Aliases for ARHGEF3 Gene
External Ids for ARHGEF3 Gene
Previous GeneCards Identifiers for ARHGEF3 Gene
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF3 Gene
ARHGEF3 (Rho Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with ARHGEF3 include Methotrexate-Associated Lymphoproliferation and Osteoporosis. Among its related pathways are fMLP Pathway and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is NET1.
UniProtKB/Swiss-Prot Summary for ARHGEF3 Gene
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.