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Aliases for ARHGEF37 Gene

Aliases for ARHGEF37 Gene

  • Rho Guanine Nucleotide Exchange Factor 37 2 3 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 37 2 3

External Ids for ARHGEF37 Gene

Previous GeneCards Identifiers for ARHGEF37 Gene

  • GC05P148961
  • GC05P144107

Summaries for ARHGEF37 Gene

GeneCards Summary for ARHGEF37 Gene

ARHGEF37 (Rho Guanine Nucleotide Exchange Factor 37) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DNMBP.

UniProtKB/Swiss-Prot for ARHGEF37 Gene

  • May act as a guanine nucleotide exchange factor (GEF).

Additional gene information for ARHGEF37 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF37 Gene

Genomics for ARHGEF37 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF37 Gene

Promoters and enhancers for ARHGEF37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J149546 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.2 -1.7 -1703 6.2 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 ARHGEF37 CSNK1A1 HMGXB3 RPL7P1 RPS14 TIGD6 TCOF1 RPL29P14
GH05J149481 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.1 -65.0 -65032 9.6 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 POLR2B ARHGEF37 HMGXB3 TIGD6 MIR145 RPL29P14 CSNK1A1 CARMN IL17B MIR143 RNU6-588P
GH05J149495 Enhancer 1.4 UCNEbase Ensembl ENCODE dbSUPER 20.2 -54.4 -54355 4.1 ZNF362 ZNF664 POLR2B ZNF316 POLR2A SCRT2 FOS PRDM1 MAFK EMSY ARHGEF37 MIR145 RPL29P14 CSNK1A1 MIR143 RNU6-588P IL17B CARMN PCYOX1L ENSG00000230551
GH05J149403 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE dbSUPER 10 -136.6 -136584 23.4 FOXA2 ZFP64 ARID4B YBX1 ZNF48 ZNF121 GLIS2 ZFP91 FOS RXRA IL17B ENSG00000253865 RNU6-588P ARHGEF37 CSNK1A1 RPL29P14 AFAP1L1 ENSG00000253406 ENSG00000248647 RPL7P1
GH05J149580 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 13.3 +30.0 30024 1.9 NFIB KLF17 SIN3A KLF14 YY1 ZNF335 GLIS2 ZNF366 EGR2 ZEB2 ARHGEF37 RNU6-588P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF37 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGEF37 Gene

Genomic Locations for ARHGEF37 Gene
chr5:149,551,632-149,634,968
(GRCh38/hg38)
Size:
83,337 bases
Orientation:
Plus strand
chr5:148,931,510-149,014,531
(GRCh37/hg19)
Size:
83,022 bases
Orientation:
Plus strand

Genomic View for ARHGEF37 Gene

Genes around ARHGEF37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF37 Gene

Proteins for ARHGEF37 Gene

  • Protein details for ARHGEF37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1IGU5-ARH37_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 37
    Protein Accession:
    A1IGU5
    Secondary Accessions:
    • Q6ZW51

    Protein attributes for ARHGEF37 Gene

    Size:
    675 amino acids
    Molecular mass:
    76278 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85655.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARHGEF37 Gene

Post-translational modifications for ARHGEF37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF37 Gene

No data available for DME Specific Peptides for ARHGEF37 Gene

Domains & Families for ARHGEF37 Gene

Gene Families for ARHGEF37 Gene

Suggested Antigen Peptide Sequences for ARHGEF37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF37: view

No data available for UniProtKB/Swiss-Prot for ARHGEF37 Gene

Function for ARHGEF37 Gene

Molecular function for ARHGEF37 Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine nucleotide exchange factor (GEF).

Phenotypes From GWAS Catalog for ARHGEF37 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IBA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ARHGEF37: view
genes like me logo Genes that share phenotypes with ARHGEF37: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF37 Gene

Localization for ARHGEF37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF37 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARHGEF37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGEF37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF37 Gene

Pathways & Interactions for ARHGEF37 Gene

genes like me logo Genes that share pathways with ARHGEF37: view

Gene Ontology (GO) - Biological Process for ARHGEF37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IBA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with ARHGEF37: view

No data available for SIGNOR curated interactions for ARHGEF37 Gene

Drugs & Compounds for ARHGEF37 Gene

(3) Drugs for ARHGEF37 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF37: view

Transcripts for ARHGEF37 Gene

Unigene Clusters for ARHGEF37 Gene

Rho guanine nucleotide exchange factor (GEF) 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF37 Gene

No ASD Table

Relevant External Links for ARHGEF37 Gene

GeneLoc Exon Structure for
ARHGEF37
ECgene alternative splicing isoforms for
ARHGEF37

Expression for ARHGEF37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF37 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for ARHGEF37 Gene

This gene is overexpressed in Salivary gland (9.8) and Bone marrow mesenchymal stem cell (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF37 Gene



Protein tissue co-expression partners for ARHGEF37 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF37 Gene:

ARHGEF37

SOURCE GeneReport for Unigene cluster for ARHGEF37 Gene:

Hs.256206

Evidence on tissue expression from TISSUES for ARHGEF37 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with ARHGEF37: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF37 Gene

Orthologs for ARHGEF37 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF37 34 33
  • 98.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF37 34 33
  • 87.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF37 34 33
  • 86.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef37 33
  • 82.57 (n)
mouse
(Mus musculus)
Mammalia Arhgef37 16 34 33
  • 81.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF37 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGEF37 34 33
  • 64.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF37 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef37 33
  • 53.59 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883655 33
  • 51.61 (n)
CU074314.1 34
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37A1B.17 34
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for ARHGEF37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF37 Gene

ENSEMBL:
Gene Tree for ARHGEF37 (if available)
TreeFam:
Gene Tree for ARHGEF37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGEF37: view image

Paralogs for ARHGEF37 Gene

Paralogs for ARHGEF37 Gene

(2) SIMAP similar genes for ARHGEF37 Gene using alignment to 2 proteins:

  • ARH37_HUMAN
  • D6RJH4_HUMAN
genes like me logo Genes that share paralogs with ARHGEF37: view

Variants for ARHGEF37 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF37 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000082139 -- 149,584,502(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000107762 -- 149,608,034(+) C/T intron_variant
rs1000143839 -- 149,619,154(+) C/T intron_variant
rs1000175249 -- 149,604,631(+) C/T intron_variant
rs1000182634 -- 149,578,491(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF37 Gene

Variant ID Type Subtype PubMed ID
dgv1146e214 CNV gain 21293372
esv24490 CNV gain 19812545
esv2671746 CNV deletion 23128226
esv28001 CNV loss 19812545
esv3607148 CNV loss 21293372
nsv516760 CNV loss 19592680

Variation tolerance for ARHGEF37 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.13; 99.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF37 Gene

Disorders for ARHGEF37 Gene

Additional Disease Information for ARHGEF37

No disorders were found for ARHGEF37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF37 Gene

Publications for ARHGEF37 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) GENDEP Investigators … STAR*D Investigators (The American journal of psychiatry 2013) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for ARHGEF37 Gene

Sources for ARHGEF37 Gene

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