This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by Ig... See more...

Aliases for ARID4B Gene

Aliases for ARID4B Gene

  • AT-Rich Interaction Domain 4B 2 3 5
  • AT-Rich Interactive Domain-Containing Protein 4B 3 4
  • Histone Deacetylase Complex Subunit SAP180 3 4
  • AT Rich Interactive Domain 4B (RBP1-Like) 2 3
  • Breast Cancer-Associated Antigen BRCAA1 3 4
  • Retinoblastoma-Binding Protein 1-Like 1 3 4
  • 180 KDa Sin3-Associated Polypeptide 3 4
  • ARID Domain-Containing Protein 4B 3 4
  • Sin3-Associated Polypeptide P180 3 4
  • RBBP1L1 3 4
  • RBP1L1 3 4
  • BRCAA1 3 4
  • SAP180 3 4
  • AT Rich Interactive Domain 4B (RBP1- Like) 2
  • Retinoblastoma Binding Protein 1-Like 1 2
  • Breast Carcinoma-Associated Antigen 3
  • Breast Cancer-Associated Antigen 1 3
  • SIN3A-Associated Protein 180 3
  • Rb-Binding Protein Homolog 3
  • BCAA 3

External Ids for ARID4B Gene

Previous HGNC Symbols for ARID4B Gene

  • RBP1L1

Previous GeneCards Identifiers for ARID4B Gene

  • GC01M232336
  • GC01M232371
  • GC01M231621
  • GC01M233396
  • GC01M235295
  • GC01M205778
  • GC01M235296
  • GC01M235298

Summaries for ARID4B Gene

Entrez Gene Summary for ARID4B Gene

  • This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID4B Gene

ARID4B (AT-Rich Interaction Domain 4B) is a Protein Coding gene. Diseases associated with ARID4B include Retinoblastoma and Breast Cancer. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include transcription regulatory region DNA binding. An important paralog of this gene is ARID4A.

UniProtKB/Swiss-Prot Summary for ARID4B Gene

  • Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).

Gene Wiki entry for ARID4B Gene

Additional gene information for ARID4B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARID4B Gene

Genomics for ARID4B Gene

GeneHancer (GH) Regulatory Elements for ARID4B Gene

Promoters and enhancers for ARID4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J235324 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 572 -0.1 -101 7.6 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 NCOR1 ARID4B GGPS1 lnc-B3GALNT2-2 lnc-TBCE-3 piR-59064 RPS21P1 IRF2BP2 TARBP1 LDHAP2 B3GALNT2
GH01J234598 Promoter/Enhancer 3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 119.1 +716.4 716404 27 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 IRF2BP2 ARID4B RPS21P1 TARBP1 LINC01354 GGPS1 B3GALNT2 COA6-AS1 LINC00184 ENSG00000228830
GH01J234714 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 140.3 +606.7 606704 14.7 EP300 FOXK2 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 ZNF300 POLR2G piR-40121 ARID4B RPS21P1 IRF2BP2 COA6-AS1 ENSG00000228830 B3GALNT2 LINC01354 ENSG00000212144 GGPS1
GH01J234968 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 87.1 +349.3 349281 21.3 EP300 FOXK2 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 ZNF300 POLR2G ENSG00000258082 lnc-GGPS1-16 ARID4B GGPS1 RPS21P1 IRF2BP2 ENSG00000238005 TARBP1 ENSG00000228830 LINC01354
GH01J235502 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 56.2 -176.0 -176003 4.2 RXRA EP300 HNRNPK ZNF217 CTCF ZSCAN5C SIN3A TCF12 NRF1 MYC B3GALNT2 piR-38051-025 lnc-TBCE-7 ARID4B RPS21P1 IRF2BP2 GGPS1 NID1 LDHAP2 RBM34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARID4B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARID4B

Top Transcription factor binding sites by QIAGEN in the ARID4B gene promoter:
  • CUTL1
  • FOXO4
  • HOXA9
  • HOXA9B
  • IRF-7A
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Sox9
  • YY1

Genomic Locations for ARID4B Gene

Genomic Locations for ARID4B Gene
chr1:235,131,634-235,328,298
(GRCh38/hg38)
Size:
196,665 bases
Orientation:
Minus strand
chr1:235,294,949-235,491,534
(GRCh37/hg19)
Size:
196,586 bases
Orientation:
Minus strand

Genomic View for ARID4B Gene

Genes around ARID4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID4B Gene

Proteins for ARID4B Gene

  • Protein details for ARID4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4LE39-ARI4B_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 4B
    Protein Accession:
    Q4LE39
    Secondary Accessions:
    • A1L465
    • Q3MHV4
    • Q5HY99
    • Q5T2C2
    • Q5T2C3
    • Q5T2C4
    • Q5T2C5
    • Q5T2C6
    • Q6P600
    • Q86UX1
    • Q86WR4
    • Q9H915
    • Q9NYU3
    • Q9NZB6
    • Q9NZG4
    • Q9P2W4
    • Q9UF62
    • Q9Y6E1

    Protein attributes for ARID4B Gene

    Size:
    1312 amino acids
    Molecular mass:
    147809 Da
    Quaternary structure:
    • Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (PubMed:12724404). Interacts with ARID4A (PubMed:17043311). Interacts with AR (By similarity).
    SequenceCaution:
    • Sequence=AAD41239.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF23433.3; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB14428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE06114.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID4B Gene

Post-translational modifications for ARID4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARID4B Gene

Domains & Families for ARID4B Gene

Gene Families for ARID4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ARID4B Gene

Blocks:
  • Tudor domain
  • ARID (AT-rich interaction domain) protein
  • Chromo domain
  • RBB1NT
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARID4B Gene

GenScript: Design optimal peptide antigens:
  • ARID4B protein (A0PJ81_HUMAN)
  • Retinoblastoma-binding protein 1-like 1 (ARI4B_HUMAN)
  • AT rich interactive domain 4B (RBP1-like) (B0QZ34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4LE39

UniProtKB/Swiss-Prot:

ARI4B_HUMAN :
  • The C-terminus mediates interaction with mSin3A corepressor complex.
Domain:
  • The C-terminus mediates interaction with mSin3A corepressor complex.
  • The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
  • The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.
genes like me logo Genes that share domains with ARID4B: view

Function for ARID4B Gene

Molecular function for ARID4B Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).

Phenotypes From GWAS Catalog for ARID4B Gene

Gene Ontology (GO) - Molecular Function for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20195357
GO:0044212 transcription regulatory region DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ARID4B: view
genes like me logo Genes that share phenotypes with ARID4B: view

Animal Models for ARID4B Gene

MGI Knock Outs for ARID4B:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID4B Gene

Localization for ARID4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID4B Gene

Nucleus. Cytoplasm. Note=Cytoplasmic in breast cancer cells. {ECO:0000269 PubMed:15247124}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARID4B gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARID4B: view

Pathways & Interactions for ARID4B Gene

genes like me logo Genes that share pathways with ARID4B: view

Pathways by source for ARID4B Gene

1 GeneGo (Thomson Reuters) pathway for ARID4B Gene
  • Transcription Sin3 and NuRD in transcription regulation

Gene Ontology (GO) - Biological Process for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with ARID4B: view

No data available for SIGNOR curated interactions for ARID4B Gene

Drugs & Compounds for ARID4B Gene

No Compound Related Data Available

Transcripts for ARID4B Gene

mRNA/cDNA for ARID4B Gene

3 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARID4B Gene

No ASD Table

Relevant External Links for ARID4B Gene

GeneLoc Exon Structure for
ARID4B

Expression for ARID4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARID4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARID4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Gallbladder (11.1), CD8 Tcells (10.3), and Cerebrospinal fluid (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARID4B Gene



Protein tissue co-expression partners for ARID4B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARID4B

SOURCE GeneReport for Unigene cluster for ARID4B Gene:

Hs.575782

mRNA Expression by UniProt/SwissProt for ARID4B Gene:

Q4LE39-ARI4B_HUMAN
Tissue specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.

Evidence on tissue expression from TISSUES for ARID4B Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with ARID4B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARID4B Gene

Orthologs for ARID4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID4B 31 30
  • 99.67 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ARID4B 31 30
  • 93.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARID4B 31 30
  • 90.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arid4b 17 31 30
  • 88.27 (n)