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Aliases for ARHGEF35 Gene

Aliases for ARHGEF35 Gene

  • Rho Guanine Nucleotide Exchange Factor 35 2 3 5
  • Rho Guanine Nucleotide Exchange Factor 5-Like Protein 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 35 2 3
  • ARHGEF5L 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 5-Like 2

External Ids for ARHGEF35 Gene

Previous HGNC Symbols for ARHGEF35 Gene

  • ARHGEF5L

Previous GeneCards Identifiers for ARHGEF35 Gene

  • GC07M143883
  • GC07M138082

Summaries for ARHGEF35 Gene

GeneCards Summary for ARHGEF35 Gene

ARHGEF35 (Rho Guanine Nucleotide Exchange Factor 35) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR.

Additional gene information for ARHGEF35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF35 Gene

Genomics for ARHGEF35 Gene

GeneHancer (GH) Regulatory Elements for ARHGEF35 Gene

Promoters and enhancers for ARHGEF35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I144195 Promoter 1 EPDnew Ensembl 550.8 -0.1 -103 1.6 ARHGEF35 ENSG00000244198 LOC101928605 OR2A42
GH07I143898 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 15.2 +292.5 292542 9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 TCAF1 ARHGEF35 CASP2 OR2A13P OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1 LOC105375549
GH07I144018 Enhancer 1 Ensembl ENCODE 25.5 +175.6 175589 3.4 MEIS2 SOX13 JUN CEBPG BMI1 FOSL1 CTBP1 GATA3 POLR2A EGR1 ARHGEF35 OR2A5 OR2F1 LOC154761 OR6B1
GH07I143884 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11.8 +310.4 310409 1.4 CTCF MXI1 PKNOX1 ZBTB7B CHAMP1 ZNF335 ZFHX2 POLR2A EGR1 VEZF1 TCAF1 LOC105375549 ARHGEF35 GC07M143854
GH07I143933 Enhancer 0.7 ENCODE 23.7 +260.3 260293 2.9 FOXA2 RFX1 HLF MAFG CEBPG ZFHX2 ATF4 MAFF JUND ZNF316 OR2F2 ARHGEF35 OR2F1 TCAF1 OR2A7 LOC100422324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ARHGEF35 Gene

Genomic Locations for ARHGEF35 Gene
chr7:144,186,083-144,195,698
(GRCh38/hg38)
Size:
9,616 bases
Orientation:
Minus strand
chr7:143,883,176-143,991,230
(GRCh37/hg19)

Genomic View for ARHGEF35 Gene

Genes around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF35 Gene

Proteins for ARHGEF35 Gene

  • Protein details for ARHGEF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5YM69-ARG35_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 35
    Protein Accession:
    A5YM69
    Secondary Accessions:
    • Q6ZUI2

    Protein attributes for ARHGEF35 Gene

    Size:
    484 amino acids
    Molecular mass:
    53287 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGEF35 Gene

Post-translational modifications for ARHGEF35 Gene

No Post-translational modifications

Other Protein References for ARHGEF35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF35 Gene

Domains & Families for ARHGEF35 Gene

Gene Families for ARHGEF35 Gene

Protein Domains for ARHGEF35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARHGEF35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF35: view

No data available for UniProtKB/Swiss-Prot for ARHGEF35 Gene

Function for ARHGEF35 Gene

Phenotypes From GWAS Catalog for ARHGEF35 Gene

genes like me logo Genes that share phenotypes with ARHGEF35: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF35 Gene

Localization for ARHGEF35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF35 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARHGEF35 Gene

Pathways & Interactions for ARHGEF35 Gene

genes like me logo Genes that share pathways with ARHGEF35: view

Interacting Proteins for ARHGEF35 Gene

Gene Ontology (GO) - Biological Process for ARHGEF35 Gene

None

No data available for SIGNOR curated interactions for ARHGEF35 Gene

Drugs & Compounds for ARHGEF35 Gene

No Compound Related Data Available

Transcripts for ARHGEF35 Gene

mRNA/cDNA for ARHGEF35 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGEF35 Gene

Rho guanine nucleotide exchange factor (GEF) 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF35 Gene

No ASD Table

Relevant External Links for ARHGEF35 Gene

GeneLoc Exon Structure for
ARHGEF35
ECgene alternative splicing isoforms for
ARHGEF35

Expression for ARHGEF35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF35 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.4), Esophagus - Mucosa (x4.9), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for ARHGEF35 Gene

This gene is overexpressed in Islet of Langerhans (51.6) and Placenta (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF35 Gene



Protein tissue co-expression partners for ARHGEF35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF35 Gene:

ARHGEF35

SOURCE GeneReport for Unigene cluster for ARHGEF35 Gene:

Hs.534621
genes like me logo Genes that share expression patterns with ARHGEF35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF35 Gene

Orthologs for ARHGEF35 Gene

Evolution for ARHGEF35 Gene

ENSEMBL:
Gene Tree for ARHGEF35 (if available)
TreeFam:
Gene Tree for ARHGEF35 (if available)

No data available for Orthologs for ARHGEF35 Gene

Paralogs for ARHGEF35 Gene

(2) SIMAP similar genes for ARHGEF35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF35: view

No data available for Paralogs for ARHGEF35 Gene

Variants for ARHGEF35 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF35 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000492238 -- 144,186,998(-) G/A coding_sequence_variant, synonymous_variant
rs1001929716 -- 144,190,407(-) G/A intron_variant
rs1001982186 -- 144,192,085(-) G/C intron_variant
rs1004049686 -- 144,192,425(-) A/G intron_variant
rs1004342940 -- 144,197,104(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF35 Gene

Variant ID Type Subtype PubMed ID
nsv515040 CNV gain 21397061
nsv482116 CNV gain 20164927
nsv471454 CNV gain 19718026
nsv433394 CNV gain 18776910
nsv428188 CNV gain+loss 18775914
nsv1148453 CNV duplication 26484159
nsv1141557 CNV duplication 24896259
nsv1119234 CNV duplication 24896259
nsv1032320 CNV gain 25217958
nsv1016831 CNV gain 25217958
esv3891225 CNV gain 25118596
esv3432947 CNV duplication 20981092
esv3411711 CNV duplication 20981092
esv3379639 CNV duplication 20981092
esv3369041 CNV duplication 20981092
esv33253 CNV gain 17666407
esv2759570 CNV gain+loss 17122850
esv24292 CNV gain+loss 19812545
esv1682998 OTHER inversion 17803354
esv1003295 OTHER inversion 20482838
dgv6730n100 CNV loss 25217958
dgv6729n100 CNV gain 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6727n100 CNV loss 25217958
dgv6726n100 CNV gain 25217958
dgv6725n100 CNV gain 25217958
dgv3968e59 CNV duplication 20981092
dgv3967e59 CNV duplication 20981092
dgv3966e59 CNV duplication 20981092
dgv3965e59 CNV duplication 20981092
dgv253n111 CNV duplication 26073780
dgv24n31 CNV gain 19718026
dgv152e203 CNV gain+loss 21179565
dgv11669n54 CNV loss 21841781
dgv11668n54 CNV gain 21841781
nsv970956 CNV duplication 23825009
nsv831176 CNV loss 17160897
nsv831175 CNV loss 17160897
nsv831174 CNV loss 17160897
nsv824360 CNV gain 20364138
nsv8227 CNV gain+loss 18304495
nsv821609 CNV duplication 20802225
nsv819701 CNV insertion 19587683
nsv7411 OTHER inversion 18451855
nsv608721 CNV gain 21841781
nsv608699 CNV gain 21841781

Variation tolerance for ARHGEF35 Gene

Gene Damage Index Score: 1.25; 24.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF35 Gene

Disorders for ARHGEF35 Gene

Additional Disease Information for ARHGEF35

No disorders were found for ARHGEF35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF35 Gene

Publications for ARHGEF35 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ARHGEF35 Gene

Sources for ARHGEF35 Gene

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