Free for academic non-profit institutions. Other users need a Commercial license
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]
ARID5A (AT-Rich Interaction Domain 5A) is a Protein Coding gene. Diseases associated with ARID5A include Schizophrenia and Currarino Syndrome. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is ARID5B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0003677 | DNA binding | TAS | 15640446 |
GO:0003714 | transcription corepressor activity | IDA | 15941852 |
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 15941852 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 15941852 |
GO:0002376 | immune system process | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0045087 | innate immune response | IEA | -- |
GO:0045892 | negative regulation of transcription, DNA-templated | TAS | 15640446 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP9: | - | - | |||||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||||||
SP11: | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ARID5A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ARID5A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ARID5A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Arid5a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Arid5a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | ARID5A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ARID5A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ARID5A 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | arid5a 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG34422 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv607e201 | CNV | deletion | 23290073 |
esv2720413 | CNV | deletion | 23290073 |
esv3425717 | CNV | duplication | 20981092 |
esv5003 | OTHER | complex | 18987735 |
nsv1135873 | CNV | deletion | 24896259 |
nsv1138818 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
schizophrenia |
|
|
currarino syndrome |
|
|