Aliases for ARL13A Gene

Aliases for ARL13A Gene

  • ADP Ribosylation Factor Like GTPase 13A 2 3 5
  • ADP-Ribosylation Factor-Like Protein 13A 3 4
  • ADP-Ribosylation Factor-Like 13 2 3
  • ADP-Ribosylation Factor Like GTPase 13A 2
  • ADP-Ribosylation Factor-Like 13A 3
  • DJ341D10.2 3
  • ARL13A 5
  • ARL13 3

External Ids for ARL13A Gene

Previous HGNC Symbols for ARL13A Gene

  • ARL13

Previous GeneCards Identifiers for ARL13A Gene

  • GC0XP100035
  • GC0XP100111
  • GC0XP100224
  • GC0XP090022

Summaries for ARL13A Gene

GeneCards Summary for ARL13A Gene

ARL13A (ADP Ribosylation Factor Like GTPase 13A) is a Protein Coding gene. Diseases associated with ARL13A include Retinitis Pigmentosa 2 and Spontaneous Ocular Nystagmus. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL13B.

Additional gene information for ARL13A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL13A Gene

Genomics for ARL13A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARL13A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ101616 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 14.8 +648.5 648490 2.2 CREB1 CTCF ZNF692 POLR2A ZHX2 JUND PATZ1 REST SMAD5 ZNF501 ARMCX6 lnc-ARMCX6-2 ARL13A ARMCX3 lnc-ARMCX3-5 ARMCX1
GH0XJ101390 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.7 +422.9 422910 3.4 GATAD2A CTCF PRDM10 ZNF629 REST TFE3 LEF1 IKZF1 ZNF692 POLR2A RPL36A BTK RPL36A-HNRNPH2 ARMCX4 ARMCX2 ARL13A ZMAT1 CENPI PPIAP90 BEX5
GH0XJ101383 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 13.1 +416.3 416269 3.8 RFX1 IKZF1 POLR2A PRDM1 MTA2 PKNOX1 SMAD5 NR2C1 IKZF2 TRIM22 BTK lnc-BTK-1 lnc-ARMCX4-3 ARMCX4 ARL13A GLA BEX5 ARMCX3 TIMM8A
GH0XJ100403 Promoter 1.5 EPDnew Ensembl CraniofacialAtlas 11 -561.5 -561511 7.8 TARDBP PRDM1 ZSCAN4 POLR2A EZH2 ZNF600 ZNF341 ZBTB20 ZNF512B RAD21 PCDH19 ARL13A MN298708
GH0XJ100974 Enhancer 0.5 Ensembl ENCODE 0.7 +4.7 4739 0.8 FOS JUN piR-55657-264 piR-56022-610 piR-49732-636 piR-43408-260 piR-48301-452 piR-61028-625 ARL13A piR-57134-122 TRMT2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL13A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL13A

Top Transcription factor binding sites by QIAGEN in the ARL13A gene promoter:
  • aMEF-2
  • FOXI1
  • GATA-1
  • GATA-2
  • GATA-3
  • HFH-3
  • MEF-2A
  • POU2F1
  • POU2F1a
  • RORalpha1

Genomic Locations for ARL13A Gene

Genomic Locations for ARL13A Gene
chrX:100,969,011-100,990,831
(GRCh38/hg38)
Size:
21,821 bases
Orientation:
Plus strand
chrX:100,224,697-100,245,820
(GRCh37/hg19)
Size:
21,124 bases
Orientation:
Plus strand

Genomic View for ARL13A Gene

Genes around ARL13A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL13A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL13A Gene

Proteins for ARL13A Gene

  • Protein details for ARL13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H913-AR13A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 13A
    Protein Accession:
    Q5H913
    Secondary Accessions:
    • B2RTT6
    • B4DX50

    Protein attributes for ARL13A Gene

    Size:
    290 amino acids
    Molecular mass:
    33003 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARL13A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL13A Gene

Post-translational modifications for ARL13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL13A Gene

No data available for DME Specific Peptides for ARL13A Gene

Domains & Families for ARL13A Gene

Gene Families for ARL13A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL13A Gene

Suggested Antigen Peptide Sequences for ARL13A Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like protein 13A (AR13A_HUMAN)
  • ARL13A protein (B2RTT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5H913

UniProtKB/Swiss-Prot:

AR13A_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL13A: view

Function for ARL13A Gene

Phenotypes From GWAS Catalog for ARL13A Gene

Gene Ontology (GO) - Molecular Function for ARL13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL13A: view
genes like me logo Genes that share phenotypes with ARL13A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL13A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARL13A Gene

Localization for ARL13A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL13A gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARL13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IBA 21873635
GO:0031514 motile cilium IBA 21873635
GO:0060170 ciliary membrane IBA 21873635
GO:0097730 non-motile cilium IBA 21873635
genes like me logo Genes that share ontologies with ARL13A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL13A Gene

Pathways & Interactions for ARL13A Gene

PathCards logo

SuperPathways for ARL13A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097500 receptor localization to non-motile cilium IBA 21873635
GO:1905515 non-motile cilium assembly IBA 21873635
genes like me logo Genes that share ontologies with ARL13A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL13A Gene

Drugs & Compounds for ARL13A Gene

No Compound Related Data Available

Transcripts for ARL13A Gene

mRNA/cDNA for ARL13A Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL13A

Alternative Splicing Database (ASD) splice patterns (SP) for ARL13A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: - - -
SP3:

Relevant External Links for ARL13A Gene

GeneLoc Exon Structure for
ARL13A

Expression for ARL13A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL13A Gene

This gene is overexpressed in Testis (x31.9).

Protein differential expression in normal tissues from HIPED for ARL13A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL13A Gene



Protein tissue co-expression partners for ARL13A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL13A

SOURCE GeneReport for Unigene cluster for ARL13A Gene:

Hs.147237

Evidence on tissue expression from TISSUES for ARL13A Gene

  • Lung(2.8)
  • Nervous system(2.2)
  • Kidney(2.1)
  • Liver(2)
  • Eye(2)
genes like me logo Genes that share expression patterns with ARL13A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL13A Gene

Orthologs for ARL13A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL13A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARL13A 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ARL13A 30
  • 82.2 (n)
Rat
(Rattus norvegicus)
Mammalia Arl13a 30
  • 77.42 (n)
Mouse
(Mus musculus)
Mammalia Arl13a 30 17 31
  • 75.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ARL13A 30 31
  • 74.66 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ARL13A 31
  • 42 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARL13A 31
  • 34 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii arl13a 31
  • 20 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG17819 31
  • 25 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.2 31
  • 21 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL3 31
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for ARL13A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ARL13A Gene

ENSEMBL:
Gene Tree for ARL13A (if available)
TreeFam:
Gene Tree for ARL13A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL13A: view image

Paralogs for ARL13A Gene

(4) SIMAP similar genes for ARL13A Gene using alignment to 3 proteins:

  • AR13A_HUMAN
  • H0YH34_HUMAN
  • J3KPB3_HUMAN
genes like me logo Genes that share paralogs with ARL13A: view

Variants for ARL13A Gene

Additional dbSNP identifiers (rs#s) for ARL13A Gene

Structural Variations from Database of Genomic Variants (DGV) for ARL13A Gene

Variant ID Type Subtype PubMed ID
nsv515758 CNV gain 19592680
nsv517937 CNV gain 19592680
nsv7012 CNV insertion 18451855

Variation tolerance for ARL13A Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL13A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL13A Gene

Disorders for ARL13A Gene

MalaCards: The human disease database

(13) MalaCards diseases for ARL13A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ARL13A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL13A Gene

Publications for ARL13A Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ARL13A Gene

Sources for ARL13A Gene