Aliases for ARHGEF4 Gene
External Ids for ARHGEF4 Gene
Previous GeneCards Identifiers for ARHGEF4 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
GeneCards Summary for ARHGEF4 Gene
ARHGEF4 (Rho Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with ARHGEF4 include Locked-In Syndrome and Epidermolysis Bullosa Simplex, Dowling-Meara Type. Among its related pathways are Development HGF signaling pathway and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and Rho guanyl-nucleotide exchange factor activity.
UniProtKB/Swiss-Prot Summary for ARHGEF4 Gene
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.