Aliases for ARL10 Gene

Aliases for ARL10 Gene

  • ADP Ribosylation Factor Like GTPase 10 2 3 5
  • ADP-Ribosylation Factor-Like Protein 10 3 4
  • ADP-Ribosylation Factor-Like 10A 2 3
  • ARL10A 3 4
  • ADP-Ribosylation Factor-Like Membrane-Associated Protein 3
  • ADP-Ribosylation Factor Like GTPase 10 2

External Ids for ARL10 Gene

Previous HGNC Symbols for ARL10 Gene

  • ARL10A

Previous GeneCards Identifiers for ARL10 Gene

  • GC05P175726
  • GC05P175792
  • GC05P170718

Summaries for ARL10 Gene

GeneCards Summary for ARL10 Gene

ARL10 (ADP Ribosylation Factor Like GTPase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ARL9.

Additional gene information for ARL10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARL10 Gene

Genomics for ARL10 Gene

GeneHancer (GH) Regulatory Elements for ARL10 Gene

Promoters and enhancers for ARL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176364 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 750.6 +0.3 311 2 HCFC1 HDGF NKRF POLR2A MLLT1 ZNF687 CREM ZBTB33 GLIS2 BACH1 ARL10 KIAA1191 FAM153B SIMC1 MIR1271 RF00017-5132 RF00017-5131
GH05J176367 Promoter 0.3 Ensembl 750.6 +1.7 1726 0.4 ARL10 MIR1271 RF00017-5132 RF00017-5131
GH05J176410 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.2 +49.4 49442 8.8 ZNF24 SP1 CTCF SREBF1 POLR2A MIXL1 MYC NFYC ZNF701 L3MBTL2 CLTB ARL10 UIMC1 ENSG00000251414 FAF2 NSD1 HIGD2A UNC5A GPRIN1 NOP16
GH05J176529 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +175.0 174955 22.5 SIN3A SP1 ZBTB40 CTCF FOXA1 MLX SMARCE1 POLR2A TCF7L2 USF2 RNF44 CDHR2 FAF2 ZNF346 NSD1 ZNF346-IT1 ENSG00000251414 ENSG00000250909 LMAN2 MXD3
GH05J176386 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +22.9 22948 4.1 E2F8 ZNF785 SIN3A SP1 ZBTB40 SIX5 ZBTB6 RBPJ POLR2A CTBP1 HIGD2A NOP16 lnc-CLTB-1 FAF2 NSD1 UIMC1 ENSG00000251414 ENSG00000250909 ENSG00000240729 ZNF346-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARL10 gene promoter:
  • AML1a
  • AREB6
  • CUTL1
  • FOXO3a
  • ITF-2
  • Lhx3a
  • LHX3b
  • Nkx6-1
  • RORalpha1
  • Tal-1beta

Genomic Locations for ARL10 Gene

Genomic Locations for ARL10 Gene
chr5:176,365,474-176,415,463
(GRCh38/hg38)
Size:
49,990 bases
Orientation:
Plus strand
chr5:175,792,471-175,828,866
(GRCh37/hg19)
Size:
36,396 bases
Orientation:
Plus strand

Genomic View for ARL10 Gene

Genes around ARL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL10 Gene

Proteins for ARL10 Gene

  • Protein details for ARL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8L6-ARL10_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 10
    Protein Accession:
    Q8N8L6

    Protein attributes for ARL10 Gene

    Size:
    244 amino acids
    Molecular mass:
    27459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL10 Gene

Post-translational modifications for ARL10 Gene

  • Ubiquitination at Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL10 Gene

No data available for DME Specific Peptides for ARL10 Gene

Domains & Families for ARL10 Gene

Gene Families for ARL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ARL10 Gene

Suggested Antigen Peptide Sequences for ARL10 Gene

GenScript: Design optimal peptide antigens:
  • ADP-ribosylation factor-like protein 10 (ARL10_HUMAN)
  • ARL10 protein (Q6PCE2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8L6

UniProtKB/Swiss-Prot:

ARL10_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL10: view

Function for ARL10 Gene

Phenotypes From GWAS Catalog for ARL10 Gene

Gene Ontology (GO) - Molecular Function for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL10: view
genes like me logo Genes that share phenotypes with ARL10: view

Animal Models for ARL10 Gene

MGI Knock Outs for ARL10:
  • Arl10 Arl10<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL10

CRISPR Products

miRNA for ARL10 Gene

miRTarBase miRNAs that target ARL10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL10 Gene

Localization for ARL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL10 gene
Compartment Confidence
extracellular 2
mitochondrion 0
endoplasmic reticulum 0
lysosome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARL10 Gene

Pathways & Interactions for ARL10 Gene

PathCards logo

SuperPathways for ARL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARL10 Gene

Drugs & Compounds for ARL10 Gene

No Compound Related Data Available

Transcripts for ARL10 Gene

mRNA/cDNA for ARL10 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL10 Gene

No ASD Table

Relevant External Links for ARL10 Gene

GeneLoc Exon Structure for
ARL10
ECgene alternative splicing isoforms for
ARL10

Expression for ARL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL10 Gene

Protein differential expression in normal tissues from HIPED for ARL10 Gene

This gene is overexpressed in Fetal Brain (45.7), Islet of Langerhans (13.9), and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARL10 Gene



Protein tissue co-expression partners for ARL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL10 Gene:

ARL10

SOURCE GeneReport for Unigene cluster for ARL10 Gene:

Hs.424552

Evidence on tissue expression from TISSUES for ARL10 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ARL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL10 Gene

Orthologs for ARL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL10 33 32
  • 98.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARL10 33 32
  • 91.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl10 32
  • 86.51 (n)
mouse
(Mus musculus)
Mammalia Arl10 17 33 32
  • 85.73 (n)
cow
(Bos Taurus)
Mammalia ARL10 33
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL10 33
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARL10 33 32
  • 64.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL10 33
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl10 32
  • 51.91 (n)
zebrafish
(Danio rerio)
Actinopterygii arl10 33 32
  • 55.02 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gie 33
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-8 33
  • 33 (a)
OneToMany
Species where no ortholog for ARL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL10 Gene

ENSEMBL:
Gene Tree for ARL10 (if available)
TreeFam:
Gene Tree for ARL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARL10: view image

Paralogs for ARL10 Gene

(19) SIMAP similar genes for ARL10 Gene using alignment to 5 proteins:

  • ARL10_HUMAN
  • H0Y8L6_HUMAN
  • H0Y9R6_HUMAN
  • L0R582_HUMAN
  • Q6PCE2_HUMAN
genes like me logo Genes that share paralogs with ARL10: view

Variants for ARL10 Gene

Sequence variations from dbSNP and Humsavar for ARL10 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000027940 -- 176,400,004(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000043248 -- 176,391,571(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000108407 -- 176,384,619(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000162708 -- 176,405,779(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000189102 -- 176,365,469(+) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARL10 Gene

Variant ID Type Subtype PubMed ID
esv2731167 CNV deletion 23290073
esv2731168 CNV deletion 23290073
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Variation tolerance for ARL10 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL10 Gene

Disorders for ARL10 Gene

Additional Disease Information for ARL10

No disorders were found for ARL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL10 Gene

Publications for ARL10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. (PMID: 15033445) Louro R … Reis EM (Biochemical and biophysical research communications 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for ARL10 Gene

Sources for ARL10 Gene