Aliases for ARHGEF5 Gene
External Ids for ARHGEF5 Gene
Previous GeneCards Identifiers for ARHGEF5 Gene
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF5 Gene
ARHGEF5 (Rho Guanine Nucleotide Exchange Factor 5) is a Protein Coding gene. Diseases associated with ARHGEF5 include Warsaw Breakage Syndrome and Sveinsson Chorioretinal Atrophy. Among its related pathways are fMLP Pathway and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include GTP binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.
UniProtKB/Swiss-Prot Summary for ARHGEF5 Gene
Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).