Aliases for ARHGEF35 Gene

Aliases for ARHGEF35 Gene

  • Rho Guanine Nucleotide Exchange Factor 35 2 3 3 4 5
  • Rho Guanine Nucleotide Exchange Factor 5-Like Protein 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 35 2 3
  • ARHGEF5L 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 5-Like 2
  • ARHGEF35 5
  • FLJ43692 2
  • CTAGE4 2

External Ids for ARHGEF35 Gene

Previous HGNC Symbols for ARHGEF35 Gene


Previous GeneCards Identifiers for ARHGEF35 Gene

  • GC07M143883
  • GC07M138082

Summaries for ARHGEF35 Gene

GeneCards Summary for ARHGEF35 Gene

ARHGEF35 (Rho Guanine Nucleotide Exchange Factor 35) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. An important paralog of this gene is ARHGEF5.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGEF35 Gene

Genomics for ARHGEF35 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGEF35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J144195 Promoter 0.7 EPDnew Ensembl 255.1 +0.2 178 2.6 ARHGEF35 ARHGEF35-AS1 LOC112267987 CTAGE4 RF00017-6179
GH07J143898 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 15.2 +292.7 292723 9 BCLAF1 SP1 MYC NCOR1 IKZF1 SSRP1 ZNF580 ZMYM3 KLF9 CEBPA TCAF1 ARHGEF35 CASP2 OR2A13P OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1 lnc-OR2F1-1
GH07J143881 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.8 +312.1 312085 5.2 SSRP1 POLR2A HOMEZ ZBTB7B SIN3A THAP11 FOXA2 SMAD4 RXRA SAP130 TCAF1 ARHGEF35 OR2A13P LOC105375549 lnc-CTAGE6-1 CTAGE6
GH07J144018 Enhancer 0.9 Ensembl ENCODE 25.5 +175.8 175770 3.4 JUND CEBPA CEBPB EP300 CTBP1 CUX1 STAT3 TCF7L2 ZNF217 SMARCE1 ARHGEF35 OR2A5 OR2F1 LOC154761 lnc-OR6B1-1 OR6B1 HSALNG0061982
GH07J143933 Enhancer 0.8 Ensembl ENCODE 23.7 +260.5 260474 2.9 FOXA2 MAFF ZNF316 MAFK MAFG JUND ATF4 RFX1 POLR2A HLF OR2F2 ARHGEF35 OR2F1 TCAF1 OR2A7 lnc-OR2F1-1 CAPZA1P5 lnc-TCAF1-1 OR6B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF35 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGEF35

Genomic Locations for ARHGEF35 Gene

Latest Assembly
9,797 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
9,797 bases
Minus strand

(GRCh37/hg19 by Ensembl)
108,055 bases
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr7(PATCHES):140,648-150,440 (-)

Genomic View for ARHGEF35 Gene

Genes around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF35 Gene

Proteins for ARHGEF35 Gene

  • Protein details for ARHGEF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 35
    Protein Accession:
    Secondary Accessions:
    • Q6ZUI2

    Protein attributes for ARHGEF35 Gene

    484 amino acids
    Molecular mass:
    53287 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGEF35 Gene

Post-translational modifications for ARHGEF35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF35 Gene

Domains & Families for ARHGEF35 Gene

Gene Families for ARHGEF35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGEF35 Gene


Suggested Antigen Peptide Sequences for ARHGEF35 Gene

GenScript: Design optimal peptide antigens:
  • Rho guanine nucleotide exchange factor 5-like protein (ARG35_HUMAN)
genes like me logo Genes that share domains with ARHGEF35: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGEF35 Gene

Function for ARHGEF35 Gene

Phenotypes From GWAS Catalog for ARHGEF35 Gene

genes like me logo Genes that share phenotypes with ARHGEF35: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF35 Gene

Localization for ARHGEF35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF35 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARHGEF35 Gene

Pathways & Interactions for ARHGEF35 Gene

genes like me logo Genes that share pathways with ARHGEF35: view

Gene Ontology (GO) - Biological Process for ARHGEF35 Gene


No data available for SIGNOR curated interactions for ARHGEF35 Gene

Drugs & Compounds for ARHGEF35 Gene

No Compound Related Data Available

Transcripts for ARHGEF35 Gene

mRNA/cDNA for ARHGEF35 Gene

7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF35

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF35 Gene

No ASD Table

Relevant External Links for ARHGEF35 Gene

GeneLoc Exon Structure for

Expression for ARHGEF35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF35 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.4), Esophagus - Mucosa (x4.9), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for ARHGEF35 Gene

This gene is overexpressed in Islet of Langerhans (51.6) and Placenta (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF35 Gene

Protein tissue co-expression partners for ARHGEF35 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGEF35

SOURCE GeneReport for Unigene cluster for ARHGEF35 Gene:

genes like me logo Genes that share expression patterns with ARHGEF35: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF35 Gene

Orthologs for ARHGEF35 Gene

Evolution for ARHGEF35 Gene

Gene Tree for ARHGEF35 (if available)
Gene Tree for ARHGEF35 (if available)
Evolutionary constrained regions (ECRs) for ARHGEF35: view image
Alliance of Genome Resources:
Additional Orthologs for ARHGEF35

No data available for Orthologs for ARHGEF35 Gene

Paralogs for ARHGEF35 Gene

Paralogs for ARHGEF35 Gene

(2) SIMAP similar genes for ARHGEF35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF35: view

Variants for ARHGEF35 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARHGEF35 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF35 Gene

Variant ID Type Subtype PubMed ID
dgv11668n54 CNV gain 21841781
dgv11669n54 CNV loss 21841781
dgv152e203 CNV gain+loss 21179565
dgv24n31 CNV gain 19718026
dgv253n111 CNV duplication 26073780
dgv3965e59 CNV duplication 20981092
dgv3966e59 CNV duplication 20981092
dgv3967e59 CNV duplication 20981092
dgv3968e59 CNV duplication 20981092
dgv6725n100 CNV gain 25217958
dgv6726n100 CNV gain 25217958
dgv6727n100 CNV loss 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6729n100 CNV gain 25217958
dgv6730n100 CNV loss 25217958
esv1003295 OTHER inversion 20482838
esv1682998 OTHER inversion 17803354
esv24292 CNV gain+loss 19812545
esv2759570 CNV gain+loss 17122850
esv33253 CNV gain 17666407
esv3369041 CNV duplication 20981092
esv3379639 CNV duplication 20981092
esv3411711 CNV duplication 20981092
esv3432947 CNV duplication 20981092
esv3891225 CNV gain 25118596
nsv1016831 CNV gain 25217958
nsv1032320 CNV gain 25217958
nsv1119234 CNV duplication 24896259
nsv1141557 CNV duplication 24896259
nsv1148453 CNV duplication 26484159
nsv428188 CNV gain+loss 18775914
nsv433394 CNV gain 18776910
nsv471454 CNV gain 19718026
nsv482116 CNV gain 20164927
nsv515040 CNV gain 21397061
nsv608699 CNV gain 21841781
nsv608721 CNV gain 21841781
nsv7411 OTHER inversion 18451855
nsv819701 CNV insertion 19587683
nsv821609 CNV duplication 20802225
nsv8227 CNV gain+loss 18304495
nsv824360 CNV gain 20364138
nsv831174 CNV loss 17160897
nsv831175 CNV loss 17160897
nsv831176 CNV loss 17160897
nsv970956 CNV duplication 23825009

Variation tolerance for ARHGEF35 Gene

Gene Damage Index Score: 1.25; 24.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ARHGEF35 Gene

Disorders for ARHGEF35 Gene

Additional Disease Information for ARHGEF35

No disorders were found for ARHGEF35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF35 Gene

Publications for ARHGEF35 Gene

  1. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  2. Transcriptional fates of human-specific segmental duplications in brain. (PMID: 30228200) Dougherty ML … Eichler EE (Genome research 2018) 3
  3. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (PMID: 28700943) Martin TD … Elledge SJ (Cell reports 2017) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ARHGEF35 Gene

Sources for ARHGEF35 Gene