Aliases for ARHGEF38 Gene

Aliases for ARHGEF38 Gene

  • Rho Guanine Nucleotide Exchange Factor 38 2 3 3 4 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 38 2 3
  • ARHGEF38 5
  • FLJ20184 2

External Ids for ARHGEF38 Gene

Previous GeneCards Identifiers for ARHGEF38 Gene

  • GC04P106474
  • GC04P102208

Summaries for ARHGEF38 Gene

GeneCards Summary for ARHGEF38 Gene

ARHGEF38 (Rho Guanine Nucleotide Exchange Factor 38) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DNMBP.

UniProtKB/Swiss-Prot Summary for ARHGEF38 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGEF38 Gene

Genomics for ARHGEF38 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGEF38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF38 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGEF38

Genomic Locations for ARHGEF38 Gene

Latest Assembly
chr4:105,552,604-105,708,093
(GRCh38/hg38)
Size:
155,490 bases
Orientation:
Plus strand

Previous Assembly
chr4:106,473,777-106,602,071
(GRCh37/hg19 by Entrez Gene)
Size:
128,295 bases
Orientation:
Plus strand

chr4:106,473,777-106,629,250
(GRCh37/hg19 by Ensembl)
Size:
155,474 bases
Orientation:
Plus strand

Genomic View for ARHGEF38 Gene

Genes around ARHGEF38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF38 Gene

Proteins for ARHGEF38 Gene

  • Protein details for ARHGEF38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXL2-ARH38_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 38
    Protein Accession:
    Q9NXL2
    Secondary Accessions:
    • C9JIB4

    Protein attributes for ARHGEF38 Gene

    Size:
    777 amino acids
    Molecular mass:
    89078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGEF38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF38 Gene

Post-translational modifications for ARHGEF38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF38 Gene

No data available for DME Specific Peptides for ARHGEF38 Gene

Domains & Families for ARHGEF38 Gene

Gene Families for ARHGEF38 Gene

Protein Domains for ARHGEF38 Gene

Suggested Antigen Peptide Sequences for ARHGEF38 Gene

GenScript: Design optimal peptide antigens:
  • Rho guanine nucleotide exchange factor 38 (ARH38_HUMAN)
genes like me logo Genes that share domains with ARHGEF38: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGEF38 Gene

Function for ARHGEF38 Gene

Molecular function for ARHGEF38 Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine-nucleotide releasing factor.

Phenotypes From GWAS Catalog for ARHGEF38 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IBA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ARHGEF38: view

Phenotypes for ARHGEF38 Gene

genes like me logo Genes that share phenotypes with ARHGEF38: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF38

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF38 Gene

Localization for ARHGEF38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF38 gene
Compartment Confidence
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGEF38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF38 Gene

Pathways & Interactions for ARHGEF38 Gene

genes like me logo Genes that share pathways with ARHGEF38: view

Gene Ontology (GO) - Biological Process for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ARHGEF38: view

No data available for SIGNOR curated interactions for ARHGEF38 Gene

Drugs & Compounds for ARHGEF38 Gene

No Compound Related Data Available

Transcripts for ARHGEF38 Gene

mRNA/cDNA for ARHGEF38 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF38

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF38 Gene

No ASD Table

Relevant External Links for ARHGEF38 Gene

GeneLoc Exon Structure for
ARHGEF38

Expression for ARHGEF38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF38 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF38 Gene

This gene is overexpressed in Pancreas (x9.5), Prostate (x6.2), Breast - Mammary Tissue (x6.1), and Minor Salivary Gland (x5.5).

Protein differential expression in normal tissues from HIPED for ARHGEF38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF38 Gene



Protein tissue co-expression partners for ARHGEF38 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGEF38

SOURCE GeneReport for Unigene cluster for ARHGEF38 Gene:

Hs.585224

Evidence on tissue expression from TISSUES for ARHGEF38 Gene

  • Intestine(4.3)
  • Lung(2.8)
genes like me logo Genes that share expression patterns with ARHGEF38: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF38 Gene

Orthologs for ARHGEF38 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF38 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARHGEF38 29 30
  • 99.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 90 (a)
OneToMany
ARHGEF38 29
  • 88.76 (n)
-- 30
  • 69 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ARHGEF38 29 30
  • 87.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Arhgef38 30
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arhgef38 29
  • 81.61 (n)
Oppossum
(Monodelphis domestica)
Mammalia ARHGEF38 30
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 73 (a)
OneToMany
-- 30
  • 72 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ARHGEF38 29 30
  • 72.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARHGEF38 30
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia arhgef38 29
  • 66.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii arhgef38 29
  • 59.36 (n)
ARHGEF38 30
  • 44 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y37A1B.17 30
  • 11 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 35 (a)
OneToMany
Species where no ortholog for ARHGEF38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ARHGEF38 Gene

ENSEMBL:
Gene Tree for ARHGEF38 (if available)
TreeFam:
Gene Tree for ARHGEF38 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGEF38: view image
Alliance of Genome Resources:
Additional Orthologs for ARHGEF38

Paralogs for ARHGEF38 Gene

Paralogs for ARHGEF38 Gene

(2) SIMAP similar genes for ARHGEF38 Gene using alignment to 1 proteins:

  • ARH38_HUMAN
genes like me logo Genes that share paralogs with ARHGEF38: view

Variants for ARHGEF38 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGEF38 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
VAR_038928 A breast cancer sample p.Lys67Asn
rs2276970 -- p.Met88Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARHGEF38 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF38 Gene

Variant ID Type Subtype PubMed ID
dgv5354n100 CNV loss 25217958
esv22942 CNV loss 19812545
esv2662994 CNV deletion 23128226
esv2728101 CNV deletion 23290073
esv2728102 CNV deletion 23290073
esv2728103 CNV deletion 23290073
esv3309216 CNV mobile element insertion 20981092
esv3365323 CNV insertion 20981092
esv3368333 CNV insertion 20981092
esv3392752 CNV insertion 20981092
esv3601664 CNV loss 21293372
esv3601667 CNV loss 21293372
nsv1000196 CNV loss 25217958
nsv1142403 CNV tandem duplication 24896259
nsv290938 CNV deletion 16902084
nsv291273 CNV deletion 16902084
nsv461610 CNV loss 19166990
nsv517837 CNV loss 19592680
nsv518958 CNV gain 19592680
nsv524424 CNV loss 19592680
nsv595008 CNV loss 21841781

Variation tolerance for ARHGEF38 Gene

Gene Damage Index Score: 8.36; 85.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF38
Leiden Open Variation Database (LOVD)
ARHGEF38

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF38 Gene

Disorders for ARHGEF38 Gene

Additional Disease Information for ARHGEF38

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ARHGEF38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF38 Gene

Publications for ARHGEF38 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  4. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PMID: 24023788) Ong BA … Hakonarson H (PloS one 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ARHGEF38 Gene

Sources for ARHGEF38 Gene