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This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structur... See more...
Aliases for ARID3A Gene
Aliases for ARID3A Gene
External Ids for ARID3A Gene
- HGNC: 3031
- Entrez Gene: 1820
- Ensembl: ENSG00000116017
- OMIM: 603265
- UniProtKB: Q99856
Previous HGNC Symbols for ARID3A Gene
- DRIL1
Previous GeneCards Identifiers for ARID3A Gene
- GC19P000880
- GC19P000877
- GC19P000699
Summaries for ARID3A Gene
-
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARID3A Gene
ARID3A (AT-Rich Interaction Domain 3A) is a Protein Coding gene. Diseases associated with ARID3A include Retinitis Pigmentosa 18 and 46,Xy Sex Reversal 8. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is ARID3B.
UniProtKB/Swiss-Prot Summary for ARID3A Gene
-
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
Additional gene information for ARID3A Gene
- HGNC(3031)
- Entrez Gene(1820)
- Ensembl(ENSG00000116017)
- OMIM(603265)
- UniProtKB(Q99856)
- Open Targets Platform(ENSG00000116017)
- Search for ARID3A at DataMed
- Search for ARID3A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARID3A Gene
Genomics for ARID3A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ARID3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ARID3A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARID3A
- Top Transcription factor binding sites by QIAGEN in the ARID3A gene promoter:
-
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- p53
Genomic Locations for ARID3A Gene
Genomic Locations for ARID3A Gene
- chr19:925,733-975,939
- (GRCh38/hg38)
- Size:
- 50,207 bases
- Orientation:
- Plus strand
- chr19:925,781-975,939
- (GRCh37/hg19)
- Size:
- 50,159 bases
- Orientation:
- Plus strand
Genomic View for ARID3A Gene
Genes around ARID3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by HGNC
- 19p13.3 by Entrez Gene
- 19p13.3 by Ensembl
ARID3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARID3A Gene
Proteins for ARID3A Gene
-
Protein details for ARID3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99856-ARI3A_HUMAN
- Recommended name:
- AT-rich interactive domain-containing protein 3A
- Protein Accession:
- Q99856
- Q5I858
- Q6P9C6
- Q8IZA7
- Q8N4Z3
Protein attributes for ARID3A Gene
- Size:
- 593 amino acids
- Molecular mass:
- 62889 Da
- Quaternary structure:
-
- Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.
- SequenceCaution:
-
- Sequence=AAW30734.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for ARID3A Gene
Post-translational modifications for ARID3A Gene
Other Protein References for ARID3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ARID3A
- Novus Biologicals Antibodies for ARID3A
-
Abcam antibodies for ARID3A
- Invitrogen Antibodies for ARID3A (AFLGC-ARID3A)
-
Biorbyt antibodies for ARID3A
-
Boster Bio Antibodies for ARID3A
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARID3A
- Sino Biological Antibodies for ARID3A
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ARID3A
- Origene Custom Protein Services for ARID3A
-
Abcam proteins for ARID3A
No data available for DME Specific Peptides for ARID3A Gene
Domains & Families for ARID3A Gene
Gene Families for ARID3A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ARID3A Gene
- InterPro:
- Blocks:
-
- ARID (AT-rich interaction domain) protein
- ProtoNet:
Suggested Antigen Peptide Sequences for ARID3A Gene
- GenScript: Design optimal peptide antigens:
-
- E2F-binding protein 1 (ARI3A_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARID3A Gene
Function for ARID3A Gene
Molecular function for ARID3A Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
- UniProtKB/Swiss-Prot Induction:
- By p53/TP53 following DNA damage.
Phenotypes From GWAS Catalog for ARID3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IBA | 21873635 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,IBA | 21873635 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
Phenotypes for ARID3A Gene
- MGI mutant phenotypes for ARID3A:
-
inferred from 2 alleles
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- growth/size/body region phenotype
- liver/biliary system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for ARID3A:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased NF-kappaB reporter expression
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage; decreased viability in pancreas lineage
Animal Models for ARID3A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARID3A - Select products 50% OFF >
- * ARID3A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for ARID3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARID3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARID3A
miRNA for ARID3A Gene
- miRTarBase miRNAs that target ARID3A
-
- mmu-miR-125b-5p (MIRT004797)
- hsa-let-7b-5p (MIRT005059)
- hsa-miR-30b-5p (MIRT023439)
- hsa-miR-98-5p (MIRT027857)
- hsa-let-7d-5p (MIRT032173)
- hsa-miR-484 (MIRT041956)
- hsa-miR-425-3p (MIRT042421)
- hsa-miR-125b-5p (MIRT052991)
- bta-miR-146a (MIRT053917)
- bta-miR-146b (MIRT053933)
- hsa-miR-30a-5p (MIRT152409)
- hsa-miR-148a-3p (MIRT152411)
- hsa-miR-30c-5p (MIRT152412)
- hsa-miR-30d-5p (MIRT152413)
- hsa-miR-152-3p (MIRT152417)
- hsa-miR-30e-5p (MIRT152419)
- hsa-miR-148b-3p (MIRT152420)
- hsa-miR-3171 (MIRT152426)
- hsa-miR-6757-5p (MIRT152443)
- hsa-miR-8485 (MIRT152452)
- hsa-let-7c-5p (MIRT439171)
- hsa-miR-6722-3p (MIRT494676)
- hsa-miR-1909-3p (MIRT494677)
- hsa-miR-6836-5p (MIRT494678)
- hsa-miR-6132 (MIRT494679)
- hsa-miR-202-3p (MIRT494680)
- hsa-miR-4500 (MIRT494681)
- hsa-let-7f-5p (MIRT494682)
- hsa-let-7g-5p (MIRT494683)
- hsa-miR-4458 (MIRT494684)
- hsa-let-7i-5p (MIRT494685)
- hsa-let-7a-5p (MIRT494686)
- hsa-let-7e-5p (MIRT494687)
- hsa-miR-1277-5p (MIRT509998)
- hsa-miR-190a-3p (MIRT509999)
- hsa-miR-5011-5p (MIRT510000)
- hsa-miR-6083 (MIRT524870)
- hsa-miR-4753-3p (MIRT524871)
- hsa-miR-130b-5p (MIRT524872)
- mmu-miR-376b-3p (MIRT584822)
- mmu-miR-3060-3p (MIRT584823)
- mmu-miR-692 (MIRT601199)
- mmu-miR-129-5p (MIRT601200)
- hsa-miR-1238-3p (MIRT613318)
- hsa-miR-670-3p (MIRT613319)
- hsa-miR-6749-3p (MIRT613320)
- hsa-miR-6792-3p (MIRT613321)
- hsa-miR-4691-5p (MIRT613322)
- hsa-miR-660-3p (MIRT613323)
- hsa-miR-5193 (MIRT613324)
- hsa-miR-7856-5p (MIRT615142)
- hsa-miR-556-3p (MIRT615990)
- hsa-miR-6809-3p (MIRT707561)
- hsa-miR-99b-5p (MIRT735257)
- hsa-miR-125a-5p (MIRT735258)
- hsa-miR-129-5p (MIRT783449)
- hsa-miR-3140-3p (MIRT784634)
- hsa-miR-6885-3p (MIRT789304)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARID3A
- Browse OriGene Inhibitory RNA Products For ARID3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARID3A
Clone Products
- Applied Biological Materials (abm): Clones for ARID3A - Select products 50% OFF >
- * ARID3A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ARID3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARID3A
Cell Line Products
-
Horizon Cell Lines for ARID3A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID3A Gene
Localization for ARID3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARID3A Gene
- Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0045121 | membrane raft | IDA | 21955986 |
Pathways & Interactions for ARID3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | TP53 Regulates Transcription of Cell Cycle Genes | ||
| 3 | Regulation of TP53 Activity | ||
| 4 | Direct p53 effectors | ||
Pathways by source for ARID3A Gene
1 BioSystems pathway for ARID3A Gene
Interacting Proteins for ARID3A Gene
Selected Interacting proteins:
Q99856-ARI3A_HUMAN
ENSP00000263620
for ARID3A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ARID3A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for ARID3A Gene
Transcripts for ARID3A Gene
mRNA/cDNA for ARID3A Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000585895 377 nts (view in UCSC)
- ENST00000263620 5948 nts (view in UCSC)
- ENST00000592216 564 nts (view in UCSC)
- ENST00000587532 1016 nts (view in UCSC)
- ENST00000457152 549 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ARID3A - Select products 50% OFF >
- * ARID3A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ARID3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARID3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARID3A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARID3A
- Browse OriGene Inhibitory RNA Products For ARID3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARID3A
Clone Products
- Applied Biological Materials (abm): Clones for ARID3A - Select products 50% OFF >
- * ARID3A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ARID3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARID3A
Relevant External Links for ARID3A Gene
- GeneLoc Exon Structure for
- ARID3A
Expression for ARID3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for ARID3A Gene
This gene is overexpressed in Whole Blood (x9.8).
This gene is overexpressed in Fetal gut (28.0), Placenta (19.2), and Monocytes (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARID3A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARID3A
SOURCE GeneReport for Unigene cluster for ARID3A Gene:
Hs.501296mRNA Expression by UniProt/SwissProt for ARID3A Gene:
Q99856-ARI3A_HUMAN
Tissue specificity:
Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
Evidence on tissue expression from TISSUES for ARID3A Gene
- Blood(2.6)
- Skin(2.5)
- Intestine(2.4)
- Liver(2.4)
- Bone marrow(2.2)
- Kidney(2.1)
- Lung(2.1)
- Nervous system(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for ARID3A
-
OriGene qPCR primer pairs and template standards for ARID3A
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARID3A Gene
Orthologs for ARID3A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ARID3A 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ARID3A 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ARID3A 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ARID3A 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Arid3a 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Arid3a 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ARID3A 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ARID3A 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | arid3a 30 |
|
||
| Str.11240 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.26694 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC562799 30 |
|
||
| ARID3A 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | retn 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cfi-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6971 31 |
|
OneToMany |
- Species where no ortholog for ARID3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ARID3A Gene
- ENSEMBL:
- Gene Tree for ARID3A (if available)
- TreeFam:
- Gene Tree for ARID3A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ARID3A: view image
Paralogs for ARID3A Gene
Variants for ARID3A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARID3A Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 727639 | Benign: not provided | 971,936(+) | C/T | SYNONYMOUS_VARIANT | |
| 783810 | Benign: not provided | 929,763(+) | G/A | MISSENSE_VARIANT | |
| 784382 | Benign: not provided | 968,475(+) | G/A | SYNONYMOUS_VARIANT | |
| 785596 | Benign: not provided | 966,714(+) | A/G | SYNONYMOUS_VARIANT | |
| 788008 | Benign: not provided | 966,831(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv134n111 | CNV | deletion | 26073780 |
| esv1501734 | CNV | deletion | 17803354 |
| esv2665746 | CNV | deletion | 23128226 |
| esv2673891 | CNV | deletion | 23128226 |
| esv2717811 | CNV | deletion | 23290073 |
| esv2717812 | CNV | deletion | 23290073 |
| esv2717813 | CNV | deletion | 23290073 |
| esv2758743 | CNV | gain+loss | 17122850 |
| esv3453 | CNV | loss | 18987735 |
| esv3643377 | CNV | loss | 21293372 |
| esv3643378 | CNV | loss | 21293372 |
| esv3643379 | CNV | gain | 21293372 |
| nsv1072834 | CNV | deletion | 25765185 |
| nsv1072835 | CNV | deletion | 25765185 |
| nsv1127642 | CNV | deletion | 24896259 |
| nsv1160555 | CNV | deletion | 26073780 |
| nsv469845 | CNV | loss | 16826518 |
| nsv470101 | CNV | loss | 18288195 |
| nsv578188 | CNV | loss | 21841781 |
| nsv833704 | CNV | gain | 17160897 |
| nsv953938 | CNV | deletion | 24416366 |
| nsv9662 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.28;
40.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ARID3A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3A Gene
Disorders for ARID3A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 18 |
|
|
| 46,xy sex reversal 8 |
|
|
| hypercholesterolemia, familial, 4 |
|
|
| 46,xy sex reversal |
|
|
| brain cancer |
|
|
Search ARID3A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ARID3A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ARID3A Gene
Publications for ARID3A Gene
- The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome. (PMID: 9722953) Kortschak RD … Jenne DE (Genomics 1998) 2 3 4
- Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target. (PMID: 20455271) Liu G … Montelione GT (Proteins 2010) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- A genome-wide association study of optic disc parameters. (PMID: 20548946) Ramdas WD … van Duijn CM (PLoS genetics 2010) 3 41
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
ExternalLinks
Products for ARID3A Gene
- Custom Antibody ServicesOriGene Antibodies for ARID3A
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ARID3A
- Origene Custom Protein Services for ARID3A
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ARID3A
- Browse OriGene Inhibitory RNA Products For ARID3A
- OriGene qPCR primer pairs for ARID3A
- OriGene qPCR primer pairs and template standards for ARID3A
- OriGene CRISPR knockouts for ARID3A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ARID3A
- Sino Biological Human cDNA Clone for ARID3A
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- Sino Biological Antibodies for ARID3A
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ARID3A
- Novus Biologicals proteins and lysates for ARID3A
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- Abcam antibodies for ARID3A
- Abcam proteins for ARID3A
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- Invitrogen Antibodies for ARID3A (AFLGC-ARID3A)
- VectorBuilder Custom and pre-made DNA vectors for ARID3A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ARID3A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ARID3A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ARID3A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ARID3A
- antibodies-online: Show 13 available ARID3A Antibodies ranked by validation data
- Compare Top ARID3A Antibodies
- antibodies-online: Search results for available ARID3A related products ranked by validation data
- antibodies-online: Show 5 available ARID3A Proteins ranked by validation data
- Compare Top ARID3A Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ARID3A
- Search Santa Cruz Biotechnology (SCBT) for ARID3A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ARID3A
- Horizon Cell Lines for ARID3A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ARID3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ARID3A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ARID3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARID3A
- Boster Bio Antibodies for ARID3A
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ARID3A
Sources for ARID3A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB