Aliases for ARHGEF4 Gene
External Ids for ARHGEF4 Gene
Previous GeneCards Identifiers for ARHGEF4 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
GeneCards Summary for ARHGEF4 Gene
ARHGEF4 (Rho Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with ARHGEF4 include Locked-In Syndrome. Among its related pathways are Guidance Cues and Growth Cone Motility and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is SPATA13.
UniProtKB/Swiss-Prot Summary for ARHGEF4 Gene
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.