This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010] See more...

Aliases for ARL11 Gene

Aliases for ARL11 Gene

  • ADP Ribosylation Factor Like GTPase 11 2 3 5
  • ARLTS1 2 3 4
  • ADP-Ribosylation Factor-Like Tumor Suppressor Protein 1 3 4
  • ADP-Ribosylation Factor-Like Tumor Suppressor Gene 1 2 3
  • ADP-Ribosylation Factor-Like Protein 11 3 4
  • ADP-Ribosylation Factor Like GTPase 11 2
  • ADP-Ribosylation Factor-Like 11 3
  • FLJ33930 2
  • ARL11 5

External Ids for ARL11 Gene

Previous GeneCards Identifiers for ARL11 Gene

  • GC13P048000
  • GC13P049100
  • GC13P050202
  • GC13P030995

Summaries for ARL11 Gene

Entrez Gene Summary for ARL11 Gene

  • This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

GeneCards Summary for ARL11 Gene

ARL11 (ADP Ribosylation Factor Like GTPase 11) is a Protein Coding gene. Diseases associated with ARL11 include Leukemia, Chronic Lymphocytic and Familial Ovarian Cancer. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL14.

UniProtKB/Swiss-Prot Summary for ARL11 Gene

Gene Wiki entry for ARL11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL11 Gene

Genomics for ARL11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARL11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARL11

Top Transcription factor binding sites by QIAGEN in the ARL11 gene promoter:
  • AML1a
  • c-Myc
  • GR
  • GR-alpha
  • GR-beta
  • Lmo2
  • Max
  • NF-1
  • Pax-2
  • Pax-2a

Genomic Locations for ARL11 Gene

Latest Assembly
chr13:49,628,456-49,633,872
(GRCh38/hg38)
Size:
5,417 bases
Orientation:
Plus strand

Previous Assembly
chr13:50,202,643-50,208,008
(GRCh37/hg19 by Entrez Gene)
Size:
5,366 bases
Orientation:
Plus strand

chr13:50,202,435-50,208,008
(GRCh37/hg19 by Ensembl)
Size:
5,574 bases
Orientation:
Plus strand

Genomic View for ARL11 Gene

Genes around ARL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL11 Gene

Proteins for ARL11 Gene

  • Protein details for ARL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q4-ARL11_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 11
    Protein Accession:
    Q969Q4

    Protein attributes for ARL11 Gene

    Size:
    196 amino acids
    Molecular mass:
    21391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL11 Gene

Post-translational modifications for ARL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL11 Gene

Domains & Families for ARL11 Gene

Gene Families for ARL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ARL11 Gene

InterPro:
Blocks:
  • ADP-ribosylation factor

Suggested Antigen Peptide Sequences for ARL11 Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like tumor suppressor protein 1 (ARL11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969Q4

UniProtKB/Swiss-Prot:

ARL11_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL11: view

Function for ARL11 Gene

Molecular function for ARL11 Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis. May act as a tumor suppressor.

Phenotypes From GWAS Catalog for ARL11 Gene

Gene Ontology (GO) - Molecular Function for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with ARL11: view
genes like me logo Genes that share phenotypes with ARL11: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL11 Gene

Localization for ARL11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL11 gene
Compartment Confidence
plasma membrane 3
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with ARL11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL11 Gene

Pathways & Interactions for ARL11 Gene

PathCards logo

SuperPathways for ARL11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0016192 vesicle-mediated transport IBA 21873635
genes like me logo Genes that share ontologies with ARL11: view

No data available for Pathways by source and SIGNOR curated interactions for ARL11 Gene

Drugs & Compounds for ARL11 Gene

No Compound Related Data Available

Transcripts for ARL11 Gene

mRNA/cDNA for ARL11 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARL11

Alternative Splicing Database (ASD) splice patterns (SP) for ARL11 Gene

No ASD Table

Relevant External Links for ARL11 Gene

GeneLoc Exon Structure for
ARL11

Expression for ARL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL11 Gene

mRNA differential expression in normal tissues according to GTEx for ARL11 Gene

This gene is overexpressed in Whole Blood (x31.0).

Protein differential expression in normal tissues from HIPED for ARL11 Gene

This gene is overexpressed in Monocytes (39.3) and Spleen (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL11 Gene



Protein tissue co-expression partners for ARL11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARL11

SOURCE GeneReport for Unigene cluster for ARL11 Gene:

Hs.558599

mRNA Expression by UniProt/SwissProt for ARL11 Gene:

Q969Q4-ARL11_HUMAN
Tissue specificity: Expressed in lung and leukocytes.

Evidence on tissue expression from TISSUES for ARL11 Gene

  • Spleen(4.2)
  • Bone marrow(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL11 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with ARL11: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARL11 Gene

Orthologs for ARL11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARL11 29 30
  • 99.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Arl11 29 16 30
  • 83.9 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arl11 29
  • 81.7 (n)
Cow
(Bos Taurus)
Mammalia ARL11 29 30
  • 80.7 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ARL11 30
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ARL11 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ARL11 29 30
  • 61.88 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490310 29
  • 60.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii arl11 29 30
  • 56.7 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 30
  • 38 (a)
OneToMany
Species where no ortholog for ARL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ARL11 Gene

ENSEMBL:
Gene Tree for ARL11 (if available)
TreeFam:
Gene Tree for ARL11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL11: view image
Alliance of Genome Resources:
Additional Orthologs for ARL11

Paralogs for ARL11 Gene

(27) SIMAP similar genes for ARL11 Gene using alignment to 1 proteins:

  • ARL11_HUMAN
genes like me logo Genes that share paralogs with ARL11: view

Variants for ARL11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARL11 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs34301344 Benign: not provided 49,630,893(+) G/A
NM_138450.6(ARL11):c.446G>A (p.Trp149Ter)
NONSENSE
rs764419423 Likely Benign: not provided 49,630,573(+) C/T
NM_138450.6(ARL11):c.126C>T (p.Pro42=)
SYNONYMOUS
rs146850453 -- p.Glu164Lys
rs147120792 -- p.Pro131Leu
rs147389782 -- p.Ser22Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARL11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARL11 Gene

Variant ID Type Subtype PubMed ID
esv3632050 CNV gain 21293372

Variation tolerance for ARL11 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL11 Gene

Human Gene Mutation Database (HGMD)
ARL11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL11
Leiden Open Variation Database (LOVD)
ARL11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL11 Gene

Disorders for ARL11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ARL11 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
familial ovarian cancer
  • familial ovarian malignant tumor
familial colorectal cancer
  • colorectal cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search ARL11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ARL11_HUMAN
  • Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for ARL11

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ARL11: view

No data available for Genatlas for ARL11 Gene

Publications for ARL11 Gene

  1. Familial cancer associated with a polymorphism in ARLTS1. (PMID: 15843669) Calin GA … Croce CM (The New England journal of medicine 2005) 3 4 40 72
  2. Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PMID: 16353159) Frank B … Burwinkel B (International journal of cancer 2006) 3 22 40
  3. ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. (PMID: 20358297) Akisik E … Dalay N (Molecular biology reports 2011) 3 40
  4. Association of the ARLTS1 variants with familial ovarian cancer risk in China. (PMID: 19509554) Yang XY … Peng ZL (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2009) 3 40
  5. ARLTS1 - a novel tumor suppressor gene. (PMID: 18375053) Yendamuri S … Calin GA (Cancer letters 2008) 3 22

Products for ARL11 Gene

Sources for ARL11 Gene