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Aliases for ARHGEF6 Gene

Aliases for ARHGEF6 Gene

  • Rac/Cdc42 Guanine Nucleotide Exchange Factor 6 2 3 4 5
  • Rac/Cdc42 Guanine Nucleotide Exchange Factor (GEF) 6 2 3
  • Rac/Cdc42 Guanine Exchange Factor (GEF) 6 2 3
  • Rho Guanine Nucleotide Exchange Factor 6 2 3
  • PAK-Interacting Exchange Factor, Alpha 2 3
  • COOL2 3 4
  • PIXA 3 4
  • PAK-Interacting Exchange Factor Alpha 4
  • Mental Retardation, X-Linked 46 2
  • Alpha-PIX 3
  • Alpha-Pix 4
  • AlphaPIX 3
  • KIAA0006 4
  • Cool-2 3
  • COOL-2 4
  • MRX46 3

External Ids for ARHGEF6 Gene

Previous HGNC Symbols for ARHGEF6 Gene

  • MRX46

Previous GeneCards Identifiers for ARHGEF6 Gene

  • GC0XM130319
  • GC0XM132593
  • GC0XM133692
  • GC0XM134453
  • GC0XM135473
  • GC0XM135575
  • GC0XM135747
  • GC0XM125018

Summaries for ARHGEF6 Gene

Entrez Gene Summary for ARHGEF6 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF6 Gene

ARHGEF6 (Rac/Cdc42 Guanine Nucleotide Exchange Factor 6) is a Protein Coding gene. Diseases associated with ARHGEF6 include X-Linked Non-Specific Intellectual Disability and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are ERK Signaling and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for ARHGEF6 Gene

  • Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Gene Wiki entry for ARHGEF6 Gene

Additional gene information for ARHGEF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF6 Gene

Genomics for ARHGEF6 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF6 Gene

Promoters and enhancers for ARHGEF6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ136778 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 660.7 +0.6 631 6.9 PKNOX1 ATF1 NEUROD1 FOS RCOR1 RUNX3 HCFC1 CEBPB GATAD2B ELF1 ARHGEF6 LOC100420958 RNU6-972P
GH0XJ136878 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.5 -98.0 -97982 2.9 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B RBMX GC0XM136880 GC0XM136881 SNORD61 SRRM1P3 LOC100420958 ARHGEF6 ENSG00000232611
GH0XJ136764 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 13.3 +14.8 14790 4.6 PKNOX1 ATF1 ARNT FEZF1 TCF12 GLIS2 GATA2 ZNF143 FOS ATF7 ARHGEF6 LOC100420958 PIR61624 GC0XP136774
GH0XJ136744 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 +35.5 35455 3.6 HDAC1 MEIS2 TEAD4 TAL1 MAX CCNT2 TCF12 CTBP1 NCOR1 POLR2A ARHGEF6 PIR61624 GC0XP136652
GH0XJ136749 Enhancer 0.6 dbSUPER 11.4 +32.0 32033 1.5 MEIS2 CEBPB REST CEBPG DPF2 ATF2 IRF9 FOSL1 ATF4 KLF16 ARHGEF6 PIR61624 GC0XP136652
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARHGEF6 gene promoter:
  • MRF-2
  • Nkx2-5
  • POU3F2
  • CHOP-10
  • FOXI1
  • HFH-3
  • HOXA9
  • HOXA9B
  • C/EBPalpha
  • Meis-1b

Genomic Locations for ARHGEF6 Gene

Genomic Locations for ARHGEF6 Gene
116,542 bases
Minus strand
116,542 bases
Minus strand

Genomic View for ARHGEF6 Gene

Genes around ARHGEF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF6 Gene

Proteins for ARHGEF6 Gene

  • Protein details for ARHGEF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 6
    Protein Accession:
    Secondary Accessions:
    • A6NMW9
    • A8K6S7
    • B1AL37
    • Q15396
    • Q5JQ66
    • Q7Z3W1
    • Q86XH0

    Protein attributes for ARHGEF6 Gene

    776 amino acids
    Molecular mass:
    87499 Da
    Quaternary structure:
    • Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
    • Sequence=BAA02796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF6 Gene

    Alternative splice isoforms for ARHGEF6 Gene


neXtProt entry for ARHGEF6 Gene

Post-translational modifications for ARHGEF6 Gene

  • Ubiquitination at Lys736, posLast=722722, Lys712, and Lys682
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGEF6 Gene

Domains & Families for ARHGEF6 Gene

Gene Families for ARHGEF6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF6: view

No data available for UniProtKB/Swiss-Prot for ARHGEF6 Gene

Function for ARHGEF6 Gene

Molecular function for ARHGEF6 Gene

UniProtKB/Swiss-Prot Function:
Acts as a RAC1 guanine nucleotide exchange factor (GEF).

Gene Ontology (GO) - Molecular Function for ARHGEF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS,NAS --
GO:0005096 GTPase activator activity NAS 9582122
GO:0005515 protein binding IPI 11864573
genes like me logo Genes that share ontologies with ARHGEF6: view
genes like me logo Genes that share phenotypes with ARHGEF6: view

Human Phenotype Ontology for ARHGEF6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ARHGEF6 Gene

MGI Knock Outs for ARHGEF6:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for ARHGEF6 Gene

Localization for ARHGEF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF6 Gene

Cell projection, lamellipodium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF6 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGEF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030027 lamellipodium ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARHGEF6: view

Pathways & Interactions for ARHGEF6 Gene

genes like me logo Genes that share pathways with ARHGEF6: view

Gene Ontology (GO) - Biological Process for ARHGEF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 11564864
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007254 JNK cascade NAS 11564864
GO:0030032 lamellipodium assembly ISS --
GO:0035023 regulation of Rho protein signal transduction IEA --
genes like me logo Genes that share ontologies with ARHGEF6: view

No data available for SIGNOR curated interactions for ARHGEF6 Gene

Drugs & Compounds for ARHGEF6 Gene

(3) Drugs for ARHGEF6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF6: view

Transcripts for ARHGEF6 Gene

mRNA/cDNA for ARHGEF6 Gene

Unigene Clusters for ARHGEF6 Gene

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF6 Gene

No ASD Table

Relevant External Links for ARHGEF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.6) and Lymph node (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF6 Gene

Protein tissue co-expression partners for ARHGEF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF6 Gene:


SOURCE GeneReport for Unigene cluster for ARHGEF6 Gene:


mRNA Expression by UniProt/SwissProt for ARHGEF6 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ARHGEF6 Gene

  • Nervous system(4.7)
  • Bone marrow(4.2)
  • Liver(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
  • lung
  • rib
  • rib cage
  • pelvis
  • testicle
  • urinary bladder
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ARHGEF6: view

No data available for mRNA differential expression in normal tissues for ARHGEF6 Gene

Orthologs for ARHGEF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF6 34 33
  • 96.5 (n)
(Bos Taurus)
Mammalia ARHGEF6 34 33
  • 92.44 (n)
(Canis familiaris)
Mammalia ARHGEF6 34 33
  • 91.61 (n)
(Rattus norvegicus)
Mammalia Arhgef6 33
  • 89.06 (n)
(Mus musculus)
Mammalia Arhgef6 16 34 33
  • 88.83 (n)
(Ornithorhynchus anatinus)
Mammalia ARHGEF6 34
  • 81 (a)
(Monodelphis domestica)
Mammalia ARHGEF6 34
  • 80 (a)
(Gallus gallus)
Aves ARHGEF6 34 33
  • 72.21 (n)
(Anolis carolinensis)
Reptilia ARHGEF6 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef6 33
  • 70.27 (n)
(Danio rerio)
Actinopterygii LOC558288 33
  • 63.32 (n)
arhgef6 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta rtGEF 34 35
  • 15 (a)
(Caenorhabditis elegans)
Secernentea pix-1 34
  • 26 (a)
K11E4.4 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2909 34
  • 39 (a)
Species where no ortholog for ARHGEF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF6 Gene

Gene Tree for ARHGEF6 (if available)
Gene Tree for ARHGEF6 (if available)
Evolutionary constrained regions (ECRs) for ARHGEF6: view image

Paralogs for ARHGEF6 Gene

(6) SIMAP similar genes for ARHGEF6 Gene using alignment to 2 proteins:

  • B7Z3C7_HUMAN
genes like me logo Genes that share paralogs with ARHGEF6: view

Variants for ARHGEF6 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1008606304 uncertain-significance, Non-syndromic X-linked intellectual disability 136,667,942(-) A/G 3_prime_UTR_variant
rs1057515774 uncertain-significance, Non-syndromic X-linked intellectual disability 136,665,903(-) C/T 3_prime_UTR_variant
rs1057515775 uncertain-significance, Non-syndromic X-linked intellectual disability 136,666,077(-) T/C 3_prime_UTR_variant
rs1057515776 uncertain-significance, Non-syndromic X-linked intellectual disability 136,667,434(-) G/A 3_prime_UTR_variant
rs1057515778 uncertain-significance, Non-syndromic X-linked intellectual disability 136,667,905(-) GAGAGAGAGAGAGAGA/GAGAGAGAGAGA 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF6 Gene

Variant ID Type Subtype PubMed ID
nsv7109 CNV insertion 18451855

Variation tolerance for ARHGEF6 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF6 Gene

Disorders for ARHGEF6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ARHGEF6 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
x-linked non-specific intellectual disability
  • x-linked non-syndromic intellectual disability
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
syndromic x-linked intellectual disability
  • syndromic intellectual disability, x-linked
supraglottis cancer
  • ca larynx - supraglottis
respiratory system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards


  • Mental retardation, X-linked 46 (MRX46) [MIM:300436]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:11017088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ARHGEF6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ARHGEF6: view

No data available for Genatlas for ARHGEF6 Gene

Publications for ARHGEF6 Gene

  1. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. (PMID: 11017088) Kutsche K … Gal A (Nature genetics 2000) 3 4 22 58
  2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 44 58
  3. PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation. (PMID: 16897755) Gringel A … Linder S (Journal of cellular physiology 2006) 3 22 58
  4. Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin. (PMID: 16320026) Yokota T … Tsunoda T (Acta neuropathologica 2006) 3 22 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58

Products for ARHGEF6 Gene

Sources for ARHGEF6 Gene

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