Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL14 Gene

Aliases for ARL14 Gene

  • ADP Ribosylation Factor Like GTPase 14 2 3 5
  • ADP-Ribosylation Factor 7 2 3 4
  • ARF7 3 4
  • ADP-Ribosylation Factor-Like Protein 14 3
  • ADP-Ribosylation Factor Like GTPase 14 2
  • ADP-Ribosylation Factor-Like 14 3

External Ids for ARL14 Gene

Previous HGNC Symbols for ARL14 Gene

  • ARF7

Previous GeneCards Identifiers for ARL14 Gene

  • GC03P161881
  • GC03P160394
  • GC03P157793

Summaries for ARL14 Gene

GeneCards Summary for ARL14 Gene

ARL14 (ADP Ribosylation Factor Like GTPase 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is ARF3.

UniProtKB/Swiss-Prot for ARL14 Gene

  • GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

Additional gene information for ARL14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL14 Gene

Genomics for ARL14 Gene

GeneHancer (GH) Regulatory Elements for ARL14 Gene

Promoters and enhancers for ARL14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J160675 Enhancer 1 Ensembl ENCODE 650.7 +0.8 798 4.8 ELF3 FOXA2 ZSCAN4 ARID4B RAD21 RFX5 ZNF614 ZNF366 RCOR1 FOS ARL14 KPNA4 IFT80 ENSG00000207084
GH03J160885 Enhancer 1.1 Ensembl ENCODE 9.8 +208.8 208815 1.4 PKNOX1 ATF1 IRF4 YY1 TCF12 GLIS2 ZNF213 KLF7 RUNX3 ZNF610 SPTSSB ARL14 B3GALNT1 PIR58593 PPM1L
GH03J160935 Enhancer 0.8 ENCODE 9.8 +258.4 258409 0.2 ELF3 FOXA2 DNMT3B ZNF48 RAD21 YY1 EGR1 FOS RCOR1 THAP11 PPM1L ARL14 PIR58593
GH03J160665 Enhancer 1.1 Ensembl ENCODE 0.4 -10.5 -10502 3.3 HDGF IRF4 GLIS2 ATF7 FOS RUNX3 DEK JUNB TSHZ1 MAFF ENSG00000207084 KPNA4 ARL14 GC03P160584
GH03J160670 Enhancer 0.6 ENCODE 0.4 -5.8 -5829 1.4 SRF IRF2 RB1 ZNF514 SP1 POLR2A FOXK2 ZNF143 ZNF207 MLLT1 ENSG00000207084 KPNA4 ARL14 GC03P160584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL14 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • AP-4
  • Evi-1

Genomic Locations for ARL14 Gene

Genomic Locations for ARL14 Gene
1,294 bases
Plus strand
1,289 bases
Plus strand

Genomic View for ARL14 Gene

Genes around ARL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL14 Gene

Proteins for ARL14 Gene

  • Protein details for ARL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 14
    Protein Accession:
    Secondary Accessions:
    • Q9H655

    Protein attributes for ARL14 Gene

    192 amino acids
    Molecular mass:
    21588 Da
    Quaternary structure:
    • Interacts with ARL14EP.

neXtProt entry for ARL14 Gene

Post-translational modifications for ARL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL14 Gene

Domains & Families for ARL14 Gene

Gene Families for ARL14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL14 Gene

Suggested Antigen Peptide Sequences for ARL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL14: view

Function for ARL14 Gene

Molecular function for ARL14 Gene

UniProtKB/Swiss-Prot Function:
GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

Phenotypes From GWAS Catalog for ARL14 Gene

Gene Ontology (GO) - Molecular Function for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21458045
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL14: view
genes like me logo Genes that share phenotypes with ARL14: view

Animal Model Products

CRISPR Products

miRNA for ARL14 Gene

miRTarBase miRNAs that target ARL14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL14 Gene

Localization for ARL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL14 Gene

Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL14 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ARL14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARL14 Gene

Pathways & Interactions for ARL14 Gene

SuperPathways for ARL14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL14 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL14 Gene

Drugs & Compounds for ARL14 Gene

No Compound Related Data Available

Transcripts for ARL14 Gene

mRNA/cDNA for ARL14 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL14 Gene

ADP-ribosylation factor-like 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL14

Alternative Splicing Database (ASD) splice patterns (SP) for ARL14 Gene

No ASD Table

Relevant External Links for ARL14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL14 Gene

This gene is overexpressed in Stomach (x18.6), Colon - Transverse (x15.8), Pancreas (x5.4), Small Intestine - Terminal Ileum (x5.0), and Bladder (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of ARL14 Gene:


SOURCE GeneReport for Unigene cluster for ARL14 Gene:


mRNA Expression by UniProt/SwissProt for ARL14 Gene:

Tissue specificity: Expressed in immature dendritic cells.

Evidence on tissue expression from TISSUES for ARL14 Gene

  • Intestine(4.1)
  • Skin(4.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ARL14: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL14 Gene

Orthologs for ARL14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL14 34 33
  • 99.48 (n)
(Canis familiaris)
Mammalia ARL14 34 33
  • 88.02 (n)
(Bos Taurus)
Mammalia ARL14 34 33
  • 84.55 (n)
(Rattus norvegicus)
Mammalia Arl14 33
  • 79.65 (n)
(Mus musculus)
Mammalia Arl14 16 34 33
  • 78.77 (n)
(Monodelphis domestica)
Mammalia ARL14 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ARL14 34
  • 69 (a)
(Gallus gallus)
Aves LOC101749876 33
  • 65.07 (n)
ARL14 34
  • 62 (a)
(Anolis carolinensis)
Reptilia ARL14 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl14 33
  • 67.19 (n)
(Danio rerio)
Actinopterygii arl14 34 33
  • 57.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 34
  • 36 (a)
Species where no ortholog for ARL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL14 Gene

Gene Tree for ARL14 (if available)
Gene Tree for ARL14 (if available)
Evolutionary constrained regions (ECRs) for ARL14: view image

Paralogs for ARL14 Gene

(28) SIMAP similar genes for ARL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL14: view

Variants for ARL14 Gene

Sequence variations from dbSNP and Humsavar for ARL14 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000391861 -- 160,678,119(+) TGTG/TG 3_prime_UTR_variant
rs1003562444 -- 160,675,192(+) A/G upstream_transcript_variant
rs1003933696 -- 160,677,129(+) A/G upstream_transcript_variant
rs1004615641 -- 160,678,884(+) G/C downstream_transcript_variant
rs1005607016 -- 160,675,349(+) A/G upstream_transcript_variant

Variation tolerance for ARL14 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL14 Gene

Disorders for ARL14 Gene

Additional Disease Information for ARL14

No disorders were found for ARL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL14 Gene

Publications for ARL14 Gene

  1. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PMID: 21458045) Paul P … Neefjes J (Cell 2011) 3 4 58
  2. Human RAS superfamily proteins and related GTPases. (PMID: 15367757) Colicelli J (Science's STKE : signal transduction knowledge environment 2004) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation. (PMID: 24583629) Senapati S … Thelma BK (Pharmacogenetics and genomics 2014) 3 58

Products for ARL14 Gene

Sources for ARL14 Gene

Loading form....