ARID5A Gene (Protein Coding)

AT-Rich Interaction Domain 5A

GC02P096536
GIFtS:
38
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008] See more...

Aliases for ARID5A Gene

Aliases for ARID5A Gene

  • AT-Rich Interaction Domain 5A 2 3 5
  • Modulator Recognition Factor 1 2 3 4
  • MRF-1 2 3 4
  • AT-Rich Interactive Domain-Containing Protein 5A 3 4
  • AT Rich Interactive Domain 5A (MRF1-Like) 2 3
  • ARID Domain-Containing Protein 5A 3 4
  • RP11-363D14 2 3
  • MRF1 3 4
  • Modulator Recognition Factor I 3
  • RFVG5814 3
  • ARID5A 5

External Ids for ARID5A Gene

Previous GeneCards Identifiers for ARID5A Gene

  • GC02P096672
  • GC02P096624
  • GC02P097203
  • GC02P091165

Summaries for ARID5A Gene

Entrez Gene Summary for ARID5A Gene

  • Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARID5A Gene

ARID5A (AT-Rich Interaction Domain 5A) is a Protein Coding gene. Diseases associated with ARID5A include Schizophrenia and Currarino Syndrome. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is ARID5B.

UniProtKB/Swiss-Prot Summary for ARID5A Gene

  • Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity).

Additional gene information for ARID5A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARID5A Gene

Genomics for ARID5A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ARID5A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARID5A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARID5A

Top Transcription factor binding sites by QIAGEN in the ARID5A gene promoter:
  • aMEF-2
  • AREB6
  • Cdc5
  • HTF
  • IRF-1
  • MEF-2
  • MEF-2A
  • POU2F1
  • POU2F1a
  • STAT5A

Genomic Locations for ARID5A Gene

Latest Assembly
chr2:96,536,743-96,552,638
(GRCh38/hg38)
Size:
15,896 bases
Orientation:
Plus strand

Previous Assembly
chr2:97,202,489-97,218,375
(GRCh37/hg19 by Entrez Gene)
Size:
15,887 bases
Orientation:
Plus strand

chr2:97,202,480-97,218,375
(GRCh37/hg19 by Ensembl)
Size:
15,896 bases
Orientation:
Plus strand

Genomic View for ARID5A Gene

Genes around ARID5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID5A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ARID5A Gene

Proteins for ARID5A Gene

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  • Protein details for ARID5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03989-ARI5A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 5A
    Protein Accession:
    Q03989
    Secondary Accessions:
    • C9J1Q0
    • Q6NX37

    Protein attributes for ARID5A Gene

    Size:
    594 amino acids
    Molecular mass:
    64074 Da
    Quaternary structure:
    • Interacts with SOX9 (By similarity). Interacts with ESR1 (PubMed:15941852). Interacts with RORC (By similarity).
    SequenceCaution:
    • Sequence=AAA36325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID5A Gene

Protein Expression for ARID5A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ARID5A Gene

  • Phosphorylated by MAPK14 on serine residues involving a TLR4 signaling pathway upon lipopolysaccharide (LPS) stimulation leading to its ubiquitination and proteasomal degradation.
  • Ubiquitinated leading to proteasomal degradation; involving WWP1 linked to MAPK14-mediated phosphorylation upon LPS stimulation.
  • Ubiquitination at Lys85 and Lys94
  • Modification sites at PhosphoSitePlus

Other Protein References for ARID5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID5A Gene

Domains & Families for ARID5A Gene

Gene Families for ARID5A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ARID5A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARID5A Gene

GenScript: Design optimal peptide antigens:
  • Modulator recognition factor 1 (ARI5A_HUMAN)
genes like me logo Genes that share domains with ARID5A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARID5A Gene

Function for ARID5A Gene

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  6. Cell Lines for research

Molecular function for ARID5A Gene

UniProtKB/Swiss-Prot Function:
Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity).

Phenotypes From GWAS Catalog for ARID5A Gene

Gene Ontology (GO) - Molecular Function for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003677 DNA binding TAS 15640446
GO:0003714 transcription corepressor activity IDA 15941852
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 15941852
genes like me logo Genes that share ontologies with ARID5A: view
genes like me logo Genes that share phenotypes with ARID5A: view

Animal Models for ARID5A Gene

MGI Knock Outs for ARID5A:

Animal Models for research

miRNA for ARID5A Gene

miRTarBase miRNAs that target ARID5A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARID5A

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID5A Gene

Localization for ARID5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID5A Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARID5A gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ARID5A: view

Pathways & Interactions for ARID5A Gene

PathCards logo

SuperPathways for ARID5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 15941852
GO:0002376 immune system process IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045087 innate immune response IEA --
GO:0045892 negative regulation of transcription, DNA-templated TAS 15640446
genes like me logo Genes that share ontologies with ARID5A: view

No data available for Pathways by source and SIGNOR curated interactions for ARID5A Gene

Drugs & Compounds for ARID5A Gene

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No Compound Related Data Available

Transcripts for ARID5A Gene

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mRNA/cDNA for ARID5A Gene

8 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARID5A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ARID5A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: - - - -
SP9: - -
SP10: -
SP11: - - -

Relevant External Links for ARID5A Gene

GeneLoc Exon Structure for
ARID5A

Expression for ARID5A Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARID5A Gene

mRNA expression in normal human tissues for ARID5A Gene
mRNA expression by GTEx for ARID5A GenemRNA expression by BioGPS for ARID5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID5A Gene

This gene is overexpressed in Whole Blood (x9.3).

Protein differential expression in normal tissues from HIPED for ARID5A Gene

This gene is overexpressed in Plasma (59.3) and Adipocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARID5A Gene



Protein tissue co-expression partners for ARID5A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARID5A

SOURCE GeneReport for Unigene cluster for ARID5A Gene:

Hs.920

Evidence on tissue expression from TISSUES for ARID5A Gene

  • Bone marrow(2)
genes like me logo Genes that share expression patterns with ARID5A: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARID5A Gene

Orthologs for ARID5A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID5A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ARID5A 30 31
  • 96.35 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ARID5A 30 31
  • 86.64 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ARID5A 30 31
  • 84.89 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Arid5a 30 17 31
  • 80.46 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Arid5a 30
  • 78.3 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ARID5A 31
  • 62 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ARID5A 30 31
  • 58.74 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ARID5A 31
  • 36 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii arid5a 31
  • 28 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG34422 31
  • 5 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 17 (a)
 OneToMany
Species where no ortholog for ARID5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ARID5A Gene

ENSEMBL:
Gene Tree for ARID5A (if available)
TreeFam:
Gene Tree for ARID5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARID5A: view image

Paralogs for ARID5A Gene

Paralogs for ARID5A Gene

genes like me logo Genes that share paralogs with ARID5A: view

Variants for ARID5A Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARID5A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARID5A Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv2720413 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv1138818 CNV deletion 24896259

Variation tolerance for ARID5A Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARID5A Gene

Human Gene Mutation Database (HGMD)
ARID5A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARID5A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARID5A Gene

Disorders for ARID5A Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARID5A Gene - From: CVR and COP

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
currarino syndrome
  • currarino triad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ARID5A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ARID5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARID5A Gene

Publications for ARID5A Gene

  1. Repression by a differentiation-specific factor of the human cytomegalovirus enhancer. (PMID: 8649988) Huang TH … Itakura K (Nucleic acids research 1996) 2 3 4
  2. Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha. (PMID: 15941852) Georgescu SP … Mendelsohn ME (Molecular endocrinology (Baltimore, Md.) 2005) 3 4
  3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

ExternalLinks

View latest publications for ARID5A gene in Mastermind

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