Aliases for ARHGEF33 Gene

Aliases for ARHGEF33 Gene

  • Rho Guanine Nucleotide Exchange Factor 33 2 3 3 4 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 33 2 3
  • DH And Coiled-Coil Domain-Containing Protein ENSP00000381780 3
  • ARHGEF33 5

External Ids for ARHGEF33 Gene

Previous GeneCards Identifiers for ARHGEF33 Gene

  • GC02P039118

Summaries for ARHGEF33 Gene

GeneCards Summary for ARHGEF33 Gene

ARHGEF33 (Rho Guanine Nucleotide Exchange Factor 33) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot Summary for ARHGEF33 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ARHGEF33 Gene

Genomics for ARHGEF33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ARHGEF33 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ARHGEF33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ARHGEF33

Genomic Locations for ARHGEF33 Gene

Latest Assembly
chr2:38,889,875-38,975,454
(GRCh38/hg38)
Size:
85,580 bases
Orientation:
Plus strand

Previous Assembly
chr2:39,117,016-39,202,595
(GRCh37/hg19 by Entrez Gene)
Size:
85,580 bases
Orientation:
Plus strand

chr2:39,117,021-39,202,590
(GRCh37/hg19 by Ensembl)
Size:
85,570 bases
Orientation:
Plus strand

Genomic View for ARHGEF33 Gene

Genes around ARHGEF33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF33 Gene

Proteins for ARHGEF33 Gene

  • Protein details for ARHGEF33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MVX0-ARG33_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 33
    Protein Accession:
    A8MVX0
    Secondary Accessions:
    • J3KPX2

    Protein attributes for ARHGEF33 Gene

    Size:
    844 amino acids
    Molecular mass:
    94633 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DV080278; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF33 Gene

Post-translational modifications for ARHGEF33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF33 Gene

No data available for DME Specific Peptides for ARHGEF33 Gene

Domains & Families for ARHGEF33 Gene

Gene Families for ARHGEF33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARHGEF33 Gene

Suggested Antigen Peptide Sequences for ARHGEF33 Gene

GenScript: Design optimal peptide antigens:
  • Rho guanine nucleotide exchange factor 33 (ARG33_HUMAN)
genes like me logo Genes that share domains with ARHGEF33: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ARHGEF33 Gene

Function for ARHGEF33 Gene

Molecular function for ARHGEF33 Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine-nucleotide releasing factor.

Phenotypes From GWAS Catalog for ARHGEF33 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF33: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF33

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF33 Gene

Localization for ARHGEF33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF33 gene
Compartment Confidence
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF33 Gene

Pathways & Interactions for ARHGEF33 Gene

genes like me logo Genes that share pathways with ARHGEF33: view

Interacting Proteins for ARHGEF33 Gene

Gene Ontology (GO) - Biological Process for ARHGEF33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with ARHGEF33: view

No data available for SIGNOR curated interactions for ARHGEF33 Gene

Drugs & Compounds for ARHGEF33 Gene

No Compound Related Data Available

Transcripts for ARHGEF33 Gene

mRNA/cDNA for ARHGEF33 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ARHGEF33

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF33 Gene

No ASD Table

Relevant External Links for ARHGEF33 Gene

GeneLoc Exon Structure for
ARHGEF33

Expression for ARHGEF33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF33 Gene

This gene is overexpressed in Brain - Cerebellum (x12.1) and Brain - Cerebellar Hemisphere (x5.9).

Protein differential expression in normal tissues from HIPED for ARHGEF33 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF33 Gene



Protein tissue co-expression partners for ARHGEF33 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ARHGEF33

SOURCE GeneReport for Unigene cluster for ARHGEF33 Gene:

Hs.99841

Evidence on tissue expression from TISSUES for ARHGEF33 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ARHGEF33: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF33 Gene

Orthologs for ARHGEF33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARHGEF33 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ARHGEF33 29 30
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ARHGEF33 29 30
  • 93.49 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ARHGEF33 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Arhgef33 29 16 30
  • 88.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Arhgef33 29
  • 86.81 (n)
Cow
(Bos Taurus)
Mammalia ARHGEF33 30
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 82 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ARHGEF33 29 30
  • 70.31 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ARHGEF33 30
  • 65 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ARHGEF33 30
  • 30 (a)
OneToOne
Species where no ortholog for ARHGEF33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ARHGEF33 Gene

ENSEMBL:
Gene Tree for ARHGEF33 (if available)
TreeFam:
Gene Tree for ARHGEF33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ARHGEF33: view image
Alliance of Genome Resources:
Additional Orthologs for ARHGEF33

Paralogs for ARHGEF33 Gene

No data available for Paralogs for ARHGEF33 Gene

Variants for ARHGEF33 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ARHGEF33 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for ARHGEF33 Gene

Gene Damage Index Score: 2.15; 39.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARHGEF33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF33
Leiden Open Variation Database (LOVD)
ARHGEF33

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ARHGEF33 Gene

Disorders for ARHGEF33 Gene

Additional Disease Information for ARHGEF33

No disorders were found for ARHGEF33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF33 Gene

Publications for ARHGEF33 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. (PMID: 31753913) Kim JJ … Miller KM (Genes & development 2019) 3
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3

Products for ARHGEF33 Gene

Sources for ARHGEF33 Gene