like me logo Genes that share paralogs with ARL15: view

Variants for ARL15 Gene

Additional dbSNP identifiers (rs#s) for ARL15 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARL15 Gene

Variant ID Type Subtype PubMed ID
dgv5666n100 CNV gain 25217958
dgv5668n100 CNV gain 25217958
dgv9786n54 CNV gain 21841781
esv1766790 CNV insertion 17803354
esv2542415 CNV deletion 19546169
esv2663755 CNV deletion 23128226
esv2730185 CNV deletion 23290073
esv3570146 CNV loss 25503493
esv3605079 CNV loss 21293372
esv3605080 CNV loss 21293372
esv3605081 CNV gain 21293372
esv3605082 CNV loss 21293372
esv3605083 CNV loss 21293372
esv7542 CNV loss 19470904
esv997418 CNV insertion 20482838
nsv1024281 CNV gain 25217958
nsv328114 CNV deletion 16902084
nsv329076 CNV insertion 16902084
nsv329660 CNV deletion 16902084
nsv472823 CNV novel sequence insertion 20440878
nsv476695 CNV novel sequence insertion 20440878
nsv4829 CNV insertion 18451855
nsv4830 CNV deletion 18451855
nsv524694 CNV gain 19592680
nsv598175 CNV gain 21841781
nsv598178 CNV loss 21841781
nsv823074 CNV loss 20364138
nsv830298 CNV gain 17160897
nsv830299 CNV gain 17160897

Variation tolerance for ARL15 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL15 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL15 Gene

Disorders for ARL15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARL15 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ARL15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ARL15

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ARL15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL15 Gene

Publications for ARL15 Gene

  1. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. (PMID: 20011104) Richards JB … GIANT Consortium (PLoS genetics 2009) 3 23 41
  2. ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity. (PMID: 28322786) Zhao J … Zhang X (Biochemical and biophysical research communications 2017) 2 3
  3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 41
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41

Products for ARL15 Gene

Sources for ARL15 Gene